CY1108301T1 - Συνθεση περιλαμβανουσα αναστολεα αποακετυλασης ιστονης εμφανιζουσα διφασικη απελευθερωση - Google Patents

Συνθεση περιλαμβανουσα αναστολεα αποακετυλασης ιστονης εμφανιζουσα διφασικη απελευθερωση

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Publication number
CY1108301T1
CY1108301T1 CY20081100925T CY081100925T CY1108301T1 CY 1108301 T1 CY1108301 T1 CY 1108301T1 CY 20081100925 T CY20081100925 T CY 20081100925T CY 081100925 T CY081100925 T CY 081100925T CY 1108301 T1 CY1108301 T1 CY 1108301T1
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Cyprus
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distribution
differental
bison
applicable
free
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CY20081100925T
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English (en)
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Hanshermann Dr Franke
Peter Dr Lennartz
Alexander B Dr Maurer
Bernd Dr Hentsch
Sascha Dr Hövelmann
Elke Dr Martin
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Topotarget Germany Ag
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Publication of CY1108301T1 publication Critical patent/CY1108301T1/el

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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61K9/5021—Organic macromolecular compounds
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία διαθέσιμη δια του στόματος γαληνική σύνθεση βαλπροϊκού οξέως ή παραγώγων του η οποία εμφανίζει μία συγκεκριμένη διφασική φαρμακοκινητική κατανομή βελτιστοποιημένη για μέγιστη αναστολή των αποακετυλασών ιστόνης σε ένα θεραπευτικό περιβάλλον. Αυτή η συγκεκριμένη γαληνική σύνθεση είναι σχεδιασμένη για την αγωγή κακοηθών παθήσεων και παθήσεων σχετιζόμενων με την υποακετυλίωση των ιστονών ή στις οποίες η επαγωγή υπερακετυλιώσεως έχει μία ευεργετική δράση, π.χ. δι' επαγωγής της διαφοροποιήσεως και/ή της αποπτώσεως. Λόγω της διφασικής κατανομής απελευθερώσεως η προκύπτουσα φαρμακοκινητική μορφή είναι ικανή να αναστέλλει αποτελεσματικότερα τα ένζυμα στόχους HDAC και εν συνεχεία να επάγει υπερακετυλίωση των ιστονών κατά ταχύ καθώς και μακράς διαρκείας τρόπο. Αυτή η κατανομή εξασφαλίζει την αποτελεσματική ρύθμιση της εκφράσεως ενός επιθυμητού γονιδίου στόχου το οποίο συμβάλλει στο θεραπευτικό όφελος.
CY20081100925T 2004-04-30 2008-08-28 Συνθεση περιλαμβανουσα αναστολεα αποακετυλασης ιστονης εμφανιζουσα διφασικη απελευθερωση CY1108301T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04010333A EP1591109B1 (en) 2004-04-30 2004-04-30 Formulation comprising histone deacetylase inhibitor exhibiting biphasic release

Publications (1)

Publication Number Publication Date
CY1108301T1 true CY1108301T1 (el) 2014-02-12

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CY20081100925T CY1108301T1 (el) 2004-04-30 2008-08-28 Συνθεση περιλαμβανουσα αναστολεα αποακετυλασης ιστονης εμφανιζουσα διφασικη απελευθερωση

Country Status (19)

Country Link
US (1) US20070232528A1 (el)
EP (1) EP1591109B1 (el)
JP (1) JP4789927B2 (el)
CN (1) CN1980647B (el)
AT (1) ATE399539T1 (el)
AU (1) AU2005237251B2 (el)
BR (1) BRPI0509340A (el)
CA (1) CA2564877A1 (el)
CY (1) CY1108301T1 (el)
DE (1) DE602004014723D1 (el)
DK (1) DK1591109T3 (el)
ES (1) ES2308065T3 (el)
MX (1) MXPA06012568A (el)
NZ (1) NZ550879A (el)
PL (1) PL1591109T3 (el)
PT (1) PT1591109E (el)
SI (1) SI1591109T1 (el)
WO (1) WO2005105055A1 (el)
ZA (1) ZA200608714B (el)

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WO2005105055A1 (en) 2005-11-10
AU2005237251A1 (en) 2005-11-10
JP4789927B2 (ja) 2011-10-12
CN1980647A (zh) 2007-06-13
DE602004014723D1 (de) 2008-08-14
JP2007535518A (ja) 2007-12-06
EP1591109B1 (en) 2008-07-02
CA2564877A1 (en) 2005-11-10
DK1591109T3 (da) 2008-10-06
SI1591109T1 (sl) 2008-10-31
PL1591109T3 (pl) 2008-11-28
ATE399539T1 (de) 2008-07-15
BRPI0509340A (pt) 2007-09-18
NZ550879A (en) 2010-05-28
US20070232528A1 (en) 2007-10-04
ZA200608714B (en) 2008-07-30
ES2308065T3 (es) 2008-12-01
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AU2005237251B2 (en) 2010-11-04
EP1591109A1 (en) 2005-11-02
CN1980647B (zh) 2010-08-18

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