CS235341B2 - Method of 1,5,10-triazadecanes production substituted in 1%position by means of (omega-quanidinelakanoyl) amino acid's residue - Google Patents
Method of 1,5,10-triazadecanes production substituted in 1%position by means of (omega-quanidinelakanoyl) amino acid's residue Download PDFInfo
- Publication number
- CS235341B2 CS235341B2 CS836397A CS639783A CS235341B2 CS 235341 B2 CS235341 B2 CS 235341B2 CS 836397 A CS836397 A CS 836397A CS 639783 A CS639783 A CS 639783A CS 235341 B2 CS235341 B2 CS 235341B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- triazadecane
- group
- formula
- guanidino
- acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 51
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 125000000405 phenylalanyl group Chemical group 0.000 description 1
- 125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical class NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 125000002072 seryl group Chemical group 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- UKHWJBVVWVYFEY-UHFFFAOYSA-M silver;hydroxide Chemical compound [OH-].[Ag+] UKHWJBVVWVYFEY-UHFFFAOYSA-M 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- ZIQRIAYNHAKDDU-UHFFFAOYSA-N sodium;hydroiodide Chemical compound [Na].I ZIQRIAYNHAKDDU-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- GQZZMJDEWJRWRP-UHFFFAOYSA-N tert-butyl n-(4-aminobutyl)-n-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCN(C(=O)OC(C)(C)C)CCCCN GQZZMJDEWJRWRP-UHFFFAOYSA-N 0.000 description 1
- ARFOHBSEMARNPK-UHFFFAOYSA-N tert-butyl n-[4-[(2-amino-4-hydroxybutanoyl)amino]butyl]-n-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCN(C(=O)OC(C)(C)C)CCCCNC(=O)C(N)CCO ARFOHBSEMARNPK-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57151698A JPS5942356A (ja) | 1982-09-02 | 1982-09-02 | スパガリン関連化合物およびその製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS235341B2 true CS235341B2 (en) | 1985-05-15 |
Family
ID=15524303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS836397A CS235341B2 (en) | 1982-09-02 | 1983-09-02 | Method of 1,5,10-triazadecanes production substituted in 1%position by means of (omega-quanidinelakanoyl) amino acid's residue |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4529549A (fr) |
| EP (1) | EP0105193B1 (fr) |
| JP (1) | JPS5942356A (fr) |
| KR (1) | KR900008137B1 (fr) |
| AR (1) | AR241650A1 (fr) |
| AT (1) | ATE36701T1 (fr) |
| AU (1) | AU560073B2 (fr) |
| CA (1) | CA1199641A (fr) |
| CS (1) | CS235341B2 (fr) |
| DE (1) | DE3377795D1 (fr) |
| DK (1) | DK160089C (fr) |
| ES (1) | ES8506267A1 (fr) |
| HU (1) | HU190730B (fr) |
| MX (1) | MX8257A (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5862152A (ja) * | 1981-10-08 | 1983-04-13 | Microbial Chem Res Found | Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法 |
| JPS61129119A (ja) * | 1984-11-13 | 1986-06-17 | Microbial Chem Res Found | 新規免疫抑制剤 |
| JPS61165322A (ja) * | 1985-01-14 | 1986-07-26 | Microbial Chem Res Found | スパガリン類の注射用凍結乾燥製剤 |
| JPH075538B2 (ja) * | 1985-08-27 | 1995-01-25 | 財団法人微生物化学研究会 | フエニレン基を有するスパガリン関連ニトリル化合物及びその製造法 |
| ES2039213T3 (es) * | 1986-04-04 | 1993-09-16 | Microbial Chemistry Research Foundation | Procedimiento para producir nuevos compuestos relacionados con espergualina. |
| US4873253A (en) * | 1987-03-30 | 1989-10-10 | Shosuke Okamoto | Phenylalanine derivative and proteinase inhibitor |
| JPH0794424B2 (ja) * | 1987-09-30 | 1995-10-11 | 財団法人微生物化学研究会 | 新スパガリン関連化合物およびその製造法 |
| US5061787A (en) * | 1988-06-24 | 1991-10-29 | Nippon Kayaku Kabushiki Kaisha | Novel spergualin-related compounds and compositions |
| JPH0776204B2 (ja) * | 1988-07-01 | 1995-08-16 | 寳酒造株式会社 | スパガリン類の精製法 |
| US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
