CS189391A3 - Dialkoxypiridylbenzimidazole derivatives, process of their preparation and their pharmaceutical use - Google Patents

Dialkoxypiridylbenzimidazole derivatives, process of their preparation and their pharmaceutical use

Info

Publication number
CS189391A3
CS189391A3 CS911893A CS189391A CS189391A3 CS 189391 A3 CS189391 A3 CS 189391A3 CS 911893 A CS911893 A CS 911893A CS 189391 A CS189391 A CS 189391A CS 189391 A3 CS189391 A3 CS 189391A3
Authority
CS
Czechoslovakia
Prior art keywords
dialkoxypiridylbenzimidazole
derivatives
preparation
pharmaceutical use
pharmaceutical
Prior art date
Application number
CS911893A
Other languages
English (en)
Inventor
Arne Elof Brandstrom
Per Lennart Lindberg
Gunnel Elisabeth Senden
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9002207A external-priority patent/SE9002207D0/xx
Priority claimed from SE9002206A external-priority patent/SE9002206D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of CS189391A3 publication Critical patent/CS189391A3/cs
Publication of CZ279434B6 publication Critical patent/CZ279434B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS911893A 1990-06-20 1991-06-20 Dialkoxypyridylbenzimidazolové deriváty, způsob jejich výroby a farmaceutický prostředek, který j e obsahuje a použití dialkoxypyridylbenzimidazolo vých derivátů k výrobě léčiva. CZ279434B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002207A SE9002207D0 (sv) 1990-06-20 1990-06-20 New compounds i
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (2)

Publication Number Publication Date
CS189391A3 true CS189391A3 (en) 1992-06-17
CZ279434B6 CZ279434B6 (cs) 1995-04-12

Family

ID=26660803

Country Status (29)

Country Link
US (1) US5430042A (cs)
EP (1) EP0593463B1 (cs)
JP (1) JP3049367B2 (cs)
CN (1) CN1058213A (cs)
AP (1) AP253A (cs)
AT (1) ATE184602T1 (cs)
AU (1) AU649456B2 (cs)
BG (1) BG97198A (cs)
CA (1) CA2083606C (cs)
CZ (1) CZ279434B6 (cs)
DE (1) DE69131627T2 (cs)
EG (1) EG19752A (cs)
ES (1) ES2140391T3 (cs)
FI (1) FI925767A7 (cs)
HU (1) HUT62882A (cs)
IE (1) IE912026A1 (cs)
IL (1) IL98472A (cs)
IS (1) IS3720A7 (cs)
LV (1) LV10269B (cs)
MA (1) MA22198A1 (cs)
NO (1) NO924650D0 (cs)
NZ (1) NZ238545A (cs)
OA (1) OA09683A (cs)
PL (2) PL166209B1 (cs)
PT (1) PT98036A (cs)
RO (1) RO110497B1 (cs)
TN (1) TNSN91050A1 (cs)
WO (1) WO1991019712A1 (cs)
YU (1) YU104091A (cs)

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ES2100142T3 (es) * 1994-07-08 2002-03-01 Astrazeneca Ab Forma de dosificacion en tabletas i constituida por unidades multiples.
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
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US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
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US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
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AU2003259154B2 (en) * 2002-07-19 2006-12-07 The Regents Of The University Of California Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor
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TWI367759B (en) * 2003-02-20 2012-07-11 Santarus Inc A novel formulation, omeprazole antacid complex-immediate release, for rapid and sustained suppression of gastric acid
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JP2006528182A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 薬学的製剤および酸に起因する消化器疾患の治療法
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2004314693B2 (en) 2003-09-26 2011-04-07 Alza Corporation Drug coating providing high drug loading and methods for providing the same
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
WO2005082338A2 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Prodrugs for the intravenous administration of proton pump inhibitors
AU2005216862A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
TW200606163A (en) * 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
AU2005268056B2 (en) * 2004-08-06 2008-07-31 Eisai R&D Management Co., Ltd. Salts of benzimidazole derivative with amines and process for production thereof
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
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US20110009624A9 (en) * 2006-10-13 2011-01-13 Masato Ueda Benzimidazole compounds having gastric acid secretion inhibitory action
WO2008057802A2 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
CA2716367C (en) 2008-02-20 2015-05-26 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
CN102209529A (zh) 2008-09-09 2011-10-05 阿斯利康(瑞典)有限公司 将药物组合物递送至有需要的患者的方法
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
WO2013101897A2 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid

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US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
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SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
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DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
WO1989003829A1 (en) * 1987-10-30 1989-05-05 Aktiebolaget Hässle Omeprazole for treatment of diseases related to bone loss
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Also Published As

Publication number Publication date
IL98472A (en) 1995-08-31
EG19752A (en) 1996-01-31
NZ238545A (en) 1993-08-26
PL166209B1 (pl) 1995-04-28
LV10269A (lv) 1994-10-20
PL297295A1 (cs) 1992-07-13
NO924650L (no) 1992-12-02
LV10269B (en) 1995-10-20
JPH05507714A (ja) 1993-11-04
AU649456B2 (en) 1994-05-26
OA09683A (en) 1993-05-15
HU9204034D0 (en) 1993-03-29
FI925767A0 (fi) 1992-12-18
WO1991019712A1 (en) 1991-12-26
ATE184602T1 (de) 1999-10-15
PL297294A1 (cs) 1992-07-13
IE912026A1 (en) 1992-01-01
HUT62882A (en) 1993-06-28
FI925767A7 (fi) 1992-12-18
JP3049367B2 (ja) 2000-06-05
NO924650D0 (no) 1992-12-02
BG97198A (bg) 1993-12-24
EP0593463B1 (en) 1999-09-15
AU8061791A (en) 1992-01-07
EP0593463A1 (en) 1994-04-27
PL165898B1 (pl) 1995-02-28
IL98472A0 (en) 1992-07-15
US5430042A (en) 1995-07-04
AP9100286A0 (en) 1991-07-31
DE69131627D1 (de) 1999-10-21
CA2083606C (en) 2001-08-21
RO110497B1 (ro) 1996-01-30
DE69131627T2 (de) 2000-04-27
CA2083606A1 (en) 1991-12-21
AP253A (en) 1993-05-03
ES2140391T3 (es) 2000-03-01
YU104091A (sh) 1994-01-20
IS3720A7 (is) 1991-12-21
MA22198A1 (fr) 1992-04-01
PT98036A (pt) 1992-03-31
TNSN91050A1 (fr) 1992-10-25
CN1058213A (zh) 1992-01-29
CZ279434B6 (cs) 1995-04-12

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