CY1110403T1 - Μεθοδος παρασκευης μικροσωματιδιων που εχουν επιλεγμενο μοριακο βαρος πολυμερους - Google Patents

Μεθοδος παρασκευης μικροσωματιδιων που εχουν επιλεγμενο μοριακο βαρος πολυμερους

Info

Publication number
CY1110403T1
CY1110403T1 CY20081101054T CY081101054T CY1110403T1 CY 1110403 T1 CY1110403 T1 CY 1110403T1 CY 20081101054 T CY20081101054 T CY 20081101054T CY 081101054 T CY081101054 T CY 081101054T CY 1110403 T1 CY1110403 T1 CY 1110403T1
Authority
CY
Cyprus
Prior art keywords
molecular weight
selected polymer
particulars
preparation
small
Prior art date
Application number
CY20081101054T
Other languages
English (en)
Inventor
Steven G Wright
Michael E Rickey
J Michael Ramstack
Shawn L Lyons
Joyce M Hotz
Original Assignee
Alkermes, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24298824&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110403(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes, Inc. filed Critical Alkermes, Inc.
Publication of CY1110403T1 publication Critical patent/CY1110403T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyamides (AREA)

Abstract

Μέθοδος παρασκευής μικροσωματιδίων που έχουν επιλεγμένο μοριακό βάρος πολυμερούς. Ο χρόνος παραμονής και η θερμοκρασία διαλύματος περιέχοντος νουκλεόφιλη ένωση και πολυμερές με ένα αρχικό μοριακό βάρος ελέγχονται έτσι ώστε να ελέγχεται το μοριακό βάρος του πολυμερούς στο τελειωμένο προϊόν μικροσωματιδίων. Με τον τρόπο αυτόν, μπορεί να επιτευχθεί ένα επιλεγμένο μοριακό βάρος του πολυμερούς στο τελειωμένο μικροσωματιδιακό προϊόν από μία ποικιλία μοριακών βαρών του αρχικού υλικού.
CY20081101054T 2000-05-19 2008-09-24 Μεθοδος παρασκευης μικροσωματιδιων που εχουν επιλεγμενο μοριακο βαρος πολυμερους CY1110403T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/575,075 US6264987B1 (en) 2000-05-19 2000-05-19 Method for preparing microparticles having a selected polymer molecular weight
EP01928630A EP1282404B1 (en) 2000-05-19 2001-04-19 Method for preparing microparticles having a selected polymer molecular weight

Publications (1)

Publication Number Publication Date
CY1110403T1 true CY1110403T1 (el) 2015-04-29

Family

ID=24298824

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20081101054T CY1110403T1 (el) 2000-05-19 2008-09-24 Μεθοδος παρασκευης μικροσωματιδιων που εχουν επιλεγμενο μοριακο βαρος πολυμερους
CY20121100773T CY1113082T1 (el) 2000-05-19 2012-08-28 Μεθοδος παρασκευης μικροσωματιδιων τα οποια εχουν επιλεγμενο μοριακο βαρος πολυμερους

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20121100773T CY1113082T1 (el) 2000-05-19 2012-08-28 Μεθοδος παρασκευης μικροσωματιδιων τα οποια εχουν επιλεγμενο μοριακο βαρος πολυμερους

Country Status (12)

