CR20180143A - Nuevos compuestos biciclicos como inhibidores duales de atx/ca - Google Patents

Nuevos compuestos biciclicos como inhibidores duales de atx/ca

Info

Publication number
CR20180143A
CR20180143A CR20180143A CR20180143A CR20180143A CR 20180143 A CR20180143 A CR 20180143A CR 20180143 A CR20180143 A CR 20180143A CR 20180143 A CR20180143 A CR 20180143A CR 20180143 A CR20180143 A CR 20180143A
Authority
CR
Costa Rica
Prior art keywords
atx
compounds
dual inhibitors
new bicycle
bicycle compounds
Prior art date
Application number
CR20180143A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Hunziker
Jérôme Hert
Petra Schmitz
Patrizio Mattei
Markus Rudolph
Christoph; Ullmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20180143A publication Critical patent/CR20180143A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CR20180143A 2015-09-24 2016-09-20 Nuevos compuestos biciclicos como inhibidores duales de atx/ca CR20180143A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24
PCT/EP2016/072277 WO2017050747A1 (en) 2015-09-24 2016-09-20 New bicyclic compounds as dual atx/ca inhibitors

Publications (1)

Publication Number Publication Date
CR20180143A true CR20180143A (es) 2018-05-03

Family

ID=54199040

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180143A CR20180143A (es) 2015-09-24 2016-09-20 Nuevos compuestos biciclicos como inhibidores duales de atx/ca

Country Status (19)

Country Link
US (2) US10738053B2 (cg-RX-API-DMAC7.html)
EP (1) EP3353181B1 (cg-RX-API-DMAC7.html)
JP (1) JP6845230B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180053408A (cg-RX-API-DMAC7.html)
CN (1) CN107614505B (cg-RX-API-DMAC7.html)
AR (1) AR106100A1 (cg-RX-API-DMAC7.html)
AU (1) AU2016328365B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017026682A2 (cg-RX-API-DMAC7.html)
CA (1) CA2984585A1 (cg-RX-API-DMAC7.html)
CL (1) CL2018000649A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017011152A2 (cg-RX-API-DMAC7.html)
CR (1) CR20180143A (cg-RX-API-DMAC7.html)
IL (1) IL255511B (cg-RX-API-DMAC7.html)
MX (1) MX2017015034A (cg-RX-API-DMAC7.html)
PE (1) PE20180233A1 (cg-RX-API-DMAC7.html)
PH (1) PH12018500409A1 (cg-RX-API-DMAC7.html)
RU (1) RU2725138C2 (cg-RX-API-DMAC7.html)
TW (1) TW201725206A (cg-RX-API-DMAC7.html)
WO (1) WO2017050747A1 (cg-RX-API-DMAC7.html)

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JP6877413B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
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KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
DK4003978T3 (da) 2019-07-22 2024-07-22 Boehringer Ingelheim Int N-methyl, n-(6-(methoxy)pyridazin-3-yl) aminderivater som autotaxin (atx) modulatorer til behandlingen af inflammatoriske luftvejs- eller fibrotiske sygdomme
JP2024502337A (ja) 2021-01-05 2024-01-18 ザイダス ライフサイエンシズ リミティド オートタキシンの新規阻害剤

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