CS242088A2 - Method of 1-cyclopropyl-7-substituted-6-fluor-4-oxo-1,4-dihydroquinoline-3-carboxylic acid's derivatives production - Google Patents
Method of 1-cyclopropyl-7-substituted-6-fluor-4-oxo-1,4-dihydroquinoline-3-carboxylic acid's derivatives productionInfo
- Publication number
- CS242088A2 CS242088A2 CS882420A CS242088A CS242088A2 CS 242088 A2 CS242088 A2 CS 242088A2 CS 882420 A CS882420 A CS 882420A CS 242088 A CS242088 A CS 242088A CS 242088 A2 CS242088 A2 CS 242088A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- general formula
- chemical structure
- salt
- compound
- piperazinyl
- Prior art date
Links
- -1 1-cyclopropyl-7-substituted-6-fluor-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 4
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU871505A HU198709B (en) | 1987-04-08 | 1987-04-08 | Process for producing quinoline-carboxylic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS242088A2 true CS242088A2 (en) | 1990-09-12 |
| CS274460B2 CS274460B2 (en) | 1991-04-11 |
Family
ID=10954767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS242088A CS274460B2 (en) | 1987-04-08 | 1988-04-08 | Method of 1-cyclopropyl-7-substituted-6-fluor-4-oxo-1,4-dihydroquinoline-3-carboxylic acid's derivatives production |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5091530A (cs) |
| EP (1) | EP0309537B1 (cs) |
| JP (1) | JP2693987B2 (cs) |
| CN (1) | CN1025616C (cs) |
| AT (1) | ATE124687T1 (cs) |
| AU (1) | AU612648B2 (cs) |
| CS (1) | CS274460B2 (cs) |
| DD (1) | DD269848A5 (cs) |
| DE (1) | DE3854109T2 (cs) |
| DK (1) | DK175037B1 (cs) |
| HU (1) | HU198709B (cs) |
| SU (1) | SU1701110A3 (cs) |
| WO (1) | WO1988007993A1 (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU198709B (en) * | 1987-04-08 | 1989-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
| HU203746B (en) * | 1988-12-22 | 1991-09-30 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
| JPH0778065B2 (ja) * | 1990-07-06 | 1995-08-23 | 杏林製薬株式会社 | （６，７―置換―８―アルコキシ―１―シクロプロピル―１，４―ジヒドロ―４―オキソ―３―キノリンカルボン酸―ｏ▲上３▼，ｏ▲上４▼）ビス（アシルオキシ―ｏ）ホウ素化合物及びその塩並びにその製造方法 |
| GB9118183D0 (en) * | 1991-08-23 | 1991-10-09 | Solanki Kishor K | Imaging of infections |
| SI9200377A (en) * | 1992-12-11 | 1994-06-30 | Krka | Process for the preparation of 1-substituted 6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxilic acid, novel intermediate used in this process and process for its preparation |
| US5440061A (en) * | 1994-03-29 | 1995-08-08 | The Procter & Gamble Company | Hydrolysis of methyl esters in dimethylsulfoxide for production of fatty acids |
| NZ260530A (en) * | 1994-05-16 | 1997-06-24 | Nigel Paul Maynard | Organoborate complexes of divalent metal; use as timber treament agents |
| ES2092963B1 (es) * | 1995-04-12 | 1997-12-16 | Sint Quimica Sa | Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales. |
| ES2095809B1 (es) * | 1995-07-27 | 1997-12-16 | Sint Quimica Sa | Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales. |
| CN101671302B (zh) * | 2008-12-30 | 2011-03-30 | 广东海康兽药有限公司 | 禽畜用抗菌药恩诺沙星的生产工艺 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3033157A1 (de) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3142854A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| US4670444B1 (en) * | 1980-09-03 | 1999-02-09 | Bayer Ag | and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds |
| JPS5980683A (ja) * | 1982-10-30 | 1984-05-10 | Koei Chem Co Ltd | ６−フルオロ−１，８−ナフチリジン誘導体およびその製造法 |