Country Link
US (6) US6264987B1 (el)
EP (3) EP2258348A3 (el)
JP (1) JP4903344B2 (el)
AT (1) ATE399535T1 (el)
AU (2) AU5546501A (el)
CA (1) CA2405787C (el)
CY (2) CY1110403T1 (el)
DE (1) DE60134640D1 (el)
DK (2) DK1282404T3 (el)
ES (2) ES2391315T5 (el)
PT (2) PT1925297E (el)
WO (1) WO2001089482A2 (el)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US7666445B2 (en) 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
AU2002220002B2 (en) * 2000-10-31 2006-12-14 Evonik Corporation Methods and compositions for enhanced delivery of bioactive molecules
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
WO2003054161A2 (en) * 2001-12-20 2003-07-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US20030176929A1 (en) * 2002-01-28 2003-09-18 Steve Gardner User interface for a bioinformatics system
AU2003226021B2 (en) * 2002-03-26 2008-07-17 Teva Pharmaceutical Industries Ltd. Drug microparticles
WO2004005325A2 (en) * 2002-07-10 2004-01-15 The Ohio State University Research Foundation Antigen-polymer compositions
DE10235556A1 (de) * 2002-08-03 2004-02-19 Hf Arzneimittelforschung Gmbh Medikament und Verfahren zur Verringerung des Alkohol- und/oder Tabakkonsums
AU2003286512A1 (en) * 2002-10-18 2004-05-04 Charles N. Ellis Method for rating severity of psoriasis
US7658998B2 (en) * 2003-01-22 2010-02-09 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
WO2005003180A2 (en) * 2003-04-10 2005-01-13 Pr Pharmaceuticals A method for the production of emulsion-based micro particles
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
AU2004245057B2 (en) * 2003-06-04 2008-07-31 Alkermes Pharma Ireland Limited Polymorphic forms of naltrexone
US8871269B2 (en) * 2003-07-15 2014-10-28 Evonik Corporation Method for the preparation of controlled release formulations
ES2600554T3 (es) 2003-07-18 2017-02-09 Oakwood Laboratories L.L.C. Prevención de la reducción del peso molecular del polímero, de la formación de impurezas y de la gelificación en composiciones poliméricas
US8900636B2 (en) * 2003-07-23 2014-12-02 Evonik Corporation Controlled release compositions
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
WO2005021026A2 (en) * 2003-08-29 2005-03-10 Amylin Pharmaceuticals, Inc. Methods for treating or ameliorating ghrelin-associated diseases and disorders
US20080305140A1 (en) * 2004-01-12 2008-12-11 University Of Pennsylvania Long-Term Delivery Formulations and Methods of Use Thereof
US8329203B2 (en) 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
DE602005021858D1 (de) 2004-02-11 2010-07-29 Amylin Pharmaceuticals Inc Peptide der amylin familie, verfahren zu deren herstellung und verwendung
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ， インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
US7399744B2 (en) * 2004-03-04 2008-07-15 Amylin Pharmaceuticals, Inc. Methods for affecting body composition
US20050245461A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
US20050245541A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
US7919499B2 (en) * 2004-04-22 2011-04-05 Alkermes, Inc. Naltrexone long acting formulations and methods of use
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
EP1814590B2 (en) 2004-11-01 2013-12-11 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
WO2006105345A2 (en) 2005-03-31 2006-10-05 Amylin Pharmaceuticals, Inc. Compositions and methods for the control, prevention, and treatment of obesity and eating disorders
KR101272402B1 (ko) 2004-12-13 2013-06-10 아스트라제네카 파마수티컬스 엘피 췌장 폴리펩티드 족 모티프, 폴리펩티드 및 이를 포함하는방법
WO2006078841A1 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
US8404637B2 (en) 2005-02-11 2013-03-26 Amylin Pharmaceuticals, Llc GIP analog and hybrid polypeptides with selectable properties
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
KR20130042041A (ko) * 2005-05-25 2013-04-25 트랜스셉트 파마슈티칼스, 인코포레이티드 야반 불면증을 치료하기 위한 고체 조성물 및 방법
EP1909689A4 (en) * 2005-07-18 2011-11-16 Univ Pennsylvania IMPLANTS CONTAINING A MEDICAMENT AND METHOD OF USE
US20070066514A1 (en) * 2005-08-30 2007-03-22 Acologix, Inc. Regulation of mineral and skeletal metabolism
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US20070081972A1 (en) * 2005-09-30 2007-04-12 The University Of Iowa Research Foundation Polymer-based delivery system for immunotherapy of cancer
WO2007130134A2 (en) * 2005-12-02 2007-11-15 (Osi) Eyetech, Inc. Controlled release microparticles
US8309522B2 (en) 2007-02-05 2012-11-13 Amylin Pharmaceuticals, Llc Neuromedin and FN-38 peptides for treating psychiatric diseases
