CS8701093A2 - Method of new cycloalkano/1,2-b/-indolesulphoamides production - Google Patents

Method of new cycloalkano/1,2-b/-indolesulphoamides production

Info

Publication number
CS8701093A2
CS8701093A2 CS871093A CS109387A CS8701093A2 CS 8701093 A2 CS8701093 A2 CS 8701093A2 CS 871093 A CS871093 A CS 871093A CS 109387 A CS109387 A CS 109387A CS 8701093 A2 CS8701093 A2 CS 8701093A2
Authority
CS
Czechoslovakia
Prior art keywords
indolesulphoamides
production
cycloalkano
new
new cycloalkano
Prior art date
Application number
CS871093A
Other languages
English (en)
Other versions
CS275837B6 (en
Inventor
Horst Dr Boshagen
Ulrich Dr Rosentreter
Folker Dr Lieb
Hermann Dr Oediger
Friedel Dr Seuter
Elisabeth Dr Perzborn
Volker-Bernd Dr Fiedler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Priority to CS886891A priority Critical patent/CS276468B6/cs
Priority to CS886892A priority patent/CS276469B6/cs
Publication of CS8701093A2 publication Critical patent/CS8701093A2/cs
Publication of CS275837B6 publication Critical patent/CS275837B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS871093A 1986-02-21 1987-02-19 Method of production of new cycloalkan0-|1,2b¨-indole sulfonamides CS275837B6 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS886891A CS276468B6 (cs) 1986-02-21 1987-02-19 Způsob výroby nových /fenylsulfonamidoalkyl/ /fenylsulfonamido/eykloalkano/l,2-b/indolů
CS886892A CS276469B6 (cs) 1986-02-21 1988-10-19 Způsob výroby cykloalkanonsulfonamidů

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3605566 1986-02-21
DE19863631824 DE3631824A1 (de) 1986-02-21 1986-09-19 Cycloalkano(1.2-b)indol-sulfonamide

Publications (2)

Publication Number Publication Date
CS8701093A2 true CS8701093A2 (en) 1990-11-14
CS275837B6 CS275837B6 (en) 1992-03-18

Family

ID=25841196

Family Applications (1)

Application Number Title Priority Date Filing Date
CS871093A CS275837B6 (en) 1986-02-21 1987-02-19 Method of production of new cycloalkan0-|1,2b¨-indole sulfonamides

Country Status (19)

Country Link
US (3) US4827032A (cs)
EP (1) EP0242518B1 (cs)
JP (1) JPH075552B2 (cs)
KR (2) KR940007302B1 (cs)
AU (1) AU595855B2 (cs)
CA (1) CA1309414C (cs)
CS (1) CS275837B6 (cs)
DE (2) DE3631824A1 (cs)
DK (1) DK167009B1 (cs)
ES (1) ES2028801T3 (cs)
FI (1) FI86544C (cs)
GR (1) GR3001763T3 (cs)
HU (1) HU198686B (cs)
IE (1) IE59470B1 (cs)
IL (1) IL81611A (cs)
NO (1) NO171633C (cs)
NZ (1) NZ219319A (cs)
PH (1) PH24491A (cs)
PT (1) PT84316B (cs)

Families Citing this family (36)

