CS235333B2 - Method of 7 alpha-acetylthio-15,16-amethylen-3-keto-17 alpha-pregna-1,4-dien-21,17-carbolactones production - Google Patents
Method of 7 alpha-acetylthio-15,16-amethylen-3-keto-17 alpha-pregna-1,4-dien-21,17-carbolactones production Download PDFInfo
- Publication number
- CS235333B2 CS235333B2 CS835482A CS548283A CS235333B2 CS 235333 B2 CS235333 B2 CS 235333B2 CS 835482 A CS835482 A CS 835482A CS 548283 A CS548283 A CS 548283A CS 235333 B2 CS235333 B2 CS 235333B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- alpha
- carbolactones
- pregna
- keto
- acetylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823227598 DE3227598A1 (de) | 1982-07-22 | 1982-07-22 | 7(alpha)-acylthio-15.16-methylen-3-oxo-17(alpha)-pregna-1.4-dien-21,17-carbolactone, verfahren zu ihrer herstellung und verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
CS235333B2 true CS235333B2 (en) | 1985-05-15 |
Family
ID=6169184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS835482A CS235333B2 (en) | 1982-07-22 | 1983-07-21 | Method of 7 alpha-acetylthio-15,16-amethylen-3-keto-17 alpha-pregna-1,4-dien-21,17-carbolactones production |
Country Status (17)
Country | Link |
---|---|
US (1) | US4500522A (no) |
EP (1) | EP0099853B1 (no) |
JP (1) | JPS5921699A (no) |
AT (1) | ATE27606T1 (no) |
AU (1) | AU557559B2 (no) |
CA (1) | CA1202301A (no) |
CS (1) | CS235333B2 (no) |
DD (1) | DD210061B3 (no) |
DE (2) | DE3227598A1 (no) |
DK (1) | DK159457C (no) |
ES (1) | ES524363A0 (no) |
FI (1) | FI78112C (no) |
GR (1) | GR78904B (no) |
HU (1) | HU187114B (no) |
IE (1) | IE55667B1 (no) |
NO (1) | NO157297C (no) |
ZA (1) | ZA835390B (no) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3481707D1 (de) * | 1983-08-17 | 1990-04-26 | Schering Ag | 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en-21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. |
DE3402329A1 (de) * | 1984-01-20 | 1985-08-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3427090A1 (de) * | 1984-07-19 | 1986-01-23 | Schering AG, 1000 Berlin und 4709 Bergkamen | 7(alpha)-thiosubstituierte 19-hydroxy-15(beta),16(beta)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3506100A1 (de) * | 1985-02-18 | 1986-08-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPS6248694A (ja) * | 1985-08-28 | 1987-03-03 | Shionogi & Co Ltd | 抗アルドステロン活性ステロイド誘導体 |
DE3544661A1 (de) * | 1985-12-13 | 1987-06-19 | Schering Ag | Verfahren zur herstellung von 7(alpha)-acetylthiosteroiden |
DE3718109A1 (de) * | 1987-05-27 | 1988-12-22 | Schering Ag | Verfahren zur trennung von verfahrensprodukten der mespirenonsynthese |
JPH01165155U (no) * | 1988-05-02 | 1989-11-17 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE792624A (fr) * | 1972-05-22 | 1973-06-12 | Merck & Co Inc | Composes inhibiteurs de l'aldosterone et leur obtention |
DE2237143A1 (de) * | 1972-07-28 | 1974-02-14 | Hoechst Ag | Verfahren zur herstellung von beta(3-keto-7alpha-acetylthio-17beta-hydroxy4-androsten-17alpha-yl)-propionsaeuregamma-lacton und dessen 1-dehydro-derivat |
US3890304A (en) * | 1973-11-09 | 1975-06-17 | Searle & Co | 7{60 -carbam oyl-17-hydroxy-3-oxo-17{60 -pregn-4-ene-21-carboxylic acid {65 -lactone and related compounds |
DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
DE2922500A1 (de) * | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
-
1982
- 1982-07-22 DE DE19823227598 patent/DE3227598A1/de not_active Withdrawn
-
1983
- 1983-07-07 JP JP58122449A patent/JPS5921699A/ja active Granted
- 1983-07-12 AU AU16756/83A patent/AU557559B2/en not_active Ceased
- 1983-07-19 DD DD83253197A patent/DD210061B3/de not_active IP Right Cessation
- 1983-07-19 FI FI832627A patent/FI78112C/fi not_active IP Right Cessation
- 1983-07-20 EP EP83730074A patent/EP0099853B1/en not_active Expired
- 1983-07-20 DE DE8383730074T patent/DE3371909D1/de not_active Expired
- 1983-07-20 GR GR71989A patent/GR78904B/el unknown
- 1983-07-20 AT AT83730074T patent/ATE27606T1/de not_active IP Right Cessation
- 1983-07-21 HU HU832580A patent/HU187114B/hu unknown
- 1983-07-21 CA CA000432905A patent/CA1202301A/en not_active Expired
- 1983-07-21 IE IE1708/83A patent/IE55667B1/en not_active IP Right Cessation
- 1983-07-21 CS CS835482A patent/CS235333B2/cs unknown
