CY1106411T1 - Διαδepμικο θepαπευτικο συστημα με fentanyl - Google Patents

Διαδepμικο θepαπευτικο συστημα με fentanyl

Info

Publication number
CY1106411T1
CY1106411T1 CY20071100407T CY071100407T CY1106411T1 CY 1106411 T1 CY1106411 T1 CY 1106411T1 CY 20071100407 T CY20071100407 T CY 20071100407T CY 071100407 T CY071100407 T CY 071100407T CY 1106411 T1 CY1106411 T1 CY 1106411T1
Authority
CY
Cyprus
Prior art keywords
fentanyl
active substance
weight
saturation solubility
therapeutic system
Prior art date
Application number
CY20071100407T
Other languages
English (en)
Inventor
Walter Müller
Thomas Hille
Original Assignee
Lts Lohmann Therapie-Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7696568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1106411(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lts Lohmann Therapie-Systeme Ag filed Critical Lts Lohmann Therapie-Systeme Ag
Publication of CY1106411T1 publication Critical patent/CY1106411T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αφορά σε ένα διαδερμικό θεραπευτικό σύστημα (TTS), που αποτελείται από ένα μη διαπερατό από την δραστική ουσία οπίσθιο στρώμα, τουλάχιστον ένα στρώμα μήτρας που περιέχει Fentanyl ή μία ανάλογη προς το Fentanyl δραστική ουσία με βάση πολυακρυλικό εστέρα και ένα προστατευτικό στρώμα που απομακρύνεται πριν την χρήση, το οποίο χαρακτηρίζεται από το γεγονός, ότι το πολυακρυλικό πολυμερές είναι αυτοκόλλητο και ελεύθερο από ομάδες καρβοξυλίου, εμφανίζει για το Fentanyl μία διαλυτότητα κορεσμού μεταξύ 3 και 20 % κατά βάρος, κατά προτίμηση μία διαλυτότητα κορεσμού μεταξύ 4 και 12% και κατά ιδιαίτερη προτίμηση μία διαλυτότητα κορεσμού μεταξύ 5 και 10 % κατά βάρος και ότι τα στρώματα που περιέχουν δραστική ουσία περιέχουν τουλάχιστον 80 % κατά βάρος της εισαχθείσας με κατεργασία δραστικής ουσίας σε μοριακά διάσπαρτη διαλυμένη μορφή.
CY20071100407T 2001-08-24 2007-03-22 Διαδepμικο θepαπευτικο συστημα με fentanyl CY1106411T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10141650A DE10141650C1 (de) 2001-08-24 2001-08-24 Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
PCT/EP2002/007664 WO2003018075A2 (de) 2001-08-24 2002-07-10 Transdermales therapeutisches system mit fentanyl bzw. verwandten substanzen

Publications (1)

Publication Number Publication Date
CY1106411T1 true CY1106411T1 (el) 2011-10-12

Family

ID=7696568

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100407T CY1106411T1 (el) 2001-08-24 2007-03-22 Διαδepμικο θepαπευτικο συστημα με fentanyl

Country Status (17)

Country Link
US (3) US10568845B2 (el)
EP (3) EP1418894B1 (el)
JP (2) JP5405709B2 (el)
KR (1) KR100895189B1 (el)
CN (2) CN1713899A (el)
AT (1) ATE352293T1 (el)
AU (1) AU2002328328B2 (el)
BR (1) BR0212026A (el)
CA (1) CA2457401C (el)
CY (1) CY1106411T1 (el)
DE (2) DE10141650C1 (el)
DK (1) DK1418894T3 (el)
ES (1) ES2280563T3 (el)
MX (1) MXPA04001676A (el)
PT (1) PT1418894E (el)
WO (1) WO2003018075A2 (el)
ZA (1) ZA200400314B (el)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004509222A (ja) * 2000-09-19 2004-03-25 ナショナル　スターチ　アンド　ケミカル　インベストメント　ホールディング　コーポレイション 経皮薬物送達システムにおいて有用な非反応型接着剤
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
US20050208117A1 (en) * 2001-03-16 2005-09-22 Venkatraman Subramanian S Transdermal administration of fentanyl and analogs thereof
NZ528148A (en) * 2001-03-16 2006-02-24 Alza Corp Transdermal patch for administering fentanyl
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
CA2487123C (en) * 2002-05-28 2011-10-18 Labtec Gesellschaft Fuer Technologische Forschung Und Entwicklung Mbh Patch containing fentanyl
DE10223835A1 (de) * 2002-05-28 2003-12-11 Labtec Gmbh Pflaster, enthaltend Fentanylum
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
AU2005235075A1 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of fentany-based agents
EP1937226A2 (en) * 2005-09-23 2008-07-02 Alza Corporation Transdermal galantamine delivery system
EP2308480B1 (en) 2005-09-23 2014-08-13 ALZA Corporation High Enhancer-Loading Polyacrylate Formulation for Transdermal Applications
WO2007035940A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal norelgestromin delivery system
JP5114042B2 (ja) * 2005-10-19 2013-01-09 ニプロパッチ株式会社 貼付剤、及び貼付剤の製造方法
DE102006054733A1 (de) 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
DE102007020799A1 (de) * 2007-05-03 2008-11-06 Novosis Ag Transdermales therapeutisches System mit Remifentanil
JP5224163B2 (ja) * 2007-07-24 2013-07-03 コスメディ製薬株式会社 経皮吸収テープ製剤
MY154027A (en) * 2007-10-15 2015-04-30 Alza Corp Once-a-day replacement transdermal administration of fentanyl
CN101925355B (zh) 2008-01-28 2013-05-29 帝国制药株式会社 含芬太尼的外用贴剂
KR20090101579A (ko) * 2008-03-24 2009-09-29 조선대학교산학협력단 펜타닐을 함유한 경피 흡수제
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