MX354603B (es) 2007-05-25 2018-03-13 Indivior Uk Ltd Formulaciones de transferencia sostenida de compuestos de risperidona.
WO2010030763A2 (en) 2008-09-10 2010-03-18 Bind Biosciences, Inc. High throughput fabrication of nanoparticles
US20100189800A1 (en) * 2009-01-23 2010-07-29 Peter Markland Continous double emulsion process for making microparticles
US20100196436A1 (en) * 2009-01-30 2010-08-05 Gooberman Lance L Implants containing disulfiram and an anti-inflammatory agent
US8791093B2 (en) * 2009-05-29 2014-07-29 Lance L. Gooberman Pharmaceutical delivery systems for treatment of substance abuse and other addictions
US20130165459A1 (en) 2010-01-12 2013-06-27 Norvartis Pharma Ag Pharmaceutical composition and dosage forms of elinogrel and methods of use thereof
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
CA2812951A1 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Llc Engineered polypeptides having enhanced duration of action
CA2813038C (en) 2010-09-28 2021-12-28 Amylin Pharmaceuticals, Llc Highly soluble leptins
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US8987285B2 (en) 2010-12-03 2015-03-24 Portola Pharmaceuticals, Inc. Pharmaceutical compositions, dosage forms and new forms of the compound of formula (I), and methods of use thereof
US9382304B2 (en) 2011-07-08 2016-07-05 Amylin Pharmaceuticals, Llc Engineered polypeptides having enhanced duration of action with reduced immunogenicity
WO2013009539A1 (en) 2011-07-08 2013-01-17 Amylin Pharmaceuticals, Inc. Engineered polypeptides having enhanced duration of action and reduced immunogenicity
BRPI1106938A2 (pt) * 2011-10-17 2015-12-08 Fbm Indústria Farmacêutica Ltda composição farmacêutica de liberação controlada contendo naltrexona e topiramato
RU2471478C1 (ru) * 2011-12-08 2013-01-10 Станислав Анатольевич Кедик Фармацевтическая композиция для лечения алкоголизма, наркомании и токсикомании с улучшенным профилем высвобождения налтрексона
JP6464154B2 (ja) 2013-06-20 2019-02-06 ファーマシェン エス．エー． Ｓ字型放出プロファイルを有するポリラクチド−ポリグリコリド微小粒子の調製
PL3010962T5 (pl) 2013-06-20 2023-05-15 Pharmathen S.A. Wytwarzanie mikrocząstek polilaktydowo-poliglikolidowych mających esowaty profil uwalniania
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
NZ731309A (en) 2014-11-07 2022-02-25 Indivior Uk Ltd Buprenorphine dosing regimens
EP3303585A4 (en) 2015-06-03 2018-10-31 Board of Regents of the University of Nebraska Dna editing using single-stranded dna
US20190029969A1 (en) * 2015-09-07 2019-01-31 Nipro Corporation Risperidone-containing microcapsule, method for preparing same and release control method
KR20230137362A (ko) 2016-05-05 2023-10-04 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
WO2018031771A1 (en) 2016-08-11 2018-02-15 University Of Iowa Research Foundation CATIONIC CaMKII INHIBITING NANOPARTICLES FOR THE TREATMENT OF ALLERGIC ASTHMA
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
CN109718212A (zh) * 2017-10-30 2019-05-07 浙江圣兆药物科技股份有限公司 一种减少利培酮微球中低挥发溶剂苯甲醇的方法
JP2022516720A (ja) * 2018-12-27 2022-03-02 ▲ユ▼展新藥生技股分有限公司 ナルトレキソンの注射可能な徐放性製剤
KR102072968B1 (ko) * 2019-05-28 2020-02-04 주식회사 울트라브이 생분해성 고분자 미세 입자의 제조 방법 및 조직 수복용 생분해성 재료
WO2021076794A1 (en) 2019-10-15 2021-04-22 Cornell University Methods for modulating level of expression from gene therapy expression cassette
BR112022007010A2 (pt) 2019-10-16 2022-07-12 Univ Cornell Terapia gênica para doença de alzheimer
WO2021086973A2 (en) 2019-10-28 2021-05-06 University Of Iowa Research Foundation Formulation for delivery of lubricin gene
CN114829390A (zh) 2019-11-25 2022-07-29 康奈尔大学 Apoe基因疗法
CN113546060B (zh) * 2020-04-08 2023-04-07 江苏长泰药业有限公司 一种纳曲酮微球
AU2021259858A1 (en) 2020-04-23 2022-12-15 University Of Iowa Research Foundation GPER proteolytic targeting chimeras
US20230293678A1 (en) 2020-08-21 2023-09-21 Aliasger K. Salem Cationic nanoparticle adjuvants
US20230414787A1 (en) 2020-08-27 2023-12-28 University Of Iowa Research Foundation Gene knock-out for treatment of glaucoma
CN112245434A (zh) * 2020-11-09 2021-01-22 深圳善康医疗健康产业有限公司 一种纳曲酮和利培酮复方缓释组合物
WO2022125963A1 (en) 2020-12-11 2022-06-16 University Of Iowa Research Foundation Compositions comprising molecules for cystic fibrosis treatment
US20240238383A1 (en) 2021-05-21 2024-07-18 University Of Lowa Research Foundation Anti-oxidant containing particles and methods of use
US20240293322A1 (en) 2021-06-23 2024-09-05 University Of Iowa Research Foundation Sustained release formulations comprising a selective androgen receptor modulator
WO2024197165A1 (en) 2023-03-21 2024-09-26 University Of Iowa Research Foundation Broad spectrum antifungal keto-alkyl-pyridinium compounds

