CS210680B2 - Manufacturing process of phophonic acids - Google Patents
Manufacturing process of phophonic acids Download PDFInfo
- Publication number
- CS210680B2 CS210680B2 CS788751A CS875178A CS210680B2 CS 210680 B2 CS210680 B2 CS 210680B2 CS 788751 A CS788751 A CS 788751A CS 875178 A CS875178 A CS 875178A CS 210680 B2 CS210680 B2 CS 210680B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- acid
- water
- alanyl
- amino
- melting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5366877 | 1977-12-23 | ||
| GB7845272 | 1978-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS210680B2 true CS210680B2 (en) | 1982-01-29 |
Family
ID=26267312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS788751A CS210680B2 (en) | 1977-12-23 | 1978-12-21 | Manufacturing process of phophonic acids |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4250085A (it) |
| EP (1) | EP0002822B1 (it) |
| JP (1) | JPS5492922A (it) |
| AR (1) | AR222479A1 (it) |
| AT (1) | AT365166B (it) |
| AU (1) | AU4258178A (it) |
| BR (1) | BR7808474A (it) |
| CA (1) | CA1108125A (it) |
| CS (1) | CS210680B2 (it) |
| DE (2) | DE2861980D1 (it) |
| DK (1) | DK581178A (it) |
| ES (2) | ES476264A1 (it) |
| FI (1) | FI783959A7 (it) |
| FR (3) | FR2453866A1 (it) |
| GR (1) | GR72974B (it) |
| IL (1) | IL56241A0 (it) |
| IT (1) | IT1102755B (it) |
| LU (1) | LU80715A1 (it) |
| MC (1) | MC1243A1 (it) |
| NL (1) | NL7812314A (it) |
| NO (1) | NO784354L (it) |
| NZ (1) | NZ189205A (it) |
| PT (1) | PT68978A (it) |
| SE (1) | SE7813274L (it) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0026867A1 (de) * | 1979-09-28 | 1981-04-15 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Peptidylphosphonsäuren, deren Herstellung und Verwendung und sie enthaltende pharmazeutische Präparate |
| EP0061172B1 (en) * | 1981-03-20 | 1985-06-19 | Kyowa Hakko Kogyo Co., Ltd. | Phosphorus-containing oligopeptides, processes for preparation thereof and a pharmaceutical composition containing the same |
| JPS5831992A (ja) * | 1981-08-19 | 1983-02-24 | Kyowa Hakko Kogyo Co Ltd | 新規生理活性物質ｋ−４およびその製造法 |
| JPS57156498A (en) * | 1981-03-20 | 1982-09-27 | Kyowa Hakko Kogyo Co Ltd | Novel physiologically active substance k-26 |
| JPS5885897A (ja) * | 1981-11-17 | 1983-05-23 | Kyowa Hakko Kogyo Co Ltd | 光学活性な１−アミノ−２−（４−ヒドロキシフエニル）エチルホスホン酸およびその誘導体 |
| DE3368418D1 (en) * | 1982-09-17 | 1987-01-29 | Kyowa Hakko Kogyo Kk | Phosphorus-containing peptide derivative |
| US4482488A (en) * | 1982-09-27 | 1984-11-13 | Eli Lilly And Company | Antibiotic A53868 and process for production thereof |
| PT77368A (en) * | 1982-09-27 | 1983-10-01 | Lilly Co Eli | Improved process for preparing immunomodulating agents or rela-ting there to |
| FR2584077B1 (fr) * | 1985-06-28 | 1988-07-08 | Irceba | L-di ou tripeptides possedant une activite biologique utilisable en medecine humaine et veterinaire, procede pour leur obtention et medicament en contenant |
| JPH02503440A (ja) * | 1988-03-03 | 1990-10-18 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | １，２‐ヒドロキシホスホネートおよびその誘導体 |
| JPH03505875A (ja) * | 1988-07-08 | 1991-12-19 | スミスクライン・ベックマン・コーポレイション | レトロウイルス・プロテアーゼ結合ペプチド |
| WO1990009172A1 (en) * | 1989-02-16 | 1990-08-23 | Pfizer Inc. | Phosphorus containing renin inhibitors |
| US5468732A (en) * | 1989-02-16 | 1995-11-21 | Pfizer Inc. | Phosphorus containing renin inhibitors |
| DE4417478A1 (de) | 1994-05-19 | 1995-11-23 | Basf Ag | Verfahren zur Herstellung N-Z-geschützter N-methylierter Aminosäuren |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL48835A (en) * | 1975-01-27 | 1979-05-31 | Sparamedica Ag | Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem |
| CA1057082A (en) * | 1976-05-13 | 1979-06-26 | Dale K. Bell | Air piston differential lockout |
| JPS6037745Y2 (ja) * | 1976-05-18 | 1985-11-11 | 富士写真フイルム株式会社 | 磁気テ−プカセツト |
| IT1081511B (it) * | 1976-07-13 | 1985-05-21 | Hoffmann La Roche | Derivati di peptidi e loro preparazione |
-
1978
- 1978-12-08 CA CA317,617A patent/CA1108125A/en not_active Expired
- 1978-12-15 AU AU42581/78A patent/AU4258178A/en active Pending
- 1978-12-18 IL IL56241A patent/IL56241A0/xx unknown
- 1978-12-18 NZ NZ189205A patent/NZ189205A/xx unknown
- 1978-12-19 NL NL7812314A patent/NL7812314A/xx not_active Application Discontinuation
- 1978-12-19 FR FR7835650A patent/FR2453866A1/fr not_active Withdrawn
- 1978-12-20 MC MC781350A patent/MC1243A1/xx unknown
- 1978-12-20 US US05/971,156 patent/US4250085A/en not_active Expired - Lifetime
