AT351026B - Verfahren zur herstellung von neuen isochinolinderivaten, ihren saeureadditions- salzen und quartaeren ammomiumsalzen - Google Patents
Verfahren zur herstellung von neuen isochinolinderivaten, ihren saeureadditions- salzen und quartaeren ammomiumsalzenInfo
- Publication number
- AT351026B AT351026B AT981974A AT981974A AT351026B AT 351026 B AT351026 B AT 351026B AT 981974 A AT981974 A AT 981974A AT 981974 A AT981974 A AT 981974A AT 351026 B AT351026 B AT 351026B
- Authority
- AT
- Austria
- Prior art keywords
- salts
- quartaine
- ammomium
- producing new
- acid additional
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000002537 isoquinolines Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT748077A ATA748077A (de) | 1973-12-10 | 1977-10-19 | Verfahren zur herstellung von neuen iso- chinolinderivaten, ihren saeureadditionssalzen und qurataeren ammoniumsalzen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2361390A DE2361390A1 (de) | 1973-12-10 | 1973-12-10 | Isochinolinderivate und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA981974A ATA981974A (de) | 1978-12-15 |
| AT351026B true AT351026B (de) | 1979-07-10 |
Family
ID=5900348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT981974A AT351026B (de) | 1973-12-10 | 1974-12-09 | Verfahren zur herstellung von neuen isochinolinderivaten, ihren saeureadditions- salzen und quartaeren ammomiumsalzen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3985881A (de) |
| JP (1) | JPS5088077A (de) |
| AT (1) | AT351026B (de) |
| BE (1) | BE823027A (de) |
| CA (1) | CA1053675A (de) |
| CH (1) | CH605776A5 (de) |
| CS (1) | CS188933B2 (de) |
| DD (1) | DD115666A5 (de) |
| DE (1) | DE2361390A1 (de) |
| DK (1) | DK137007C (de) |
| ES (1) | ES432716A1 (de) |
| FR (1) | FR2253522B1 (de) |
| GB (1) | GB1447611A (de) |
| HU (1) | HU171483B (de) |
| IL (1) | IL46160A0 (de) |
| NL (1) | NL7416050A (de) |
| SE (1) | SE7415247L (de) |
| ZA (1) | ZA747820B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2504250A1 (de) * | 1975-02-01 | 1976-08-05 | Merck Patent Gmbh | Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung |
| US4232160A (en) * | 1978-10-18 | 1980-11-04 | Miles Laboratories, Inc. | Isoquinoline propionamides exhibiting analgesic properties |
| US4556712A (en) * | 1981-05-20 | 1985-12-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines |
| GB8601796D0 (en) * | 1986-01-24 | 1986-02-26 | Zambeletti Spa L | Compounds |
| DE3713743A1 (de) * | 1987-04-24 | 1988-11-17 | Boehringer Ingelheim Kg | Kondensierte bis-(3,4-dihydro-l-pyridinyl)methane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| ES2061972T3 (es) * | 1988-02-19 | 1994-12-16 | Smithkline Beecham Farma | 1,2,3,4-tetrahidroisoquinoleinas, procedimiento para su preparacion y su uso como agonistas kapa-receptores. |
| KR890012970A (ko) * | 1988-02-23 | 1989-09-20 | 추후보충 | 테트라히드로 이소퀴놀린 유도체 |
| DE3827727A1 (de) * | 1988-08-16 | 1990-02-22 | Boehringer Ingelheim Kg | Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion |
| GB8827479D0 (en) * | 1988-11-24 | 1988-12-29 | Zambeletti Spa L | Novel compounds |
| GB8916395D0 (en) * | 1989-07-18 | 1989-09-06 | Zambeletti Spa L | Pharmaceuticals |
| US5389638A (en) * | 1993-09-10 | 1995-02-14 | Abbott Laboratories | Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors |
| GB0225884D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| PL2935222T3 (pl) | 2012-12-21 | 2019-02-28 | Epizyme Inc | Inhibitory PRMT5 i ich zastosowania |