DE102010026879A1 (de) 2010-02-11 2011-08-11 AMW GmbH, 83627 Transdermales System mit Immunmodulator
DE102010026883A1 (de) 2010-03-11 2011-12-15 Amw Gmbh Transdermales System mit Aromatasehemmer
JP5686986B2 (ja) * 2010-04-07 2015-03-18 久光製薬株式会社 経皮投与製剤
DE102011100619A1 (de) 2010-05-05 2012-01-05 Amw Gmbh Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum
DE102010026903A1 (de) 2010-07-12 2012-01-12 Amw Gmbh Transdermales therapeutisches System mit Avocadoöl oder Palmöl als Hilfsstoff
PT2468274E (pt) * 2010-12-14 2015-09-21 Acino Ag Sistema terapêutico transdérmico para a administração de uma substância ativa
WO2013042989A1 (ko) * 2011-09-22 2013-03-28 주식회사 트랜스덤 펜타닐 및 이의 동족체를 함유하는 경피 흡수성 제제
CN107106552A (zh) * 2014-12-19 2017-08-29 3M创新有限公司 包含芬太尼的透皮药物递送装置
US9650338B1 (en) 2016-07-29 2017-05-16 VDM Biochemicals, Inc. Opioid antagonist compounds and methods of making and using
US10300454B2 (en) 2017-04-18 2019-05-28 Breakthrough Technologies, Llc. Sulfur production

Family Cites Families (311)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US965861A (en) 1909-01-02 1910-08-02 Louis Berwanger Trap for sewer vent-pipes.
US2618708A (en) 1942-08-06 1952-11-18 Automatic Elect Lab Telephone system with main and secondary register
US2884126A (en) * 1955-11-18 1959-04-28 Minnesota Mining & Mfg Pressure-sensitive adhesive sheet material
CA677797A (en) 1955-11-18 1964-01-14 Minnesota Mining And Manufacturing Company Sheet material having a pressure-sensitive adhesive coating of acrylate ester copolymer
US3900610A (en) 1973-04-09 1975-08-19 Monsanto Co Process of making a pressure sensitive adhesive article
US3886126A (en) * 1973-04-09 1975-05-27 Monsanto Co Solutions of pressure-sensitive resin solutions with improved viscosity and flow
US4053604A (en) 1975-11-26 1977-10-11 Ayerst, Mckenna & Harrison Limited Method for improving anesthesia and compositions therefor
GB2079194B (en) 1980-07-09 1983-08-03 Westering Insulation Systems L Coil shaping apparatus
US4508715A (en) * 1981-07-01 1985-04-02 University Of Georgia Research Foundation, Inc. Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs
US4486423A (en) 1983-04-21 1984-12-04 Janssen Pharmaceutica Inc. Stable fentanyl composition
US4599342A (en) 1984-01-16 1986-07-08 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4626539A (en) 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
DE3586707T2 (de) 1984-10-05 1993-02-11 Hercon Lab System zur transdermalen applikation eines arzneimittels.
US5785989A (en) 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
US5122127A (en) * 1985-05-01 1992-06-16 University Of Utah Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US5560922A (en) 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
US5820876A (en) 1986-08-28 1998-10-13 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system
US4938759A (en) 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
AU601528B2 (en) 1986-12-22 1990-09-13 Ortho-Mcneil Pharmaceutical, Inc. Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers
AU607172B2 (en) * 1986-12-22 1991-02-28 Cygnus, Inc. Diffusion matrix for transdermal drug administration
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
US4822802A (en) * 1987-02-24 1989-04-18 Alza Corporation Method of fentanly administration for postoperative pain relief
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5000886A (en) * 1987-05-26 1991-03-19 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules and process of making the same
US4879297A (en) 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
DE3729299A1 (de) 1987-09-02 1989-03-23 Beiersdorf Ag Transdermales therapeutisches system
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5474783A (en) 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5236714A (en) 1988-11-01 1993-08-17 Alza Corporation Abusable substance dosage form having reduced abuse potential
JP2693212B2 (ja) * 1989-03-28 1997-12-24 日東電工株式会社 疾患治療用テープ製剤
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
DE3924393A1 (de) 1989-07-24 1991-01-31 Roehm Gmbh Wasserloeslicher druckempfindlicher hauthaftkleber, dessen verwendung und damit ausgeruestete mittel
US5405997A (en) * 1989-07-25 1995-04-11 The Upjohn Company Antiarrhythmic methanesulfonamides
US5187849A (en) * 1989-08-24 1993-02-23 Nitto Kogyo Co., Ltd. Fixing roll for electrophotography having an outer fluoro-resin coating
AU644815B2 (en) * 1989-09-08 1993-12-23 Ortho-Mcneil Pharmaceutical, Inc. Solid matrix system for transdermal drug delivery
US5462744A (en) 1989-12-01 1995-10-31 Boehringer Ingelheim Kg Transdermal system for the administration of pharmacological compounds under pH-controlled conditions
US5167616A (en) 1989-12-14 1992-12-01 Alza Corporation Iontophoretic delivery method
ATE100385T1 (de) * 1989-12-21 1994-02-15 Von Roll Seilbahnen Ag Seilfoerderanlage.
