CS219939B2 - Method of making the octapeptide with antagonistic effect in respect of angiotensine 1 - Google Patents

Method of making the octapeptide with antagonistic effect in respect of angiotensine 1 Download PDF

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Publication number
CS219939B2
CS219939B2 CS81323A CS32381A CS219939B2 CS 219939 B2 CS219939 B2 CS 219939B2 CS 81323 A CS81323 A CS 81323A CS 32381 A CS32381 A CS 32381A CS 219939 B2 CS219939 B2 CS 219939B2
Authority
CS
Czechoslovakia
Prior art keywords
group
radical
solution
acid
nitrogen atom
Prior art date
Application number
CS81323A
Other languages
Czech (cs)
English (en)
Inventor
Olga Nyeki
Lajos Kisfaludy
Egon Karpati
Laszlo Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of CS219939B2 publication Critical patent/CS219939B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CS81323A 1980-01-18 1981-01-16 Method of making the octapeptide with antagonistic effect in respect of angiotensine 1 CS219939B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU8080100A HU181008B (en) 1980-01-18 1980-01-18 Process for producing angiotenzin-ii analogues of antagonistic activity containing sarcosyl-group at the 1-positon,and an alpha-hydroxy-carboxylic acid at the 8-position

Publications (1)

Publication Number Publication Date
CS219939B2 true CS219939B2 (en) 1983-03-25

Family

ID=10947908

Family Applications (1)

Application Number Title Priority Date Filing Date
CS81323A CS219939B2 (en) 1980-01-18 1981-01-16 Method of making the octapeptide with antagonistic effect in respect of angiotensine 1

Country Status (19)

Country Link
US (1) US4330532A (fi)
EP (1) EP0034260B1 (fi)
JP (1) JPS56142251A (fi)
AT (1) ATE4197T1 (fi)
AU (1) AU541000B2 (fi)
CA (1) CA1149377A (fi)
CS (1) CS219939B2 (fi)
DE (1) DE3160608D1 (fi)
DK (1) DK149777C (fi)
ES (1) ES8201129A1 (fi)
FI (1) FI73225C (fi)
HU (1) HU181008B (fi)
IL (1) IL61922A (fi)
IN (1) IN153279B (fi)
NO (1) NO151409C (fi)
PH (1) PH17196A (fi)
PL (1) PL130448B1 (fi)
SU (1) SU993816A3 (fi)
YU (1) YU42550B (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182264A (en) * 1986-03-07 1993-01-26 Schering Corporation Angiotensin II receptor blockers as antiglaucoma agents
DE19529604A1 (de) * 1995-08-11 1997-02-13 Bayer Ag Endoparasitizide Mittel auf Basis von Didepsipeptiden, neue Didepsipeptide und ein Verfahren zu ihrer Herstellung
US9572856B2 (en) * 2009-12-16 2017-02-21 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Method of treating low blood pressure
EP3858437A1 (en) 2013-04-26 2021-08-04 La Jolla Pharma, LLC Compositions and methods for treating renal failure
WO2015095535A1 (en) 2013-12-18 2015-06-25 The George Washington University, A Congressional Chartered Not-For-Profit Corporation Angiotensin ii alone or in combination for the treatment of hypotension
US10406201B2 (en) 2016-01-07 2019-09-10 La Jolla Pharma, Llc Methods for administering angiotensin II
WO2018191678A1 (en) 2017-04-14 2018-10-18 La Jolla Pharmaceutical Company Methods for administering angiotensin ii

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947575A (en) * 1969-06-30 1976-03-30 E. R. Squibb & Sons, Inc. Peptides as argiotensin converting enzyme inhibitors
DE2323322A1 (de) * 1973-05-09 1974-11-28 Hoechst Ag Neue peptide mit blutdrucksenkender wirkung und verfahren zu ihrer herstellung
US3923770A (en) * 1974-05-10 1975-12-02 Francis Merlin Bumpus {8 Me{hd 2{b Gly{hu 1{b , Ile{hu 8{b {9 -Anziotensin II as an angiotensin antagonist
US3923769A (en) * 1974-05-10 1975-12-02 Francis Merlin Bumpus {8 N-Me-Ile{40 ,Ile{hu 8{b {9 -Angiotensin II as an angiotensin antagonist
US3915948A (en) * 1974-08-05 1975-10-28 Morton Norwich Products Inc Sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-proline
DE2457463A1 (de) * 1974-12-05 1976-06-10 Hoechst Ag Neue peptide mit blutdrucksenkender wirkung und verfahren zu ihrer herstellung
US3975365A (en) * 1975-01-27 1976-08-17 G. D. Searle & Co. Inhibitory octapeptides angiotensin II
US3976770A (en) * 1975-02-10 1976-08-24 Francis Merlin Bumpus Sar'-(OMe)Thr8 Angiotensin II as an angiotensin II antagonist
HU177134B (en) * 1977-07-18 1981-07-28 Richter Gedeon Vegyeszet Process for preparing angiotensin ii analogues containing alpha-hydroxy-acid in position 1 with angiotensin ii antagonist activity
HU177133B (en) * 1977-07-18 1981-07-28 Richter Gedeon Vegyeszet Process for preparing angiotensin ii analogues containing alpha- amino-oxy-acid in position 1 with angiotensin ii antagonist activity

Also Published As

Publication number Publication date
JPS56142251A (en) 1981-11-06
AU541000B2 (en) 1984-12-13
PH17196A (en) 1984-06-19
PL229223A1 (fi) 1982-03-01
SU993816A3 (ru) 1983-01-30
AU6627681A (en) 1981-07-23
NO151409B (no) 1984-12-27
ES498583A0 (es) 1981-12-01
DK149777C (da) 1987-04-21
US4330532A (en) 1982-05-18
FI73225C (fi) 1987-09-10
DE3160608D1 (en) 1983-08-25
EP0034260B1 (de) 1983-07-20
NO810149L (no) 1981-07-20
FI73225B (fi) 1987-05-29
IL61922A (en) 1984-01-31
IL61922A0 (en) 1981-02-27
EP0034260A1 (de) 1981-08-26
ATE4197T1 (de) 1983-08-15
NO151409C (no) 1985-04-10
CA1149377A (en) 1983-07-05
DK20481A (da) 1981-07-19
IN153279B (fi) 1984-06-23
FI810123L (fi) 1981-07-19
PL130448B1 (en) 1984-08-31
HU181008B (en) 1983-05-30
YU42550B (en) 1988-10-31
ES8201129A1 (es) 1981-12-01
YU9381A (en) 1983-09-30
DK149777B (da) 1986-09-29

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