KR960001914B1 - Cycloalkano£1,2-b|indole-sulfonamides - Google Patents

Cycloalkano£1,2-b|indole-sulfonamides Download PDF

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Publication number
KR960001914B1
KR960001914B1 KR87008383A KR870008383A KR960001914B1 KR 960001914 B1 KR960001914 B1 KR 960001914B1 KR 87008383 A KR87008383 A KR 87008383A KR 870008383 A KR870008383 A KR 870008383A KR 960001914 B1 KR960001914 B1 KR 960001914B1
Authority
KR
South Korea
Prior art keywords
cycloalkano
sulfonamides
indole
Prior art date
Application number
KR87008383A
Other languages
English (en)
Other versions
KR890001982A (ko
Inventor
Horst Boeshagen
Ulrich Rosentreter
Folker Lieb
Hermann Oediger
Friedel Seuter
Elisabeth Perzborn
Volker-Bernd Fiedler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of KR890001982A publication Critical patent/KR890001982A/ko
Application granted granted Critical
Publication of KR960001914B1 publication Critical patent/KR960001914B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
KR87008383A 1986-02-21 1987-07-31 Cycloalkano£1,2-b|indole-sulfonamides KR960001914B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3605566 1986-02-21
DE19863631824 DE3631824A1 (de) 1986-02-21 1986-09-19 Cycloalkano(1.2-b)indol-sulfonamide

Publications (2)

Publication Number Publication Date
KR890001982A KR890001982A (ko) 1989-04-07
KR960001914B1 true KR960001914B1 (en) 1996-02-06

Family

ID=25841196

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019870001410A KR940007302B1 (ko) 1986-02-21 1987-02-20 시클로알카노 [1,2-b]인돌-술폰아미드 및 그의 제조 방법
KR87008383A KR960001914B1 (en) 1986-02-21 1987-07-31 Cycloalkano£1,2-b|indole-sulfonamides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019870001410A KR940007302B1 (ko) 1986-02-21 1987-02-20 시클로알카노 [1,2-b]인돌-술폰아미드 및 그의 제조 방법

Country Status (19)

Country Link
US (3) US4827032A (ko)
EP (1) EP0242518B1 (ko)
JP (1) JPH075552B2 (ko)
KR (2) KR940007302B1 (ko)
AU (1) AU595855B2 (ko)
CA (1) CA1309414C (ko)
CS (1) CS275837B6 (ko)
DE (2) DE3631824A1 (ko)
DK (1) DK167009B1 (ko)
ES (1) ES2028801T3 (ko)
FI (1) FI86544C (ko)
GR (1) GR3001763T3 (ko)
HU (1) HU198686B (ko)
IE (1) IE59470B1 (ko)
IL (1) IL81611A (ko)
NO (1) NO171633C (ko)
NZ (1) NZ219319A (ko)
PH (1) PH24491A (ko)
PT (1) PT84316B (ko)

Families Citing this family (35)

