CS208756B2 - Method of preparation of the 1,3,8-substituted xantines - Google Patents

Method of preparation of the 1,3,8-substituted xantines Download PDF

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Publication number
CS208756B2
CS208756B2 CS786669A CS666978A CS208756B2 CS 208756 B2 CS208756 B2 CS 208756B2 CS 786669 A CS786669 A CS 786669A CS 666978 A CS666978 A CS 666978A CS 208756 B2 CS208756 B2 CS 208756B2
Authority
CS
Czechoslovakia
Prior art keywords
preparation
methyl
compound
pyrimidinedione
added
Prior art date
Application number
CS786669A
Other languages
Czech (cs)
English (en)
Inventor
Sten H A M Bergstrand
Per G Kjellin
Carl G A Persson
Lars M Soerenby
Original Assignee
Draco Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draco Ab filed Critical Draco Ab
Publication of CS208756B2 publication Critical patent/CS208756B2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS786669A 1977-10-14 1978-10-13 Method of preparation of the 1,3,8-substituted xantines CS208756B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7711581A SE416810C (sv) 1977-10-14 1977-10-14 Forfarande for framstellning av xantinderivat med antiallergisk aktivitet

Publications (1)

Publication Number Publication Date
CS208756B2 true CS208756B2 (en) 1981-09-15

Family

ID=20332576

Family Applications (1)

Application Number Title Priority Date Filing Date
CS786669A CS208756B2 (en) 1977-10-14 1978-10-13 Method of preparation of the 1,3,8-substituted xantines

Country Status (21)

Country Link
US (1) US4233303A (hu)
EP (1) EP0001735B1 (hu)
JP (1) JPS5479296A (hu)
AT (1) AT363491B (hu)
AU (1) AU521585B2 (hu)
CA (1) CA1109470A (hu)
CS (1) CS208756B2 (hu)
DD (1) DD139855A5 (hu)
DE (1) DE2862017D1 (hu)
DK (1) DK148260C (hu)
FI (1) FI66383C (hu)
HK (1) HK6385A (hu)
HU (1) HU180219B (hu)
IE (1) IE47884B1 (hu)
IT (1) IT1109208B (hu)
NO (1) NO147562C (hu)
NZ (1) NZ188566A (hu)
SE (1) SE416810C (hu)
SG (1) SG85584G (hu)
SU (1) SU755199A3 (hu)
ZA (1) ZA785335B (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7810947L (sv) * 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
SE8002910L (sv) * 1980-04-18 1981-10-19 Draco Ab 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar
US4755517A (en) * 1986-07-31 1988-07-05 Warner-Lambert Company Derivatives of xanthine, pharmaceutical compositions and methods of use therefor
US5298508A (en) * 1988-07-19 1994-03-29 The United States Of America As Represented By The Department Of Health And Human Services Irreversible inhibitors of adenosine receptors
US5321029A (en) * 1988-11-14 1994-06-14 Beecham-Wuelfing Gmbh & Co.K.G. Xanthines
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
IT1229195B (it) * 1989-03-10 1991-07-25 Poli Ind Chimica Spa Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
US5366977A (en) * 1992-09-29 1994-11-22 The United States Of America, As Represented By The Department Of Health And Human Services Method of treating cystic fibrosis using 8-cyclopentyl-1,3-dipropylxanthine or xanthine amino congeners
US5395836A (en) * 1993-04-07 1995-03-07 Kyowa Hakko Kogyo Co., Ltd. 8-tricycloalkyl xanthine derivatives
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
EP0799040B1 (en) * 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
WO2004096228A1 (en) 2003-04-25 2004-11-11 Novacardia, Inc. Method of improved diuresis in individuals with impaired renal function
CN101094671A (zh) * 2004-04-16 2007-12-26 美国诺华卡迪亚公司 包含腺苷a1受体拮抗剂和醛固酮抑制剂的组合疗法
US20070049757A1 (en) * 2005-08-26 2007-03-01 Rieger Jayson M Methods for the synthesis of substituted amino uracils

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1911279A1 (de) * 1969-03-05 1970-11-12 Eckert Dr Theodor Verfahren zur Erhoehung der Resorptionsfaehigkeit von Arzneistoffen
US3900474A (en) * 1973-05-14 1975-08-19 Kendall & Co Trifluoroalkyl, fluorobenzyl, pentafluorobenzyl, fluorobenzenesulfonyl, and pentafluorobenzenesulfonyl theophyllines
US4061753A (en) * 1976-02-06 1977-12-06 Interx Research Corporation Treating psoriasis with transient pro-drug forms of xanthine derivatives
US4120947A (en) * 1976-03-31 1978-10-17 Cooper Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
CA1077932A (en) 1976-03-31 1980-05-20 Berlex Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases

Also Published As

Publication number Publication date
FI783126A (fi) 1979-04-15
DD139855A5 (de) 1980-01-23
FI66383B (fi) 1984-06-29
DK148260C (da) 1986-02-10
HK6385A (en) 1985-02-01
US4233303A (en) 1980-11-11
JPS5479296A (en) 1979-06-25
SE416810B (sv) 1981-02-09
IT7851499A0 (it) 1978-10-13
EP0001735B1 (en) 1982-09-01
DK453778A (da) 1979-04-15
EP0001735A1 (en) 1979-05-02
IT1109208B (it) 1985-12-16
NZ188566A (en) 1984-07-06
SE7711581L (sv) 1979-04-15
ATA714478A (de) 1980-09-15
SG85584G (en) 1985-06-07
ZA785335B (en) 1979-09-26
AT363491B (de) 1981-08-10
CA1109470A (en) 1981-09-22
HU180219B (en) 1983-02-28
SU755199A3 (en) 1980-08-07
NO147562B (no) 1983-01-24
DK148260B (da) 1985-05-20
AU521585B2 (en) 1982-04-22
IE47884B1 (en) 1984-07-11
NO147562C (no) 1983-05-18
IE782041L (en) 1979-04-14
SE416810C (sv) 1982-07-19
NO783471L (no) 1979-04-18
AU4036578A (en) 1980-04-17
FI66383C (fi) 1984-10-10
DE2862017D1 (en) 1982-10-28

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