CS201033B2 - Method of producing derivatives of n-/3-amino-2-hydroxy-propionyl/-2-amino acetic acid - Google Patents
Method of producing derivatives of n-/3-amino-2-hydroxy-propionyl/-2-amino acetic acid Download PDFInfo
- Publication number
- CS201033B2 CS201033B2 CS764736A CS473676A CS201033B2 CS 201033 B2 CS201033 B2 CS 201033B2 CS 764736 A CS764736 A CS 764736A CS 473676 A CS473676 A CS 473676A CS 201033 B2 CS201033 B2 CS 201033B2
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- Czechoslovakia
- Prior art keywords
- amino
- acid
- hydroxy
- formula
- alpha
- Prior art date
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- 239000000155 melt Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- GSYSFVSGPABNNL-UHFFFAOYSA-N methyl 2-dimethoxyphosphoryl-2-(phenylmethoxycarbonylamino)acetate Chemical group COC(=O)C(P(=O)(OC)OC)NC(=O)OCC1=CC=CC=C1 GSYSFVSGPABNNL-UHFFFAOYSA-N 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N methyl acetate Chemical group COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- HZBCXYOPFGAGJK-UHFFFAOYSA-N phenylmethoxy hydrogen carbonate Chemical compound OC(=O)OOCC1=CC=CC=C1 HZBCXYOPFGAGJK-UHFFFAOYSA-N 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB30632/75A GB1510477A (en) | 1975-07-22 | 1975-07-22 | Peptides and to amino acid intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS201033B2 true CS201033B2 (en) | 1980-10-31 |
Family
ID=10310676
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS764736A CS201033B2 (en) | 1975-07-22 | 1976-07-16 | Method of producing derivatives of n-/3-amino-2-hydroxy-propionyl/-2-amino acetic acid |
| CS793519A CS201034B2 (en) | 1975-07-22 | 1976-07-16 | Method of producing amino acid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS793519A CS201034B2 (en) | 1975-07-22 | 1976-07-16 | Method of producing amino acid |
Country Status (12)
| Country | Link |
|---|---|
| JP (2) | JPS52136118A (enExample) |
| AU (1) | AU506003B2 (enExample) |
| CA (1) | CA1104156A (enExample) |
| CH (1) | CH630892A5 (enExample) |
| CS (2) | CS201033B2 (enExample) |
| DE (2) | DE2632396C2 (enExample) |
| DK (1) | DK149110C (enExample) |
| FR (1) | FR2318863A1 (enExample) |
| GB (1) | GB1510477A (enExample) |
| HU (1) | HU183048B (enExample) |
| NL (1) | NL7608064A (enExample) |
| SE (3) | SE431642B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2725732C2 (de) | 1977-06-07 | 1983-01-05 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Bestatin-Analoga, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| DE2760007C2 (enExample) * | 1977-06-07 | 1988-10-06 | Microbial Chem Res Found | |
| JPS6026099B2 (ja) * | 1977-09-21 | 1985-06-21 | 財団法人微生物化学研究会 | ペプチド、その酸附加塩およびその製造法 |
| AU530362B2 (en) * | 1978-11-25 | 1983-07-14 | Nippon Kayaku Kabushiki Kaisha | Threo-3-amino-2-hydroxy-butanoyl-aminoacetic acids |
| US4370318A (en) * | 1980-07-07 | 1983-01-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin-related compounds as immunopotentiator |
| JPS5767516A (en) * | 1980-09-24 | 1982-04-24 | Microbial Chem Res Found | Novel analgesic agent |
| JPH0810855Y2 (ja) * | 1989-07-20 | 1996-03-29 | タナシン電機株式会社 | オートリバース式テープレコーダ |
| EP0657415B1 (en) * | 1993-06-29 | 1999-09-08 | Kaneka Corporation | Method of producing 3-amino-2-hydroxy-4-phenyl-butyric acid derivatives and 3-amino-1-nitro-4-phenyl-2-butanol intermediates |
| CZ292996B6 (cs) * | 1996-02-08 | 2004-01-14 | Nippon Kayaku Kabushiki Kaisha | Způsob přípravy opticky aktivního kyanhydrinu |
| BR9910092A (pt) * | 1998-05-01 | 2002-01-22 | Abbott Lab | Inibidores de beta-aminoácido substituìdo de metionina aminopeptidase-2 |
| US6242494B1 (en) | 1998-05-01 | 2001-06-05 | Abbott Laboratories | Substituted β-amino acid inhibitors of methionine aminopeptidase-2 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5439477B2 (enExample) * | 1974-07-01 | 1979-11-28 |
-
1975
- 1975-07-22 GB GB30632/75A patent/GB1510477A/en not_active Expired
-
1976
- 1976-06-14 SE SE7606736A patent/SE431642B/xx not_active IP Right Cessation
- 1976-07-15 AU AU15912/76A patent/AU506003B2/en not_active Expired
- 1976-07-16 CS CS764736A patent/CS201033B2/cs unknown
- 1976-07-16 CS CS793519A patent/CS201034B2/cs unknown
- 1976-07-19 DE DE2632396A patent/DE2632396C2/de not_active Expired
- 1976-07-19 DE DE2660626A patent/DE2660626C2/de not_active Expired
- 1976-07-20 CA CA257,393A patent/CA1104156A/en not_active Expired
- 1976-07-21 NL NL7608064A patent/NL7608064A/xx not_active Application Discontinuation
- 1976-07-21 CH CH933676A patent/CH630892A5/de not_active IP Right Cessation
- 1976-07-21 JP JP8599276A patent/JPS52136118A/ja active Granted
- 1976-07-21 FR FR7622279A patent/FR2318863A1/fr active Granted
- 1976-07-22 HU HU76ZA395A patent/HU183048B/hu unknown
- 1976-07-22 DK DK331276A patent/DK149110C/da not_active IP Right Cessation
-
1980
- 1980-03-13 SE SE8001959A patent/SE452318B/sv unknown
-
1982
- 1982-04-22 JP JP57066233A patent/JPS6050780B2/ja not_active Expired
-
1983
- 1983-11-09 SE SE8306145A patent/SE8306145L/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CH630892A5 (en) | 1982-07-15 |
| DE2632396C2 (de) | 1982-11-25 |
| HU183048B (en) | 1984-04-28 |
| JPS5758338B2 (enExample) | 1982-12-09 |
| CS201034B2 (en) | 1980-10-31 |
| AU1591276A (en) | 1978-01-19 |
| SE8306145D0 (sv) | 1983-11-09 |
| GB1510477A (en) | 1978-05-10 |
| DK331276A (da) | 1977-01-23 |
| JPS5823654A (ja) | 1983-02-12 |
| FR2318863B1 (enExample) | 1980-10-31 |
| NL7608064A (nl) | 1977-01-25 |
| FR2318863A1 (fr) | 1977-02-18 |
| SE431642B (sv) | 1984-02-20 |
| DE2660626C2 (de) | 1985-07-11 |
| SE452318B (sv) | 1987-11-23 |
| SE8306145L (sv) | 1983-11-09 |
| CA1104156A (en) | 1981-06-30 |
| DE2632396A1 (de) | 1977-02-03 |
| DK149110C (da) | 1986-09-08 |
| SE8001959L (sv) | 1980-03-13 |
| SE7606736L (sv) | 1977-01-23 |
| JPS52136118A (en) | 1977-11-14 |
| AU506003B2 (en) | 1979-12-13 |
| JPS6050780B2 (ja) | 1985-11-11 |
| DK149110B (da) | 1986-01-27 |
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