CO6990719A2 - Derivados de los nucleósidos sustituidos en 4´-azido, 3´-fluoro como inhibidores de la replicación del rna del vhc - Google Patents
Derivados de los nucleósidos sustituidos en 4´-azido, 3´-fluoro como inhibidores de la replicación del rna del vhcInfo
- Publication number
- CO6990719A2 CO6990719A2 CO14133951A CO14133951A CO6990719A2 CO 6990719 A2 CO6990719 A2 CO 6990719A2 CO 14133951 A CO14133951 A CO 14133951A CO 14133951 A CO14133951 A CO 14133951A CO 6990719 A2 CO6990719 A2 CO 6990719A2
- Authority
- CO
- Colombia
- Prior art keywords
- vna
- azido
- replication
- fluoro
- rna
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577712P | 2011-12-20 | 2011-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6990719A2 true CO6990719A2 (es) | 2014-07-10 |
Family
ID=47469968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14133951A CO6990719A2 (es) | 2011-12-20 | 2014-06-20 | Derivados de los nucleósidos sustituidos en 4´-azido, 3´-fluoro como inhibidores de la replicación del rna del vhc |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9708357B2 (forum.php) |
| EP (1) | EP2794628B1 (forum.php) |
| JP (1) | JP6118336B2 (forum.php) |
| KR (1) | KR101687084B1 (forum.php) |
| CN (2) | CN104011060A (forum.php) |
| AU (1) | AU2012357986B2 (forum.php) |
| BR (1) | BR112014015066A2 (forum.php) |
| CA (1) | CA2869317C (forum.php) |
| CL (1) | CL2014001599A1 (forum.php) |
| CO (1) | CO6990719A2 (forum.php) |
| CR (1) | CR20140255A (forum.php) |
| CY (1) | CY1119015T1 (forum.php) |
| DK (1) | DK2794628T3 (forum.php) |
| EA (1) | EA024847B1 (forum.php) |
| ES (1) | ES2626484T3 (forum.php) |
| HK (1) | HK1200835A1 (forum.php) |
| HU (1) | HUE033332T2 (forum.php) |
| IL (1) | IL232843B (forum.php) |
| IN (1) | IN2014CN04530A (forum.php) |
| LT (1) | LT2794628T (forum.php) |
| MA (1) | MA35749B1 (forum.php) |
| MX (1) | MX350810B (forum.php) |
| PE (1) | PE20141599A1 (forum.php) |
| PH (1) | PH12014501283A1 (forum.php) |
| PL (1) | PL2794628T3 (forum.php) |
| PT (1) | PT2794628T (forum.php) |
| SG (1) | SG11201403086YA (forum.php) |
| SI (1) | SI2794628T1 (forum.php) |
| UA (1) | UA110428C2 (forum.php) |
| WO (1) | WO2013092447A1 (forum.php) |
| ZA (1) | ZA201404444B (forum.php) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9403863B2 (en) | 2011-09-12 | 2016-08-02 | Idenix Pharmaceuticals Llc | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| CA2869317C (en) | 2011-12-20 | 2016-05-17 | F. Hoffmann-La Roche Ag | 4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication |
| HK1203514A1 (en) | 2012-05-22 | 2015-10-30 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
| EP2852605B1 (en) | 2012-05-22 | 2018-01-31 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphate prodrugs for hcv infection |
| US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
| BR112014029185B1 (pt) | 2012-05-25 | 2020-07-21 | Janssen Sciences Ireland Uc | nucleosídeos de spirooxetano uracila, seu uso, composição farmacêutica e produto que os compreendem |
| EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| PE20151318A1 (es) | 2012-10-08 | 2015-10-03 | Idenix Pharmaceuticals Inc | Analogos de 2'-cloro nucleosido para infeccion por vhc |
| EP2909222B1 (en) | 2012-10-22 | 2021-05-26 | Idenix Pharmaceuticals LLC | 2',4'-bridged nucleosides for hcv infection |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
| EP2970358B1 (en) | 2013-03-04 | 2021-06-30 | Idenix Pharmaceuticals LLC | 3'-deoxy nucleosides for the treatment of hcv |
| EP2970357B1 (en) | 2013-03-13 | 2025-01-01 | Idenix Pharmaceuticals LLC | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| BR112015028765A2 (pt) * | 2013-05-16 | 2017-07-25 | Riboscience Llc | derivados de nucleosídeo substituído 4'-azido, 3'-desoxi-3'-fluoro |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| EP3131914B1 (en) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| EP3344642A1 (en) * | 2015-09-02 | 2018-07-11 | AbbVie Inc. | Anti-viral tetrahydrofurane derivatives |
