FI870693A - Cykloalkano(1,2-b)indolsulfonamider. - Google Patents

Cykloalkano(1,2-b)indolsulfonamider. Download PDF

Info

Publication number
FI870693A
FI870693A FI870693A FI870693A FI870693A FI 870693 A FI870693 A FI 870693A FI 870693 A FI870693 A FI 870693A FI 870693 A FI870693 A FI 870693A FI 870693 A FI870693 A FI 870693A
Authority
FI
Finland
Prior art keywords
indolsulfonamider
cykloalkano
Prior art date
Application number
FI870693A
Other languages
English (en)
Other versions
FI86544C (fi
FI86544B (fi
FI870693A0 (fi
Inventor
Horst Boeshagen
Ulrich Rosentreter
Folker Lieb
Hermann Oediger
Friedel Seuter
Elisabeth Perzborn
Volker-Bernd Fiedler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI870693A0 publication Critical patent/FI870693A0/fi
Publication of FI870693A publication Critical patent/FI870693A/fi
Application granted granted Critical
Publication of FI86544B publication Critical patent/FI86544B/fi
Publication of FI86544C publication Critical patent/FI86544C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI870693A 1986-02-21 1987-02-19 Foerfarande foer framstaellning av terapeutiskt aktiva cykloalkano/1,2-b/indolsulfonamidderivat och vid foerfarandet som mellanprodukter anvaendbara bensensulfonamidoalkylcykloalkano/1,2-b/indolderivat. FI86544C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3605566 1986-02-21
DE3605566 1986-02-21
DE19863631824 DE3631824A1 (de) 1986-02-21 1986-09-19 Cycloalkano(1.2-b)indol-sulfonamide
DE3631824 1986-09-19

Publications (4)

Publication Number Publication Date
FI870693A0 FI870693A0 (fi) 1987-02-19
FI870693A true FI870693A (fi) 1987-08-22
FI86544B FI86544B (fi) 1992-05-29
FI86544C FI86544C (fi) 1992-09-10

Family

ID=25841196

Family Applications (1)

Application Number Title Priority Date Filing Date
FI870693A FI86544C (fi) 1986-02-21 1987-02-19 Foerfarande foer framstaellning av terapeutiskt aktiva cykloalkano/1,2-b/indolsulfonamidderivat och vid foerfarandet som mellanprodukter anvaendbara bensensulfonamidoalkylcykloalkano/1,2-b/indolderivat.

Country Status (19)

