CS255893B2 - Process for preparing pyridazo/1,2-a//1,2/diazepin-,diazocin-and-triazepin-1-carboxylic acids - Google Patents

Process for preparing pyridazo/1,2-a//1,2/diazepin-,diazocin-and-triazepin-1-carboxylic acids Download PDF

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Publication number
CS255893B2
CS255893B2 CS855928A CS592885A CS255893B2 CS 255893 B2 CS255893 B2 CS 255893B2 CS 855928 A CS855928 A CS 855928A CS 592885 A CS592885 A CS 592885A CS 255893 B2 CS255893 B2 CS 255893B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
compound
pyridazo
group
dioxo
Prior art date
Application number
CS855928A
Other languages
Czech (cs)
English (en)
Other versions
CS592885A2 (en
Inventor
Cedric H Hassall
Geoffrey Lawton
Sally Redshaw
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848421493A external-priority patent/GB8421493D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CS592885A2 publication Critical patent/CS592885A2/cs
Publication of CS255893B2 publication Critical patent/CS255893B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
CS855928A 1984-08-24 1985-08-15 Process for preparing pyridazo/1,2-a//1,2/diazepin-,diazocin-and-triazepin-1-carboxylic acids CS255893B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848421493A GB8421493D0 (en) 1984-08-24 1984-08-24 Bicyclic compounds
GB858513541A GB8513541D0 (en) 1984-08-24 1985-05-29 Bicyclic compounds

Publications (2)

Publication Number Publication Date
CS592885A2 CS592885A2 (en) 1987-07-16
CS255893B2 true CS255893B2 (en) 1988-03-15

Family

ID=26288155

Family Applications (1)

Application Number Title Priority Date Filing Date
CS855928A CS255893B2 (en) 1984-08-24 1985-08-15 Process for preparing pyridazo/1,2-a//1,2/diazepin-,diazocin-and-triazepin-1-carboxylic acids

Country Status (14)

Country Link
US (4) US4692438A (fi)
EP (1) EP0172552A3 (fi)
AU (1) AU583843B2 (fi)
CS (1) CS255893B2 (fi)
DK (1) DK384385A (fi)
ES (3) ES8700258A1 (fi)
FI (1) FI853174L (fi)
HU (1) HU193446B (fi)
IL (1) IL76133A (fi)
MC (1) MC1694A1 (fi)
NO (1) NO161914C (fi)
NZ (1) NZ213130A (fi)
PH (1) PH21749A (fi)
PT (1) PT81015B (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
DK0534363T3 (da) * 1991-09-27 1997-09-22 Merrell Pharma Inc 2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE.
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2130116C (en) * 1992-02-14 1998-04-07 Gary A. Flynn Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2146238C (en) * 1992-10-30 2001-03-13 Gary A. Flynn Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
WO1994022440A1 (en) * 1993-03-29 1994-10-13 Smithkline Beecham Corporation Bicyclic compounds which inhibit platelet aggregation
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
ATE177098T1 (de) * 1994-02-14 1999-03-15 Merrell Pharma Inc Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
WO1995021840A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
JPH10503468A (ja) * 1994-03-24 1998-03-31 メリル・フアーマシユウテイカルズ・インコーポレイテツド 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のメルカプトアセチルアミドジスルフィド誘導体
DE69514912T2 (de) * 1994-03-24 2000-10-05 Merrell Pharmaceuticals Inc., Cincinnati Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en) * 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
ES2252224T3 (es) 2000-05-04 2006-05-16 Vertex Pharmaceuticals Incorporated Sisntesis asimetrica de acido piperazico y derivados del mismo.
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
CN102131587B (zh) * 2008-07-25 2014-08-13 C·恩克博德 固体燃料选矿并向热电厂运输的方法
CN102686594A (zh) 2009-12-16 2012-09-19 熙德隆研究基金会 地瑞那韦的多晶型物
PT2571355T (pt) 2010-05-20 2016-10-17 Hetero Research Foundation Sal de cloridrato cristalino de darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308094A (en) * 1977-02-02 1981-12-29 Sanyo Electric Co., Ltd. Diaphragm for speaker and method of producing same
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en) * 1979-09-19 1983-06-09 Hoffmann La Roche Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

Also Published As

Publication number Publication date
ES552398A0 (es) 1987-05-01
US4692438A (en) 1987-09-08
US4785093A (en) 1988-11-15
HUT38644A (en) 1986-06-30
NZ213130A (en) 1988-05-30
ES546360A0 (es) 1986-10-01
ES8705444A1 (es) 1987-05-01
EP0172552A3 (de) 1989-01-11
ES552397A0 (es) 1987-05-01
HU193446B (en) 1987-10-28
DK384385D0 (da) 1985-08-23
NO853336L (no) 1986-02-25
EP0172552A2 (de) 1986-02-26
DK384385A (da) 1986-02-25
US4762924A (en) 1988-08-09
CS592885A2 (en) 1987-07-16
IL76133A0 (en) 1985-12-31
PT81015B (en) 1987-08-24
FI853174A0 (fi) 1985-08-19
AU583843B2 (en) 1989-05-11
ES8705443A1 (es) 1987-05-01
PT81015A (en) 1985-09-01
FI853174L (fi) 1986-02-25
NO161914B (no) 1989-07-03
ES8700258A1 (es) 1986-10-01
NO161914C (no) 1989-10-11
IL76133A (en) 1989-12-15
US4826980A (en) 1989-05-02
PH21749A (en) 1988-02-18
MC1694A1 (fr) 1986-07-18
AU4641585A (en) 1986-02-27

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