- 1978-12-21 GR GR57956A patent/GR72974B/el unknown
- 1978-12-21 CS CS788751A patent/CS210680B2/cs unknown
- 1978-12-21 AT AT0918478A patent/AT365166B/de not_active IP Right Cessation
- 1978-12-21 AR AR274942A patent/AR222479A1/es active
- 1978-12-21 FI FI783959A patent/FI783959A7/fi unknown
- 1978-12-22 NO NO784354A patent/NO784354L/no unknown
- 1978-12-22 DE DE7878101826T patent/DE2861980D1/de not_active Expired
- 1978-12-22 JP JP15773078A patent/JPS5492922A/ja active Pending
- 1978-12-22 EP EP78101826A patent/EP0002822B1/de not_active Expired
- 1978-12-22 IT IT31276/78A patent/IT1102755B/it active
- 1978-12-22 BR BR7808474A patent/BR7808474A/pt unknown
- 1978-12-22 DK DK581178A patent/DK581178A/da unknown
- 1978-12-22 LU LU80715A patent/LU80715A1/de unknown
- 1978-12-22 SE SE7813274A patent/SE7813274L/xx not_active Application Discontinuation
- 1978-12-22 PT PT68978A patent/PT68978A/pt unknown
- 1978-12-22 DE DE19782855786 patent/DE2855786A1/de not_active Withdrawn
- 1978-12-22 ES ES476264A patent/ES476264A1/es not_active Expired
-
1979
- 1979-06-29 FR FR7916924A patent/FR2446838A1/fr not_active Withdrawn
- 1979-06-29 FR FR7916925A patent/FR2453867A1/fr not_active Withdrawn
- 1979-07-16 ES ES482504A patent/ES482504A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PT68978A (en) | 1979-01-01 |
| LU80715A1 (de) | 1980-07-21 |
| DK581178A (da) | 1979-06-24 |
| FR2453867A1 (fr) | 1980-11-07 |
| IL56241A0 (en) | 1979-03-12 |
| US4250085A (en) | 1981-02-10 |
| GR72974B (it) | 1984-01-20 |
| AT365166B (de) | 1981-12-28 |
| EP0002822A1 (de) | 1979-07-11 |
| AR222479A1 (es) | 1981-05-29 |
| SE7813274L (sv) | 1979-08-08 |
| NZ189205A (en) | 1982-03-23 |
| FR2453866A1 (fr) | 1980-11-07 |
| IT7831276A0 (it) | 1978-12-22 |
| CA1108125A (en) | 1981-09-01 |
| BR7808474A (pt) | 1979-08-21 |
| NO784354L (no) | 1979-06-26 |
| DE2861980D1 (en) | 1982-09-16 |
| MC1243A1 (fr) | 1979-10-26 |
| ES476264A1 (es) | 1980-05-16 |
| JPS5492922A (en) | 1979-07-23 |
| ES482504A1 (es) | 1980-04-01 |
| ATA918478A (de) | 1981-05-15 |
| FR2446838A1 (fr) | 1980-08-14 |
| FI783959A7 (fi) | 1979-06-24 |
| IT1102755B (it) | 1985-10-07 |
| DE2855786A1 (de) | 1979-07-05 |
| NL7812314A (nl) | 1979-06-26 |
| EP0002822B1 (de) | 1982-07-28 |
| AU4258178A (en) | 1979-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CS210680B2 (en) | Manufacturing process of phophonic acids | |
| US4016148A (en) | Peptide derivatives of phosphonic and phosphinic acids and intermediates therefor | |
| DE3786250T2 (de) | Phosphinsäure-Derivate. | |
| Allen et al. | Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond | |
| Bartlett et al. | Potent inhibition of pepsin and penicillopepsin by phosphorus-containing peptide analogs | |
| DE69520499T2 (de) | Histidine und homohistidine derivate zur verwendung als protein farnesyltransferase hemmstoffe | |
| EP0320118B1 (en) | Peptides with collagenase inhibiting activity | |
| EP1240172B1 (en) | New aminopropylphosphinic acids | |
| IE51876B1 (en) | Phosphinylalkanoyl sutstituted prolines | |
| JPS6226288A (ja) | リン含有酵素阻害剤 | |
| US4128542A (en) | Peptide derivatives | |
| CA2989065A1 (en) | Novel compounds | |
| US4886813A (en) | Proline derivatives | |
| CA1331499C (en) | Amino acids and peptides having a modified tyrosine residue, their preparation and their application as medicaments | |
| GB2030148A (en) | Peptide derivatives of phosphoric acids | |
| CA1307787C (en) | Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors | |
| US20020055463A1 (en) | Pseudopeptide compounds having an inhibiting activity with respect to paths activated by proteins with active tyrosine kinase activity and pharmaceutical compositions containing same | |
| GB1577232A (en) | Peptide derivatives of phosphonic and phosphinic acids | |
| EP0279750B1 (en) | Aminoacid derivatives as antihypertensives | |
| HU199152B (en) | Process for producing phosphonate and phosphonamide endopeptidase inhibitors and pharmaceutical compositions comprising same | |
| CS211394B2 (en) | Method of making the phosphon acids | |
| JPH04505750A (ja) | Ｌｈｒｈ同族体 | |
| Camp | Design and synthesis of inhibitors for the HIV-1 protease | |
| Lee | Studies on the design and synthesis of modified tyrosine-containing peptide analogs as potential inhibitors in signal transduction pathways | |
| Xu | I. Synthesis of phosphorylated peptides and applications for studies of protein-protein interactions. II. Development of mild methods for the preparation of modified oligonucleotides |