CS209929B2 - Method of making the new substituted 4h-s-triazolo/3,4c/-thieno/2,3e/-1,4 diazepins - Google Patents
Method of making the new substituted 4h-s-triazolo/3,4c/-thieno/2,3e/-1,4 diazepins Download PDFInfo
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- CS209929B2 CS209929B2 CS794826A CS482679A CS209929B2 CS 209929 B2 CS209929 B2 CS 209929B2 CS 794826 A CS794826 A CS 794826A CS 482679 A CS482679 A CS 482679A CS 209929 B2 CS209929 B2 CS 209929B2
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- CS
- Czechoslovakia
- Prior art keywords
- triazolo
- thieno
- diazepine
- chlorophenyl
- formula
- Prior art date
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- 238000004519 manufacturing process Methods 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 24
- 239000000460 chlorine Chemical group 0.000 claims abstract description 17
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 7
- 239000001257 hydrogen Substances 0.000 claims abstract description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052794 bromium Chemical group 0.000 claims abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 7
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- 239000013543 active substance Substances 0.000 claims description 4
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- 125000005842 heteroatom Chemical group 0.000 claims description 2
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- 229940049706 benzodiazepine Drugs 0.000 claims 1
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- 125000000217 alkyl group Chemical group 0.000 abstract description 4
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- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782830782 DE2830782A1 (de) | 1978-07-13 | 1978-07-13 | Neue substituierte 4h-s-triazolo eckige klammer auf 3,4c eckige klammer zu thieno eckige klammer auf 2,3e eckige klammer zu 1,4-diazepine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS209929B2 true CS209929B2 (en) | 1981-12-31 |
Family
ID=6044278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS794826A CS209929B2 (en) | 1978-07-13 | 1979-07-10 | Method of making the new substituted 4h-s-triazolo/3,4c/-thieno/2,3e/-1,4 diazepins |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5513297A (ro) |
| AT (1) | AT370735B (ro) |
| BE (1) | BE877669A (ro) |
| BG (1) | BG34451A3 (ro) |
| CS (1) | CS209929B2 (ro) |
| DD (1) | DD144777A5 (ro) |
| DE (1) | DE2830782A1 (ro) |
| DK (1) | DK295179A (ro) |
| ES (2) | ES482442A1 (ro) |
| FI (1) | FI792185A7 (ro) |
| FR (1) | FR2430949A1 (ro) |
| GB (1) | GB2029408B (ro) |
| GR (1) | GR69815B (ro) |
| HU (1) | HU177960B (ro) |
| IL (1) | IL57776A (ro) |
| IT (1) | IT1188845B (ro) |
| LU (1) | LU81494A1 (ro) |
| NL (1) | NL7905483A (ro) |
| NO (1) | NO792319L (ro) |
| PL (1) | PL120417B1 (ro) |
| PT (1) | PT69910A (ro) |
| RO (1) | RO78104A (ro) |
| SE (1) | SE7906093L (ro) |
| SU (1) | SU833160A3 (ro) |
| ZA (1) | ZA793509B (ro) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0540766A1 (en) * | 1991-11-04 | 1993-05-12 | Korth, Ruth-Maria, Dr. med | Treatment of eosinophil-mediated diseases with Paf antagonists and procedure for determining their efficacy. |
| US5895785A (en) * | 1987-10-20 | 1999-04-20 | Ruth Korth | Treatment and prevention of disorders mediated by LA-paf or endothelial cells |