- 1983-07-21 NO NO832667A patent/NO157297C/no unknown
- 1983-07-21 DK DK335583A patent/DK159457C/da not_active IP Right Cessation
- 1983-07-22 ZA ZA835390A patent/ZA835390B/xx unknown
- 1983-07-22 US US06/516,391 patent/US4500522A/en not_active Expired - Fee Related
- 1983-07-22 ES ES524363A patent/ES524363A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
DE3227598A1 (de) | 1984-01-26 |
NO157297B (no) | 1987-11-16 |
NO157297C (no) | 1988-02-24 |
EP0099853B1 (en) | 1987-06-03 |
EP0099853A3 (en) | 1984-04-18 |
DK159457C (da) | 1991-03-18 |
FI832627A0 (fi) | 1983-07-19 |
FI78112C (fi) | 1989-06-12 |
DD210061A5 (de) | 1984-05-30 |
IE831708L (en) | 1984-01-22 |
ZA835390B (en) | 1984-03-28 |
ATE27606T1 (de) | 1987-06-15 |
GR78904B (no) | 1984-10-02 |
JPS5921699A (ja) | 1984-02-03 |
EP0099853A2 (en) | 1984-02-01 |
FI78112B (fi) | 1989-02-28 |
DK335583A (da) | 1984-01-23 |
DK159457B (da) | 1990-10-15 |
NO832667L (no) | 1984-01-23 |
AU1675683A (en) | 1984-01-26 |
CA1202301A (en) | 1986-03-25 |
HU187114B (en) | 1985-11-28 |
ES8407322A1 (es) | 1984-10-01 |
IE55667B1 (en) | 1990-12-19 |
AU557559B2 (en) | 1986-12-24 |
DE3371909D1 (en) | 1987-07-09 |
US4500522A (en) | 1985-02-19 |
DD210061B3 (de) | 1988-11-30 |
ES524363A0 (es) | 1984-10-01 |
JPH0372080B2 (no) | 1991-11-15 |
FI832627A (fi) | 1984-01-23 |
DK335583D0 (da) | 1983-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE55567B1 (en) | Copper-containing thick-film conductor compositions | |
EA014325B1 (ru) | 18-метил-9-нор-17-прегн-4-ен-21,17-карболактоны, а также лекарственные препараты, которые их содержат | |
EP0122232A1 (de) | 20-Spiroxane und Analoge mit geöffnetem Ring E, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate davon | |
PT2038294E (pt) | 18-metil-19-nor-androst-4-en-17,17-espiroéter (18-metil- 19-nor-20-spirox-4-en-3-ona), bem como preparados farmacêuticos contendo estes compostos | |
CS235333B2 (en) | Method of 7 alpha-acetylthio-15,16-amethylen-3-keto-17 alpha-pregna-1,4-dien-21,17-carbolactones production | |
US8987239B2 (en) | 19-nor-steroid derivatives with a 15α,16α-methylene group and a saturated 17,17-spirolactone ring, use thereof, and medicaments containing said derivatives | |
EP0099854B1 (en) | 17-alpha-pregn-4-ene-3-oxo-21-carboxylic acid esters, process for the preparation thereof, and use thereof as medicinal agents | |
US8937058B2 (en) | 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivative, use thereof, and medicament containing the derivative | |
AU2008342915A1 (en) | 15,16-methylene-17-(1'-propenyl)-17,3'-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative | |
EP0108033B1 (de) | Neue 7-alpha-Acylthio-1-alpha,2-alpha-Methylen-3-oxo-17-alpha-pregn-4-en-21,17-carbolactone, deren Herstellung und diese enthaltende Arzneimittel | |
EP0134529B1 (de) | 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate | |
EP0255464B1 (de) | 2,2;6,6-Diethylen-3-oxo-17alpha-pregn-4-en-21, 17-carbolactone, Verfahren zu deren Herstellung und diese enthaltende pharm. Präparate | |
US20110015162A1 (en) | 15,16-Methylene-17-hydroxy-19-nor-21-carboxylic acid-steroid Y-lactone derivative, use thereof and medicinal products containing the derivative | |
US9034856B2 (en) | 17-(1′propenyl)-17-3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative | |
US3441647A (en) | 1,2alpha;16,17alpha-bismethylene-delta**4,6-pregnadienes | |
US3234216A (en) | Acetals and ketals of 3-alkoxy-6-halo-delta3, 5-pregnadienes | |
DE3234972A1 (de) | 7(alpha)-alkyl-17(alpha)-pregn-4-en-21.17-carbolactone und -21-carbonsaeuresalze sowie verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate | |
DE102007063499A1 (de) | Steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel | |
DE3427090A1 (de) | 7(alpha)-thiosubstituierte 19-hydroxy-15(beta),16(beta)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
JPS595200A (ja) | 6β,7β−メチレン−17α−プレグネ−4−エン−21,17−カルボラクトン、その製造法及びこれを含有しアルドステロン拮抗作用を有する薬剤 | |
DE1668690A1 (de) | N-substituierte 4-Aminosteroide | |
SI8611201A8 (sl) | Postopek za pridobivanje substituiranih androsta -1,4-dien-3,17-dionov | |
DE3140823A1 (de) | 6-chlor-6.7;15ss.16ss-dimethylen-3-keto-steroid- 21.17-carbolactone, verfahren zu ihrer herstellung und verwendung als arzneimittel |