CS188933B2 - Method of producing 1-/3,4,5-trimethoxy benzamido methyl/isoquinolines and 1,2,3,4-tetrahydroisoquinolines - Google Patents
Method of producing 1-/3,4,5-trimethoxy benzamido methyl/isoquinolines and 1,2,3,4-tetrahydroisoquinolinesInfo
- Publication number
- CS188933B2 CS188933B2 CS748365A CS836574A CS188933B2 CS 188933 B2 CS188933 B2 CS 188933B2 CS 748365 A CS748365 A CS 748365A CS 836574 A CS836574 A CS 836574A CS 188933 B2 CS188933 B2 CS 188933B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- tetrahydroisoquinolines
- isoquinolines
- producing
- benzamido methyl
- trimethoxy benzamido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS761597A CS188949B2 (en) | 1973-12-10 | 1976-03-11 | Method of producing 1-3,4,5-trimethoxybenzamido-methyl/isoquinolines and-1,2,3,4-tetrahydroisoquinolines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2361390A DE2361390A1 (de) | 1973-12-10 | 1973-12-10 | Isochinolinderivate und verfahren zu ihrer herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
CS188933B2 true CS188933B2 (en) | 1979-03-30 |
Family
ID=5900348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS748365A CS188933B2 (en) | 1973-12-10 | 1974-12-06 | Method of producing 1-/3,4,5-trimethoxy benzamido methyl/isoquinolines and 1,2,3,4-tetrahydroisoquinolines |
Country Status (18)
Country | Link |
---|---|
US (1) | US3985881A (xx) |
JP (1) | JPS5088077A (xx) |
AT (1) | AT351026B (xx) |
BE (1) | BE823027A (xx) |
CA (1) | CA1053675A (xx) |
CH (1) | CH605776A5 (xx) |
CS (1) | CS188933B2 (xx) |
DD (1) | DD115666A5 (xx) |
DE (1) | DE2361390A1 (xx) |
DK (1) | DK137007C (xx) |
ES (1) | ES432716A1 (xx) |
FR (1) | FR2253522B1 (xx) |
GB (1) | GB1447611A (xx) |
HU (1) | HU171483B (xx) |
IL (1) | IL46160A0 (xx) |
NL (1) | NL7416050A (xx) |
SE (1) | SE7415247L (xx) |
ZA (1) | ZA747820B (xx) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2504250A1 (de) * | 1975-02-01 | 1976-08-05 | Merck Patent Gmbh | Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung |
US4232160A (en) * | 1978-10-18 | 1980-11-04 | Miles Laboratories, Inc. | Isoquinoline propionamides exhibiting analgesic properties |
US4556712A (en) * | 1981-05-20 | 1985-12-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines |
GB8601796D0 (en) * | 1986-01-24 | 1986-02-26 | Zambeletti Spa L | Compounds |
DE3713743A1 (de) * | 1987-04-24 | 1988-11-17 | Boehringer Ingelheim Kg | Kondensierte bis-(3,4-dihydro-l-pyridinyl)methane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE68910999T2 (de) * | 1988-02-19 | 1994-03-24 | Smithkline Beecham Farma | 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten. |
KR890012970A (ko) * | 1988-02-23 | 1989-09-20 | 추후보충 | 테트라히드로 이소퀴놀린 유도체 |
DE3827727A1 (de) * | 1988-08-16 | 1990-02-22 | Boehringer Ingelheim Kg | Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion |
GB8827479D0 (en) * | 1988-11-24 | 1988-12-29 | Zambeletti Spa L | Novel compounds |
GB8916395D0 (en) * | 1989-07-18 | 1989-09-06 | Zambeletti Spa L | Pharmaceuticals |
US5389638A (en) * | 1993-09-10 | 1995-02-14 | Abbott Laboratories | Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors |
GB0225884D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