| JPS59122470A (ja) * | 1982-12-27 | 1984-07-14 | Dai Ichi Seiyaku Co Ltd | キノリン−３−カルボン酸誘導体の製造法 |
| JPS6075489A (ja) * | 1983-10-03 | 1985-04-27 | Dai Ichi Seiyaku Co Ltd | ホウ素キレ−ト化合物 |
| JPS6078986A (ja) * | 1983-10-07 | 1985-05-04 | Dai Ichi Seiyaku Co Ltd | オキサジン誘導体の製法 |
| JPS60126290A (ja) * | 1983-12-13 | 1985-07-05 | Dai Ichi Seiyaku Co Ltd | ホウ素キレ−ト化合物の製造法 |
| HU196415B (en) * | 1985-12-09 | 1988-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing quinoline carboxylic acid boric acid anhydrides |
| HU196782B (en) * | 1985-12-09 | 1989-01-30 | Chinoin Gyogyszer Es Vegyeszet | Process for production of quinoline carbonic acid |
| HU196218B (en) * | 1985-12-09 | 1988-10-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing quinoline carboxylic acid boric acid anhydrides |
| US4940710A (en) * | 1986-01-17 | 1990-07-10 | American Cyanamid Company | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| HU198709B (en) * | 1987-04-08 | 1989-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
| YU46451B (sh) * | 1987-04-08 | 1993-10-20 | Chinoin Gyogyszer Es Vegyeszeti Ter Mekek Gyara Rt. | Postupak za dobivanje mešovitih anhidrida hinolin-karboksilne i borne kiseline |
| JP2693988B2 (ja) * | 1987-06-24 | 1997-12-24 | キノイン ギオギスゼル エス ベギエスゼチ テルメケク ギヤラ アールティー． | キノリンカルボン酸誘導体の製造方法 |
| JPS6419069A (en) * | 1987-07-14 | 1989-01-23 | Dainippon Pharmaceutical Co | Production of polyhalogenoquinoline derivative |
-
1987
- 1987-04-08 HU HU871505A patent/HU198709B/hu unknown
-
1988
- 1988-04-07 CN CN88101907A patent/CN1025616C/zh not_active Expired - Lifetime
- 1988-04-07 DD DD88314509A patent/DD269848A5/de not_active IP Right Cessation
- 1988-04-08 AU AU15721/88A patent/AU612648B2/en not_active Expired
- 1988-04-08 AT AT88903335T patent/ATE124687T1/de not_active IP Right Cessation
- 1988-04-08 CS CS242088A patent/CS274460B2/cs not_active IP Right Cessation
- 1988-04-08 WO PCT/HU1988/000019 patent/WO1988007993A1/en not_active Ceased
- 1988-04-08 US US07/290,105 patent/US5091530A/en not_active Expired - Lifetime
- 1988-04-08 JP JP63503085A patent/JP2693987B2/ja not_active Expired - Lifetime
- 1988-04-08 EP EP88903335A patent/EP0309537B1/en not_active Expired - Lifetime
- 1988-04-08 DE DE3854109T patent/DE3854109T2/de not_active Expired - Lifetime
- 1988-12-07 SU SU884613033A patent/SU1701110A3/ru active
- 1988-12-07 DK DK198806822A patent/DK175037B1/da not_active IP Right Cessation
-
1991
- 1991-09-06 US US07/756,345 patent/US5300644A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5091530A (en) | 1992-02-25 |
| EP0309537B1 (en) | 1995-07-05 |
| CN88101907A (zh) | 1988-10-26 |
| WO1988007993A1 (en) | 1988-10-20 |
| DD269848A5 (de) | 1989-07-12 |
| US5300644A (en) | 1994-04-05 |
| CS274460B2 (en) | 1991-04-11 |
| HU198709B (en) | 1989-11-28 |
| AU1572188A (en) | 1988-11-04 |
| JPH01503301A (ja) | 1989-11-09 |
| SU1701110A3 (ru) | 1991-12-23 |
| ATE124687T1 (de) | 1995-07-15 |
| EP0309537A1 (en) | 1989-04-05 |
| DE3854109T2 (de) | 1995-11-30 |
| DK682288D0 (da) | 1988-12-07 |
| JP2693987B2 (ja) | 1997-12-24 |
| AU612648B2 (en) | 1991-07-18 |
| HUT46686A (en) | 1988-11-28 |
| DK682288A (da) | 1988-12-07 |
| DE3854109D1 (de) | 1995-08-10 |
| CN1025616C (zh) | 1994-08-10 |
| DK175037B1 (da) | 2004-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MK4A | Patent expired |
Effective date: 20080408 |