CS195290B2 - Method of producing racemic or optically active derivatives of 4-substituted 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-ones - Google Patents

Method of producing racemic or optically active derivatives of 4-substituted 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-ones Download PDF

Info

Publication number
CS195290B2
CS195290B2 CS753740A CS374075A CS195290B2 CS 195290 B2 CS195290 B2 CS 195290B2 CS 753740 A CS753740 A CS 753740A CS 374075 A CS374075 A CS 374075A CS 195290 B2 CS195290 B2 CS 195290B2
Authority
CS
Czechoslovakia
Prior art keywords
phenyl
tetrahydro
group
methyl
alkyl
Prior art date
Application number
CS753740A
Other languages
Czech (cs)
English (en)
Inventor
Julia Roehrich
Lajos Kisfaludy
Laszlo Ueroegdi
Eva Palosi
Szabolcs Szeberenyi
Laszlo Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to CS17877A priority Critical patent/CS195291B2/cs
Publication of CS195290B2 publication Critical patent/CS195290B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS753740A 1974-05-29 1975-05-28 Method of producing racemic or optically active derivatives of 4-substituted 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-ones CS195290B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS17877A CS195291B2 (cs) 1974-05-29 1977-01-11 Způsob výroby racemických nebo opticky aktivních derivátů 4-substituovaných l,3,4,5-íetrahydro-2H-l,4-bEnzodiazepin-2-onů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU75RI538A HU171033B (hu) 1974-05-29 1974-05-29 Sposob poluchenija proizvodnykh benzodiazepina

Publications (1)

Publication Number Publication Date
CS195290B2 true CS195290B2 (en) 1980-01-31

Family

ID=11000949

Family Applications (1)

Application Number Title Priority Date Filing Date
CS753740A CS195290B2 (en) 1974-05-29 1975-05-28 Method of producing racemic or optically active derivatives of 4-substituted 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-ones

Country Status (21)

Country Link
US (3) US4045433A (de)
JP (2) JPS511486A (de)
AT (1) AT343665B (de)
AU (1) AU502405B2 (de)
BE (1) BE829595A (de)
BG (2) BG26529A3 (de)
CA (1) CA1063605A (de)
CH (1) CH628036A5 (de)
CS (1) CS195290B2 (de)
DD (1) DD121516A5 (de)
DE (1) DE2523250A1 (de)
DK (1) DK153479C (de)
FR (1) FR2272674B1 (de)
GB (1) GB1505543A (de)
HU (1) HU171033B (de)
IL (1) IL47268A (de)
NL (1) NL7506272A (de)
PL (2) PL98943B1 (de)
SE (1) SE426242B (de)
SU (3) SU942594A3 (de)
YU (2) YU40262B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187262B (en) * 1979-08-16 1985-12-28 Richter Gedeon Vegyeszet Process for preparing new tetrahydro-1,4-benzodiazepin-2-ones
US4329341A (en) * 1980-11-26 1982-05-11 Richter Gedeon Vegyeszeti Gyar Rt 5-Phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-ones, and pharmaceutical compositions containing them
DE3431195A1 (de) * 1984-08-24 1986-03-06 Troponwerke GmbH & Co KG, 5000 Köln Neue benzodiazepine, verfahren zu ihrer herstellung sowie ihre verwendung
JPS6225539A (ja) * 1985-07-26 1987-02-03 Nec Corp 高速デジタルインタフエ−スの疑似障害設定方式
AU5588400A (en) * 1999-05-26 2000-12-18 Du Pont Pharmaceuticals Company 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
WO2001040163A1 (en) * 1999-12-01 2001-06-07 Korea Fine Chemical Co.,Ltd. A PROCESS FOR PRODUCING AMINE COMPOUND WITH t-BUTOXYCARBONYL GROUP
GB0108595D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
FR2960890B1 (fr) 2010-06-04 2021-11-26 Eurovia Procede de fabrication d'enrobes hydrocarbone a froid, enrobes hydrocarbones a froid a maniabilite controlee et leur utilisation pour la realisation de revetements routiers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236838A (en) * 1964-06-09 1966-02-22 Hoffmann La Roche Certain 1-substituted-benzodiazepin-2-one compounds
DK112527B (da) * 1967-03-07 1968-12-23 Dumex Ltd As Fremgangsmåde til fremstilling af 1,3,4,5-tetrahydro-1,4-benzodiazepinderivater.
US3551415A (en) * 1969-09-04 1970-12-29 Hoffmann La Roche Preparation of 1,4-benzodiazepin-2-ones
CH556851A (de) * 1970-07-30 1974-12-13 Richter Gedeon Vegyeszet Verfahren zur herstellung von in 7-stellung durch die nitrogruppe substituierten 1,4-benzodiazepin-2-on-derivaten.
CH538492A (de) * 1970-10-07 1973-06-30 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
JPS4825199A (de) * 1971-08-03 1973-04-02
JPS4941392A (de) * 1972-08-17 1974-04-18

