CS231970B2 - Manufacturing process of the 4-amino-2-peperidinochinazoline derivatives - Google Patents

Manufacturing process of the 4-amino-2-peperidinochinazoline derivatives Download PDF

Info

Publication number
CS231970B2
CS231970B2 CS80607A CS60780A CS231970B2 CS 231970 B2 CS231970 B2 CS 231970B2 CS 80607 A CS80607 A CS 80607A CS 60780 A CS60780 A CS 60780A CS 231970 B2 CS231970 B2 CS 231970B2
Authority
CS
Czechoslovakia
Prior art keywords
piperidine
phenyl
amino
vacuo
evaporated
Prior art date
Application number
CS80607A
Other languages
Czech (cs)
English (en)
Other versions
CS60780A2 (en
Inventor
Simon F Campbell
John Ch Danilevitcz
Colin W Grengrass
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS60780A2 publication Critical patent/CS60780A2/cs
Publication of CS231970B2 publication Critical patent/CS231970B2/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS80607A 1979-01-31 1980-01-29 Manufacturing process of the 4-amino-2-peperidinochinazoline derivatives CS231970B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7903398 1979-01-31

Publications (2)

Publication Number Publication Date
CS60780A2 CS60780A2 (en) 1984-01-16
CS231970B2 true CS231970B2 (en) 1985-01-16

Family

ID=10502852

Family Applications (1)

Application Number Title Priority Date Filing Date
CS80607A CS231970B2 (en) 1979-01-31 1980-01-29 Manufacturing process of the 4-amino-2-peperidinochinazoline derivatives

Country Status (28)

Country Link
JP (1) JPS55104278A (ko)
AR (1) AR222208A1 (ko)
AT (1) AT373595B (ko)
BE (1) BE881448A (ko)
CA (1) CA1131636A (ko)
CS (1) CS231970B2 (ko)
DD (1) DD148720A5 (ko)
DE (1) DE3003323A1 (ko)
DK (1) DK540879A (ko)
ES (1) ES488129A0 (ko)
FI (1) FI63936C (ko)
FR (1) FR2447919A1 (ko)
GR (1) GR73626B (ko)
HU (1) HU184233B (ko)
IE (1) IE800178L (ko)
IL (1) IL59252A (ko)
IT (1) IT1149902B (ko)
LU (1) LU82115A1 (ko)
NL (1) NL8000571A (ko)
NO (1) NO800230L (ko)
NZ (1) NZ192744A (ko)
PH (1) PH15436A (ko)
PL (1) PL121890B1 (ko)
PT (1) PT70749A (ko)
SE (1) SE8000699L (ko)
SU (1) SU895291A3 (ko)
YU (1) YU22980A (ko)
ZA (1) ZA80557B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2483920A1 (fr) * 1980-06-09 1981-12-11 Synthelabo Nouveaux derives de quinazoline, leur procede de preparation et leur application en therapeutique
ES515338A0 (es) * 1981-09-09 1983-11-01 Orion Yhtymae Oy "metodo para la preparacion de piperidinilquinazolidinas substituidas".
US5280032A (en) * 1989-02-14 1994-01-18 Toyama Chemical Co., Ltd. 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same
WO2013070852A2 (en) * 2011-11-08 2013-05-16 Emory University Compounds and compositions used to epigenetically transform cells and methods related thereto

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1088068A (en) * 1977-11-16 1980-10-21 Simon F. Campbell Piperidino-quinazolines
GB2021108B (en) * 1978-05-18 1982-07-21 Pfizer Ltd 6,7 - di - 4 - amino - 2 - quinazolines

