CY1106246T1 - Ενωσεις δις(θειο-υδραζιδιο αμιδιου) για θepαπεια καρκινου διασταυρουμενης αντοχης - Google Patents
Ενωσεις δις(θειο-υδραζιδιο αμιδιου) για θepαπεια καρκινου διασταυρουμενης αντοχηςInfo
- Publication number
- CY1106246T1 CY1106246T1 CY20061101668T CY061101668T CY1106246T1 CY 1106246 T1 CY1106246 T1 CY 1106246T1 CY 20061101668 T CY20061101668 T CY 20061101668T CY 061101668 T CY061101668 T CY 061101668T CY 1106246 T1 CY1106246 T1 CY 1106246T1
- Authority
- CY
- Cyprus
- Prior art keywords
- substituted
- group
- aryl group
- cross
- aliphatic group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title 1
- 206010034133 Pathogen resistance Diseases 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44040603P | 2003-01-15 | 2003-01-15 | |
| PCT/US2004/001089 WO2004064826A1 (en) | 2003-01-15 | 2004-01-15 | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106246T1 true CY1106246T1 (el) | 2011-06-08 |
Family
ID=32771813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101668T CY1106246T1 (el) | 2003-01-15 | 2006-11-16 | Ενωσεις δις(θειο-υδραζιδιο αμιδιου) για θepαπεια καρκινου διασταυρουμενης αντοχης |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7763658B2 (https=) |
| EP (1) | EP1583524B1 (https=) |
| JP (1) | JP4852409B2 (https=) |
| AT (1) | ATE336991T1 (https=) |
| AU (1) | AU2004206865B2 (https=) |
| CA (1) | CA2512797C (https=) |
| CY (1) | CY1106246T1 (https=) |
| DE (1) | DE602004002087T2 (https=) |
| DK (1) | DK1583524T3 (https=) |
| ES (1) | ES2271839T3 (https=) |
| PT (1) | PT1583524E (https=) |
| TW (1) | TWI330079B (https=) |
| WO (1) | WO2004064826A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI297335B (en) * | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| MXPA06011219A (es) | 2004-03-29 | 2007-05-08 | Univ South Florida | Tratamiento efectivo de tumores y cancer con triciribina y compuestos relacionados. |
| PL1781604T3 (pl) * | 2004-06-23 | 2014-01-31 | Synta Pharmaceuticals Corp | Sole bis(tiohydrazydoamidu) do leczenia nowotworów |
| WO2006033913A2 (en) * | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
| WO2006062732A2 (en) * | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
| AU2005306471B2 (en) | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| MX2007012688A (es) * | 2005-04-15 | 2008-03-14 | Synta Pharmaceuticals Corp | Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida. |
| US20090042991A1 (en) * | 2005-04-15 | 2009-02-12 | James Barsoum | Methods of increasing natural killer cell activity for therapy |
| US7709683B2 (en) * | 2005-05-16 | 2010-05-04 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
| US7678832B2 (en) * | 2005-08-16 | 2010-03-16 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amide) formulation |
| WO2008024299A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| AU2007288340A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| EP2063878A2 (en) * | 2006-08-21 | 2009-06-03 | Synta Pharmaceuticals Corporation | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| WO2008024298A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
| RU2475478C2 (ru) | 2006-08-21 | 2013-02-20 | Синта Фармасьютиклз Корп. | Соединения для лечения пролиферативных расстройств |
| US8497272B2 (en) | 2006-08-21 | 2013-07-30 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| JP2010502616A (ja) * | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ |
| US20080118562A1 (en) * | 2006-09-11 | 2008-05-22 | Keizo Koya | Bis(thiohydrazide amides) formulation |
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| WO2009064374A2 (en) * | 2007-11-09 | 2009-05-22 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| US8637704B2 (en) | 2007-11-28 | 2014-01-28 | Synta Pharmaceuticals Corp. | Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide) |
| US8581004B2 (en) | 2008-02-21 | 2013-11-12 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| NZ592400A (en) | 2008-10-22 | 2013-09-27 | Synta Pharmaceuticals Corp | Transition metal complexes of bis[thiohydrazide amide] compounds |
| MX2011004114A (es) * | 2008-10-22 | 2011-08-15 | Synta Pharmaceuticals Corp | Complejos de metales de transicion de un compuesto bis (tiohidrazida amida). |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| EP2370402A2 (en) | 2008-12-01 | 2011-10-05 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
| JP2014534238A (ja) * | 2011-11-10 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）化合物の投与 |
| US20130149392A1 (en) | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
| CN112472699A (zh) | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
| UA124972C2 (uk) | 2016-07-29 | 2021-12-22 | Янссен Фармацевтика Нв | Способи лікування раку передміхурової залози |
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| WO2002094259A1 (en) | 2001-05-03 | 2002-11-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation |
| US6602907B1 (en) | 2001-06-08 | 2003-08-05 | University Of Central Florida | Treatment of breast cancer |
