CS252461B2 - Method of 2-guanidino-4-(2-subst.-amino-4-imidazolyl)thiazoles production - Google Patents

Method of 2-guanidino-4-(2-subst.-amino-4-imidazolyl)thiazoles production Download PDF

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Publication number
CS252461B2
CS252461B2 CS833184A CS318483A CS252461B2 CS 252461 B2 CS252461 B2 CS 252461B2 CS 833184 A CS833184 A CS 833184A CS 318483 A CS318483 A CS 318483A CS 252461 B2 CS252461 B2 CS 252461B2
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CS
Czechoslovakia
Prior art keywords
formula
iii
amino
compounds
nhr
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CS833184A
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Czech (cs)
English (en)
Other versions
CS318483A2 (en
Inventor
John L Lamattina
Christopher A Lipinski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS318483A2 publication Critical patent/CS318483A2/cs
Publication of CS252461B2 publication Critical patent/CS252461B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Lubricants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CS833184A 1982-05-10 1983-05-05 Method of 2-guanidino-4-(2-subst.-amino-4-imidazolyl)thiazoles production CS252461B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/376,486 US4435396A (en) 1982-05-10 1982-05-10 Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor

Publications (2)

Publication Number Publication Date
CS318483A2 CS318483A2 (en) 1987-02-12
CS252461B2 true CS252461B2 (en) 1987-09-17

Family

ID=23485203

Family Applications (1)

Application Number Title Priority Date Filing Date
CS833184A CS252461B2 (en) 1982-05-10 1983-05-05 Method of 2-guanidino-4-(2-subst.-amino-4-imidazolyl)thiazoles production

Country Status (26)

Country Link
US (1) US4435396A (de)
EP (1) EP0094191B1 (de)
JP (1) JPS58206588A (de)
KR (1) KR860000931B1 (de)
AT (1) ATE33649T1 (de)
AU (2) AU539244B2 (de)
CA (1) CA1201120A (de)
CS (1) CS252461B2 (de)
DD (1) DD209828A5 (de)
DE (1) DE3376322D1 (de)
DK (1) DK163829B (de)
EG (1) EG17029A (de)
ES (1) ES8407045A1 (de)
FI (1) FI78481C (de)
GR (1) GR79279B (de)
GT (1) GT198302123A (de)
HU (2) HU196377B (de)
IE (1) IE55229B1 (de)
IL (1) IL68630A (de)
NO (1) NO159932C (de)
NZ (1) NZ204158A (de)
PL (1) PL141199B1 (de)
PT (1) PT76662B (de)
SU (1) SU1195907A3 (de)
YU (1) YU42857B (de)
ZA (1) ZA833286B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673677A (en) * 1983-10-03 1987-06-16 Pfizer Inc. Method for treatment of gastrointestinal disorders
US4554276A (en) * 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4636498A (en) * 1984-10-11 1987-01-13 Pfizer Inc. Formulation of antiinflammatory drugs
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
WO1986003203A1 (en) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
EP0259085B1 (de) * 1986-08-29 1991-08-21 Pfizer Inc. 2-Guanidino-4-aryl-thiazole für die Behandlung von peptischen Geschwüren
EP0269239B1 (de) * 1986-10-29 1994-06-08 Pfizer Inc. Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat
CA2165344A1 (en) * 1993-06-15 1994-12-22 Peter C. Canning Immune stimulants in bacterial infections
PE20110843A1 (es) 2008-09-22 2011-12-08 Cayman Chem Co Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519637A (en) 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
DE2142585A1 (de) * 1971-08-20 1973-02-22 Schering Ag 2-(5-nitro-2-thiazolyl)-benzimidazole
FR2284601A1 (fr) * 1974-09-10 1976-04-09 Inst Francais Du Petrole Composes guanidino-heterocycliques alkyles, leur preparation et leur utilisation comme additifs pour carburants et lubrifiants
US4220654A (en) 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles

Also Published As

Publication number Publication date
PT76662B (en) 1986-04-16
EP0094191B1 (de) 1988-04-20
IL68630A0 (en) 1983-09-30
NO159932B (no) 1988-11-14
FI78481B (fi) 1989-04-28
DD209828A5 (de) 1984-05-23
DK163829B (da) 1992-04-06
SU1195907A3 (ru) 1985-11-30
EG17029A (en) 1992-06-30
GR79279B (de) 1984-10-22
IL68630A (en) 1987-03-31
PL141199B1 (en) 1987-07-31
FI78481C (fi) 1989-08-10
NZ204158A (en) 1986-05-09
ES522223A0 (es) 1984-08-16
ATE33649T1 (de) 1988-05-15
PT76662A (en) 1983-06-01
DE3376322D1 (en) 1988-05-26
HU196377B (en) 1988-11-28
HU190899B (en) 1986-12-28
KR860000931B1 (ko) 1986-07-19
FI831595A0 (fi) 1983-05-09
PL241840A1 (en) 1985-01-16
YU99683A (en) 1986-02-28
AU3081584A (en) 1984-11-08
GT198302123A (es) 1984-10-27
CS318483A2 (en) 1987-02-12
DK205883A (da) 1983-11-11
ES8407045A1 (es) 1984-08-16
FI831595L (fi) 1983-11-11
ZA833286B (en) 1984-12-24
NO159932C (no) 1989-02-22
AU539244B2 (en) 1984-09-20
CA1201120A (en) 1986-02-25
DK205883D0 (da) 1983-05-09
IE831061L (en) 1983-11-10
NO831632L (no) 1983-11-11
EP0094191A1 (de) 1983-11-16
JPS58206588A (ja) 1983-12-01
US4435396A (en) 1984-03-06
IE55229B1 (en) 1990-07-04
AU566755B2 (en) 1987-10-29
KR840004745A (ko) 1984-10-24
AU1436383A (en) 1983-11-17
YU42857B (en) 1988-12-31

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