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DE3826371A1 (de) * 1988-08-03 1990-02-08 Bayer Ag Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
DE3829455A1 (de) * 1988-08-31 1990-03-15 Boehringer Mannheim Gmbh Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) * 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) * 1990-08-29 1992-03-05 Bayer Ag Heterocyclisch substituierte indolsulfonamide
US5827871A (en) * 1991-06-26 1998-10-27 Smithkline Beecham Plc Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
DE4131346A1 (de) * 1991-09-20 1993-03-25 Bayer Ag Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ES2122982T3 (es) * 1992-12-18 1999-01-01 Smithkline Beecham Plc Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1.
DE19507751A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten 1,2,3,4-Tetrahydrocarbazolen
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE19757983A1 (de) * 1997-12-24 1999-07-01 Bayer Yakuhin Ltd Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
JP4972644B2 (ja) * 2005-08-12 2012-07-11 メルク カナダ インコーポレイテッド Ｃｒｔｈ２受容体拮抗薬としてのインドール誘導体
US7662831B2 (en) * 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) * 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
WO2008017989A1 (en) 2006-08-07 2008-02-14 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
WO2008075028A1 (en) * 2006-12-20 2008-06-26 Cardoz Ab New combination for use in the treatment of inflammatory disorders
US20100099693A1 (en) * 2007-01-16 2010-04-22 Johan Raud New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
WO2010008864A2 (en) * 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
EP2307382B1 (en) * 2008-07-15 2011-12-21 F. Hoffmann-La Roche AG Aminotetrahydroindazoloacetic acids
US8124629B2 (en) 2008-11-17 2012-02-28 Hoffmann-La Roche Inc. Naphthylacetic acids
EP2358677B1 (en) 2008-11-17 2014-01-08 F. Hoffmann-La Roche AG Naphthylacetic acids used as crth2 antagonists or partial agonists
RS52809B (en) 2008-11-17 2013-10-31 F. Hoffmann-La Roche Ag. NAPHTHYL ACID
HRP20141208T1 (hr) 2010-03-22 2015-02-13 Actelion Pharmaceuticals Ltd. Derivati 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-karbazola i njihova uporaba kao modulatora receptora prostaglandina d2
RU2596823C2 (ru) 2011-04-14 2016-09-10 Актелион Фармасьютиклз Лтд ПРОИЗВОДНЫЕ 7-(ГЕТЕРОАРИЛ-АМИНО)-6,7,8,9-ТЕТРАГИДРОПИРИДО[1,2-a]ИНДОЛ-УКСУСНОЙ КИСЛОТЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРА ПРОСТАГЛАНДИНА D2
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
MY179356A (en) 2014-03-17 2020-11-05 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
KR20160133536A (ko) 2014-03-18 2016-11-22 액테리온 파마슈티칼 리미티드 아자인돌 아세트산 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 이의 용도
US20180021302A1 (en) 2015-02-13 2018-01-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
PL3350179T3 (pl) 2015-09-15 2021-08-02 Idorsia Pharmaceuticals Ltd Krystaliczne postacie

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1415322A (fr) * 1963-12-09 1965-10-22 Eastman Kodak Co Nouveaux composés de 3-sulfamidocyclobutanone et de 3-sulfamidocyclobutanol
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
JPS4713658Y1 (cs) * 1969-12-18 1972-05-18
CH586678A5 (cs) * 1970-05-25 1977-04-15 Hoffmann La Roche
DE2226702A1 (de) * 1972-05-25 1973-12-13 Schering Ag Neue mittel zur behandlung des diabetes mellitus
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4235901A (en) * 1978-05-08 1980-11-25 American Home Products Corporation 1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

Also Published As

Publication number Publication date
DK87187A (da) 1987-08-22
KR960001914B1 (en) 1996-02-06
PT84316A (en) 1987-03-01
HUT44493A (en) 1988-03-28
PH24491A (en) 1990-07-18
KR870007885A (ko) 1987-09-22
KR890001982A (ko) 1989-04-07
US4965258A (en) 1990-10-23
EP0242518A1 (de) 1987-10-28
DK87187D0 (da) 1987-02-20
DK167009B1 (da) 1993-08-16
HU198686B (en) 1989-11-28
IE870439L (en) 1987-08-21
US4827032A (en) 1989-05-02
ES2028801T3 (es) 1992-07-16
DE3769191D1 (de) 1991-05-16
AU6880887A (en) 1987-08-27
PT84316B (pt) 1989-09-14
US4904797A (en) 1990-02-27
NO171633C (no) 1993-04-14
IE59470B1 (en) 1994-03-09
FI86544C (fi) 1992-09-10
CS275837B6 (en) 1992-03-18
NO870437L (no) 1987-08-24
EP0242518B1 (de) 1991-04-10
NO870437D0 (no) 1987-02-04
NZ219319A (en) 1990-12-21
CA1309414C (en) 1992-10-27
FI870693A7 (fi) 1987-08-22
JPH075552B2 (ja) 1995-01-25
IL81611A (en) 1991-03-10
FI86544B (fi) 1992-05-29
NO171633B (no) 1993-01-04
JPH0592954A (ja) 1993-04-16
KR940007302B1 (ko) 1994-08-12
DE3631824A1 (de) 1988-03-31
GR3001763T3 (en) 1992-11-23
FI870693A0 (fi) 1987-02-19
AU595855B2 (en) 1990-04-12

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