ES2271839T3 - Compuestos de bis(tio-hidrazida-amida) para el tratamiento de cancer resistente a multiples farmacos. - Google Patents

Compuestos de bis(tio-hidrazida-amida) para el tratamiento de cancer resistente a multiples farmacos. Download PDF

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Publication number
ES2271839T3
ES2271839T3 ES04702560T ES04702560T ES2271839T3 ES 2271839 T3 ES2271839 T3 ES 2271839T3 ES 04702560 T ES04702560 T ES 04702560T ES 04702560 T ES04702560 T ES 04702560T ES 2271839 T3 ES2271839 T3 ES 2271839T3
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ES
Spain
Prior art keywords
methyl
substituted
group
unsubstituted
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04702560T
Other languages
English (en)
Spanish (es)
Inventor
Keizo Koya
Lijun Sun
Yaming Wu
Timoty Korbut
Dan Zhou
Zhenjian Du
Shoujun Chen
Noriaki Tatsuta
Guiqing Liang
Mitsunori Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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Filing date
Publication date
Application filed by Synta Phamaceuticals Corp filed Critical Synta Phamaceuticals Corp
Application granted granted Critical
Publication of ES2271839T3 publication Critical patent/ES2271839T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES04702560T 2003-01-15 2004-01-15 Compuestos de bis(tio-hidrazida-amida) para el tratamiento de cancer resistente a multiples farmacos. Expired - Lifetime ES2271839T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44040603P 2003-01-15 2003-01-15
US440406P 2003-01-15

Publications (1)

Publication Number Publication Date
ES2271839T3 true ES2271839T3 (es) 2007-04-16

Family

ID=32771813

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04702560T Expired - Lifetime ES2271839T3 (es) 2003-01-15 2004-01-15 Compuestos de bis(tio-hidrazida-amida) para el tratamiento de cancer resistente a multiples farmacos.

Country Status (13)

Country Link
US (1) US7763658B2 (https=)
EP (1) EP1583524B1 (https=)
JP (1) JP4852409B2 (https=)
AT (1) ATE336991T1 (https=)
AU (1) AU2004206865B2 (https=)
CA (1) CA2512797C (https=)
CY (1) CY1106246T1 (https=)
DE (1) DE602004002087T2 (https=)
DK (1) DK1583524T3 (https=)
ES (1) ES2271839T3 (https=)
PT (1) PT1583524E (https=)
TW (1) TWI330079B (https=)
WO (1) WO2004064826A1 (https=)

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US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
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WO2008033494A2 (en) 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) * 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
US8637704B2 (en) 2007-11-28 2014-01-28 Synta Pharmaceuticals Corp. Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide)
US8581004B2 (en) 2008-02-21 2013-11-12 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8633323B2 (en) * 2008-03-31 2014-01-21 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
NZ592400A (en) 2008-10-22 2013-09-27 Synta Pharmaceuticals Corp Transition metal complexes of bis[thiohydrazide amide] compounds
MX2011004114A (es) * 2008-10-22 2011-08-15 Synta Pharmaceuticals Corp Complejos de metales de transicion de un compuesto bis (tiohidrazida amida).
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EP2370402A2 (en) 2008-12-01 2011-10-05 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
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JP2014534238A (ja) * 2011-11-10 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）化合物の投与
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CN112472699A (zh) 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法
UA124972C2 (uk) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Способи лікування раку передміхурової залози

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Also Published As

Publication number Publication date
PT1583524E (pt) 2006-12-29
CA2512797A1 (en) 2004-08-05
JP2006515626A (ja) 2006-06-01
WO2004064826A1 (en) 2004-08-05
AU2004206865B2 (en) 2006-07-13
DE602004002087T2 (de) 2007-03-08
CY1106246T1 (el) 2011-06-08
DE602004002087D1 (de) 2006-10-05
JP4852409B2 (ja) 2012-01-11
DK1583524T3 (da) 2006-12-27
EP1583524B1 (en) 2006-08-23
AU2004206865A1 (en) 2004-08-05
EP1583524A1 (en) 2005-10-12
CA2512797C (en) 2012-02-21
US20040225016A1 (en) 2004-11-11
US7763658B2 (en) 2010-07-27
TW200418449A (en) 2004-10-01
ATE336991T1 (de) 2006-09-15
HK1084024A1 (en) 2006-07-21
TWI330079B (en) 2010-09-11

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