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5120532A (en) * 1990-04-06 1992-06-09 The Procter & Gamble Company Hair styling shampoos
US5279594A (en) * 1990-05-23 1994-01-18 Jackson Richard R Intubation devices with local anesthetic effect for medical use
US5069909A (en) 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine
US5180716A (en) * 1990-08-01 1993-01-19 The Regents Of The University Of California Cyclodextrin complexes for neuraxial administration of drugs
WO1992016236A1 (en) * 1991-03-19 1992-10-01 Rajadhyaksha Vithal J Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers
US5416191A (en) * 1991-04-01 1995-05-16 Cortech, Inc. Bradykinin antagonists
AU1537292A (en) 1991-04-16 1992-11-17 Nippon Shinyaku Co. Ltd. Method of manufacturing solid dispersion
US5203768A (en) * 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5804213A (en) 1991-10-09 1998-09-08 Lectec Corporation Biologically active aqueous gel wound dressing
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5260066A (en) 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent
US20020052007A1 (en) * 1992-02-03 2002-05-02 Chang Kwen Jen Diarylmethylbenzylpiperazines and corresponding halobenzyl derivatives
IL101387A (en) 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
US5382451A (en) 1992-04-06 1995-01-17 Minnesota Mining And Manufacturing Method for coating adhesive polymers
DE4223004A1 (de) 1992-07-13 1994-01-20 Liedtke Pharmed Gmbh Einzeldosierte halbfeste topische Arzneiform zur Transdermaltherapie
DE69332378T2 (de) 1992-07-23 2003-07-10 Hisamitsu Pharmaceutical Co., Inc. Perkutan verabreichbare basiszusammensetzung und daraus hergestellte zusammensetzung
US20010006967A1 (en) 1992-09-21 2001-07-05 Stanley M. Crain Method of simultaneously enhancing analgesic potency and attenuating adverse side effects caused by tramadol and other bimodally-acting opioid agonists
US5543407A (en) 1992-09-30 1996-08-06 Ningbo Institute Of Microcirculation And Henbane Preparation and application of scopolamine and chlorpromazine as a drug-withdrawal agent
US5883115A (en) 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
KR100212961B1 (ko) 1992-12-31 1999-08-02 조민호 경피투여시스템
US5465151A (en) 1993-01-21 1995-11-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Sensors employing interference of electromagnetic waves passing through waveguides having functionalized surfaces
US5507277A (en) * 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US5569450A (en) 1993-03-17 1996-10-29 Minnesota Mining And Manufacturing Company Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
DE4310012A1 (de) * 1993-03-27 1994-09-29 Roehm Gmbh Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung
US5891842A (en) * 1993-04-09 1999-04-06 Trustees Of Tufts College Methodology for eliciting an analgesic response in a living subject
AU678237B2 (en) 1993-04-20 1997-05-22 Hexal Pharma Gmbh Active substance-containing plaster
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5554381A (en) 1993-08-09 1996-09-10 Cygnus, Inc. Low flux matrix system for delivering potent drugs transdermally
US5885564A (en) * 1993-08-13 1999-03-23 Lancaster Group Gmbh Functional oxygenated composition containing phospholipids and fluorocarbon
US5387466A (en) 1993-08-31 1995-02-07 Adhesives Research, Inc. Water absorbent pressure sensitive adhesive
GB2283557B (en) 1993-11-05 1998-03-25 Luk Lamellen & Kupplungsbau Rotary vibration damper
US5608035A (en) * 1994-02-02 1997-03-04 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
US5451408A (en) 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
AU2286995A (en) * 1994-04-08 1995-10-30 Alza Corporation Electrotransport system with ion exchange competitive ion capture
US5871460A (en) * 1994-04-08 1999-02-16 Alza Corporation Electrotransport system with ion exchange material providing enhanced drug delivery
US5769778A (en) * 1994-04-22 1998-06-23 Somatics, Inc. Medical magnetic non-convulsive stimulation therapy
JP3911290B2 (ja) * 1994-05-13 2007-05-09 アラダイム コーポレーション エアゾールを含む麻酔用処方
US5589480A (en) 1994-08-17 1996-12-31 Elkhoury; George F. Topical application of opioid analgesic drugs such as morphine
US5849769A (en) 1994-08-24 1998-12-15 Medivir Ab N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
DE69517816T2 (de) 1994-09-14 2000-12-28 Minnesota Mining & Mfg Matrix für transdermale wirkstofffreisetzung
DE4438989C2 (de) 1994-09-16 1999-02-25 Lohmann Therapie Syst Lts Scopolaminpflaster
US5714162A (en) * 1994-09-16 1998-02-03 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Scopolamine patch
US7027859B1 (en) 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
CA2201358C (en) 1994-09-30 2004-06-08 Jurgen Regenold Pharmaceutical composition
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US5697896A (en) 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
JPH10510540A (ja) * 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
GB9426102D0 (en) * 1994-12-23 1995-02-22 Merck Sharp & Dohme Pharmacuetical compositions
US6299901B1 (en) 1995-01-13 2001-10-09 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US5562607A (en) 1995-01-18 1996-10-08 Alza Corporation Electrotransport device having reusable controller power saver
DE69603577T2 (de) 1995-02-10 1999-11-25 Medtronic, Inc. Verfahren und vorrichtung zur verabreichung von analgetika
US5558879A (en) 1995-04-28 1996-09-24 Andrx Pharmaceuticals, Inc. Controlled release formulation for water soluble drugs in which a passageway is formed in situ