| CN109893536B (zh) * | 2018-07-02 | 2021-04-27 | 河南真实生物科技有限公司 | 4’-取代核苷的晶型、制备和应用 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU498131B2 (en) | 1974-02-26 | 1979-02-15 | Ciba-Geigy Ag | Production of cephems by cyclization |
| US4147864A (en) | 1975-02-20 | 1979-04-03 | Ciba-Geigy Corporation | Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds |
| US4322347A (en) | 1978-04-03 | 1982-03-30 | Bristol-Myers Company | 2-Carbamoyloxymethyl-penicillin derivatives |
| WO1986006380A1 (en) | 1985-04-30 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Antibacterial compounds, use and preparation thereof |
| JPS6422823A (en) * | 1987-07-17 | 1989-01-25 | Asahi Glass Co Ltd | Antiulcer agent |
| US5449664A (en) | 1988-11-21 | 1995-09-12 | Syntex (U.S.A.) Inc. | Antiviral agents |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| EA004771B1 (ru) | 1996-04-23 | 2004-08-26 | Вертекс Фармасьютикалз Инкорпорейтед | Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы |
| IL129407A0 (en) | 1996-10-18 | 2000-02-17 | Vertex Pharma | Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| PT966465E (pt) | 1997-03-14 | 2003-11-28 | Vertex Pharma | Inibidores do enzima imfdh |
| US6010848A (en) | 1997-07-02 | 2000-01-04 | Smithkline Beecham Corporation | Screening methods using an atpase protein from hepatitis C virus |
| AU757072B2 (en) | 1997-08-11 | 2003-01-30 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptide analogues |
| ATE298317T1 (de) | 1998-07-27 | 2005-07-15 | Angeletti P Ist Richerche Bio | Diketosäure-derivate als hemmstoffe von polymerasen |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| KR20010099623A (ko) | 1998-08-21 | 2001-11-09 | 비로파마 인코포레이티드 | 바이러스 감염 및 관련 질병을 치료 또는 예방하는화합물, 조성물 및 방법 |
| WO2000013708A1 (en) | 1998-09-04 | 2000-03-16 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
| WO2000018231A1 (en) | 1998-09-25 | 2000-04-06 | Viropharma Incorporated | Methods for treating or preventing viral infections and associated diseases |
| AP1498A (en) | 1999-03-19 | 2005-11-21 | Vertex Pharma | Inhibitors of impdh enzyme. |
| EP1225899A2 (en) | 1999-11-04 | 2002-07-31 | Virochem Pharma Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| US20040034041A1 (en) | 2000-05-10 | 2004-02-19 | Dashyant Dhanak | Novel anti-infectives |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| JP2005500287A (ja) | 2001-06-11 | 2005-01-06 | シャイアー バイオケム インコーポレイテッド | Ｆｌａｖｉｖｉｒｕｓ感染の処置または予防のための化合物および方法 |
| WO2002100851A2 (en) | 2001-06-11 | 2002-12-19 | Shire Biochem Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| JP4558314B2 (ja) | 2001-07-20 | 2010-10-06 | ベーリンガー インゲルハイム （カナダ） リミテッド | ウイルスポリメラーゼインヒビター |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| EP1440068A1 (en) | 2001-11-02 | 2004-07-28 | Glaxo Group Limited | Acyl dihydro pyrrole derivatives as hcv inhibitors |
| WO2003037894A1 (en) | 2001-11-02 | 2003-05-08 | Glaxo Group Limited | 4-(5-membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors |
| ES2289161T3 (es) | 2001-11-02 | 2008-02-01 | Glaxo Group Limited | Derivados de 4-(heteroaril de 6 miembros)-acil pirrolidina como inhibidores de hcv. |
| JP2005530843A (ja) | 2002-06-21 | 2005-10-13 | メルク エンド カムパニー インコーポレーテッド | Ｒｎａ依存性ｒｎａウィルスポリメラーゼ阻害剤としてのヌクレオシド誘導体 |
| WO2004014312A2 (en) | 2002-08-08 | 2004-02-19 | Sirna Therapeutics, Inc. | Small-mer compositions and methods of use |
| WO2004096235A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US20040259934A1 (en) | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| CN100457776C (zh) | 2003-05-09 | 2009-02-04 | 贝林格尔.英格海姆国际有限公司 | 丙型肝炎病毒ns5b聚合酶抑制剂结合袋 |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| KR101159575B1 (ko) | 2004-01-30 | 2012-07-06 | 얀센 알 앤드 디 아일랜드 | Ｈｃｖ ｎｓ―３ 세린 프로테아제 저해제 |
