CU23806B7 - Antagonistas del receptor 3 de la histamina - Google Patents

Antagonistas del receptor 3 de la histamina

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Publication number
CU23806B7
CU23806B7 CU20080069A CU20080069A CU23806B7 CU 23806 B7 CU23806 B7 CU 23806B7 CU 20080069 A CU20080069 A CU 20080069A CU 20080069 A CU20080069 A CU 20080069A CU 23806 B7 CU23806 B7 CU 23806B7
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CU
Cuba
Prior art keywords
formula
compound
disorders
treatment
congestion
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Application number
CU20080069A
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English (en)
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CU20080069A7 (es
Inventor
Ramalakshmi Yegna Chandrasekaran
Todd William Butler
Travis T Wager
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Pfizer Prod Inc
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Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CU20080069A7 publication Critical patent/CU20080069A7/es
Publication of CU23806B7 publication Critical patent/CU23806B7/es

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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07C233/58Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
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  • Pulmonology (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
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  • Immunology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Esta invención está dirigida a un compuesto de fórmula I, ESPACIO PARA FÓRMULA I como se define en la presente memoria, o una sal farmacéuticamente aceptable del mismo; una composición farmacéutica que contiene un compuesto de fórmula I, un procedimiento de preparación de un compuesto de fórmula I, un método de tratamiento de un trastorno o enfermedad que se puede tratar antagonizando los receptores H3 de la histamina, el método comprende administrar a un mamífero que necesita tal tratamiento un compuesto de fórmula I como se describió anteriormente, y un método de tratamiento de un trastorno o enfermedad seleccionado del grupo que consiste en depresión, trastornos del humor, esquizofrenia, trastornos de ansiedad, enfermedad de Alzheimer, trastorno de hiperactividad con déficit de atención (ADHD), trastornos psicóticos, trastornos cognitivos, trastornos de sueno, obesidad, vértigo, epilepsia, mareo, enfermedades respiratorias, alergia, reacciones de las vías respiratorias inducidas por alergia, rinitis alérgica, congestión nasal, congestión alérgica, congestión, hipotensión, dolencias cardiovasculares, enfermedades del tracto gastrointestinal, hiper e hipo motilidad y secreción ácida del tracto gastrointestinal, el método comprende administrar a un mamífero que necesita tal tratamiento un compuesto de fórmula I como se describió anteriormente.
CU20080069A 2005-10-27 2008-04-23 Antagonistas del receptor 3 de la histamina CU23806B7 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73099605P 2005-10-27 2005-10-27

Publications (2)

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CU20080069A7 CU20080069A7 (es) 2009-12-17
CU23806B7 true CU23806B7 (es) 2012-04-15

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US (2) US8158673B2 (es)
EP (1) EP1951660B1 (es)
JP (2) JP4319245B2 (es)
KR (1) KR101025358B1 (es)
CN (1) CN101296898B (es)
AP (1) AP2403A (es)
AR (1) AR056879A1 (es)
AU (1) AU2006307645B2 (es)
BR (1) BRPI0617797A2 (es)
CA (1) CA2621323C (es)
CR (1) CR9910A (es)
CU (1) CU23806B7 (es)
DK (1) DK1951660T3 (es)
DO (1) DOP2006000239A (es)
EA (1) EA013602B1 (es)
EC (1) ECSP088373A (es)
ES (1) ES2444370T3 (es)
GE (1) GEP20104937B (es)
GT (1) GT200600471A (es)
HK (1) HK1124831A1 (es)
HN (1) HN2006036385A (es)
HR (1) HRP20140061T1 (es)
IL (1) IL189866A (es)
MA (1) MA29888B1 (es)
MY (1) MY145001A (es)
NI (1) NI200800132A (es)
NL (1) NL1032713C2 (es)
NO (1) NO20082264L (es)
NZ (1) NZ566488A (es)
PE (1) PE20070720A1 (es)
PL (1) PL1951660T3 (es)
PT (1) PT1951660E (es)
RS (2) RS53153B (es)
SI (1) SI1951660T1 (es)
TN (1) TNSN08150A1 (es)
TW (1) TWI318206B (es)
UA (1) UA88719C2 (es)
UY (1) UY29882A1 (es)
WO (1) WO2007049123A1 (es)
ZA (1) ZA200803130B (es)

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