CS208493B2 - Method of making the 6a,10a-cis-hexahydrodibenzo/b,d/-pyran-9-ons - Google Patents

Method of making the 6a,10a-cis-hexahydrodibenzo/b,d/-pyran-9-ons Download PDF

Info

Publication number
CS208493B2
CS208493B2 CS791899A CS189979A CS208493B2 CS 208493 B2 CS208493 B2 CS 208493B2 CS 791899 A CS791899 A CS 791899A CS 189979 A CS189979 A CS 189979A CS 208493 B2 CS208493 B2 CS 208493B2
Authority
CS
Czechoslovakia
Prior art keywords
cis
hydroxy
pyran
formula
reaction
Prior art date
Application number
CS791899A
Other languages
Czech (cs)
English (en)
Inventor
Charles W Ryan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS208493B2 publication Critical patent/CS208493B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS791899A 1978-03-31 1979-03-22 Method of making the 6a,10a-cis-hexahydrodibenzo/b,d/-pyran-9-ons CS208493B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/892,350 US4171315A (en) 1978-03-31 1978-03-31 Preparation of cis-hexahydrodibenzopyranones

Publications (1)

Publication Number Publication Date
CS208493B2 true CS208493B2 (en) 1981-09-15

Family

ID=25399829

Family Applications (2)

Application Number Title Priority Date Filing Date
CS791899A CS208493B2 (en) 1978-03-31 1979-03-22 Method of making the 6a,10a-cis-hexahydrodibenzo/b,d/-pyran-9-ons
CS791899A CS208491B2 (en) 1978-03-31 1979-03-22 Method of making the 3,4,5,6-tetrahydro-2h-1-benzoxocines

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS791899A CS208491B2 (en) 1978-03-31 1979-03-22 Method of making the 3,4,5,6-tetrahydro-2h-1-benzoxocines

Country Status (31)

Country Link
US (1) US4171315A (da)
EP (1) EP0004753B1 (da)
JP (1) JPS5927350B2 (da)
AT (1) AT363469B (da)
AU (1) AU516719B2 (da)
BE (1) BE875089A (da)
BG (2) BG32850A3 (da)
CA (1) CA1132589A (da)
CH (1) CH638198A5 (da)
CS (2) CS208493B2 (da)
DD (1) DD143612A5 (da)
DE (1) DE2962942D1 (da)
DK (1) DK132779A (da)
EG (1) EG13932A (da)
ES (1) ES479066A1 (da)
FI (1) FI790981A (da)
FR (1) FR2421171A1 (da)
GB (1) GB2017703B (da)
GR (1) GR71467B (da)
HU (1) HU179972B (da)
IE (1) IE48446B1 (da)
IL (1) IL56944A (da)
LU (1) LU81086A1 (da)
MX (1) MX5532E (da)
NZ (1) NZ189974A (da)
PH (1) PH15168A (da)
PL (2) PL117421B1 (da)
PT (1) PT69384A (da)
RO (1) RO78155A (da)
YU (1) YU71279A (da)
ZA (1) ZA791522B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395560A (en) * 1982-05-24 1983-07-26 Eli Lilly And Company Preparation of 6a,10a-trans-hexahydrodibenzopyranones
ATE247097T1 (de) * 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
MXPA02005103A (es) 1999-10-18 2003-09-25 Alexipharma Inc Ligandos selectivos del receptor de canabinoide (cb2) perifericos.
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
JP2004532185A (ja) * 2001-01-26 2004-10-21 ユニバーシティ オブ コネチカット 新規なカンナビミメティックリガンド
US7173027B2 (en) 2001-01-29 2007-02-06 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
EP1414775B1 (en) * 2001-07-13 2012-12-19 The University of Connecticut Bicyclic cannabinoid
EP1448557A4 (en) * 2001-10-26 2005-02-02 Univ Connecticut HETEROINDANE: A NEW CLASS OF HIGH-ACTIVITY CANNABIMIMETIC LIGANDS
JP2006511460A (ja) 2002-08-23 2006-04-06 ユニバーシティ オブ コネチカット 治療適応を持つケトカンナビノイド
JP2009510078A (ja) * 2005-09-29 2009-03-12 エーエムアール テクノロジー インコーポレイテッド Δ−９−テトラヒドロカンナビノールの生成法
CA2638940C (en) * 2008-08-28 2009-09-15 Dalton Chemical Laboratories Inc. Improved synthesis of hexahydrodibenzopyranones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582564A (en) * 1976-07-06 1981-01-14 Lilly Co Eli Dibenzopyrans
GB1579137A (en) * 1976-07-06 1980-11-12 Lilly Co Eli 5-isopropylidene-2,6-methano-3,4,5,6-tetrahydro-2h-1-benzoxocins
US4054581A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor

