CO6741202A2 - Síntesis de clorhidrato de metilfenidato a baja temperatura - Google Patents
Síntesis de clorhidrato de metilfenidato a baja temperaturaInfo
- Publication number
- CO6741202A2 CO6741202A2 CO13168680A CO13168680A CO6741202A2 CO 6741202 A2 CO6741202 A2 CO 6741202A2 CO 13168680 A CO13168680 A CO 13168680A CO 13168680 A CO13168680 A CO 13168680A CO 6741202 A2 CO6741202 A2 CO 6741202A2
- Authority
- CO
- Colombia
- Prior art keywords
- synthesis
- low temperature
- methylphenidate hydrochloride
- methylphenidate
- hydrochloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Abstract
La presente invención describe un proceso para la preparación de clorhidrato de metilfenidato. El proceso implica la esterificación del ácido ritalínico y metanol en presencia de un catalizador ácido a una bala temperatura. El proceso puede involucrar opcionalmente la adición de un ortoéster.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061424424P | 2010-12-17 | 2010-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6741202A2 true CO6741202A2 (es) | 2013-08-30 |
Family
ID=45509554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13168680A CO6741202A2 (es) | 2010-12-17 | 2013-07-16 | Síntesis de clorhidrato de metilfenidato a baja temperatura |
Country Status (13)
Country | Link |
---|---|
US (1) | US9475770B2 (es) |
EP (2) | EP2651892B1 (es) |
JP (1) | JP5886869B2 (es) |
KR (2) | KR101561361B1 (es) |
CN (1) | CN103298785B (es) |
AU (1) | AU2011342894C1 (es) |
BR (1) | BR112013015072A2 (es) |
CA (1) | CA2822016C (es) |
CO (1) | CO6741202A2 (es) |
ES (1) | ES2542433T3 (es) |
MX (1) | MX343653B (es) |
NZ (1) | NZ612298A (es) |
WO (1) | WO2012080834A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014024203A1 (en) * | 2012-08-07 | 2014-02-13 | Zcl Chemicals Limited | An improved process for - the preparation of dexmethylphenidate hydrochloride. |
WO2014083572A1 (en) * | 2012-11-29 | 2014-06-05 | Zcl Chemicals Limited | A process for the preparation of d-threo-ritalinic acid salts via novel salts of intermediate thereof |
WO2015069505A1 (en) * | 2013-11-08 | 2015-05-14 | Noramco, Inc. | Process for the preparation of methylphenidate and pharmaceutical salts thereof |
CA2951072A1 (en) * | 2014-06-06 | 2015-12-10 | Rhodes Pharmaceuticals, L.P. | Methods for treating attention deficit hyperactivity disorder with methylphenidate |
CA2936741C (en) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
CN104744342A (zh) * | 2015-02-11 | 2015-07-01 | 河南中帅医药科技股份有限公司 | 盐酸右哌甲酯晶型及其制备方法 |
CN107325039B (zh) * | 2016-04-29 | 2022-12-16 | 国药集团国瑞药业有限公司 | 一种盐酸右哌甲酯的制备方法 |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
CN110698341A (zh) * | 2019-10-24 | 2020-01-17 | 安庆博曼生物技术有限公司 | 丙炔酸衍生物的环保制备方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2507631A (en) | 1944-01-19 | 1950-05-16 | Ciba Pharm Prod Inc | Pyridine and piperidine compounds and process of making same |
US2957880A (en) | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
US2838519A (en) | 1953-12-23 | 1958-06-10 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
US4347374A (en) | 1980-07-21 | 1982-08-31 | Merck & Co., Inc. | Acid addition salts of N-trityl-α-fluoromethylhistidine enantiomer derivatives |
US5733756A (en) | 1996-01-05 | 1998-03-31 | Celgene Corporation | Lactams and processes for stereoselective enrichment of lactams, amides, and esters |
US6242464B1 (en) | 1996-01-22 | 2001-06-05 | Chiroscience Limited | Single isomer methylphenidate and resolution process |
GB9604943D0 (en) | 1996-03-08 | 1996-05-08 | Chiroscience Ltd | Resolution |
CA2272373A1 (en) | 1996-12-13 | 1998-06-18 | Medeva Europe Limited | The preparation of enantiomerically-enriched threo-methylphenidate |
GB9700912D0 (en) * | 1997-01-17 | 1997-03-05 | Chiroscience Ltd | Resolution |
US5936091A (en) | 1997-05-22 | 1999-08-10 | Celgene Corporation | Processes and intermediates for resolving piperidyl acetamide stereoisomers |
US6548522B1 (en) | 1999-10-12 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for treating conditions related to the glutamate receptor using carboxylic acid amide derivatives |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
CA2514612A1 (en) | 2003-01-30 | 2004-08-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta |
CH712083B1 (de) | 2003-02-05 | 2017-07-31 | Siegfried Ag | Verfahren zur Herstellung von d-threo-2-Phenyl-2-piperidin-2-yl-essigsäureestern. |
US20050032873A1 (en) | 2003-07-30 | 2005-02-10 | Wyeth | 3-Amino chroman and 2-amino tetralin derivatives |
US7229557B2 (en) | 2004-02-04 | 2007-06-12 | Konec, Inc. | Method to separate stereoisomers |
KR20090063220A (ko) | 2006-08-24 | 2009-06-17 | 오스트레일리언뉴클리어사이언스앤드테크놀로지오거나이제이션 | 말초 벤조디아제핀 수용체를 표적화하기 위한 플루오르화된리간드 |
