CS242188A2 - Method of 6-substituted 2,3-dideoxynucleosides production - Google Patents

Method of 6-substituted 2,3-dideoxynucleosides production

Info

Publication number
CS242188A2
CS242188A2 CS882421A CS242188A CS242188A2 CS 242188 A2 CS242188 A2 CS 242188A2 CS 882421 A CS882421 A CS 882421A CS 242188 A CS242188 A CS 242188A CS 242188 A2 CS242188 A2 CS 242188A2
Authority
CS
Czechoslovakia
Prior art keywords
dideoxynucleosides
substituted
production
dideoxynucleosides production
Prior art date
Application number
CS882421A
Other languages
English (en)
Other versions
CS274461B2 (en
Inventor
George W Koszalka
Thomas A Krenitsky
Janet L Rideout
Charlene L Burns
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878708512A external-priority patent/GB8708512D0/en
Priority claimed from GB878712691A external-priority patent/GB8712691D0/en
Priority claimed from GB878723013A external-priority patent/GB8723013D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of CS242188A2 publication Critical patent/CS242188A2/cs
Publication of CS274461B2 publication Critical patent/CS274461B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CS242188A 1987-04-09 1988-04-08 Method of 6-substituted 2,3-dideoxynucleosides production CS274461B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878708512A GB8708512D0 (en) 1987-04-09 1987-04-09 Therapeutic nucleosides
GB878712691A GB8712691D0 (en) 1987-05-29 1987-05-29 Therapeutic nucleosides
GB878723013A GB8723013D0 (en) 1987-09-30 1987-09-30 Therapeutic nucleosides

Publications (2)

Publication Number Publication Date
CS242188A2 true CS242188A2 (en) 1990-09-12
CS274461B2 CS274461B2 (en) 1991-04-11

Family

ID=27263377

Family Applications (1)

Application Number Title Priority Date Filing Date
CS242188A CS274461B2 (en) 1987-04-09 1988-04-08 Method of 6-substituted 2,3-dideoxynucleosides production

Country Status (20)

Country Link
US (1) US5068320A (cs)
EP (1) EP0286425B1 (cs)
JP (1) JP2763888B2 (cs)
KR (1) KR880012630A (cs)
AP (1) AP78A (cs)
AT (1) ATE116984T1 (cs)
AU (1) AU608590B2 (cs)
CA (1) CA1326237C (cs)
CS (1) CS274461B2 (cs)
DE (1) DE3852710T2 (cs)
DK (1) DK191688A (cs)
FI (1) FI87214C (cs)
HU (1) HU201954B (cs)
IL (1) IL86007A0 (cs)
MC (1) MC1915A1 (cs)
NO (1) NO171641C (cs)
NZ (1) NZ224189A (cs)
PL (1) PL154956B1 (cs)
PT (1) PT87191B (cs)
RU (1) RU1779256C (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
JPH02164881A (ja) * 1988-10-24 1990-06-25 Wellcome Found Ltd:The 治療用ヌクレオシド化合物
WO1990006312A1 (de) * 1988-11-29 1990-06-14 Institut Für Molekularbiologie Und Analytik (Ima) Gmbh 2', 3'-didesoxyribofuranoside und ein verfahren zu ihrer herstellung
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
US5013829A (en) * 1989-04-26 1991-05-07 University Of Iowa Research Foundation Stable congener of 2',3'-dideoxyadenosine
DE4020529A1 (de) * 1989-09-12 1991-03-21 Roxana Vasiloiu Multifunktionelle(s) enzym(e) mit nucleosid-didesoxyribosyltransferase(n) und/oder nucleoside-desoxyribosyltransferasen(n) und/oder kinease- und/oder reduktase- und/oder desaminase- und/oder polymerase-aktivitaet
JPH0637391B2 (ja) * 1989-09-29 1994-05-18 日本製紙株式会社 抗エイズウイルス剤
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
CA2075490A1 (en) * 1990-02-09 1991-08-10 Hiroaki Mitsuya 6-halo-and 2-amino-6-halo-purine 2',3'-dideoxy nucleosides and their use as antiviral agents
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
ES2209532T3 (es) * 1998-12-23 2004-06-16 Shire Biochem Inc. Analogos de nucleosidos antivirales.
CN101220071B (zh) * 2008-01-17 2011-04-06 南京长澳医药科技有限公司 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物
CN102234280B (zh) * 2010-04-26 2014-01-08 北京大学 D,l-鸟嘌呤核苷类似物及其制备方法和应用
CA2810928A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
CA2837207A1 (en) 2011-06-01 2012-12-06 Janus Biotherapeutics, Inc. Novel immune system modulators
WO2013096680A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
EP2827876A4 (en) 2012-03-22 2015-10-28 Alios Biopharma Inc PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG
US9469644B2 (en) * 2013-03-05 2016-10-18 Hoffmann-La Roche Inc. Inhibitors of Bruton's tyrosine kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
DK164392C (da) * 1985-03-16 1992-11-09 Wellcome Found Anvendelse af 3'-azido-3'-desoxythymidin til fremstilling af et laegemiddel til behandling af eller profylakse for en human retrovirusinfektion
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
AU570855B2 (en) * 1985-08-26 1988-03-24 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Inhibition of in vitro infectivity and cytopathic effect of htlv-111/lav by 2' 3' -dideoxycytidine
DE3650741T2 (de) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
IT1203558B (it) * 1986-05-20 1989-02-15 Firestone Int Dev Spa Metodo per la realizzazione di un pneumatico radiale di prima fase per veicoli
AU613026B2 (en) * 1987-03-24 1991-07-25 Nycomed As 2',3' dideoxyribofuranoxide derivatives
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
IL87149A (en) * 1987-07-20 1994-05-30 Merck & Co Inc 6-Piperazinyl derivatives of purine and its 3- and 9-deaza isosteres, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE116984T1 (de) 1995-01-15
NO171641B (no) 1993-01-04
PL271722A1 (en) 1989-01-23
DK191688A (da) 1988-10-10
NO881537L (no) 1988-10-10
RU1779256C (ru) 1992-11-30
FI87214C (fi) 1992-12-10
FI881651A0 (fi) 1988-04-08
NO171641C (no) 1993-04-14
PL154956B1 (en) 1991-10-31
CS274461B2 (en) 1991-04-11
NZ224189A (en) 1991-09-25
FI881651L (fi) 1988-10-10
DK191688D0 (da) 1988-04-08
US5068320A (en) 1991-11-26
EP0286425B1 (en) 1995-01-11
FI87214B (fi) 1992-08-31
MC1915A1 (fr) 1989-04-06
HU201954B (en) 1991-01-28
NO881537D0 (no) 1988-04-08
PT87191A (pt) 1988-05-01
EP0286425A2 (en) 1988-10-12
AP8800086A0 (en) 1988-02-01
EP0286425A3 (en) 1990-12-05
DE3852710D1 (de) 1995-02-23
JP2763888B2 (ja) 1998-06-11
AU608590B2 (en) 1991-04-11
KR880012630A (ko) 1988-11-28
DE3852710T2 (de) 1995-05-24
IL86007A0 (en) 1988-09-30
CA1326237C (en) 1994-01-18
AP78A (en) 1990-03-12
PT87191B (pt) 1993-02-26
HUT48269A (en) 1989-05-29
JPS63267796A (ja) 1988-11-04
AU1444488A (en) 1988-10-13