JP6678455B2 (ja) * | 2012-12-21 | 2020-04-08 | エピザイム,インコーポレイティド | Prmt5阻害剤およびその使用 |
US10273213B2 (en) | 2015-09-01 | 2019-04-30 | Merck Patent Gmbh | Method for the production of praziquantel and precursors thereof |
CA3001857A1 (en) * | 2015-10-14 | 2017-04-20 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
JP7307723B2 (ja) | 2017-10-18 | 2023-07-12 | ジュビラント エピパッド エルエルシー | Pad阻害剤としてのイミダゾ-ピリジン化合物 |
MX2020004699A (es) | 2017-11-06 | 2022-10-26 | Jubilant Prodel LLC | Derivados de pirimidina como inhibidores de la activacion de pd1/pd-l1. |
CA3083374A1 (en) | 2017-11-24 | 2019-05-31 | Jubilant Episcribe Llc | Heterocyclic compounds as prmt5 inhibitors |
CN112105610B (zh) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2612503A (en) * | 1949-04-19 | 1952-09-30 | Smith Kline French Lab | Basic ether-substituted isoquinolines |
US2640829A (en) * | 1950-11-10 | 1953-06-02 | Smith Kline French Lab | Isoquinolyl heterocyclic ethers |
US3021331A (en) * | 1959-07-20 | 1962-02-13 | Pfizer & Co C | Azabenzopyridocolines |
US3483206A (en) * | 1967-12-15 | 1969-12-09 | Ciba Geigy Corp | N-isoquinolylalkanoyl-n-arylamines |
US3600394A (en) * | 1968-05-17 | 1971-08-17 | Searle & Co | 2-aminoalkyl-3-arylisocarbostyrils |
-
1973
- 1973-12-10 DE DE2361390A patent/DE2361390A1/de active Pending
-
1974
- 1974-11-29 IL IL46160A patent/IL46160A0/xx unknown
- 1974-12-05 SE SE7415247A patent/SE7415247L/xx unknown
- 1974-12-06 CS CS748365A patent/CS188933B2/cs unknown
- 1974-12-06 FR FR7440041A patent/FR2253522B1/fr not_active Expired
- 1974-12-06 BE BE151221A patent/BE823027A/xx unknown
- 1974-12-06 CA CA215,386A patent/CA1053675A/en not_active Expired
- 1974-12-09 ES ES432716A patent/ES432716A1/es not_active Expired
- 1974-12-09 HU HU74ME00001812A patent/HU171483B/hu unknown
- 1974-12-09 ZA ZA00747820A patent/ZA747820B/xx unknown
- 1974-12-09 DK DK639674A patent/DK137007C/da active
- 1974-12-09 CH CH1632774A patent/CH605776A5/xx not_active IP Right Cessation
- 1974-12-09 DD DD182514A patent/DD115666A5/xx unknown
- 1974-12-09 AT AT981974A patent/AT351026B/de not_active IP Right Cessation
- 1974-12-09 GB GB5319174A patent/GB1447611A/en not_active Expired
- 1974-12-09 JP JP49141945A patent/JPS5088077A/ja active Pending
- 1974-12-09 US US05/530,551 patent/US3985881A/en not_active Expired - Lifetime
- 1974-12-10 NL NL7416050A patent/NL7416050A/xx not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BE823027A (fr) | 1975-06-06 |
PL93405B1 (xx) | 1977-05-30 |
NL7416050A (nl) | 1975-06-12 |
DK137007C (da) | 1978-06-05 |
AU7625774A (en) | 1976-06-10 |
ES432716A1 (es) | 1977-03-01 |
ZA747820B (en) | 1975-12-31 |
HU171483B (hu) | 1978-01-28 |
DD115666A5 (xx) | 1975-10-12 |
IL46160A0 (en) | 1975-02-10 |
FR2253522B1 (xx) | 1978-06-30 |
US3985881A (en) | 1976-10-12 |
JPS5088077A (xx) | 1975-07-15 |
GB1447611A (en) | 1976-08-25 |
CA1053675A (en) | 1979-05-01 |
CH605776A5 (xx) | 1978-10-13 |
DK639674A (xx) | 1975-08-11 |
SE7415247L (xx) | 1975-06-11 |
DK137007B (da) | 1978-01-02 |
FR2253522A1 (xx) | 1975-07-04 |
DE2361390A1 (de) | 1975-06-19 |
AT351026B (de) | 1979-07-10 |
ATA981974A (de) | 1978-12-15 |
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