CR20140415A - Anticuerpos humanos anti-cd27, métodos, y usos - Google Patents

Anticuerpos humanos anti-cd27, métodos, y usos

Info

Publication number
CR20140415A
CR20140415A CR20140415A CR20140415A CR20140415A CR 20140415 A CR20140415 A CR 20140415A CR 20140415 A CR20140415 A CR 20140415A CR 20140415 A CR20140415 A CR 20140415A CR 20140415 A CR20140415 A CR 20140415A
Authority
CR
Costa Rica
Prior art keywords
human antibodies
methods
cell proliferation
antibodies
activity
Prior art date
Application number
CR20140415A
Other languages
English (en)
Spanish (es)
Inventor
John Chen
Johan Fransson
Natalie Fursov
Damon Hamel
Thomas Malia
Galina Obmolova
Tatiana Ort
Michael Rycyzyn
Michael Scully
Raymond Sweet
Alexey Teplyakov
John Wheeler
Juan Carlos Almagro
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of CR20140415A publication Critical patent/CR20140415A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CR20140415A 2012-03-15 2014-09-09 Anticuerpos humanos anti-cd27, métodos, y usos CR20140415A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261611332P 2012-03-15 2012-03-15
PCT/US2013/031314 WO2013138586A1 (fr) 2012-03-15 2013-03-14 Anticorps anti-cd27 humains, leurs procédés et leurs utilisations

Publications (1)

Publication Number Publication Date
CR20140415A true CR20140415A (es) 2014-11-18

Family

ID=49157853

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140415A CR20140415A (es) 2012-03-15 2014-09-09 Anticuerpos humanos anti-cd27, métodos, y usos

Country Status (28)

Country Link
US (6) US9102737B2 (fr)
EP (1) EP2825200A4 (fr)
JP (1) JP6487839B2 (fr)
KR (1) KR102153374B1 (fr)
CN (1) CN104284678B (fr)
AR (1) AR090356A1 (fr)
AU (1) AU2013232087B2 (fr)
BR (2) BR122020002414B1 (fr)
CA (1) CA2867299C (fr)
CL (1) CL2014002416A1 (fr)
CO (1) CO7071095A2 (fr)
CR (1) CR20140415A (fr)
EA (1) EA030828B1 (fr)
EC (1) ECSP14018641A (fr)
GT (1) GT201400193A (fr)
HK (1) HK1206251A1 (fr)
JO (1) JO3787B1 (fr)
MX (1) MX363946B (fr)
MY (1) MY175224A (fr)
NZ (1) NZ629697A (fr)
PE (1) PE20142242A1 (fr)
PH (2) PH12014502011B1 (fr)
SG (2) SG10201710574UA (fr)
TW (2) TW201730214A (fr)
UA (1) UA121844C2 (fr)
UY (1) UY34680A (fr)
WO (1) WO2013138586A1 (fr)
ZA (2) ZA201407440B (fr)

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Also Published As

Publication number Publication date
US20170320957A1 (en) 2017-11-09
TW201345922A (zh) 2013-11-16
TWI576354B (zh) 2017-04-01
PH12017501908A1 (en) 2018-10-01
CA2867299C (fr) 2019-08-27
US20130243795A1 (en) 2013-09-19
AU2013232087A1 (en) 2014-09-25
SG10201710574UA (en) 2018-02-27
WO2013138586A1 (fr) 2013-09-19
SG11201405437QA (en) 2014-10-30
AU2013232087B2 (en) 2018-02-08
CN104284678A (zh) 2015-01-14
EA030828B1 (ru) 2018-10-31
US20150299330A1 (en) 2015-10-22
TW201730214A (zh) 2017-09-01
US20200277393A1 (en) 2020-09-03
ZA201500887B (en) 2016-01-27
UY34680A (es) 2013-09-30
CA2867299A1 (fr) 2013-09-19
PE20142242A1 (es) 2015-01-08
CO7071095A2 (es) 2014-09-30
ZA201407440B (en) 2016-07-27
US9683046B2 (en) 2017-06-20
MX363946B (es) 2019-04-09
GT201400193A (es) 2017-06-14
NZ629697A (en) 2017-01-27
MX2014011100A (es) 2014-12-05
US10689453B2 (en) 2020-06-23
KR102153374B1 (ko) 2020-09-10
MY175224A (en) 2020-06-16
BR122020002414B1 (pt) 2022-03-03
US10301392B2 (en) 2019-05-28
PH12017501908B1 (en) 2018-10-01
HK1206251A1 (en) 2016-01-08
EP2825200A1 (fr) 2015-01-21
US20190248910A1 (en) 2019-08-15
PH12014502011A1 (en) 2014-11-24
JO3787B1 (ar) 2021-01-31
JP2015511965A (ja) 2015-04-23
PH12014502011B1 (en) 2014-11-24
CL2014002416A1 (es) 2015-01-16
JP6487839B2 (ja) 2019-03-20
US20240141055A1 (en) 2024-05-02
CN104284678B (zh) 2018-04-24
KR20140133940A (ko) 2014-11-20
ECSP14018641A (es) 2018-10-31
UA121844C2 (uk) 2020-08-10
BR112014022812A2 (pt) 2017-07-18
AR090356A1 (es) 2014-11-05
US11732050B2 (en) 2023-08-22
EA201491700A1 (ru) 2015-02-27
EP2825200A4 (fr) 2015-08-26
US9102737B2 (en) 2015-08-11

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