| US6924312B2 (en) | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| NZ533397A (en) | 2001-11-28 | 2005-12-23 | Sod Conseils Rech Applic | 5-sulphanyl-4H-1,2,4-triazole derivatives and their use as a medicament |
| TW200408407A (en) | 2001-11-30 | 2004-06-01 | Dana Farber Cancer Inst Inc | Methods and compositions for modulating the immune system and uses thereof |
| AU2006228035B2 (en) | 2003-01-15 | 2010-02-18 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
| SI1611112T1 (sl) | 2003-02-11 | 2012-12-31 | Vernalis (R&D) Limited | Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov |
| KR100575251B1 (ko) | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | ｐ38／ＪＴＶ－1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법 |
| EP1493445A1 (en) | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
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| KR100544347B1 (ko) | 2003-12-11 | 2006-01-23 | 한국생명공학연구원 | 디아릴이소옥사졸계 화합물을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물 |
| CA2560954A1 (en) | 2004-03-26 | 2005-10-20 | Amphora Discovery Corporation | Certain triazole-based compounds, compositions, and uses thereof |
| PL1781604T3 (pl) | 2004-06-23 | 2014-01-31 | Synta Pharmaceuticals Corp | Sole bis(tiohydrazydoamidu) do leczenia nowotworów |
| WO2006033913A2 (en) | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
| WO2006062732A2 (en) | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
| AU2005306471B2 (en) | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| MX2007009888A (es) | 2005-02-17 | 2007-10-16 | Synta Pharmaceuticals Corp | Compuestos para el tratamiento de trastornos proliferativos. |
| WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
| US20090042991A1 (en) | 2005-04-15 | 2009-02-12 | James Barsoum | Methods of increasing natural killer cell activity for therapy |
| MX2007012688A (es) | 2005-04-15 | 2008-03-14 | Synta Pharmaceuticals Corp | Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida. |
| US7709683B2 (en) | 2005-05-16 | 2010-05-04 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
| US7678832B2 (en) | 2005-08-16 | 2010-03-16 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amide) formulation |
| WO2007139955A2 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| WO2008024298A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
| EP2063878A2 (en) | 2006-08-21 | 2009-06-03 | Synta Pharmaceuticals Corporation | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| US8497272B2 (en) | 2006-08-21 | 2013-07-30 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2008024299A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| AU2007288340A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| RU2475478C2 (ru) | 2006-08-21 | 2013-02-20 | Синта Фармасьютиклз Корп. | Соединения для лечения пролиферативных расстройств |
| JP2010502616A (ja) | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ |
| US20080118562A1 (en) | 2006-09-11 | 2008-05-22 | Keizo Koya | Bis(thiohydrazide amides) formulation |
| JP2010503674A (ja) | 2006-09-14 | 2010-02-04 | シンタ ファーマシューティカルズ コーポレーション | 血管形成治療用化合物 |
| WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US20090093538A1 (en) | 2007-01-03 | 2009-04-09 | Synta Pharmaceuticals Corp | Method for treating cancer |
| US8729111B2 (en) | 2007-08-07 | 2014-05-20 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
-
2004
- 2004-01-14 TW TW093100878A patent/TWI330079B/zh not_active IP Right Cessation
- 2004-01-15 ES ES04702560T patent/ES2271839T3/es not_active Expired - Lifetime
- 2004-01-15 WO PCT/US2004/001089 patent/WO2004064826A1/en not_active Ceased
- 2004-01-15 AU AU2004206865A patent/AU2004206865B2/en not_active Ceased
- 2004-01-15 AT AT04702560T patent/ATE336991T1/de active
- 2004-01-15 EP EP04702560A patent/EP1583524B1/en not_active Expired - Lifetime
- 2004-01-15 DK DK04702560T patent/DK1583524T3/da active
- 2004-01-15 US US10/758,589 patent/US7763658B2/en not_active Expired - Fee Related
- 2004-01-15 PT PT04702560T patent/PT1583524E/pt unknown
- 2004-01-15 DE DE602004002087T patent/DE602004002087T2/de not_active Expired - Lifetime
- 2004-01-15 CA CA2512797A patent/CA2512797C/en not_active Expired - Fee Related
- 2004-01-15 JP JP2006500976A patent/JP4852409B2/ja not_active Expired - Fee Related
-
2006
- 2006-11-16 CY CY20061101668T patent/CY1106246T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1583524E (pt) | 2006-12-29 |
| CA2512797A1 (en) | 2004-08-05 |
| JP2006515626A (ja) | 2006-06-01 |
| WO2004064826A1 (en) | 2004-08-05 |
| AU2004206865B2 (en) | 2006-07-13 |
| DE602004002087T2 (de) | 2007-03-08 |
| DE602004002087D1 (de) | 2006-10-05 |
| JP4852409B2 (ja) | 2012-01-11 |
| DK1583524T3 (da) | 2006-12-27 |
| EP1583524B1 (en) | 2006-08-23 |
| AU2004206865A1 (en) | 2004-08-05 |
| EP1583524A1 (en) | 2005-10-12 |
| ES2271839T3 (es) | 2007-04-16 |
| CA2512797C (en) | 2012-02-21 |
| US20040225016A1 (en) | 2004-11-11 |
| US7763658B2 (en) | 2010-07-27 |
| TW200418449A (en) | 2004-10-01 |
| ATE336991T1 (de) | 2006-09-15 |
| HK1084024A1 (en) | 2006-07-21 |
| TWI330079B (en) | 2010-09-11 |
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