Country Link
US (3) US4827032A (fi)
EP (1) EP0242518B1 (fi)
JP (1) JPH075552B2 (fi)
KR (2) KR940007302B1 (fi)
AU (1) AU595855B2 (fi)
CA (1) CA1309414C (fi)
CS (1) CS275837B6 (fi)
DE (2) DE3631824A1 (fi)
DK (1) DK167009B1 (fi)
ES (1) ES2028801T3 (fi)
FI (1) FI86544C (fi)
GR (1) GR3001763T3 (fi)
HU (1) HU198686B (fi)
IE (1) IE59470B1 (fi)
IL (1) IL81611A (fi)
NO (1) NO171633C (fi)
NZ (1) NZ219319A (fi)
PH (1) PH24491A (fi)
PT (1) PT84316B (fi)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3826371A1 (de) * 1988-08-03 1990-02-08 Bayer Ag Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
DE3829455A1 (de) * 1988-08-31 1990-03-15 Boehringer Mannheim Gmbh Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) * 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) * 1990-08-29 1992-03-05 Bayer Ag Heterocyclisch substituierte indolsulfonamide
US5827871A (en) * 1991-06-26 1998-10-27 Smithkline Beecham Plc Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
DE4131346A1 (de) * 1991-09-20 1993-03-25 Bayer Ag Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ES2122982T3 (es) * 1992-12-18 1999-01-01 Smithkline Beecham Plc Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1.
DE19507751A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten 1,2,3,4-Tetrahydrocarbazolen
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE19757983A1 (de) 1997-12-24 1999-07-01 Bayer Yakuhin Ltd Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
AU2006281937B2 (en) * 2005-08-12 2011-11-17 Merck Canada Inc. Indole derivatives as CRTH2 receptor antagonists
US7601856B2 (en) * 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
US7662831B2 (en) * 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
PL2051962T3 (pl) 2006-08-07 2012-03-30 Actelion Pharmaceuticals Ltd Pochodne kwasu (3-amino-1,2,3,4-tetrahydro-9h-karbazol-9-ilo)-octowego
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
EP2107907B1 (en) * 2006-12-20 2012-02-01 Cardoz AB Combination of pemirolast and ramatroban for use in the treatment of inflammatory disorders
CA2675520A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
EP2300425A4 (en) * 2008-06-24 2012-03-21 Panmira Pharmaceuticals Llc PROSTAGLANDIN D2 RECEPTOR CYCLOALCANEÝBINDLUCK ANTAGONISTS
CA2728311A1 (en) 2008-07-15 2010-01-21 F. Hoffmann-La Roche Ag Aminotetrahydroindazoloacetic acids
US8124629B2 (en) 2008-11-17 2012-02-28 Hoffmann-La Roche Inc. Naphthylacetic acids
US8188090B2 (en) 2008-11-17 2012-05-29 Hoffman-La Roche Inc. Naphthylacetic acids
EP2346819B1 (en) 2008-11-17 2013-04-10 F. Hoffmann-La Roche AG Naphthylacetic acids
BR112012024114B1 (pt) 2010-03-22 2021-02-09 Idorsia Pharmaceuticals Ltd Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica
HUE028972T2 (en) 2011-04-14 2017-01-30 Actelion Pharmaceuticals Ltd 7- (Heteroarylamino) -6,7,8,9-tetrahydropyrido [1,2-a] indole acetic acid derivatives and their use as prostaglandin D2 receptor modulators
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
SI3119779T1 (sl) 2014-03-17 2018-10-30 Idorsia Pharmaceuticals Ltd Derivati azaindolocetne kisline in njihova uporaba kot modulatorji prostaglandinskega receptorja D2
JP6484644B2 (ja) 2014-03-18 2019-03-13 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ アザインドール酢酸誘導体及びプロスタグランジンｄ２受容体調節剤としてのそれらの使用
JP6833852B2 (ja) 2015-09-15 2021-02-24 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 結晶形

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1415322A (fr) * 1963-12-09 1965-10-22 Eastman Kodak Co Nouveaux composés de 3-sulfamidocyclobutanone et de 3-sulfamidocyclobutanol
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
JPS4713658Y1 (fi) * 1969-12-18 1972-05-18
CH586678A5 (fi) * 1970-05-25 1977-04-15 Hoffmann La Roche
DE2226702A1 (de) * 1972-05-25 1973-12-13 Schering Ag Neue mittel zur behandlung des diabetes mellitus
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4235901A (en) * 1978-05-08 1980-11-25 American Home Products Corporation 1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