| DE540767T1 (de) * | 1991-11-04 | 2001-10-25 | Ruth-Maria Korth | Behandlung und Vorbeugung von von erhöhten Lyso-PAF-Spiegel mediierten mentalen Erkrankungen mit PAF-Antagonisten |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3709899A (en) * | 1971-04-28 | 1973-01-09 | Upjohn Co | 6-phenyl-4h-s-triazolo(4,3-a)(1,4)benzodiazepines and their production |
| AT338799B (de) * | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze |
| FI63033C (fi) * | 1977-07-21 | 1983-04-11 | Boehringer Sohn Ingelheim | Foerfarande foer framstaellning av anxiolytiska tranquilliserande sedativa och/eller neuroleptiska substituerade 1-piperazinyl-4h-s-triazolo(3,4-c)tieno(2,3-e)-1,4-diazepiner |
-
1978
- 1978-07-13 DE DE19782830782 patent/DE2830782A1/de not_active Withdrawn
-
1979
- 1979-07-04 AT AT0465279A patent/AT370735B/de not_active IP Right Cessation
- 1979-07-09 GR GR59552A patent/GR69815B/el unknown
- 1979-07-09 SU SU792783396A patent/SU833160A3/ru active
- 1979-07-10 CS CS794826A patent/CS209929B2/cs unknown
- 1979-07-11 DD DD79214271A patent/DD144777A5/de unknown
- 1979-07-11 PL PL1979217029A patent/PL120417B1/pl unknown
- 1979-07-11 IT IT49724/79A patent/IT1188845B/it active
- 1979-07-11 BG BG044296A patent/BG34451A3/xx unknown
- 1979-07-12 ZA ZA00793509A patent/ZA793509B/xx unknown
- 1979-07-12 DK DK295179A patent/DK295179A/da not_active Application Discontinuation
- 1979-07-12 ES ES482442A patent/ES482442A1/es not_active Expired
- 1979-07-12 GB GB7924357A patent/GB2029408B/en not_active Expired
- 1979-07-12 LU LU81494A patent/LU81494A1/de unknown
- 1979-07-12 ES ES482437A patent/ES482437A1/es not_active Expired
- 1979-07-12 BE BE0/196277A patent/BE877669A/fr not_active IP Right Cessation
- 1979-07-12 NO NO792319A patent/NO792319L/no unknown
- 1979-07-12 HU HU79BO1796A patent/HU177960B/hu unknown
- 1979-07-12 JP JP8754479A patent/JPS5513297A/ja active Pending
- 1979-07-12 PT PT69910A patent/PT69910A/pt unknown
- 1979-07-12 IL IL57776A patent/IL57776A/xx unknown
- 1979-07-12 FI FI792185A patent/FI792185A7/fi not_active Application Discontinuation
- 1979-07-12 RO RO7998143A patent/RO78104A/ro unknown
- 1979-07-12 SE SE7906093A patent/SE7906093L/xx not_active Application Discontinuation
- 1979-07-13 FR FR7918300A patent/FR2430949A1/fr active Granted
- 1979-07-13 NL NL7905483A patent/NL7905483A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL217029A1 (ro) | 1980-08-11 |
| AT370735B (de) | 1983-04-25 |
| GB2029408A (en) | 1980-03-19 |
| IL57776A0 (en) | 1979-11-30 |
| NL7905483A (nl) | 1980-01-15 |
| ES482442A1 (es) | 1980-04-01 |
| ES482437A1 (es) | 1980-04-01 |
| ATA465279A (de) | 1982-09-15 |
| FR2430949A1 (fr) | 1980-02-08 |
| JPS5513297A (en) | 1980-01-30 |
| DK295179A (da) | 1980-01-14 |
| RO78104A (ro) | 1982-02-01 |
| SE7906093L (sv) | 1980-01-14 |
| LU81494A1 (de) | 1980-08-08 |
| PT69910A (de) | 1979-08-01 |
| PL120417B1 (en) | 1982-02-27 |
| IL57776A (en) | 1983-06-15 |
| BE877669A (fr) | 1980-01-14 |
| DD144777A5 (de) | 1980-11-05 |
| IT7949724A0 (it) | 1979-07-11 |
| IT1188845B (it) | 1988-01-28 |
| NO792319L (no) | 1980-01-15 |
| GB2029408B (en) | 1982-07-28 |
| SU833160A3 (ru) | 1981-05-23 |
| ZA793509B (en) | 1981-03-25 |
| FI792185A7 (fi) | 1981-01-01 |
| HU177960B (en) | 1982-02-28 |
| BG34451A3 (bg) | 1983-09-15 |
| GR69815B (ro) | 1982-07-13 |
| DE2830782A1 (de) | 1980-01-24 |
| FR2430949B1 (ro) | 1982-11-05 |
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