IE960312A1 (en) 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
US6881208B1 (en) * 1995-06-05 2005-04-19 Joseph B. Phipps Method and device for transdermal electrotransport delivery of fentanyl and sufentanil
US6425892B2 (en) 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
IE960375A1 (en) 1995-06-05 1996-12-11 Alza Corp Device for transdermal electrotransport delivery of fentanyl¹and sufentanil
US5693335A (en) 1995-06-07 1997-12-02 Cygnus, Inc. Skin permeation enhancer composition for use with sex steroids
IL122499A (en) 1995-06-07 2003-02-12 Oneil Alexander G B Patient controlled drug delivery device
US6093419A (en) 1995-06-07 2000-07-25 Lectec Corporation Compliance verification method and device in compulsory drug administration
US5780050A (en) * 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
DE19527925C2 (de) * 1995-07-29 1997-07-03 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit einer trennmittelbeschichteten Schutzschicht
AUPN603895A0 (en) 1995-10-19 1995-11-09 University Of Queensland, The Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids
GB9522403D0 (en) 1995-11-01 1996-01-03 Hoechst Roussel Ltd Intravaginal drug delivery device
AU730495B2 (en) * 1995-11-13 2001-03-08 North West University Administration media for analgesic, antiinflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
US5998434A (en) 1995-12-06 1999-12-07 Eli Lilly And Company Composition for treating pain
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
CA2250042A1 (en) 1996-03-25 1997-10-02 Eli Lilly And Company Treating pain using a synergistic combination of an atypical antipsychotic and a drug used in treatment of pain
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
US5886164A (en) * 1996-04-15 1999-03-23 Zeneca Limited DNA encoding enzymes related to ethylene biosynthesis and ripening from banana
US6271240B1 (en) 1996-05-06 2001-08-07 David Lew Simon Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals
GB9609779D0 (en) * 1996-05-10 1996-07-17 Univ Bruxelles Freeze dried liposome encapsulated amphiphilic drug compositions and a process for the preparation thereof
TW411277B (en) * 1996-05-13 2000-11-11 Hisamitsu Pharmaceutical Co Percutaneous tape preparation containing fentanyl
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US6718201B1 (en) 1996-06-07 2004-04-06 Alza Corporation Electrotransport agent delivery method and apparatus
IL127956A0 (en) 1996-07-11 1999-11-30 Farmarc Nederland Bv Inclusion complex containing indole selective serotonin agonist
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
KR20000029784A (ko) * 1996-08-02 2000-05-25 나까도미 히로다카 경구제제용캡슐과경구캡슐제제
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
WO1998013085A1 (en) 1996-09-26 1998-04-02 Akzo Nobel N.V. Needle-less injector
AU4320997A (en) 1996-09-26 1998-04-17 Hokuriku Seiyaku Co. Ltd Percutaneous preparations
AU5081298A (en) 1996-10-15 1998-05-11 R. John Hurlbert Surgical method and composition therefor
US6650934B2 (en) * 1996-12-17 2003-11-18 Alza Corp Polymeric foam reservoirs for an electrotransport delivery device
US6246904B1 (en) 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
DE19653605C2 (de) * 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
DE19653606A1 (de) 1996-12-20 1998-06-25 Roehm Gmbh Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher
WO1998029736A1 (en) * 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
DE19706824C1 (de) * 1997-02-21 1998-03-26 Lohmann Therapie Syst Lts Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften
DE19709704C2 (de) 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
AUPO612397A0 (en) 1997-04-11 1997-05-08 University Of Queensland, The Novel diflunisal esters and related compounds
GB9707934D0 (en) 1997-04-18 1997-06-04 Danbiosyst Uk Improved delivery of drugs to mucosal surfaces
US5976547A (en) 1997-04-22 1999-11-02 Niblick Pharmaceuticals, Inc. Analgesic and antiphlogistic compositions and therapeutic wrap for topical delivery
US5919473A (en) 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
ATE221770T1 (de) * 1997-05-14 2002-08-15 Galen Chemicals Ltd Topische mittel
US5861149A (en) * 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US20020128248A1 (en) 1997-06-20 2002-09-12 Metaphore Pharmaceuticals, Inc SODm therapy for prevention and/or treatment of inflammatory disease
US7150881B2 (en) 1997-06-26 2006-12-19 Mylan Technologies, Inc. Adhesive mixture for transdermal delivery of highly plasticizing drugs
GB9714650D0 (en) 1997-07-11 1997-09-17 Strakan Ltd Block copolymer
US6004577A (en) 1997-08-12 1999-12-21 Murdock; Thomas O. Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions
US5948433A (en) 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
DE69819748T2 (de) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen
RS49982B (sr) 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
AU1302499A (en) * 1997-11-12 1999-05-31 Alza Corporation Buffered drug formulations for transdermal electrotransport delivery
US6039977A (en) * 1997-12-09 2000-03-21 Alza Corporation Pharmaceutical hydrogel formulations, and associated drug delivery devices and methods
US6210705B1 (en) * 1997-12-15 2001-04-03 Noven Pharmaceuticals, Nc. Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
ES2281940T3 (es) * 1997-12-17 2007-10-01 Alza Corporation Iontoforesis con ajuste programado de la corriente electrica.