Also Published As

Publication number Publication date
DE3631824A1 (de) 1988-03-31
DE3769191D1 (de) 1991-05-16
HUT44493A (en) 1988-03-28
KR960001914B1 (en) 1996-02-06
PH24491A (en) 1990-07-18
JPH075552B2 (ja) 1995-01-25
PT84316B (pt) 1989-09-14
NO171633B (no) 1993-01-04
IE59470B1 (en) 1994-03-09
US4827032A (en) 1989-05-02
IL81611A (en) 1991-03-10
JPH0592954A (ja) 1993-04-16
IE870439L (en) 1987-08-21
US4965258A (en) 1990-10-23
EP0242518A1 (de) 1987-10-28
KR890001982A (ko) 1989-04-07
CS275837B6 (en) 1992-03-18
ES2028801T3 (es) 1992-07-16
DK87187D0 (da) 1987-02-20
AU6880887A (en) 1987-08-27
FI86544C (fi) 1992-09-10
CS8701093A2 (en) 1990-11-14
KR940007302B1 (ko) 1994-08-12
NO171633C (no) 1993-04-14
NZ219319A (en) 1990-12-21
US4904797A (en) 1990-02-27
CA1309414C (en) 1992-10-27
AU595855B2 (en) 1990-04-12
HU198686B (en) 1989-11-28
DK167009B1 (da) 1993-08-16
FI86544B (fi) 1992-05-29
GR3001763T3 (en) 1992-11-23
NO870437L (no) 1987-08-24
EP0242518B1 (de) 1991-04-10
PT84316A (en) 1987-03-01
NO870437D0 (no) 1987-02-04
KR870007885A (ko) 1987-09-22
DK87187A (da) 1987-08-22
FI870693A0 (fi) 1987-02-19

Similar Documents

Publication Publication Date Title
DE3769191D1 (de) Cycloalkano(1,2-b)indol-sulfonamide.
LV5742B4 (lv) 3,5-divalizvietoti pirokatehina atvasinajumi
FI873584A (fi) Mjuk, sockerfri, poroes soetsaks- resp. bakverkssammansaettning.
DE3764686D1 (de) N,n'-dihalo-2-imidazolidinone.
DE3783669D1 (de) Alpha-aryl-alpha-phenethyl-1h-1,2,4-triazol-1-propan-nitrile.
FI872594A (fi) Cementprodukter, vilka innehaoller ytbehandlade oorganiska partiklar.
FI875619A (fi) 6-benzoxazinyl- och 6-benzotiazonyl-2,3,4,5-tetrahydropyridazin-3-oner.
DE3763411D1 (de) 1,2,3,6-tetrahydro-5-nitro-pyrimidin-derivate.
FI881322A0 (fi) Haestsko, skaerskilt foer travhaestar.
FI874428A0 (fi) Foerfarande foer framstaellning av vinylklorid medelst termisk spjaelkning av 1,2-dikloretan.
FI872267A0 (fi) Stabila, vattenhaltiga suspensionskoncentratkompositioner.
FI874864A (fi) Oformade, eldfasta massor.
DE3765646D1 (de) 2,5,6,7-tetranor-4,8-inter-m-phenylen-pgi2-derivate.
FI872598A0 (fi) N-1h-tetrazol-5-yl-2-tiofen-, n-1h -tetrazol-5-yl-2-pyrrol- och n-1h-tetrazol-5-yl-2-furankarboxamider.
DE3766518D1 (de) Substituierte 1,3,4,9-tetrahydropyrano(3,4-b)indol-1-acetate.
DE3788163T2 (de) 1,3,5-Trithian-Derivate.
FI871432A (fi) Foerkopplingsdrossel, speciellt foer gasurladdningslampor.
FI874479A (fi) Golvskoetselanordning, speciellt munstycke foer dammsugare.
FI875128A (fi) Kabelmuff, isynnerhet en intagningskabelmuff foer partraods intagningskabel.
FI870924A0 (fi) Aromatiska -alkylimino-tetrahydro-6h -1,3-tiazin-6-onderivater.
DE3761091D1 (de) 2,6-dimethyl-p-benzochinontetraalkylketale.
ATE62477T1 (de) Cycloalkano(1,2-b>indol-sulfonamide.
ATE58901T1 (de) Substituierte 1,3,4,9-tetrahydropyrano(3,4b>indol-1-acetate.
ATE54146T1 (de) 1,2,3,6-tetrahydro-5-nitro-pyrimidin-derivate.
ATE50254T1 (de) 3,4-dihydro-4-oxo-2h-1-benzopyranyloxy-alkansaeu e-derivate.

Legal Events

Date Code Title Description
FG Patent granted

Owner name: BAYER YAKUHIN, LTD

MA Patent expired