| EP0467280B1 (fr) * | 1990-07-20 | 1994-09-28 | Nippon Kayaku Kabushiki Kaisha | Composés apparantés de sperguline et leur utilisation |
| WO1994004140A1 (fr) * | 1992-08-19 | 1994-03-03 | Nippon Kayaku Kabushiki Kaisha | Medicament anti-protozoose |
| FR2698628B1 (fr) * | 1992-12-02 | 1995-02-17 | Fournier Ind & Sante | Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique. |
| FR2716451B1 (fr) * | 1994-02-24 | 1996-04-26 | Fournier Ind & Sante | Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique. |
| FR2716452B1 (fr) * | 1994-02-24 | 1996-05-10 | Fournier Ind & Sante | Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique. |
| FR2737891B1 (fr) * | 1995-08-17 | 1997-10-24 | Fournier Ind & Sante | Analogues chiraux de la 15-deoxyspergualine, procede de preparation et utilisation en therapeutique |
| CA2187281A1 (fr) * | 1995-02-10 | 1996-08-15 | Luc Lebreton | Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation |
| FR2730488B1 (fr) * | 1995-02-10 | 1997-04-30 | Fournier Ind & Sante | Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation |
| FR2734263B1 (fr) * | 1995-05-17 | 1997-06-20 | Fournier Ind & Sante | Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique |
| US20020142000A1 (en) * | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2051494B1 (fr) * | 1969-04-02 | 1974-04-12 | Taiho Pharmaceutical Co Ltd | |
| JPS507057B1 (fr) * | 1970-10-28 | 1975-03-20 | ||
| US3937805A (en) * | 1971-11-10 | 1976-02-10 | Colgate-Palmolive Company | Method of making dentifrice compositions containing insolubilized salts of 1,6-di-(p-chlorophenyl biguanido) hexane |
| JPS5748957A (en) * | 1980-09-08 | 1982-03-20 | Microbial Chem Res Found | Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient |
| DE3217693A1 (de) * | 1981-05-11 | 1982-12-02 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | N-(4-(3-aminopropyl)-aminobutyl)-2,2-dihydroxyaethanamid und verfahren zu seiner synthese |
-
1982
- 1982-09-02 JP JP57151698A patent/JPS5942356A/ja active Granted
-
1983
- 1983-08-17 AU AU18074/83A patent/AU560073B2/en not_active Ceased
- 1983-08-18 US US06/524,354 patent/US4529549A/en not_active Expired - Lifetime
- 1983-08-30 KR KR1019830004071A patent/KR900008137B1/ko not_active IP Right Cessation
- 1983-08-31 ES ES525278A patent/ES8506267A1/es not_active Expired
- 1983-08-31 AT AT83108567T patent/ATE36701T1/de not_active IP Right Cessation
- 1983-08-31 DE DE8383108567T patent/DE3377795D1/de not_active Expired
- 1983-08-31 AR AR83294077A patent/AR241650A1/es active
- 1983-08-31 EP EP83108567A patent/EP0105193B1/fr not_active Expired
- 1983-09-01 DK DK398583A patent/DK160089C/da active
- 1983-09-01 HU HU833047A patent/HU190730B/hu not_active IP Right Cessation
- 1983-09-01 CA CA000435865A patent/CA1199641A/fr not_active Expired
- 1983-09-02 CS CS836397A patent/CS235341B2/cs unknown
- 1983-09-02 MX MX825783A patent/MX8257A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR241650A1 (es) | 1992-10-30 |
| EP0105193A2 (fr) | 1984-04-11 |
| ES525278A0 (es) | 1985-07-01 |
| MX8257A (es) | 1994-01-31 |
| AU560073B2 (en) | 1987-03-26 |
| KR900008137B1 (ko) | 1990-10-31 |
| JPH0149256B2 (fr) | 1989-10-24 |
| CA1199641A (fr) | 1986-01-21 |
| DK160089B (da) | 1991-01-28 |
| ATE36701T1 (de) | 1988-09-15 |
| DK398583A (da) | 1984-03-03 |
| HU190730B (en) | 1986-10-28 |
| DK398583D0 (da) | 1983-09-01 |
| ES8506267A1 (es) | 1985-07-01 |
| EP0105193A3 (en) | 1985-04-03 |
| KR840006332A (ko) | 1984-11-29 |
| AU1807483A (en) | 1984-03-08 |
| JPS5942356A (ja) | 1984-03-08 |
| EP0105193B1 (fr) | 1988-08-24 |
| US4529549A (en) | 1985-07-16 |
| DE3377795D1 (en) | 1988-09-29 |
| DK160089C (da) | 1991-06-24 |
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