US6163720A (en) 1997-12-18 2000-12-19 Alza Corporation Layered rate controlling membranes for use in an electrotransport device
US6267984B1 (en) 1997-12-22 2001-07-31 Alza Corporation Skin permeation enhancer compositions comprising a monoglyceride and ethyl palmitate
JP4215188B2 (ja) * 1997-12-22 2009-01-28 インターシア セラピューティクス，インコーポレイティド 薬剤供給を調節するデバイスのための速度調節膜
WO1999038564A1 (en) * 1998-01-28 1999-08-05 Alza Corporation Electrochemically reactive cathodes for an electrotransport device
US6143278A (en) 1998-02-23 2000-11-07 Elkhoury; George F. Topical application of opioid analgesic drugs such as morphine
WO1999045906A1 (en) 1998-03-09 1999-09-16 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
KR19980025307A (ko) * 1998-04-11 1998-07-06 조태임 진통효과를 갖는 약물의 경피흡수제제
JP4205778B2 (ja) 1998-04-17 2009-01-07 久光製薬株式会社 貼付製剤
DE19818955C2 (de) * 1998-04-28 2000-06-29 Lohmann Therapie Syst Lts Zusammensetzung, enthaltend Polyacrylat, Polyterpen, Nitroglycerin und wahlweise Polyvinylacetat
GB9810126D0 (el) 1998-05-13 1998-07-08 Glaxo Group Ltd
US6398481B2 (en) 1998-05-14 2002-06-04 Avision Inc. Printer collators for collating printed papers in more than one positions
EP1079807B1 (en) * 1998-05-27 2006-09-13 Euro-Celtique S.A. Use of preparations for the application of antiseptic agents and/or agents promoting the healing of wounds to the lower respiratory tract
EP1082056B1 (en) * 1998-06-03 2007-11-14 Scott Laboratories, Inc. Apparatus for providing a conscious patient relief from pain and anxiety associated with medical or surgical procedures
US6717030B2 (en) 1998-07-06 2004-04-06 The Regents Of The University Of California Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse
US6946144B1 (en) * 1998-07-08 2005-09-20 Oryxe Transdermal delivery system
BR9912827A (pt) * 1998-07-16 2001-05-02 Sloan Kettering Inst Cancer Composições tópicas compreendendo um analgésico opióide e um antagonista de nmda
AU5102799A (en) 1998-07-16 2000-02-07 Memorial Sloan-Kettering Cancer Center Multiple splice variants of the mu-opioid receptor gene
CA2343100A1 (en) 1998-09-08 2000-05-04 Srinivasan Venkateshwaran Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs
SE9803240D0 (sv) 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
US6955819B2 (en) 1998-09-29 2005-10-18 Zars, Inc. Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances
US7001609B1 (en) 1998-10-02 2006-02-21 Regents Of The University Of Minnesota Mucosal originated drug delivery systems and animal applications
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
HUP0104383A3 (en) * 1998-11-02 2002-12-28 Alza Corp Mountain View Electrotransport drug delivery device including a compatible antimicrobial agent
DE19850517B4 (de) * 1998-11-03 2004-02-12 Lts Lohmann Therapie-Systeme Ag Verwendung eines wirkstoffhaltigen transdermalen therapeutischen Systems in einer Kombinationsbehandlung mit und ohne Ultraschall
WO2000031123A2 (en) 1998-11-19 2000-06-02 Elan Corporation, Plc Retro-inversion peptides that target gastro-intestinal tract transport receptors and use thereof
US6660715B2 (en) 1998-11-19 2003-12-09 Massachusetts Institute Of Technology Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
EP1133571B1 (en) 1998-11-23 2006-06-28 Proteome Sciences, Inc. Methods and compositions for pain management
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US6275728B1 (en) 1998-12-22 2001-08-14 Alza Corporation Thin polymer film drug reservoirs
US6355657B1 (en) * 1998-12-30 2002-03-12 Atrix Laboratories, Inc. System for percutaneous delivery of opioid analgesics
WO2000041538A2 (en) 1999-01-14 2000-07-20 Noven Pharmaceuticals, Inc. Dermal compositions
DE19901687B4 (de) * 1999-01-18 2006-06-01 Grünenthal GmbH Opioide Analgetika mit kontrollierter Wirkstofffreisetzung
PE20001396A1 (es) 1999-01-18 2000-12-23 Gruenenthal Chemie Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista
US6753337B2 (en) 1999-01-27 2004-06-22 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
WO2000047203A1 (en) 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
CH693625A5 (it) * 1999-02-18 2003-11-28 Inpharma Sa Composizioni farmaceutiche contenenti composti ad attività promotrice di assorbimento di principi attivi.