Also Published As

Publication number Publication date
RO78155A (ro) 1982-02-01
LU81086A1 (fr) 1979-06-19
FI790981A (fi) 1979-10-01
NZ189974A (en) 1980-10-08
ATA234679A (de) 1981-01-15
CH638198A5 (fr) 1983-09-15
EG13932A (en) 1983-03-31
PT69384A (en) 1979-04-01
BG32851A3 (en) 1982-10-15
CS208491B2 (en) 1981-09-15
PH15168A (en) 1982-08-31
HU179972B (en) 1983-01-28
IL56944A (en) 1982-08-31
GR71467B (da) 1983-05-30
PL214573A1 (da) 1980-03-10
AU4536179A (en) 1979-10-04
BE875089A (fr) 1979-09-26
YU71279A (en) 1982-10-31
IE791293L (en) 1979-09-30
EP0004753B1 (en) 1982-05-26
PL123995B1 (en) 1982-12-31
DD143612A5 (de) 1980-09-03
GB2017703A (en) 1979-10-10
AU516719B2 (en) 1981-06-18
ES479066A1 (es) 1979-12-16
GB2017703B (en) 1982-10-06
PL117421B1 (en) 1981-08-31
US4171315A (en) 1979-10-16
EP0004753A1 (en) 1979-10-17
JPS5927350B2 (ja) 1984-07-05
ZA791522B (en) 1980-11-26
JPS54132575A (en) 1979-10-15
AT363469B (de) 1981-08-10
FR2421171A1 (fr) 1979-10-26
DK132779A (da) 1979-10-01
MX5532E (es) 1983-09-23
BG32850A3 (en) 1982-10-15
FR2421171B1 (da) 1982-12-31
IE48446B1 (en) 1985-01-23
CA1132589A (en) 1982-09-28
IL56944A0 (en) 1979-05-31
DE2962942D1 (en) 1982-07-15

Similar Documents

Publication Publication Date Title
CS208493B2 (en) Method of making the 6a,10a-cis-hexahydrodibenzo/b,d/-pyran-9-ons
JPS5912654B2 (ja) 光学活性ノルピネン誘導体およびその製造法
US7321047B2 (en) Separation of tetrahydrocannabinols
US20230339914A1 (en) Intermediate of biliverdin, and preparation method and use thereof
HU177309B (en) Process for producing 2,6-methano-2h-1-benzoxocines
RU2004116696A (ru) Получение ретиноидов
JP6686012B2 (ja) ハロ置換トリフルオロアセトフェノンを調製する方法
Sato et al. Radical reaction using an organocopper reagent derived from ethyl bromodifluoroacetate
US4131614A (en) Process for preparing cis-hexahydrodibenzopyranones
US4096280A (en) Arylenedioxy-bis-diketones
KR820000076B1 (ko) dl-시스-1-하이드록시-3-치환-6.6-디메틸-6,6a,7,8,10,10a-헥사하이드로-9H-디벤조 [b,d] 피란-9-온의 제조방법
KR100225003B1 (ko) 비스페놀 유도체 및 그 제조방법bisphenol derivative and its manufacturing method
JPS5943465B2 (ja) ６ａ，１０ａ−シス−ヘキサヒドロジベンゾピラノン類の製法
Boyle et al. NMR elucidation of some ligands derived from the pentacycloundecane skeleton
US4075230A (en) Preparation of optically active trans-hexahydrodibenzopyranones
KR820002112B1 (ko) 시스-헥사 하이드로 디벤조 피라논의 제조방법
KR820000850B1 (ko) 6,6-디메틸노르피넨 화합물의 제조방법
EP4269389A1 (en) Preparation method for biliverdin or derivative thereof
JPS5943466B2 (ja) シス−ヘキサヒドロジベンゾピラノン類の製法
US8258322B2 (en) Synthesis of hexahydrodibenzopyranones
KR810000429B1 (ko) 트랜스-헥사하이드로디벤조피라논의 제조방법
KR810000428B1 (ko) 2, 6-메타노-2h-1-벤즈옥소신 유도체의 제조방법
Dreiding et al. The Structure of the Solid Product from the Condensation of Methyl γ-Bromocrotonate with Sodium Methoxide1
SU389072A1 (ru) СПОСОБ ПОЛУЧЕНИЯ НЕПРЕДЕЛЬНЫХ БИСФЕНОЛОВ С ДВОЙНОЙ СВЯЗЬЮ В УГЛЕВОДОРОДНОМ МОСТИКЕ1Изобретение относитс к способу получени непредельных бисфенолов, примен емых в качестве полупродуктов дл синтеза эпоксидных смол, поликарбонатов, полиарилатов, ле^карст- вен'ных eeniecTB, а также в качестве антиоксн- дантое.Известен анособ 'получени ^бисфенолов путем конденсации фенолов с ацетиленовыми углеводородами. Однако изучены только бнсфе- нолы р да диоксистильбена и димеры изопро- пенил'фенолов.Предлагаемый способ, основа-нный на известной реакции, .позвол ет 'получать новые, не описанные IB , лигературе соединени общей формулы
US4638104A (en) Preparation of terpinen-4-ols and intermediates