CS188933B2 - Method of producing 1-/3,4,5-trimethoxy benzamido methyl/isoquinolines and 1,2,3,4-tetrahydroisoquinolines - Google Patents

Method of producing 1-/3,4,5-trimethoxy benzamido methyl/isoquinolines and 1,2,3,4-tetrahydroisoquinolines

Info

Publication number
CS188933B2
CS188933B2 CS748365A CS836574A CS188933B2 CS 188933 B2 CS188933 B2 CS 188933B2 CS 748365 A CS748365 A CS 748365A CS 836574 A CS836574 A CS 836574A CS 188933 B2 CS188933 B2 CS 188933B2
Authority
CS
Czechoslovakia
Prior art keywords
tetrahydroisoquinolines
isoquinolines
producing
benzamido methyl
trimethoxy benzamido
Prior art date
Application number
CS748365A
Other languages
English (en)
Inventor
Werner Mehrhof
Rolf Pohlke
Karl H Becker
Hans-J Schliep
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Priority to CS761597A priority Critical patent/CS188949B2/cs
Publication of CS188933B2 publication Critical patent/CS188933B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CS748365A 1973-12-10 1974-12-06 Method of producing 1-/3,4,5-trimethoxy benzamido methyl/isoquinolines and 1,2,3,4-tetrahydroisoquinolines CS188933B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS761597A CS188949B2 (en) 1973-12-10 1976-03-11 Method of producing 1-3,4,5-trimethoxybenzamido-methyl/isoquinolines and-1,2,3,4-tetrahydroisoquinolines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2361390A DE2361390A1 (de) 1973-12-10 1973-12-10 Isochinolinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CS188933B2 true CS188933B2 (en) 1979-03-30

Family

ID=5900348

Family Applications (1)

Application Number Title Priority Date Filing Date
CS748365A CS188933B2 (en) 1973-12-10 1974-12-06 Method of producing 1-/3,4,5-trimethoxy benzamido methyl/isoquinolines and 1,2,3,4-tetrahydroisoquinolines

Country Status (18)

Country Link
US (1) US3985881A (cs)
JP (1) JPS5088077A (cs)
AT (1) AT351026B (cs)
BE (1) BE823027A (cs)
CA (1) CA1053675A (cs)
CH (1) CH605776A5 (cs)
CS (1) CS188933B2 (cs)
DD (1) DD115666A5 (cs)
DE (1) DE2361390A1 (cs)
DK (1) DK137007C (cs)
ES (1) ES432716A1 (cs)
FR (1) FR2253522B1 (cs)
GB (1) GB1447611A (cs)
HU (1) HU171483B (cs)
IL (1) IL46160A0 (cs)
NL (1) NL7416050A (cs)
SE (1) SE7415247L (cs)
ZA (1) ZA747820B (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504250A1 (de) * 1975-02-01 1976-08-05 Merck Patent Gmbh Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung
US4232160A (en) * 1978-10-18 1980-11-04 Miles Laboratories, Inc. Isoquinoline propionamides exhibiting analgesic properties
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
DE3713743A1 (de) * 1987-04-24 1988-11-17 Boehringer Ingelheim Kg Kondensierte bis-(3,4-dihydro-l-pyridinyl)methane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE68910999T2 (de) * 1988-02-19 1994-03-24 Smithkline Beecham Farma 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
KR890012970A (ko) * 1988-02-23 1989-09-20 추후보충 테트라히드로 이소퀴놀린 유도체
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
GB0225884D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
LT2935222T (lt) * 2012-12-21 2018-12-27 Epizyme, Inc. Prmt5 slopikliai ir jų panaudojimas
BR112018002881B1 (pt) * 2015-09-01 2022-06-07 Merck Patent Gmbh Métodos para produção de praziquantel e de seus precursores
CA3001857A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
CA3076476A1 (en) 2017-10-18 2019-04-25 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
WO2019087214A1 (en) 2017-11-06 2019-05-09 Jubilant Biosys Limited Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
PL3704120T3 (pl) 2017-11-24 2024-09-16 Jubilant Episcribe Llc Związki heterocykliczne jako inhibitory prmt5
BR112020018610A2 (pt) 2018-03-13 2020-12-29 Jubilant Prodel LLC Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2612503A (en) * 1949-04-19 1952-09-30 Smith Kline French Lab Basic ether-substituted isoquinolines
US2640829A (en) * 1950-11-10 1953-06-02 Smith Kline French Lab Isoquinolyl heterocyclic ethers
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3483206A (en) * 1967-12-15 1969-12-09 Ciba Geigy Corp N-isoquinolylalkanoyl-n-arylamines
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils

Also Published As

Publication number Publication date
DK639674A (cs) 1975-08-11
FR2253522B1 (cs) 1978-06-30
DK137007C (da) 1978-06-05
SE7415247L (cs) 1975-06-11
ZA747820B (en) 1975-12-31
CH605776A5 (cs) 1978-10-13
BE823027A (fr) 1975-06-06
NL7416050A (nl) 1975-06-12
ES432716A1 (es) 1977-03-01
AU7625774A (en) 1976-06-10
ATA981974A (de) 1978-12-15
PL93405B1 (cs) 1977-05-30
AT351026B (de) 1979-07-10
IL46160A0 (en) 1975-02-10
DE2361390A1 (de) 1975-06-19
JPS5088077A (cs) 1975-07-15
DD115666A5 (cs) 1975-10-12
FR2253522A1 (cs) 1975-07-04
US3985881A (en) 1976-10-12
CA1053675A (en) 1979-05-01
HU171483B (hu) 1978-01-28
GB1447611A (en) 1976-08-25
DK137007B (da) 1978-01-02

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