US6680071B1 (en) 1999-03-03 2004-01-20 R. P. Scherer Technologies, Inc. Opioid agonist in a fast dispersing dosage form
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
DE19912477A1 (de) 1999-03-19 2000-09-28 Lohmann Therapie Syst Lts Transdermales therapeutisches System und Verfahren zu seiner Herstellung
ES2244422T3 (es) 1999-04-01 2005-12-16 Alza Corporation Dispositivos para la administracion transdermica de farmacos que comprenden un deposito de poliuretano para farmacos.
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
WO2000061120A1 (fr) * 1999-04-13 2000-10-19 Hisamitsu Pharmaceutical Co., Inc. Préparations destinées à être absorbées par voie percutanée
US6319510B1 (en) 1999-04-20 2001-11-20 Alayne Yates Gum pad for delivery of medication to mucosal tissues
DE19918106A1 (de) 1999-04-22 2000-10-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern
US7186260B2 (en) 1999-04-29 2007-03-06 Hyson Morton I Medicated wrap
DE19923427A1 (de) 1999-05-21 2000-11-23 Lohmann Therapie Syst Lts Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
DE19925613A1 (de) * 1999-06-04 2000-12-07 Lohmann Therapie Syst Lts Verbundlaminat und Verfahren zu seiner Herstellung
AU5325000A (en) 1999-06-05 2000-12-28 David Houze Solubility enhancement of drugs in transdermal drug delivery systems and methodsof use
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
DE19938823A1 (de) 1999-08-19 2001-02-22 Boehringer Ingelheim Pharma Medikamentöse Behandlung des Restless Leg Syndroms
ATE279186T1 (de) 1999-08-31 2004-10-15 Gruenenthal Gmbh Retardierte darreichungsform enthaltend tramadolsaccharinat
EP1217975A1 (en) 1999-09-08 2002-07-03 Watson Pharmaceuticals, Inc. Using quaternary ammonium salts for transdermal drug delivery
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US20020147197A1 (en) 1999-10-08 2002-10-10 Newman Michael J. Methods and compositions for enhancing pharmaceutical treatments
KR20010036685A (ko) * 1999-10-11 2001-05-07 김윤 펜타닐을 함유하는 매트릭스형 경피투여제
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
US20040131665A1 (en) 1999-10-22 2004-07-08 Wepfer Scott T. Topical anesthetic formulation
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
JP2003515588A (ja) 1999-12-06 2003-05-07 マリンクロッド・インコーポレイテッド アルフェンタニル、スフェンタニルおよびレミフェンタニルの新合成法
US6716895B1 (en) * 1999-12-15 2004-04-06 C.R. Bard, Inc. Polymer compositions containing colloids of silver salts
US6562368B2 (en) 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers
GB9930071D0 (en) 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
EP1242421A1 (en) 1999-12-22 2002-09-25 Ortho-McNeil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1] octan-3-yl)] aminobenzoic acid derivatives
EP1138330A1 (en) 1999-12-23 2001-10-04 Warner-Lambert Company Combination of trimebutine with an opioid analgesic
ITMI992711A1 (it) 1999-12-27 2001-06-27 Novartis Ag Composti organici
US6596261B1 (en) 2000-01-25 2003-07-22 Aeropharm Technology Incorporated Method of administering a medicinal aerosol formulation
US20010039343A1 (en) 2000-01-28 2001-11-08 Mulvihill Mark Joseph Process to intermediates for biologically active compounds
US6716449B2 (en) * 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
US6471688B1 (en) 2000-02-15 2002-10-29 Microsolutions, Inc. Osmotic pump drug delivery systems and methods
US6464688B1 (en) 2000-02-15 2002-10-15 Microsolutions, Inc. Osmotic pump delivery system with flexible drug compartment
WO2001064149A1 (en) 2000-02-29 2001-09-07 Jie Zhang Improved transdermal drug patch
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
JP4216502B2 (ja) * 2000-03-24 2009-01-28 ファルマシア コーポレーション 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物
KR100393478B1 (ko) 2000-03-29 2003-08-06 주식회사종근당 자가유화 매트릭스형 경점막·경피흡수제제
US6872786B2 (en) 2000-04-10 2005-03-29 The Johns Hopkins University Molecularly imprinted polymeric sensor for the detection of explosives
US6682473B1 (en) 2000-04-14 2004-01-27 Solace Therapeutics, Inc. Devices and methods for attenuation of pressure waves in the body
US6761895B2 (en) 2000-04-17 2004-07-13 Yamanouchi Pharmaceutical Co., Ltd. Drug delivery system for averting pharmacokinetic drug interaction and method thereof