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137652C (el) 1962-07-11
BE744162A (fr) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2010115A1 (de) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
JPS523342B2 (el) 1972-01-26 1977-01-27
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
JPS523653A (en) 1975-06-27 1977-01-12 Fuji Photo Film Co Ltd Process for producing fine polymer particles
US4384975A (en) 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE59361B1 (en) 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
WO1989003678A1 (en) 1987-10-30 1989-05-05 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
US5158952A (en) 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
IL92344A0 (en) 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
EP0471036B2 (en) 1989-05-04 2004-06-23 Southern Research Institute Encapsulation process
US5478564A (en) 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5486362A (en) * 1991-05-07 1996-01-23 Dynagen, Inc. Controlled, sustained release delivery system for treating drug dependency
HU222501B1 (hu) 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
US5658593A (en) 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
ATE193037T1 (de) 1992-02-28 2000-06-15 Collagen Corp Hochkonzentrierte homogenisierte kollagenzusammensetzungen
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
JPH07507768A (ja) * 1992-03-12 1995-08-31 アルカーメス　コントロールド　セラピューティクス，インコーポレイテッド Ａｃｔｈ含有マイクロスフェアの制御放出
FR2692147B1 (fr) * 1992-06-15 1995-02-24 Centre Nat Rech Scient Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament.
DK0669128T3 (da) 1992-11-17 2000-06-19 Yoshitomi Pharmaceutical Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme
WO1994012158A1 (en) 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
PL314481A1 (en) 1993-11-19 1996-09-16 Janssen Pharmaceutica Nv Microencapsulated substituted 3-piperidinyl 1,2-benzoisoxazoles and 1,2-benzoisothiazoles
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
EP0998917A1 (en) * 1993-11-19 2000-05-10 Alkermes Controlled Therapeutics Inc. II Preparation of biodegradable microparticles containing a biologically active agent
US5904935A (en) 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
GB9718986D0 (en) 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
US6306425B1 (en) * 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
US6331317B1 (en) * 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6495166B1 (en) * 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight

