CR20160123A - Inhibidores de polimerasa hcv - Google Patents
Inhibidores de polimerasa hcvInfo
- Publication number
- CR20160123A CR20160123A CR20160123A CR20160123A CR20160123A CR 20160123 A CR20160123 A CR 20160123A CR 20160123 A CR20160123 A CR 20160123A CR 20160123 A CR20160123 A CR 20160123A CR 20160123 A CR20160123 A CR 20160123A
- Authority
- CR
- Costa Rica
- Prior art keywords
- hcv polymerase
- polymerase inhibitors
- prophylaxis
- hepatitis
- variables
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1351026 | 2013-09-04 | ||
| SE1351169 | 2013-10-03 | ||
| SE1450152 | 2014-02-12 | ||
| PCT/SE2014/051005 WO2015034420A1 (en) | 2013-09-04 | 2014-09-02 | Hcv polymerase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20160123A true CR20160123A (es) | 2016-07-20 |
Family
ID=52628746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20160123A CR20160123A (es) | 2013-09-04 | 2016-03-10 | Inhibidores de polimerasa hcv |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9481703B2 (show.php) |
| EP (2) | EP3041855B1 (show.php) |
| JP (2) | JP6456958B2 (show.php) |
| KR (1) | KR20160078337A (show.php) |
| CN (3) | CN108558973A (show.php) |
| AU (2) | AU2014315715B2 (show.php) |
| BR (1) | BR112016004919A2 (show.php) |
| CA (1) | CA2921899A1 (show.php) |
| CL (2) | CL2016000493A1 (show.php) |
| CR (1) | CR20160123A (show.php) |
| CY (1) | CY1119587T1 (show.php) |
| DK (1) | DK3041855T3 (show.php) |
| EA (1) | EA028974B1 (show.php) |
| HR (1) | HRP20171435T1 (show.php) |
| HU (1) | HUE036365T2 (show.php) |
| IL (2) | IL244389B (show.php) |
| ME (1) | ME02875B (show.php) |
| MX (1) | MX2016002849A (show.php) |
| MY (1) | MY177804A (show.php) |
| PH (2) | PH12016500402B1 (show.php) |
| PL (1) | PL3041855T3 (show.php) |
| PT (1) | PT3041855T (show.php) |
| RS (1) | RS56383B1 (show.php) |
| SA (1) | SA516370684B1 (show.php) |
| SG (2) | SG11201601474UA (show.php) |
| SI (1) | SI3041855T1 (show.php) |
| UA (1) | UA117375C2 (show.php) |
| WO (1) | WO2015034420A1 (show.php) |
Families Citing this family (53)
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|---|---|---|---|---|
| JP5767643B2 (ja) | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | １’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
| PE20130400A1 (es) | 2010-07-22 | 2013-04-10 | Gilead Sciences Inc | Metodos y compuestos para tratar infecciones virales por paramyxoviridae |
| CN104151360B (zh) * | 2013-05-14 | 2019-02-22 | 北京美倍他药物研究有限公司 | 磷酸/膦酸衍生物及其医药用途 |
| UA117375C2 (uk) * | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
| BR112016011949A8 (pt) | 2013-11-27 | 2020-04-28 | Idenix Pharmaceuticals Llc | composto, composição farmacêutica, e, uso dos mesmos |
| EP3074399A1 (en) * | 2013-11-27 | 2016-10-05 | Idenix Pharmaceuticals LLC | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
| CA2946867C (en) * | 2014-04-24 | 2023-03-07 | Cocrystal Pharma, Inc. | 2'-disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
| WO2016015638A1 (zh) * | 2014-07-30 | 2016-02-04 | 南京圣和药业股份有限公司 | 丙型肝炎病毒抑制剂及其应用 |
| TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| EP3240413B1 (en) * | 2014-12-30 | 2020-05-13 | Dow Agrosciences LLC | Picolinamide compounds with fungicidal activity |
| CN107205386B (zh) | 2014-12-30 | 2021-07-23 | 美国陶氏益农公司 | 具有杀真菌活性的吡啶酰胺 |
| RU2708392C2 (ru) | 2014-12-30 | 2019-12-06 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Соединения пиколинамида с фунгицидной активностью |
| CA2972408A1 (en) | 2014-12-30 | 2016-07-07 | Dow Agrosciences Llc | Use of picolinamide compounds with fungicidal activity |
| WO2016134057A1 (en) * | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Anti-viral compounds |
| WO2016140615A1 (en) * | 2015-03-02 | 2016-09-09 | Medivir Ab | Nucleotide derivatives which are hcv inhibitors for use in the treatment of hepatitis c |
| AU2016226647A1 (en) * | 2015-03-02 | 2017-09-21 | Medivir Ab | Nucleotide phosphoramidate formulation |
| US10618926B2 (en) | 2015-04-02 | 2020-04-14 | Merck Sharp & Dohme | Process for making phosphoramidate protected nucleoside compounds |
| MX382566B (es) * | 2015-05-01 | 2025-03-13 | Univ Emory | Analogos de nucleosidos para el tratamiento de la familia de virus flaviviridae y cancer |