WO2001082914A2 (en) * 2000-04-28 2001-11-08 Memorial Sloan-Kettering Cancer Center Topical anesthetic/opioid formulations and uses thereof
US7049326B2 (en) 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
KR100452972B1 (ko) 2000-05-16 2004-10-14 주식회사 삼양사 경피투여용 하이드로젤 조성물
DE10025949A1 (de) 2000-05-26 2001-11-29 Gruenenthal Gmbh Arzneimittel zur Bekämpfung von Atemdepression
DE10025948A1 (de) 2000-05-26 2001-11-29 Gruenenthal Gmbh Wirkstoffkombination
DE10025946A1 (de) 2000-05-26 2001-11-29 Gruenenthal Gmbh Wirkstoffkombination
AU2001274307A1 (en) 2000-06-22 2002-01-02 Pharmasol Ltd Pharmaceutical compositions
GB0015617D0 (en) 2000-06-26 2000-08-16 Vectura Ltd Improved preparations for dermal delivery of active substances
US20020019421A1 (en) 2000-07-05 2002-02-14 Roni Biberman Compositions and therapy for substance addiction
US20020038310A1 (en) 2000-07-17 2002-03-28 Reitberg Donald P. Single-patient drug trials used with accumulated database: genomic markers
DK1307194T4 (da) * 2000-07-31 2011-07-18 Nycomed Danmark Aps Fentanylpræparat til nasal administration
AR030312A1 (es) 2000-08-03 2003-08-20 Antares Pharma Ipl Ag Composicion novedosa para la administracion transdermica y/o transmucosica de compuestos activos, que asegura adecuados niveles terapeuticos
US6528520B2 (en) 2000-08-15 2003-03-04 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US20020045572A1 (en) 2000-08-15 2002-04-18 Cpd, Llc Method of treating the syndrome of type 2 diabetes in humans
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
AU2001290719B2 (en) 2000-09-11 2006-06-22 Alza Corporation Transdermal electrotransport device and method for manufacturing same
JP2004509222A (ja) * 2000-09-19 2004-03-25 ナショナル　スターチ　アンド　ケミカル　インベストメント　ホールディング　コーポレイション 経皮薬物送達システムにおいて有用な非反応型接着剤
EP1326642A2 (en) 2000-09-29 2003-07-16 Board of Trustees operating Michigan State University Catecholamine pharmaceutical compositions and methods
US20020119187A1 (en) 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
GB0026137D0 (en) 2000-10-25 2000-12-13 Euro Celtique Sa Transdermal dosage form
EP1353909B1 (en) 2000-10-31 2005-04-06 Rensselaer Polytechnic Institute 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioidreceptor binding agents
US6682757B1 (en) * 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
ATE365536T1 (de) 2000-11-29 2007-07-15 Lyotropic Therapeutics Inc Lösungsmittelsysteme für pharmazeutische mittel
US20020106407A1 (en) 2000-12-11 2002-08-08 Dennis Coleman Method and apparatus for treating breakthrough pain
US6887876B2 (en) 2000-12-14 2005-05-03 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
US20050019381A1 (en) 2001-01-29 2005-01-27 Hans-Ulrich Petereit Binding agent which is stable in storage and used for pharmaceutical applications
GB0102902D0 (en) 2001-02-06 2001-03-21 Innovata Biomed Ltd Medicaments
US20020160043A1 (en) 2001-02-27 2002-10-31 Dennis Coleman Compositions and method of manufacture for oral dissolvable dosage forms
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
US7988991B2 (en) * 2001-03-07 2011-08-02 Hisamitsu Pharmaceutical Co., Inc. Adhesive patch
JP4850346B2 (ja) 2001-03-15 2012-01-11 救急薬品工業株式会社 粘膜貼付剤
US20050208117A1 (en) 2001-03-16 2005-09-22 Venkatraman Subramanian S Transdermal administration of fentanyl and analogs thereof
EP1757280A1 (en) 2001-03-16 2007-02-28 ALZA Corporation Transdermal patch for administering sufentanyl
NZ528148A (en) 2001-03-16 2006-02-24 Alza Corp Transdermal patch for administering fentanyl
US20020176841A1 (en) 2001-03-19 2002-11-28 Praecis Pharmaceuticals Inc. Pharmaceutical formulations for sustained release
WO2002076388A2 (en) 2001-03-23 2002-10-03 Albert Einstein College Of Medecine Of Yeshiva University Methods for increasing analgesic potency and attenuating adverse excitatory effects of bimodally-acting opioid agonists by inhibiting gm1-ganglioside
NZ528750A (en) 2001-04-04 2005-10-28 Alza Corp Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
US7112319B2 (en) 2001-04-06 2006-09-26 The Research Foundation Of The City University Of New York Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using microelectrodes with microvoltammetry