US20100022446A1 (en) | 2007-01-18 | 2010-01-28 | Novo Nordisk A/S | Use of Peptides in Combination with Surgical Intervention for the Treatment of Obesity |
WO2010080787A1 (en) | 2009-01-09 | 2010-07-15 | Mallinckrodt Inc. | Synthesis of methylphenidate and analogs thereof |
EP2507212B1 (en) * | 2009-12-01 | 2014-04-16 | Harman Finochem Limited | Process for preparing methyl phenidate hydrochloride |
-
2011
- 2011-12-16 US US13/994,393 patent/US9475770B2/en active Active
- 2011-12-16 CN CN201180060441.5A patent/CN103298785B/zh not_active Expired - Fee Related
- 2011-12-16 NZ NZ612298A patent/NZ612298A/en not_active IP Right Cessation
- 2011-12-16 MX MX2013007020A patent/MX343653B/es active IP Right Grant
- 2011-12-16 AU AU2011342894A patent/AU2011342894C1/en not_active Ceased
- 2011-12-16 EP EP20110811127 patent/EP2651892B1/en active Active
- 2011-12-16 EP EP15164269.1A patent/EP2937336A1/en not_active Withdrawn
- 2011-12-16 BR BR112013015072A patent/BR112013015072A2/pt active Search and Examination
- 2011-12-16 CA CA2822016A patent/CA2822016C/en not_active Expired - Fee Related
- 2011-12-16 KR KR1020137018653A patent/KR101561361B1/ko active IP Right Grant
- 2011-12-16 JP JP2013543902A patent/JP5886869B2/ja not_active Expired - Fee Related
- 2011-12-16 WO PCT/IB2011/003140 patent/WO2012080834A1/en active Application Filing
- 2011-12-16 KR KR20157005468A patent/KR20150029769A/ko not_active Application Discontinuation
- 2011-12-16 ES ES11811127.7T patent/ES2542433T3/es active Active
-
2013
- 2013-07-16 CO CO13168680A patent/CO6741202A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2011342894C1 (en) | 2015-07-30 |
KR20150029769A (ko) | 2015-03-18 |
KR101561361B1 (ko) | 2015-10-16 |
AU2011342894A1 (en) | 2013-05-02 |
US9475770B2 (en) | 2016-10-25 |
JP5886869B2 (ja) | 2016-03-16 |
CN103298785B (zh) | 2016-04-20 |
ES2542433T3 (es) | 2015-08-05 |
EP2651892A1 (en) | 2013-10-23 |
CA2822016C (en) | 2016-10-25 |
EP2651892B1 (en) | 2015-04-22 |
AU2011342894B2 (en) | 2015-05-07 |
BR112013015072A2 (pt) | 2016-07-12 |
JP2014503530A (ja) | 2014-02-13 |
US20150038720A1 (en) | 2015-02-05 |
EP2937336A1 (en) | 2015-10-28 |
CA2822016A1 (en) | 2012-06-21 |
NZ612298A (en) | 2014-06-27 |
CN103298785A (zh) | 2013-09-11 |
WO2012080834A1 (en) | 2012-06-21 |
KR20130115322A (ko) | 2013-10-21 |
MX343653B (es) | 2016-11-07 |
WO2012080834A8 (en) | 2012-09-13 |
MX2013007020A (es) | 2014-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6741202A2 (es) | Síntesis de clorhidrato de metilfenidato a baja temperatura | |
BR112012025693A2 (pt) | métodos para operar um motor com um reformador de álcool | |
CY1121742T1 (el) | Αντισωματα s100a4 και θεραπευτικες χρησεις αυτων | |
BR112013025718A2 (pt) | processos para produzir e resfriar gás de síntese | |
ES2829950T8 (es) | Procedimiento para producir componentes endurecidos | |
BR112013031019A2 (pt) | teste diagnóstico molecular para câncer | |
BR112012025690A2 (pt) | métodos para operar um motor | |
EA201391602A1 (ru) | Контролируемое высвобождение иммунодепрессантов из синтетических наноносителей | |
BR112013014431A2 (pt) | camisa para tanque de armazenagem de gás | |
BRPI1010689A2 (pt) | "dsrna formulado por lipídios direcionados para o gene pcsk9" | |
MX2013009175A (es) | Composiciones que comprenden acido peroxi alfa-cetocarboxilico y metodos para producirlas y usarlas. | |
BR112012022208A2 (pt) | método para produção de combustível com alta octanagem derivado de biomassa | |
BR112014000164A2 (pt) | método para manufatura de uma casca de confeitaria aerada | |
BR112013029444A2 (pt) | composições e métodos para cultivar células a partir de epitélio tubo-ovariano humano normal e tumores tubo-ovarianos humanos | |
BR112014013862A2 (pt) | processos incluindo de alta produtividade, para fermentar gás de síntese | |
ES1073581Y (es) | Soporte para aparatos reproductores audio-visuales. | |
BR112013014103A2 (pt) | método para produzir um l-aminoácido | |
BR112013021775A2 (pt) | bactéria corineforme, e, método para produzir um l-aminoácido | |
BR112013015429A2 (pt) | conjunto de conexão para bombas submersíveis transportadas através de tubulação | |
CO6450617A2 (es) | Produccion de hidrocarburos de isopreno mejorada que usa cianobacterias diseñadas geneticamente | |
IT1403244B1 (it) | Procedimento per la produzione di lipidi da biomassa. | |
BR112012020855B8 (pt) | método para produzir um conjugado de biomolécula | |
IT1397886B1 (it) | Procedimento per la produzione di componenti di carburanti per autotrazione. | |
BRPI1007069A2 (pt) | Método para produzir um l-aminoácido. | |
SMT201600183B (it) | Base d’appoggio per torri |