LV10269B - Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use - Google Patents
Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use Download PDFInfo
- Publication number
- LV10269B LV10269B LVP-93-820A LV930820A LV10269B LV 10269 B LV10269 B LV 10269B LV 930820 A LV930820 A LV 930820A LV 10269 B LV10269 B LV 10269B
- Authority
- LV
- Latvia
- Prior art keywords
- methyl
- compound
- pyridinyl
- benzimidazole
- preparation
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 48
- 238000000034 method Methods 0.000 title claims description 11
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 129
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 28
- -1 -C2HS Chemical group 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 11
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
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- 239000000543 intermediate Substances 0.000 claims description 6
- 159000000000 sodium salts Chemical class 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 3
- FBJXSVXBUDQNGI-UHFFFAOYSA-N 1-[2-([1,3]dioxolo[4,5-c]pyridin-4-ylmethylsulfanyl)-6-methyl-1h-benzimidazol-5-yl]ethanone Chemical compound N1C=2C=C(C)C(C(=O)C)=CC=2N=C1SCC1=NC=CC2=C1OCO2 FBJXSVXBUDQNGI-UHFFFAOYSA-N 0.000 claims description 2
- 159000000003 magnesium salts Chemical class 0.000 claims description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- BHVRHDLXKLRTEY-UHFFFAOYSA-N 2-sulfinyl-1,3-dihydrobenzimidazole Chemical compound C1=CC=C2NC(=S=O)NC2=C1 BHVRHDLXKLRTEY-UHFFFAOYSA-N 0.000 claims 1
- RFJGNWGMCBFYTP-UHFFFAOYSA-N methyl 2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-6-methyl-1h-benzimidazole-5-carboxylate Chemical compound N1C=2C=C(C)C(C(=O)OC)=CC=2N=C1S(=O)CC1=NC=CC(OC)=C1OC RFJGNWGMCBFYTP-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9002206A SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | New compounds |
| SE9002207A SE9002207D0 (sv) | 1990-06-20 | 1990-06-20 | New compounds i |
| PCT/SE1991/000416 WO1991019712A1 (en) | 1990-06-20 | 1991-06-11 | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV10269A LV10269A (lv) | 1994-10-20 |
| LV10269B true LV10269B (en) | 1995-10-20 |
Family
ID=26660803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-93-820A LV10269B (en) | 1990-06-20 | 1993-06-30 | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5430042A (cs) |
| EP (1) | EP0593463B1 (cs) |
| JP (1) | JP3049367B2 (cs) |
| CN (1) | CN1058213A (cs) |
| AP (1) | AP253A (cs) |
| AT (1) | ATE184602T1 (cs) |
| AU (1) | AU649456B2 (cs) |
| BG (1) | BG97198A (cs) |
| CA (1) | CA2083606C (cs) |
| CZ (1) | CZ279434B6 (cs) |
| DE (1) | DE69131627T2 (cs) |
| EG (1) | EG19752A (cs) |
| ES (1) | ES2140391T3 (cs) |
| FI (1) | FI925767A7 (cs) |
| HU (1) | HUT62882A (cs) |
| IE (1) | IE912026A1 (cs) |
| IL (1) | IL98472A (cs) |
| IS (1) | IS3720A7 (cs) |
| LV (1) | LV10269B (cs) |
| MA (1) | MA22198A1 (cs) |
| NO (1) | NO924650L (cs) |
| NZ (1) | NZ238545A (cs) |
| OA (1) | OA09683A (cs) |
| PL (2) | PL165898B1 (cs) |
| PT (1) | PT98036A (cs) |
| RO (1) | RO110497B1 (cs) |
| TN (1) | TNSN91050A1 (cs) |
| WO (1) | WO1991019712A1 (cs) |
| YU (1) | YU104091A (cs) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103776D0 (sv) * | 1991-12-19 | 1991-12-19 | Astra Ab | New compounds |
| TNSN95062A1 (fr) * | 1994-05-27 | 1996-02-06 | Astra Ab | Nouveaux derives dialkoxy-pyridinyle-benzimidazole |
| MX9600857A (es) * | 1994-07-08 | 1997-06-28 | Astra Ab | Forma de dosificacion i en tabletas, con unidades multiples. |
| SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| GB9423970D0 (en) * | 1994-11-28 | 1995-01-11 | Astra Ab | Oxidation |
| SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
| US5545661A (en) * | 1995-05-16 | 1996-08-13 | Eli Lilly And Company | Methods for inhibiting bone loss with bis-pyrone oxovanadium compounds |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
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1991
- 1991-06-11 PL PL91297295A patent/PL165898B1/pl unknown
- 1991-06-11 JP JP3511436A patent/JP3049367B2/ja not_active Expired - Fee Related
- 1991-06-11 AT AT91911618T patent/ATE184602T1/de not_active IP Right Cessation
- 1991-06-11 HU HU924034A patent/HUT62882A/hu unknown
- 1991-06-11 PL PL91297294A patent/PL166209B1/pl unknown
- 1991-06-11 DE DE69131627T patent/DE69131627T2/de not_active Expired - Fee Related
- 1991-06-11 AU AU80617/91A patent/AU649456B2/en not_active Ceased
- 1991-06-11 CA CA002083606A patent/CA2083606C/en not_active Expired - Fee Related
- 1991-06-11 ES ES91911618T patent/ES2140391T3/es not_active Expired - Lifetime
- 1991-06-11 WO PCT/SE1991/000416 patent/WO1991019712A1/en active IP Right Grant
- 1991-06-11 EP EP91911618A patent/EP0593463B1/en not_active Expired - Lifetime
- 1991-06-11 RO RO92-01543A patent/RO110497B1/ro unknown
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- 1991-06-12 IL IL9847291A patent/IL98472A/en not_active IP Right Cessation
- 1991-06-14 NZ NZ238545A patent/NZ238545A/xx unknown
- 1991-06-14 IE IE202691A patent/IE912026A1/en unknown
- 1991-06-18 MA MA22461A patent/MA22198A1/fr unknown
- 1991-06-18 EG EG38491A patent/EG19752A/xx active
- 1991-06-19 TN TNTNSN91050A patent/TNSN91050A1/fr unknown
- 1991-06-19 AP APAP/P/1991/000286A patent/AP253A/en active
- 1991-06-19 PT PT98036A patent/PT98036A/pt not_active Application Discontinuation
- 1991-06-20 CZ CS911893A patent/CZ279434B6/cs unknown
- 1991-06-20 US US07/718,188 patent/US5430042A/en not_active Expired - Lifetime
- 1991-06-20 IS IS3720A patent/IS3720A7/is unknown
- 1991-06-20 CN CN91105025A patent/CN1058213A/zh active Pending
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1992
- 1992-11-27 OA OA60307A patent/OA09683A/en unknown
- 1992-12-02 NO NO92924650A patent/NO924650L/no unknown
- 1992-12-18 FI FI925767A patent/FI925767A7/fi not_active Application Discontinuation
- 1992-12-18 BG BG097198A patent/BG97198A/bg unknown
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1993
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