| AU2016316436B2 (en) * | 2015-09-01 | 2021-04-29 | Merck Patent Gmbh | Method for the production of praziquantel and precursors thereof |
| CA3001857A1 (en) * | 2015-10-14 | 2017-04-20 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
| BR112020005489A2 (pt) | 2017-09-22 | 2020-09-24 | Jubilant Epipad Llc, | composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| EP3707135A1 (de) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Pyrimidinderivate als inhibitoren der pd1/pd-l1-aktivierung |
| IL274762B2 (en) | 2017-11-24 | 2023-10-01 | Jubilant Episcribe Llc | Novel heterocyclic compounds as prmt5 inhibitors |
| EP3765453A1 (de) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Bicyclische verbindungen als inhibitoren der pd1/pd-l1-interaktion/aktivierung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2612503A (en) * | 1949-04-19 | 1952-09-30 | Smith Kline French Lab | Basic ether-substituted isoquinolines |
| US2640829A (en) * | 1950-11-10 | 1953-06-02 | Smith Kline French Lab | Isoquinolyl heterocyclic ethers |
| US3021331A (en) * | 1959-07-20 | 1962-02-13 | Pfizer & Co C | Azabenzopyridocolines |
| US3483206A (en) * | 1967-12-15 | 1969-12-09 | Ciba Geigy Corp | N-isoquinolylalkanoyl-n-arylamines |
| US3600394A (en) * | 1968-05-17 | 1971-08-17 | Searle & Co | 2-aminoalkyl-3-arylisocarbostyrils |
-
1973
- 1973-12-10 DE DE2361390A patent/DE2361390A1/de active Pending
-
1974
- 1974-11-29 IL IL46160A patent/IL46160A0/xx unknown
- 1974-12-05 SE SE7415247A patent/SE7415247L/xx unknown
- 1974-12-06 CA CA215,386A patent/CA1053675A/en not_active Expired
- 1974-12-06 FR FR7440041A patent/FR2253522B1/fr not_active Expired
- 1974-12-06 BE BE151221A patent/BE823027A/xx unknown
- 1974-12-06 CS CS748365A patent/CS188933B2/cs unknown
- 1974-12-09 DK DK639674A patent/DK137007C/da active
- 1974-12-09 CH CH1632774A patent/CH605776A5/xx not_active IP Right Cessation
- 1974-12-09 JP JP49141945A patent/JPS5088077A/ja active Pending
- 1974-12-09 DD DD182514A patent/DD115666A5/xx unknown
- 1974-12-09 AT AT981974A patent/AT351026B/de not_active IP Right Cessation
- 1974-12-09 US US05/530,551 patent/US3985881A/en not_active Expired - Lifetime
- 1974-12-09 HU HU74ME00001812A patent/HU171483B/hu unknown
- 1974-12-09 ES ES432716A patent/ES432716A1/es not_active Expired
- 1974-12-09 GB GB5319174A patent/GB1447611A/en not_active Expired
- 1974-12-09 ZA ZA00747820A patent/ZA747820B/xx unknown
- 1974-12-10 NL NL7416050A patent/NL7416050A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US3985881A (en) | 1976-10-12 |
| DK639674A (de) | 1975-08-11 |
| DK137007B (da) | 1978-01-02 |
| ATA981974A (de) | 1978-12-15 |
| PL93405B1 (de) | 1977-05-30 |
| JPS5088077A (de) | 1975-07-15 |
| ES432716A1 (es) | 1977-03-01 |
| IL46160A0 (en) | 1975-02-10 |
| SE7415247L (de) | 1975-06-11 |
| CA1053675A (en) | 1979-05-01 |
| HU171483B (hu) | 1978-01-28 |
| BE823027A (fr) | 1975-06-06 |
| FR2253522B1 (de) | 1978-06-30 |
| CS188933B2 (en) | 1979-03-30 |
| GB1447611A (en) | 1976-08-25 |
| AU7625774A (en) | 1976-06-10 |
| DK137007C (da) | 1978-06-05 |
| DD115666A5 (de) | 1975-10-12 |
| ZA747820B (en) | 1975-12-31 |
| NL7416050A (nl) | 1975-06-12 |
| CH605776A5 (de) | 1978-10-13 |
| FR2253522A1 (de) | 1975-07-04 |
| DE2361390A1 (de) | 1975-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee | ||
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |