CS244697B2 - Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives - Google Patents

Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives Download PDF

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Publication number
CS244697B2
CS244697B2 CS846319A CS631984A CS244697B2 CS 244697 B2 CS244697 B2 CS 244697B2 CS 846319 A CS846319 A CS 846319A CS 631984 A CS631984 A CS 631984A CS 244697 B2 CS244697 B2 CS 244697B2
Authority
CS
Czechoslovakia
Prior art keywords
compound
formula
mixture
hydrogen
mmol
Prior art date
Application number
CS846319A
Other languages
Czech (cs)
English (en)
Inventor
Howard J Schaeffer
Thomas A Krenitsky
Lilia M Beauchamp
Original Assignee
Wellcome Foundation Lmd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/434,395 external-priority patent/US4609662A/en
Priority claimed from US06/434,384 external-priority patent/US4544634A/en
Priority claimed from GB838320309A external-priority patent/GB8320309D0/en
Priority claimed from CS753083A external-priority patent/CS244679B2/cs
Application filed by Wellcome Foundation Lmd filed Critical Wellcome Foundation Lmd
Publication of CS244697B2 publication Critical patent/CS244697B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS846319A 1982-10-14 1984-08-21 Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives CS244697B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US43439482A 1982-10-14 1982-10-14
US43439382A 1982-10-14 1982-10-14
US06/434,395 US4609662A (en) 1982-10-14 1982-10-14 Method for using purine derivatives
US06/434,384 US4544634A (en) 1982-10-14 1982-10-14 Method of producing acyclovir
GB838320309A GB8320309D0 (en) 1983-07-28 1983-07-28 Antiviral compounds
CS753083A CS244679B2 (en) 1982-10-14 1983-10-13 Production method of anti virus effective compound

Publications (1)

Publication Number Publication Date
CS244697B2 true CS244697B2 (en) 1986-08-14

Family

ID=27516520

Family Applications (1)

Application Number Title Priority Date Filing Date
CS846319A CS244697B2 (en) 1982-10-14 1984-08-21 Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives

Country Status (19)

Country Link
EP (2) EP0108285B1 (fr)
JP (1) JPS5989682A (fr)
KR (1) KR890001487B1 (fr)
AT (2) ATE33653T1 (fr)
AU (1) AU573540B2 (fr)
CA (1) CA1308714C (fr)
CS (1) CS244697B2 (fr)
DE (2) DE3376325D1 (fr)
DK (1) DK472683A (fr)
FI (1) FI74468C (fr)
GB (2) GB2130204B (fr)
GR (1) GR79681B (fr)
IE (1) IE56416B1 (fr)
MC (1) MC1551A1 (fr)
NO (1) NO161116C (fr)
NZ (1) NZ205955A (fr)
PL (1) PL143208B1 (fr)
PT (2) PT77494B (fr)
ZW (1) ZW22283A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US5250688A (en) * 1984-09-20 1993-10-05 Beecham Group P.L.C. Purine derivatives
IL74881A0 (en) * 1984-04-13 1985-07-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
EP0182024B1 (fr) * 1984-09-20 1991-04-03 Beecham Group Plc Dérivés de purine et leur utilisation pharmaceutique
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
EP0203736B1 (fr) * 1985-05-02 1989-11-23 The Wellcome Foundation Limited Composés antiviraux
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
MY101126A (en) * 1985-12-13 1991-07-31 Beecham Group Plc Novel compounds
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
JPS63280026A (ja) * 1987-04-24 1988-11-17 ザ　ウエルカム　フアウンデーション　リミテッド 抗ウイルス配合組成物
DE3889248T2 (de) * 1987-05-04 1994-11-17 Kemijski Inst Verfahren zu Herstellung von Purinverbindungen.
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
GB8713695D0 (en) * 1987-06-11 1987-07-15 Beecham Group Plc Process
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
EP0363320A3 (fr) * 1988-10-06 1991-11-21 Ciba-Geigy Ag 9H-purine substituée
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
DE3941658A1 (de) * 1989-12-16 1991-06-20 Hoechst Ag Verfahren zur herstellung von 2-acylamino-9-acyl-6-halogen-purin
US5994361A (en) * 1994-06-22 1999-11-30 Biochem Pharma Substituted purinyl derivatives with immunomodulating activity
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
JPS58135885A (ja) * 1982-02-01 1983-08-12 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 置換されたプリン、その製造方法およびそれからなる抗ウイルス剤
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents

Also Published As

Publication number Publication date
GB2151222B (en) 1987-02-25
DE3376326D1 (en) 1988-05-26
FI833730A0 (fi) 1983-10-13
IE56416B1 (en) 1991-07-31
GB2130204A (en) 1984-05-31
GB8327513D0 (en) 1983-11-16
EP0108285A2 (fr) 1984-05-16
GR79681B (fr) 1984-10-31
EP0158847B1 (fr) 1988-04-20
GB2151222A (en) 1985-07-17
DK472683A (da) 1984-04-15
KR890001487B1 (ko) 1989-05-04
ATE33654T1 (de) 1988-05-15
NO833722L (no) 1984-04-16
FI833730A (fi) 1984-04-15
NO161116C (no) 1989-07-05
PT77494A (en) 1983-11-01
PL143208B1 (en) 1988-01-30
PL244141A1 (en) 1985-06-18
CA1308714C (fr) 1992-10-13
GB2130204B (en) 1986-03-05
EP0158847A1 (fr) 1985-10-23
PT79813A (en) 1985-02-01
GB8421849D0 (en) 1984-10-03
PT77494B (en) 1986-08-14
JPH0549674B2 (fr) 1993-07-26
NO161116B (no) 1989-03-28
DK472683D0 (da) 1983-10-13
ZW22283A1 (en) 1985-05-22
FI74468B (fi) 1987-10-30
KR840006483A (ko) 1984-11-30
EP0108285B1 (fr) 1988-04-20
PT79813B (en) 1986-10-28
FI74468C (fi) 1988-02-08
EP0108285A3 (en) 1985-05-15
ATE33653T1 (de) 1988-05-15
IE832409L (en) 1984-04-14
AU573540B2 (en) 1988-06-16
JPS5989682A (ja) 1984-05-23
AU2016383A (en) 1984-04-19
NZ205955A (en) 1988-02-29
DE3376325D1 (en) 1988-05-26
MC1551A1 (fr) 1984-08-31

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