| WO2017040889A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040896A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040898A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| CN108350016B (zh) * | 2015-09-02 | 2021-07-27 | 艾伯维公司 | 抗病毒四氢呋喃衍生物 |
| WO2017040895A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040892A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| PT3349758T (pt) | 2015-09-16 | 2022-07-13 | Gilead Sciences Inc | Métodos para o tratamento de infeções pelo vírus arenaviridae |
| CN105367505A (zh) * | 2015-12-01 | 2016-03-02 | 苏利制药科技江阴有限公司 | 一种新型合成3,6-二甲基-2,5-哌嗪二酮的方法 |
| AU2017208970A1 (en) | 2016-01-18 | 2018-08-02 | Arisan Therapeutics | Adamatane derivatives for the treatment of filovirus infection |
| CA3033858A1 (en) * | 2016-08-19 | 2018-02-22 | Sandoz Ag | Sofosbuvir derivatives for the treatment of hepatitis c |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
| US11191269B2 (en) | 2017-05-02 | 2021-12-07 | Dow Agrosciences Llc | Use of an acyclic picolinamide compound as a fungicide for fungal diseases on turfgrasses |
| TW201842851A (zh) | 2017-05-02 | 2018-12-16 | 美商陶氏農業科學公司 | 用於穀類中的真菌防治之協同性混合物 |
| TWI774761B (zh) | 2017-05-02 | 2022-08-21 | 美商科迪華農業科技有限責任公司 | 用於穀物中的真菌防治之協同性混合物 |
| US10675296B2 (en) | 2017-07-11 | 2020-06-09 | Gilead Sciences, Inc. | Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections |
| US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
| BR102019004480B1 (pt) | 2018-03-08 | 2023-03-28 | Dow Agrosciences Llc | Picolinamidas como fungicidas |
| AU2019232478B2 (en) | 2018-03-09 | 2024-06-06 | Medivir Aktiebolag | Cancer treatment with (2,2-bishydroxymethyl) methylenecyclopropane nucleotides |
| US11639334B2 (en) | 2018-10-15 | 2023-05-02 | Corteva Agriscience Llc | Methods for synthesis of oxypicolinamides |
| CN109762040A (zh) * | 2019-01-14 | 2019-05-17 | 歌礼生物制药(杭州)有限公司 | 一种核苷类ns5b聚合酶抑制剂的制备方法 |
| EP4044811A4 (en) | 2019-10-18 | 2023-09-27 | Corteva Agriscience LLC | METHOD FOR SYNTHESIS OF PICOLINAMIDS |
| CN118766947A (zh) | 2020-01-27 | 2024-10-15 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CN111269263A (zh) * | 2020-03-09 | 2020-06-12 | 上海龙翔生物医药开发有限公司 | 一种瑞德西韦侧链中间体及其制备方法 |
| CA3169340A1 (en) | 2020-03-12 | 2021-09-16 | Pavel R. Badalov | Methods of preparing 1'-cyano nucleosides |
| JP7482250B2 (ja) | 2020-04-06 | 2024-05-13 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノ置換カルバヌクレオシド類似体の吸入製剤 |
| CN111848679A (zh) * | 2020-04-17 | 2020-10-30 | 山东科巢生物制药有限公司 | 一种利用微通道反应技术合成瑞德西韦的方法 |
| PL4157272T3 (pl) | 2020-05-29 | 2025-10-20 | Gilead Sciences, Inc. | Remdesiwir do leczenia zakażeń wirusowych |
| JP2023531524A (ja) | 2020-06-24 | 2023-07-24 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノヌクレオシド類似体及びその使用 |
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2014
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- 2014-09-02 MX MX2016002849A patent/MX2016002849A/es unknown
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- 2014-09-02 EP EP14789434.9A patent/EP3041855B1/en active Active
- 2014-09-02 CA CA2921899A patent/CA2921899A1/en not_active Abandoned
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- 2014-09-02 CN CN201810473163.XA patent/CN108558973A/zh active Pending
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- 2014-09-02 SI SI201430401T patent/SI3041855T1/sl unknown
- 2014-09-02 AU AU2014315715A patent/AU2014315715B2/en not_active Ceased
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- 2014-09-02 EA EA201690452A patent/EA028974B1/ru not_active IP Right Cessation
- 2014-09-02 BR BR112016004919A patent/BR112016004919A2/pt not_active Application Discontinuation
- 2014-09-02 KR KR1020167008381A patent/KR20160078337A/ko not_active Withdrawn
- 2014-09-02 MY MYPI2016700722A patent/MY177804A/en unknown
- 2014-09-02 PL PL14789434T patent/PL3041855T3/pl unknown
- 2014-09-02 WO PCT/SE2014/051005 patent/WO2015034420A1/en not_active Ceased
- 2014-09-02 HU HUE14789434A patent/HUE036365T2/hu unknown
- 2014-09-02 EP EP17176973.0A patent/EP3252066B1/en active Active
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2015
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2019
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