| CA2590115A1 (en) | 2004-12-10 | 2006-06-15 | Emory University | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
| CA2618335C (en) | 2005-08-15 | 2015-03-31 | F.Hoffmann-La Roche Ag | Antiviral phosphoramidates of 4'-substituted pronucleotides |
| AU2007215114A1 (en) | 2006-02-14 | 2007-08-23 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| GB2442001A (en) | 2006-08-11 | 2008-03-26 | Chembiotech | Nanoparticle - i-motif nucleic acid bioconjugates |
| AU2007342367B2 (en) | 2007-01-05 | 2012-12-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| GB0709791D0 (en) | 2007-05-22 | 2007-06-27 | Angeletti P Ist Richerche Bio | Antiviral agents |
| EP2166016A1 (en) * | 2008-09-18 | 2010-03-24 | Centocor Ortho Biotech Products L.P. | Phosphoramidate Derivatives of Nucleosides |
| US8759318B2 (en) * | 2009-01-09 | 2014-06-24 | Inhibitex, Inc. | Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections |
| EP2483288B1 (en) * | 2009-09-29 | 2016-11-16 | Janssen Products, L.P. | Phosphoramidate derivatives of nucleosides |
| KR102108864B1 (ko) | 2010-07-19 | 2020-05-12 | 길리애드 사이언시즈, 인코포레이티드 | 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법 |
| JP6012605B2 (ja) | 2010-09-22 | 2016-10-25 | アリオス バイオファーマ インク． | 置換されたヌクレオチドアナログ |
| ES2701020T3 (es) | 2010-09-22 | 2019-02-20 | Alios Biopharma Inc | Nucleósidos azido y análogos nucleotídicos |
| WO2012048013A2 (en) | 2010-10-06 | 2012-04-12 | Inhibitex, Inc. | Phosphorodiamidate derivatives of guanosine nucleoside compounds for treatment of viral injections |
| CA2869317C (en) | 2011-12-20 | 2016-05-17 | F. Hoffmann-La Roche Ag | 4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication |
-
2012
- 2012-12-17 CA CA2869317A patent/CA2869317C/en not_active Expired - Fee Related
- 2012-12-17 WO PCT/EP2012/075688 patent/WO2013092447A1/en active Application Filing
- 2012-12-17 HK HK15101193.6A patent/HK1200835A1/xx unknown
- 2012-12-17 LT LTEP12808791.3T patent/LT2794628T/lt unknown
- 2012-12-17 BR BR112014015066A patent/BR112014015066A2/pt not_active IP Right Cessation
- 2012-12-17 HU HUE12808791A patent/HUE033332T2/en unknown
- 2012-12-17 ES ES12808791.3T patent/ES2626484T3/es active Active
- 2012-12-17 CN CN201280064193.6A patent/CN104011060A/zh active Pending
- 2012-12-17 PT PT128087913T patent/PT2794628T/pt unknown
- 2012-12-17 AU AU2012357986A patent/AU2012357986B2/en not_active Ceased
- 2012-12-17 SG SG11201403086YA patent/SG11201403086YA/en unknown
- 2012-12-17 KR KR1020147020094A patent/KR101687084B1/ko not_active Expired - Fee Related
- 2012-12-17 EP EP12808791.3A patent/EP2794628B1/en not_active Not-in-force
- 2012-12-17 JP JP2014547882A patent/JP6118336B2/ja active Active
- 2012-12-17 IN IN4530CHN2014 patent/IN2014CN04530A/en unknown
- 2012-12-17 SI SI201230977A patent/SI2794628T1/sl unknown
- 2012-12-17 PE PE2014000990A patent/PE20141599A1/es not_active Application Discontinuation
- 2012-12-17 US US14/366,189 patent/US9708357B2/en not_active Expired - Fee Related
- 2012-12-17 MX MX2014007028A patent/MX350810B/es active IP Right Grant
- 2012-12-17 EA EA201491180A patent/EA024847B1/ru not_active IP Right Cessation
- 2012-12-17 CN CN201810341927.XA patent/CN108409820A/zh not_active Withdrawn
- 2012-12-17 DK DK12808791.3T patent/DK2794628T3/en active
- 2012-12-17 UA UAA201408090A patent/UA110428C2/uk unknown
- 2012-12-17 PL PL12808791T patent/PL2794628T3/pl unknown
-
2014
- 2014-05-28 IL IL232843A patent/IL232843B/en not_active IP Right Cessation
- 2014-05-28 CR CR20140255A patent/CR20140255A/es unknown
- 2014-06-06 PH PH12014501283A patent/PH12014501283A1/en unknown
- 2014-06-17 ZA ZA2014/04444A patent/ZA201404444B/en unknown
- 2014-06-18 CL CL2014001599A patent/CL2014001599A1/es unknown
- 2014-06-20 CO CO14133951A patent/CO6990719A2/es unknown
- 2014-06-25 MA MA37157A patent/MA35749B1/fr unknown
-
2017
- 2017-06-28 CY CY20171100679T patent/CY1119015T1/el unknown
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