Similar Documents

Publication Publication Date Title
CS242188A2 (en) Method of 6-substituted 2,3-dideoxynucleosides production
CS712688A2 (en) Method of new tetrahydrofuro- and -thienol (2,3-c) pyridine production
CS8701093A2 (en) Method of new cycloalkano/1,2-b/-indolesulphoamides production
CS567989A2 (en) Method of substituted 1,3,5-triazintriones production
PL279057A1 (en) Method for manufacturing new derivatives of 2-imine-1,3,4-dihydrothiadiazol
HUT48571A (en) Process for production of substituated 3,5-dichlor-2,4-difluor-benzol
HUT49138A (en) Process for production of pirasole /3,4-6/-piridines
EP0359118A3 (en) Method for the production of 1,1,2-trialkoxyethanes
CS591188A2 (en) Method of spiroimidazolidinedione production
PL266240A1 (en) Method of obtaining derivatives of 1,3,2-oxazaphosphorinate
CS415888A2 (en) Method of new acylderivatives production
CS1009187A2 (en) Method of new aminoalkanoyl-dibenzo (d,g) (1,3,6) dioxazocines production
HUT48280A (en) Process for production of starch-2,3,/dihydroxi-prophile/-ether
CS719288A1 (en) Method of 2,3-difluoro-6-nitrophenol production
CS399788A1 (en) Method of 9,10-antraquinone production
CS112688A1 (en) Method of 0,0-dimethyl-o-/3-methyl-4-nitrophenyl-phosphorothionate production
RO103087B1 (en) Production method of 2, 4 diamino-6-(2-diethylphosphonoethyl)-s-
CS544787A1 (en) Method of 1,3-diarylpyrazole-4-ylacetic acids production
CS281587A1 (en) Method of 1,1-dichloro-4-methyl-1,3-pentadiene production
CS357188A1 (en) Method of pentaerythril-tetrakis-/-3-/3,5-ditere-butyl-4-oxophenyl/propionate production
CS38689A1 (en) Method of 2,4,4-trichlor-5,5,5-trifluorpentanoic acid production
CS673587A1 (en) Method of 0,0-dimethyl-0-/3-methyl-4-nitrophenyl/phospohorothioate production
CS225587A1 (en) Method of fasade production
CS236489A2 (en) Method of 7-fluor-1-methyl-3-methylthio-4-quinolone production
CS779387A1 (en) Method of ferroliquid production