Also Published As

Publication number Publication date
US6534092B2 (en) 2003-03-18
AU5546501A (en) 2001-12-03
JP2003534268A (ja) 2003-11-18
EP2258348A3 (en) 2011-10-05
US6379704B2 (en) 2002-04-30
US20030211164A1 (en) 2003-11-13
WO2001089482A2 (en) 2001-11-29
CA2405787C (en) 2011-06-14
ATE399535T1 (de) 2008-07-15
DK1282404T3 (da) 2008-09-01
DK1925297T3 (da) 2012-10-08
EP1282404B1 (en) 2008-07-02
DK1925297T4 (da) 2017-11-06
JP4903344B2 (ja) 2012-03-28
ES2391315T5 (es) 2017-12-20
ES2305071T3 (es) 2008-11-01
US20020001621A1 (en) 2002-01-03
PT1925297E (pt) 2012-10-18
CA2405787A1 (en) 2001-11-29
EP1282404A2 (en) 2003-02-12
AU2001255465B2 (en) 2004-09-23
US20020119203A1 (en) 2002-08-29
DE60134640D1 (de) 2008-08-14
EP2258348A2 (en) 2010-12-08
EP1925297A1 (en) 2008-05-28
US20080058502A1 (en) 2008-03-06
WO2001089482A3 (en) 2002-02-21
EP1925297B2 (en) 2017-08-16
EP1925297B1 (en) 2012-07-11
US6264987B1 (en) 2001-07-24
ES2391315T3 (es) 2012-11-23
US20030143279A1 (en) 2003-07-31
PT1282404E (pt) 2008-07-16
CY1113082T1 (el) 2016-04-13

Similar Documents

Publication Publication Date Title
CY1110403T1 (el) Μεθοδος παρασκευης μικροσωματιδιων που εχουν επιλεγμενο μοριακο βαρος πολυμερους
DE60103536D1 (de) Verfahren zur herstellung von freiform-produkten
DE60110044D1 (de) Teilentwässertes umsetzungsprodukt, verfahren zur herstellung desselben, und dasselbe enthaltende emulsion
DE60213380D1 (de) Kontinuierliches verfahren zur herstellung von engeren molekulargewichtverteilungen konjugierten dien-polymeren und dadurch hergestellten produkten
DE60022039D1 (de) Wärmestabile polymere, verfahren zu ihrer herstellung und gegenstände daraus
ATE314395T1 (de) Humanisierte antikörper und verfahren zu ihrer herstellung
EP1398339A4 (en) POLYSILOXANE, PROCESS FOR PRODUCING THE SAME, AND RADIATION-RESISTANT RESIN COMPOSITION
DE60234952D1 (de) VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL
DE60030883D1 (de) Verfahren zur herstellung von alfentanil, sufentanil und remifentanil
DE60200038D1 (de) Verpackungsmaterial, Verfahren zu seiner Herstellung, sowie daraus hergestellte Verpackung
DE60029464D1 (de) Verfahren zur herstellung von äthylen polymere
DE60012524D1 (de) Verhfahren zur herstellung eines milchproduktes mit immunstimulierender wirkung, und dessen verwendung
DE68907447D1 (de) Geblasene, einstueckige flasche und verfahren zur herstellung derselben.
TW200637885A (en) A composition, method of authenticating, methods of making authenticatable compositions, authenticatable articles made there from
ZA200710011B (en) A method for preparing a stable immunogenic product comprising antigenic heterocomplexes of TNFα and a carrier protein
ATE327257T1 (de) Fester, stabiler und konzentrierter biologisch verdaulicher komplex von orthokieselsäure und prozess zur dessen herstellung
DE60223565D1 (de) Verfahren zur herstellung von polymerlatexharzpulver
DE60203337D1 (de) Verfahren zur Herstellung von alpha-Aluminiumoxid Formkörpern
DE68913600D1 (de) Kontinuierliches Verfahren zur hydrolytischen Herstellung von Polycaprolactam durch Tempern von nicht extrahiertem, gekörntem Polymer mit feuchtem Inertgas.
DE60138271D1 (de) Herstellung von DIBENZOÄB,FÜAZEPINE ZWISCHENPRODUKTE
DE60210778D1 (de) Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen
WO2002058635A3 (en) Nicotine immunogens and antibodies and uses thereof
DE60217249D1 (de) Verfahren zur Herstellung von pressgeformten Gegenständen
DE10085308T1 (de) Polykristallines Material, Verfahren zu dessen Herstellung und daraus hergestellte Gegenstände
DE60238816D1 (de) Prozess zur herstellung von isobutylenpolymeren mit hohem molekulargewicht