US6632217B2 (en) 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
EP2266719B1 (en) 2001-04-23 2016-06-08 Euro-Celtique S.A. Disposal system for transdermal dosage form
ATE339234T1 (de) 2001-04-30 2006-10-15 Medtronic Inc Implantierbare medizinische vorrichtung und kissenelektrodensystem
EA200301204A1 (ru) 2001-04-30 2004-04-29 Тромсдорф ГмбХ унд Ко.КГ Арцнаймиттель Фармацевтически активные производные нуклеозида, способ их получения, их применение (варианты) и содержащая их фармацевтическая композиция, способ профилактики и/или лечения заболеваний и нарушений млекопитающих (варианты), комбинация лекарственных средств и ее применение (варианты)
CA2473969A1 (en) 2001-04-30 2002-11-07 Lumimove, Inc. Electroluminescent devices fabricated with encapsulated light emitting polymer particles
DK2062573T3 (da) 2001-05-01 2012-01-30 Euro Celtique Sa Misbrugsresistent opioid indeholdende transdermale systemer
AU2002303718B2 (en) * 2001-05-11 2008-02-28 Endo Pharmaceuticals, Inc. Abuse-resistant opioid dosage form
US20020187996A1 (en) 2001-05-14 2002-12-12 Dewey Stephen L. Prevention of addiction in pain management
EP1405067A2 (en) 2001-05-23 2004-04-07 University Of Florida Method and apparatus for detecting illicit substances
AU2002312230A1 (en) 2001-06-05 2002-12-16 Elan Pharma International Limited System and method for milling materials
US6982263B2 (en) * 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
US6745944B2 (en) 2001-06-20 2004-06-08 Capital One Financial Corporation System and method for identifying applications loaded in a smart card
GB0117183D0 (en) 2001-07-13 2001-09-05 Rockwool Int Method and apparatus for growing plants
DE10141651B4 (de) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
DE20221159U1 (de) 2001-08-24 2005-04-07 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit Fentanyl bzw. verwandten Substanzen
DE10141652B4 (de) * 2001-08-24 2011-04-07 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
AUPR731901A0 (en) * 2001-08-28 2001-09-20 Goodchild, Colin Stanley Method of treatment
US7973064B2 (en) * 2001-11-27 2011-07-05 The Board Of Trustees Of The University Of Illinois Method and composition for potentiating an opiate analgesic
GB0130518D0 (en) 2001-12-21 2002-02-06 Univ Gent Pulsed bio-agent delivery systems based on degradable polymer solutions or hydrogels
US20030139396A1 (en) 2002-01-22 2003-07-24 Karen Gibson Method of treatment
GB0203276D0 (en) * 2002-02-12 2002-03-27 Novartis Ag Organic compounds
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
US20050186141A1 (en) 2002-06-25 2005-08-25 Acrux Dds Pty Ltd. Transdermal aerosol compositions
US20050181032A1 (en) 2002-06-25 2005-08-18 Acrux Dds Pty Ltd. Metastable pharmaceutical compositions
GB0218261D0 (en) 2002-08-06 2002-09-11 Charterhouse Therapeutics Ltd Improvements in pharmaceutically useful compounds
US6946150B2 (en) * 2002-08-14 2005-09-20 Gw Pharma Limited Pharmaceutical formulation
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
US20050278195A1 (en) 2004-05-28 2005-12-15 Getz Harry L Method for scheduling viewing of a live medical procedure

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US10583093B2 (en) 2020-03-10
ES2280563T3 (es) 2007-09-16
EP1782799A2 (de) 2007-05-09
CN102258501A (zh) 2011-11-30
JP2011006493A (ja) 2011-01-13
MXPA04001676A (es) 2004-05-31
KR100895189B1 (ko) 2009-04-24
US10568845B2 (en) 2020-02-25
EP1418894B1 (de) 2007-01-24
JP2005501111A (ja) 2005-01-13
PT1418894E (pt) 2007-04-30
WO2003018075A2 (de) 2003-03-06
ATE352293T1 (de) 2007-02-15
DE10141650C1 (de) 2002-11-28
WO2003018075A3 (de) 2003-11-20
AU2002328328B2 (en) 2007-03-15
US20200206148A1 (en) 2020-07-02
US20040234584A1 (en) 2004-11-25
EP1825849A1 (de) 2007-08-29
US10940122B2 (en) 2021-03-09
EP1418894A2 (de) 2004-05-19
DE50209364D1 (en) 2007-03-15
KR20040029007A (ko) 2004-04-03
DK1418894T3 (da) 2007-04-10
CN1713899A (zh) 2005-12-28
CA2457401A1 (en) 2003-03-06
BR0212026A (pt) 2004-08-03
ZA200400314B (en) 2004-11-01
EP1782799A3 (de) 2007-05-16
JP5405709B2 (ja) 2014-02-05
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US20190262277A1 (en) 2019-08-29
CA2457401C (en) 2010-09-07

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