Also Published As

Publication number Publication date
DK153479C (da) 1988-11-28
AU502405B2 (en) 1979-07-26
DK236675A (da) 1975-11-30
FR2272674A1 (de) 1975-12-26
DK153479B (da) 1988-07-18
AT343665B (de) 1978-06-12
SU776559A3 (ru) 1980-10-30
IL47268A (en) 1981-01-30
US4342755A (en) 1982-08-03
US4406835A (en) 1983-09-27
YU40409B (en) 1985-12-31
AU8095175A (en) 1976-11-11
SU1318158A3 (ru) 1987-06-15
NL7506272A (nl) 1975-12-02
JPS5455591A (en) 1979-05-02
YU136075A (en) 1982-10-31
US4045433A (en) 1977-08-30
PL100441B1 (pl) 1978-10-31
SU942594A3 (ru) 1982-07-07
JPS511486A (de) 1976-01-08
BG26529A3 (de) 1979-04-12
IL47268A0 (en) 1975-07-28
ATA406375A (de) 1977-10-15
DE2523250A1 (de) 1975-12-18
HU171033B (hu) 1977-10-28
PL98943B1 (pl) 1978-05-31
BG26377A4 (de) 1979-03-15
DD121516A5 (de) 1976-08-05
SE7506053L (sv) 1975-12-01
YU40262B (en) 1985-12-31
YU102382A (en) 1982-10-31
DE2523250C2 (de) 1988-01-07
FR2272674B1 (de) 1979-08-10
SE426242B (sv) 1982-12-20
CA1063605A (en) 1979-10-02
BE829595A (fr) 1975-09-15
JPH0122269B2 (de) 1989-04-25
GB1505543A (en) 1978-03-30
CH628036A5 (de) 1982-02-15

Similar Documents

Publication Publication Date Title
RU2124009C1 (ru) Производные 1,5-бензодиазепина, способ их получения, фармацевтическая композиция
IL85668A (en) Benzodiazepine analogues, pharmaceutical preparations containing them and a process for their preparation
JPH072800A (ja) ベンズアミド誘導体およびその製造法
RO114446B1 (ro) Derivati de 5-aminoalchil-1,4-benzodiazepina si procedee pentru prepararea acestora
CS195290B2 (en) Method of producing racemic or optically active derivatives of 4-substituted 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-ones
US5218115A (en) Cholecystokinin antagonists
CA2167308A1 (en) 1,5-benzodiazepine derivatives useful as cck or gastrin antagonists
CA2065715A1 (en) Cholecystokinin antagonists
US5620972A (en) Substituted benzene derivatives
CA1234110A (en) Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
US4395409A (en) Carbamoyloxyamino-1,4-benzodiazepines and medicaments containing these compounds
US4031079A (en) Intermediates for 2-aminobenzodiazepine-5-ones
US4587245A (en) Method of treating neuropsychic disturbances by benzodiazepine derivatives and composition therefor
SK125495A3 (en) 1,5-benzodiazepine derivatives, manufacturing process, their use and pharmaceutical compositions containing them
US4002610A (en) 2-Aminobenzodiazepine-5-ones
US3531467A (en) Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives
EP0558104B1 (de) 1,5-Benzodiazepinderivate und deren Verwendung in Heilmittel
EP0167920A2 (de) Benzodiazepin-Derivate und diese enthaltende Arzneimittel
US4244869A (en) Benzodiazepine derivatives and process of making them
US4022767A (en) 2-Aminobenzodiazepine-5-ones
CS195707B2 (en) Method of producing novel n up 4-substituted derivatives of 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-one
US3880840A (en) Pyrazino-1,4-diazepines
US4020055A (en) Intermediates for 2-aminobenzodiazepine-5-ones
US3504015A (en) N-(2-aroylphenyl)glycine derivatives
US4548750A (en) Pyrimido[4,5-d][2]benzazepines useful as sedatives and anxiolytic agents