CY1107828T1 - Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης - Google Patents
Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσηςInfo
- Publication number
- CY1107828T1 CY1107828T1 CY20071101572T CY071101572T CY1107828T1 CY 1107828 T1 CY1107828 T1 CY 1107828T1 CY 20071101572 T CY20071101572 T CY 20071101572T CY 071101572 T CY071101572 T CY 071101572T CY 1107828 T1 CY1107828 T1 CY 1107828T1
- Authority
- CY
- Cyprus
- Prior art keywords
- therapeutic
- active substance
- release
- weight
- systems
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 4
- 239000013543 active substance Substances 0.000 abstract 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000000227 bioadhesive Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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Abstract
Η παρούσα εφεύρεση σχετίζεται με ένα θεραπευτικό βιοπροσκολλητικό σύστημα βλεννογόνου παρατεταμένης αποδέσμευσης το οποίο περιέχει τουλάχιστον μια δραστική ουσία, και το οποίο παρουσιάζει μια δοκιμασία διάλυσης της δραστικής ουσίας μεγαλύτερη του 70 % σε 8 ώρες, καθώς επίσης και με την διαδικασία παρασκευής του. Το εν λόγω θεραπευτικό βιοπροσκολλητικό σύστημα περιλαμβάνει ποσότητες φυσικών πρωτεϊνών της τάξης του 50 % σε βάρος δραστικής ουσίας και τουλάχιστον 20 % σε βάρος του εν λόγω δισκίου, μεταξύ 10 % και 20 % ενός υδρόφιλου πολυμερούς, έκδοχα συμπίεσης, και επίσης περιλαμβάνει μεταξύ 4 % και 10 % ενός αλκυλθειικού αλκαλικού μετάλλου για την ενίσχυση της τοπική διαθεσιμότητας της δραστικής ουσίας και από 0,1 % έως 1 % ενός μονοϋδρικού σακχάρου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0109811A FR2827517B1 (fr) | 2001-07-23 | 2001-07-23 | Systemes therapeutiques bioadhesifs a liberation prolongee |
EP02774826A EP1408911B1 (fr) | 2001-07-23 | 2002-07-23 | Systemes therapeutiques bioadhesifs a liberation prolongee |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107828T1 true CY1107828T1 (el) | 2013-06-19 |
Family
ID=8865807
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071101572T CY1107828T1 (el) | 2001-07-23 | 2007-12-11 | Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης |
CY20081101505T CY1108796T1 (el) | 2001-07-23 | 2008-12-30 | Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101505T CY1108796T1 (el) | 2001-07-23 | 2008-12-30 | Θεραπευτικα βιοπροσκολλητικα συστηματα παρατεταμενης αποδεσμευσης |
Country Status (15)
Country | Link |
---|---|
US (5) | US6916485B2 (el) |
EP (2) | EP1408911B1 (el) |
JP (2) | JP4657603B2 (el) |
CN (2) | CN101524337A (el) |
AT (2) | ATE411003T1 (el) |
CA (1) | CA2455633C (el) |
CY (2) | CY1107828T1 (el) |
DE (2) | DE60229456D1 (el) |
DK (2) | DK1408911T3 (el) |
ES (2) | ES2316108T3 (el) |
FR (1) | FR2827517B1 (el) |
HK (1) | HK1107516A1 (el) |
IL (2) | IL159842A0 (el) |
PT (2) | PT1792610E (el) |
WO (1) | WO2003009800A1 (el) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2827517B1 (fr) * | 2001-07-23 | 2003-10-24 | Bioalliance Pharma | Systemes therapeutiques bioadhesifs a liberation prolongee |
US20050054583A1 (en) * | 2003-08-20 | 2005-03-10 | Matsumoto Dental University | Composition for an antifungal agent for suppressing fungal growth in an oral cavity |
JP2005097271A (ja) * | 2003-08-20 | 2005-04-14 | Matsumoto Shika Univ | 抗真菌剤用組成物 |
CN1302764C (zh) * | 2005-01-10 | 2007-03-07 | 凌沛学 | 一种妇科用药阴道凝胶片 |
US8679545B2 (en) * | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
US8497258B2 (en) * | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
US8865743B2 (en) * | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
EP1837020A1 (en) * | 2006-03-24 | 2007-09-26 | Bioalliance Pharma | Mucosal bioadhesive slow release carrier for delivering active principles |
EP1972332A1 (en) * | 2007-03-23 | 2008-09-24 | BioAlliance Pharma | Mucosal bioadhesive slow release carrier for delivering active principles |
EP2211845B1 (en) | 2007-10-17 | 2017-02-22 | Laboratoire HRA Pharma | Glucocorticoid receptor antagonists such as mifepristone for treating cushing's syndrome |
DK2214679T3 (da) | 2007-11-13 | 2019-05-20 | Meritage Pharma Inc | Kortikosteroidsammensætninger |
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2001
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- 2002-07-23 AT AT07006150T patent/ATE411003T1/de active
- 2002-07-23 CN CN028166205A patent/CN1547464B/zh not_active Expired - Lifetime
- 2002-07-23 AT AT02774826T patent/ATE373464T1/de active
- 2002-07-23 IL IL15984202A patent/IL159842A0/xx unknown
- 2002-07-23 PT PT07006150T patent/PT1792610E/pt unknown
- 2002-07-23 PT PT02774826T patent/PT1408911E/pt unknown
- 2002-07-23 DK DK02774826T patent/DK1408911T3/da active
- 2002-07-23 DK DK07006150T patent/DK1792610T3/da active
- 2002-07-23 EP EP07006150A patent/EP1792610B1/fr not_active Expired - Lifetime
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