ZA835390B - 7-acylthio-15,16-methylene-3-oxo-17-pregna-1,4-diene 21,17-carbolactones,their preparation and use as medicinal agents - Google Patents

7-acylthio-15,16-methylene-3-oxo-17-pregna-1,4-diene 21,17-carbolactones,their preparation and use as medicinal agents

Info

Publication number
ZA835390B
ZA835390B ZA835390A ZA835390A ZA835390B ZA 835390 B ZA835390 B ZA 835390B ZA 835390 A ZA835390 A ZA 835390A ZA 835390 A ZA835390 A ZA 835390A ZA 835390 B ZA835390 B ZA 835390B
Authority
ZA
South Africa
Prior art keywords
methylene
carbolactones
pregna
acylthio
diene
Prior art date
Application number
ZA835390A
Other languages
English (en)
Inventor
Klaus Nickisch
Dieter Bittler
Henry Laurent
Rudolf Wiechert
Wolfgang Losert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA835390B publication Critical patent/ZA835390B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA835390A 1982-07-22 1983-07-22 7-acylthio-15,16-methylene-3-oxo-17-pregna-1,4-diene 21,17-carbolactones,their preparation and use as medicinal agents ZA835390B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823227598 DE3227598A1 (de) 1982-07-22 1982-07-22 7(alpha)-acylthio-15.16-methylen-3-oxo-17(alpha)-pregna-1.4-dien-21,17-carbolactone, verfahren zu ihrer herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ZA835390B true ZA835390B (en) 1984-03-28

Family

ID=6169184

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA835390A ZA835390B (en) 1982-07-22 1983-07-22 7-acylthio-15,16-methylene-3-oxo-17-pregna-1,4-diene 21,17-carbolactones,their preparation and use as medicinal agents

Country Status (17)

Country Link
US (1) US4500522A (xx)
EP (1) EP0099853B1 (xx)
JP (1) JPS5921699A (xx)
AT (1) ATE27606T1 (xx)
AU (1) AU557559B2 (xx)
CA (1) CA1202301A (xx)
CS (1) CS235333B2 (xx)
DD (1) DD210061B3 (xx)
DE (2) DE3227598A1 (xx)
DK (1) DK159457C (xx)
ES (1) ES8407322A1 (xx)
FI (1) FI78112C (xx)
GR (1) GR78904B (xx)
HU (1) HU187114B (xx)
IE (1) IE55667B1 (xx)
NO (1) NO157297C (xx)
ZA (1) ZA835390B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3481707D1 (de) * 1983-08-17 1990-04-26 Schering Ag 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en-21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
DE3402329A1 (de) * 1984-01-20 1985-08-01 Schering AG, 1000 Berlin und 4709 Bergkamen 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3427090A1 (de) * 1984-07-19 1986-01-23 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-thiosubstituierte 19-hydroxy-15(beta),16(beta)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3506100A1 (de) * 1985-02-18 1986-08-21 Schering AG, 1000 Berlin und 4709 Bergkamen 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS6248694A (ja) * 1985-08-28 1987-03-03 Shionogi & Co Ltd 抗アルドステロン活性ステロイド誘導体
DE3544661A1 (de) * 1985-12-13 1987-06-19 Schering Ag Verfahren zur herstellung von 7(alpha)-acetylthiosteroiden
DE3718109A1 (de) * 1987-05-27 1988-12-22 Schering Ag Verfahren zur trennung von verfahrensprodukten der mespirenonsynthese
JPH01165155U (xx) * 1988-05-02 1989-11-17

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792624A (fr) * 1972-05-22 1973-06-12 Merck & Co Inc Composes inhibiteurs de l'aldosterone et leur obtention
DE2237143A1 (de) * 1972-07-28 1974-02-14 Hoechst Ag Verfahren zur herstellung von beta(3-keto-7alpha-acetylthio-17beta-hydroxy4-androsten-17alpha-yl)-propionsaeuregamma-lacton und dessen 1-dehydro-derivat
US3890304A (en) * 1973-11-09 1975-06-17 Searle & Co 7{60 -carbam oyl-17-hydroxy-3-oxo-17{60 -pregn-4-ene-21-carboxylic acid {65 -lactone and related compounds
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2922500A1 (de) * 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta

Also Published As

Publication number Publication date
DK335583D0 (da) 1983-07-21
EP0099853B1 (en) 1987-06-03
FI832627A (fi) 1984-01-23
FI78112C (fi) 1989-06-12
DK335583A (da) 1984-01-23
ES524363A0 (es) 1984-10-01
HU187114B (en) 1985-11-28
JPS5921699A (ja) 1984-02-03
DD210061B3 (de) 1988-11-30
ATE27606T1 (de) 1987-06-15
EP0099853A3 (en) 1984-04-18
DD210061A5 (de) 1984-05-30
US4500522A (en) 1985-02-19
DK159457B (da) 1990-10-15
CA1202301A (en) 1986-03-25
ES8407322A1 (es) 1984-10-01
DE3371909D1 (en) 1987-07-09
NO832667L (no) 1984-01-23
CS235333B2 (en) 1985-05-15
FI78112B (fi) 1989-02-28
AU1675683A (en) 1984-01-26
DK159457C (da) 1991-03-18
AU557559B2 (en) 1986-12-24
NO157297C (no) 1988-02-24
JPH0372080B2 (xx) 1991-11-15
DE3227598A1 (de) 1984-01-26
IE831708L (en) 1984-01-22
EP0099853A2 (en) 1984-02-01
NO157297B (no) 1987-11-16
GR78904B (xx) 1984-10-02
FI832627A0 (fi) 1983-07-19
IE55667B1 (en) 1990-12-19

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