Also Published As

Publication number Publication date
NL8000571A (nl) 1980-08-04
GR73626B (ko) 1984-03-26
FI63936C (fi) 1983-09-12
AT373595B (de) 1984-02-10
SE8000699L (sv) 1980-08-01
PT70749A (en) 1980-02-01
JPS5728711B2 (ko) 1982-06-18
YU22980A (en) 1983-02-28
IT1149902B (it) 1986-12-10
CS60780A2 (en) 1984-01-16
PL121890B1 (en) 1982-06-30
IE800178L (en) 1980-07-31
AR222208A1 (es) 1981-04-30
FI63936B (fi) 1983-05-31
SU895291A3 (ru) 1981-12-30
CA1131636A (en) 1982-09-14
PL221683A1 (ko) 1980-12-01
NZ192744A (en) 1984-03-30
DE3003323A1 (de) 1980-08-14
PH15436A (en) 1983-01-18
AU5502480A (en) 1980-08-07
ES8101583A1 (es) 1980-12-16
HU184233B (en) 1984-07-30
DK540879A (da) 1980-08-01
IT8019537A0 (it) 1980-01-29
FR2447919A1 (fr) 1980-08-29
IL59252A (en) 1983-11-30
LU82115A1 (fr) 1980-04-23
JPS55104278A (en) 1980-08-09
FR2447919B1 (ko) 1983-02-11
ZA80557B (en) 1981-08-26
IL59252A0 (en) 1980-05-30
FI800252A (fi) 1980-08-01
ATA46980A (de) 1983-06-15
ES488129A0 (es) 1980-12-16
NO800230L (no) 1980-08-01
BE881448A (fr) 1980-07-30
DD148720A5 (de) 1981-06-10

Similar Documents

Publication Publication Date Title
JP4493503B2 (ja) 複素環式化合物及びそれを有効成分とする抗腫瘍剤
EP0974583B1 (en) Phenylpiperidine derivatives
US4243666A (en) 4-Amino-2-piperidino-quinazolines
KR20030081458A (ko) 비-수화 펙소페나딘 염화수소의 제조방법 및 이 방법에의하여 얻어지는 신규 결정 형태
HU178302B (en) Process for producing n-amidino-3,5-diamino-6-substituted-2-piperazine-carboxamides
US4814343A (en) Substituted 1H-imidazoles
CZ217495A3 (en) 2,3-cyclically condensed 1,4-dihydropyridines, process of their preparation, medicaments in which said substances are comprised and their use
CS231970B2 (en) Manufacturing process of the 4-amino-2-peperidinochinazoline derivatives
JPH05186459A (ja) 2−アミノ−5−シアノ−4−キノリン−1,4−ジヒドロピリジン類
HUT70486A (en) 3-quinolyl-substituted dihydropyridine derivatives, process for producing them and their use for producing pharmaceutical compositions
GB2171997A (en) 4-Amino-6,7-dimethoxy-2-Piperazin-1-ylquinazoline derivatives
CA1270251A (en) 2-(heteroalkyl)-1,4-dihydropyridines, process for their preparation and pharmaceutical compositions containing them
US4576953A (en) Quinoline derivatives
DK158944B (da) Analogifremgangsmaade til fremstilling af substituerede methylimidazolforbindelser
US4237138A (en) Antihypertensive 4-amino-2-[4-(substituted-alkoxy)piperidino)]quinazolines
CZ177892A3 (en) AMINOMETHYL SUBSTITUTED 2,3-DIHYDROPYRAN(2,3-b)PYRIDINES, PROCESS OF THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
CA1088068A (en) Piperidino-quinazolines
US4558048A (en) Method of treating diarrhoea using indole compounds
CZ357190A3 (en) Dihydropyrimidothiazine derivatives, process of their preparation and pharmaceutical compositions containing thereof
GB2041373A (en) Quinazoline antihypertensives
JPS6391366A (ja) 1,4−ジヒドロピリジン誘導体
IE47510B1 (en) 4-amino-6,7-dialkoxy-2-substituted quinazolines
EP0707579A1 (en) Piperidinyl substituted methanoanthracenes as d1/d2-antagonists and 5ht2-serotanin-antagonists
JPH0559064A (ja) テトラヒドロオキサゼピン誘導体