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DE3826371A1 (de) * 1988-08-03 1990-02-08 Bayer Ag Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
DE3829455A1 (de) * 1988-08-31 1990-03-15 Boehringer Mannheim Gmbh Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) * 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) * 1990-08-29 1992-03-05 Bayer Ag Heterocyclisch substituierte indolsulfonamide
US5827871A (en) * 1991-06-26 1998-10-27 Smithkline Beecham Plc Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
DE4131346A1 (de) * 1991-09-20 1993-03-25 Bayer Ag Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ES2122982T3 (es) * 1992-12-18 1999-01-01 Smithkline Beecham Plc Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1.
DE19507751A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten 1,2,3,4-Tetrahydrocarbazolen
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE19757983A1 (de) 1997-12-24 1999-07-01 Bayer Yakuhin Ltd Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
CA2618550C (en) * 2005-08-12 2013-12-17 Merck Frosst Canada Ltd. Indole derivatives as crth2 receptor antagonists
US7662831B2 (en) * 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) * 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
NZ574705A (en) 2006-08-07 2011-12-22 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
EP2107907B1 (en) * 2006-12-20 2012-02-01 Cardoz AB Combination of pemirolast and ramatroban for use in the treatment of inflammatory disorders
CA2675520A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
JP2011526281A (ja) * 2008-06-24 2011-10-06 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のシクロアルカン［ｂ］インドールアンタゴニスト
WO2010006939A1 (en) * 2008-07-15 2010-01-21 F. Hoffmann-La Roche Ag Aminotetrahydroindazoloacetic acids
CN102216273A (zh) 2008-11-17 2011-10-12 霍夫曼-拉罗奇有限公司 用作crth2拮抗剂或部分激动剂的萘乙酸
AU2009315713A1 (en) 2008-11-17 2010-05-20 F. Hoffmann-La Roche Ag Naphthylacetic acids
PE20110703A1 (es) 2008-11-17 2011-10-13 Hoffmann La Roche Acidos naftilaceticos
NZ603108A (en) 2010-03-22 2014-05-30 Actelion Pharmaceuticals Ltd 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
JP5964945B2 (ja) 2011-04-14 2016-08-03 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ７−（ヘテロアリ−ル−アミノ）−６，７，８，９−テトラヒドロピリド［１，２−ａ］インド−ル酢酸誘導体及びプロスタグランジンＤ２受容体調節剤としてのそれらの使用
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
JP6152489B2 (ja) 2014-03-17 2017-06-21 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ アザインドール酢酸誘導体及びプロスタグランジンｄ２受容体調節剤としてのそれらの使用
CA2938107A1 (en) 2014-03-18 2015-09-24 Actelion Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
CA2993893A1 (en) 2015-09-15 2017-03-23 Idorsia Pharmaceuticals Ltd Crystalline forms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1415322A (fr) * 1963-12-09 1965-10-22 Eastman Kodak Co Nouveaux composés de 3-sulfamidocyclobutanone et de 3-sulfamidocyclobutanol
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
JPS4713658Y1 (ko) * 1969-12-18 1972-05-18
CH586678A5 (ko) * 1970-05-25 1977-04-15 Hoffmann La Roche
DE2226702A1 (de) * 1972-05-25 1973-12-13 Schering Ag Neue mittel zur behandlung des diabetes mellitus
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4235901A (en) * 1978-05-08 1980-11-25 American Home Products Corporation 1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

Also Published As

Publication number Publication date
CS275837B6 (en) 1992-03-18
GR3001763T3 (en) 1992-11-23
US4965258A (en) 1990-10-23
EP0242518B1 (de) 1991-04-10
JPH0592954A (ja) 1993-04-16
HU198686B (en) 1989-11-28
FI86544C (fi) 1992-09-10
FI870693A0 (fi) 1987-02-19
NO171633B (no) 1993-01-04
PT84316A (en) 1987-03-01
HUT44493A (en) 1988-03-28
PH24491A (en) 1990-07-18
AU6880887A (en) 1987-08-27
CA1309414C (en) 1992-10-27
IL81611A (en) 1991-03-10
DK87187A (da) 1987-08-22
ES2028801T3 (es) 1992-07-16
IE59470B1 (en) 1994-03-09
NO870437D0 (no) 1987-02-04
KR870007885A (ko) 1987-09-22
US4827032A (en) 1989-05-02
KR940007302B1 (ko) 1994-08-12
JPH075552B2 (ja) 1995-01-25
FI86544B (fi) 1992-05-29
EP0242518A1 (de) 1987-10-28
CS8701093A2 (en) 1990-11-14
DK87187D0 (da) 1987-02-20
NO171633C (no) 1993-04-14
DE3769191D1 (de) 1991-05-16
NO870437L (no) 1987-08-24
FI870693A (fi) 1987-08-22
DE3631824A1 (de) 1988-03-31
IE870439L (en) 1987-08-21
KR890001982A (ko) 1989-04-07
PT84316B (pt) 1989-09-14
NZ219319A (en) 1990-12-21
AU595855B2 (en) 1990-04-12
US4904797A (en) 1990-02-27
DK167009B1 (da) 1993-08-16

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Legal Events

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A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20060113

Year of fee payment: 11

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