CY1108796T1 - Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης - Google Patents

Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης

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Publication number
CY1108796T1
CY1108796T1 CY20081101505T CY081101505T CY1108796T1 CY 1108796 T1 CY1108796 T1 CY 1108796T1 CY 20081101505 T CY20081101505 T CY 20081101505T CY 081101505 T CY081101505 T CY 081101505T CY 1108796 T1 CY1108796 T1 CY 1108796T1
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CY
Cyprus
Prior art keywords
therapeutic
active substance
release
weight
systems
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Application number
CY20081101505T
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English (en)
Inventor
Jean-Marc Aiache
Dominique Constantini
Christine Chaumont
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Bioalliance Pharma
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Publication date
Application filed by Bioalliance Pharma filed Critical Bioalliance Pharma
Publication of CY1108796T1 publication Critical patent/CY1108796T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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Abstract

Η παρούσα εφεύρεση σχετίζεται με ένα θεραπευτικό βιοπροσκολλητικό σύστημα βλεννογόνου παρατεταμένης αποδέσμευσης το οποίο περιέχει τουλάχιστον μια δραστική ουσία, και το οποίο παρουσιάζει μια δοκιμασία διάλυσης της δραστικής ουσίας μεγαλύτερη του 70 % σε 8 ώρες, καθώς επίσης και με την διαδικασία παρασκευής του. Το εν λόγω θεραπευτικό βιοπροσκολλητικό σύστημα περιλαμβάνει ποσότητες φυσικών πρωτεϊνών της τάξης του 50 % σε βάρος δραστικής ουσίας και τουλάχιστον 20 % σε βάρος του εν λόγω δισκίου, μεταξύ 10 % και 20 % ενός υδρόφιλου πολυμερούς, έκδοχα συμπίεσης, και επίσης περιλαμβάνει μεταξύ 4 % και 10 % ενός αλκυλθειικού αλκαλικού μετάλλου για την ενίσχυση της τοπική διαθεσιμότητας της δραστικής ουσίας και από 0,1 % έως 1 % ενός μονοϋδρικού σακχάρου.
CY20081101505T 2001-07-23 2008-12-30 Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης CY1108796T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109811A FR2827517B1 (fr) 2001-07-23 2001-07-23 Systemes therapeutiques bioadhesifs a liberation prolongee
EP07006150A EP1792610B1 (fr) 2001-07-23 2002-07-23 Systèmes thérapeutiques bioadhésifs à libération prolongée

Publications (1)

Publication Number Publication Date
CY1108796T1 true CY1108796T1 (el) 2014-04-09

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Family Applications (2)

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CY20071101572T CY1107828T1 (el) 2001-07-23 2007-12-11 Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης
CY20081101505T CY1108796T1 (el) 2001-07-23 2008-12-30 Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης

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Country Status (15)

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US (5) US6916485B2 (el)
EP (2) EP1408911B1 (el)
JP (2) JP4657603B2 (el)
CN (2) CN101524337A (el)
AT (2) ATE411003T1 (el)
CA (1) CA2455633C (el)
CY (2) CY1107828T1 (el)
DE (2) DE60229456D1 (el)
DK (2) DK1408911T3 (el)
ES (2) ES2316108T3 (el)
FR (1) FR2827517B1 (el)
HK (1) HK1107516A1 (el)
IL (2) IL159842A0 (el)
PT (2) PT1792610E (el)
WO (1) WO2003009800A1 (el)

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CN1547464B (zh) 2011-02-09
FR2827517A1 (fr) 2003-01-24
US7651698B2 (en) 2010-01-26
US20130310335A1 (en) 2013-11-21
DE60222557T2 (de) 2008-06-19
CA2455633A1 (fr) 2003-02-06
EP1408911B1 (fr) 2007-09-19
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