AR076979A1 - 2- aminooxazolinas como ligandos de taar1 - Google Patents

2- aminooxazolinas como ligandos de taar1

Info

Publication number
AR076979A1
AR076979A1 ARP100101977A ARP100101977A AR076979A1 AR 076979 A1 AR076979 A1 AR 076979A1 AR P100101977 A ARP100101977 A AR P100101977A AR P100101977 A ARP100101977 A AR P100101977A AR 076979 A1 AR076979 A1 AR 076979A1
Authority
AR
Argentina
Prior art keywords
disorders
lower alkyl
halogen
disease
formula
Prior art date
Application number
ARP100101977A
Other languages
English (en)
Inventor
Katrin Groebke Zbinden
Roger Norcross
Guillaume Decoret
Guido Galley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR076979A1 publication Critical patent/AR076979A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Abstract

Los compuestos de la formula 1, son activos en el receptor de TAARI, y así, por lo tanto, son apropiados para el tratamiento de la depresion, los trastornos de la ansiedad, el trastorno bipolar, el trastorno de hiperactividad del déficit de atencion, los trastornos relacionados con el estrés, los trastornos psicoticos, la esquizofrenia, las enfermedades neurologicas, la enfermedad de Parkinson, los trastornos neurodegenerativos, la enfermedad de Alzheimer, la epilepsia, la migrana, el abuso de substancias y los trastornos metabolicos, los trastornos del comer, la diabetes, las complicaciones diabéticas, la obesidad, la dislipemia, los trastornos del consumo y de la asimilacion de energía, los trastornos y el mal funcionamiento de la homeostasis de la temperatura corporal, trastornos del sueno y del ritmo circardiano, y trastornos cardiovasculares. Composiciones farmacéuticas. Reivindicacion 1: Un compuesto de la formula (1) en donde, R1, es halogeno; R2, es alquilo inferior o alquilo inferior sustituido por halogeno; R2', es hidrogeno, alquilo inferior o alquilo inferior sustituido por halogeno; X, es un eslabon, -CH2-, -CH2CH2- o -CH2CH2CH2-; Y, es fenilo o ciclohexilo; y n, es 0, 1 o 2, o una sal de adicion de ácidos de éste, farmacéuticamente aceptable.
ARP100101977A 2009-06-05 2010-06-04 2- aminooxazolinas como ligandos de taar1 AR076979A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09162061 2009-06-05

Publications (1)

Publication Number Publication Date
AR076979A1 true AR076979A1 (es) 2011-07-20

Family

ID=42342699

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101977A AR076979A1 (es) 2009-06-05 2010-06-04 2- aminooxazolinas como ligandos de taar1

Country Status (4)

Country Link
US (1) US20100311798A1 (es)
AR (1) AR076979A1 (es)
TW (1) TW201103538A (es)
WO (1) WO2010139707A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS60825B1 (sr) 2016-03-17 2020-10-30 Hoffmann La Roche Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a
MA44859A (fr) 2016-05-04 2019-03-13 Purdue Pharma Lp Pseudodimères d'oxazoline, compositions pharmaceutiques et utilisation correspondantes
PL240819B1 (pl) * 2020-06-25 2022-06-06 Inst Biologii Doswiadczalnej Im M Nenckiego Polskiej Akademii Nauk Pochodne 4,5-dihydro oksazol-2-ilo aminy do zastosowania w zapobieganiu lub leczeniu choroby alkoholowej

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IL147921A0 (en) * 2002-01-31 2002-08-14 Abdulrazik Mohammad A method for treating central nervous system disorders by ocular dosing
BRPI0806940A2 (pt) * 2007-02-02 2014-05-06 Hoffmann La Roche 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc

Also Published As

Publication number Publication date
WO2010139707A1 (en) 2010-12-09
TW201103538A (en) 2011-02-01
US20100311798A1 (en) 2010-12-09

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