CS244697B2 - Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives - Google Patents

Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives Download PDF

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Publication number
CS244697B2
CS244697B2 CS846319A CS631984A CS244697B2 CS 244697 B2 CS244697 B2 CS 244697B2 CS 846319 A CS846319 A CS 846319A CS 631984 A CS631984 A CS 631984A CS 244697 B2 CS244697 B2 CS 244697B2
Authority
CS
Czechoslovakia
Prior art keywords
compound
formula
mixture
hydrogen
mmol
Prior art date
Application number
CS846319A
Other languages
Czech (cs)
English (en)
Inventor
Howard J Schaeffer
Thomas A Krenitsky
Lilia M Beauchamp
Original Assignee
Wellcome Foundation Lmd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/434,384 external-priority patent/US4544634A/en
Priority claimed from US06/434,395 external-priority patent/US4609662A/en
Priority claimed from GB838320309A external-priority patent/GB8320309D0/en
Priority claimed from CS753083A external-priority patent/CS244679B2/cs
Application filed by Wellcome Foundation Lmd filed Critical Wellcome Foundation Lmd
Publication of CS244697B2 publication Critical patent/CS244697B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS846319A 1982-10-14 1984-08-21 Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives CS244697B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US43439382A 1982-10-14 1982-10-14
US43439482A 1982-10-14 1982-10-14
US06/434,384 US4544634A (en) 1982-10-14 1982-10-14 Method of producing acyclovir
US06/434,395 US4609662A (en) 1982-10-14 1982-10-14 Method for using purine derivatives
GB838320309A GB8320309D0 (en) 1983-07-28 1983-07-28 Antiviral compounds
CS753083A CS244679B2 (en) 1982-10-14 1983-10-13 Production method of anti virus effective compound

Publications (1)

Publication Number Publication Date
CS244697B2 true CS244697B2 (en) 1986-08-14

Family

ID=27516520

Family Applications (1)

Application Number Title Priority Date Filing Date
CS846319A CS244697B2 (en) 1982-10-14 1984-08-21 Production method of 2-amono-9-(2-hydroxyethoxymethyl)purine derivatives

Country Status (19)

Country Link
EP (2) EP0108285B1 (da)
JP (1) JPS5989682A (da)
KR (1) KR890001487B1 (da)
AT (2) ATE33653T1 (da)
AU (1) AU573540B2 (da)
CA (1) CA1308714C (da)
CS (1) CS244697B2 (da)
DE (2) DE3376326D1 (da)
DK (1) DK472683A (da)
FI (1) FI74468C (da)
GB (2) GB2130204B (da)
GR (1) GR79681B (da)
IE (1) IE56416B1 (da)
MC (1) MC1551A1 (da)
NO (1) NO161116C (da)
NZ (1) NZ205955A (da)
PL (1) PL143208B1 (da)
PT (2) PT77494B (da)
ZW (1) ZW22283A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US5250688A (en) * 1984-09-20 1993-10-05 Beecham Group P.L.C. Purine derivatives
IL74881A0 (en) * 1984-04-13 1985-07-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
EP0182024B1 (en) * 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
DE3667058D1 (en) * 1985-05-02 1989-12-28 Wellcome Found Antiviral compounds
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
MY101126A (en) * 1985-12-13 1991-07-31 Beecham Group Plc Novel compounds
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
EP0289229B1 (en) * 1987-04-24 1992-01-29 The Wellcome Foundation Limited Antiviral combinations
DE3889248T2 (de) * 1987-05-04 1994-11-17 Kemijski Inst Verfahren zu Herstellung von Purinverbindungen.
GB8713695D0 (en) * 1987-06-11 1987-07-15 Beecham Group Plc Process
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
EP0363320A3 (de) * 1988-10-06 1991-11-21 Ciba-Geigy Ag Substituierte 9H-Purine
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE3941658A1 (de) * 1989-12-16 1991-06-20 Hoechst Ag Verfahren zur herstellung von 2-acylamino-9-acyl-6-halogen-purin
US5994361A (en) * 1994-06-22 1999-11-30 Biochem Pharma Substituted purinyl derivatives with immunomodulating activity
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
JPS58135885A (ja) * 1982-02-01 1983-08-12 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 置換されたプリン、その製造方法およびそれからなる抗ウイルス剤
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents

Also Published As

Publication number Publication date
NO161116C (no) 1989-07-05
IE832409L (en) 1984-04-14
PT77494A (en) 1983-11-01
PT79813A (en) 1985-02-01
GB2130204B (en) 1986-03-05
ZW22283A1 (en) 1985-05-22
PT79813B (en) 1986-10-28
CA1308714C (en) 1992-10-13
KR840006483A (ko) 1984-11-30
EP0108285A2 (en) 1984-05-16
GR79681B (da) 1984-10-31
MC1551A1 (fr) 1984-08-31
EP0158847A1 (en) 1985-10-23
EP0158847B1 (en) 1988-04-20
GB2130204A (en) 1984-05-31
IE56416B1 (en) 1991-07-31
JPS5989682A (ja) 1984-05-23
GB8327513D0 (en) 1983-11-16
DK472683D0 (da) 1983-10-13
FI74468C (fi) 1988-02-08
EP0108285B1 (en) 1988-04-20
NZ205955A (en) 1988-02-29
JPH0549674B2 (da) 1993-07-26
FI74468B (fi) 1987-10-30
DE3376325D1 (en) 1988-05-26
FI833730A0 (fi) 1983-10-13
GB2151222B (en) 1987-02-25
ATE33654T1 (de) 1988-05-15
DK472683A (da) 1984-04-15
PT77494B (en) 1986-08-14
EP0108285A3 (en) 1985-05-15
NO161116B (no) 1989-03-28
AU2016383A (en) 1984-04-19
NO833722L (no) 1984-04-16
AU573540B2 (en) 1988-06-16
DE3376326D1 (en) 1988-05-26
KR890001487B1 (ko) 1989-05-04
FI833730A (fi) 1984-04-15
GB2151222A (en) 1985-07-17
ATE33653T1 (de) 1988-05-15
GB8421849D0 (en) 1984-10-03
PL244141A1 (en) 1985-06-18
PL143208B1 (en) 1988-01-30

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