CO6460732A2 - Antagonistas del receptor de cgrp - Google Patents

Antagonistas del receptor de cgrp

Info

Publication number
CO6460732A2
CO6460732A2 CO12068979A CO12068979A CO6460732A2 CO 6460732 A2 CO6460732 A2 CO 6460732A2 CO 12068979 A CO12068979 A CO 12068979A CO 12068979 A CO12068979 A CO 12068979A CO 6460732 A2 CO6460732 A2 CO 6460732A2
Authority
CO
Colombia
Prior art keywords
cgrp
antagonists
refers
disclosure
compounds
Prior art date
Application number
CO12068979A
Other languages
English (en)
Inventor
Guanglin Luo
Gene M Dubowchik
John E Macor
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43242489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6460732(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO6460732A2 publication Critical patent/CO6460732A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Abstract

La divulgación se refiere a los compuestos nuevos de formula I,incluidas las sales farmacéuticamente aceptables, que son antagonistas del receptor de CGRP. La divulgación también se refiere a composiciones farmacéuticas y métodos para usar los compuestos en el tratamiento de trastornos relacionados con CGRP, incluidas migrañas y otras cefaleas, vasodilatación neurogénica, inflamación neurogénica, lesión térmica, shock circulatorio, sofocos asociados con la menopausia, enfermedades inflamatorias de las vías aéreas tales como asma, y enfermedad pulmonar obstructiva crónica (EPOC).
CO12068979A 2009-10-14 2012-04-26 Antagonistas del receptor de cgrp CO6460732A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25147709P 2009-10-14 2009-10-14

Publications (1)

Publication Number Publication Date
CO6460732A2 true CO6460732A2 (es) 2012-06-15

Family

ID=43242489

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12068979A CO6460732A2 (es) 2009-10-14 2012-04-26 Antagonistas del receptor de cgrp

Country Status (34)

Country Link
US (2) US8314117B2 (es)
EP (1) EP2488512B1 (es)
JP (3) JP5836279B2 (es)
KR (3) KR101755742B1 (es)
CN (1) CN102656159B (es)
AR (2) AR078638A1 (es)
AU (1) AU2010306954B2 (es)
BR (1) BR112012008828B1 (es)
CA (2) CA2968176C (es)
CL (1) CL2012000925A1 (es)
CO (1) CO6460732A2 (es)
DK (1) DK2488512T3 (es)
EA (1) EA020409B1 (es)
ES (1) ES2441192T3 (es)
FR (1) FR22C1044I2 (es)
HK (1) HK1169390A1 (es)
HR (1) HRP20140111T1 (es)
HU (1) HUS2200033I1 (es)
IL (1) IL219120A (es)
LT (1) LTPA2022516I1 (es)
MX (1) MX2012004182A (es)
NL (1) NL301187I2 (es)
NO (1) NO2022033I1 (es)
NZ (1) NZ599281A (es)
PE (1) PE20121137A1 (es)
PL (1) PL2488512T3 (es)
PT (1) PT2488512E (es)
RS (1) RS53149B (es)
SI (1) SI2488512T1 (es)
SM (1) SMT201400019B (es)
TN (1) TN2012000139A1 (es)
TW (1) TWI465448B (es)
WO (1) WO2011046997A1 (es)
ZA (1) ZA201203452B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314117B2 (en) * 2009-10-14 2012-11-20 Bristol-Myers Squibb Company CGRP receptor antagonists
US8669368B2 (en) * 2010-10-12 2014-03-11 Bristol-Myers Squibb Company Process for the preparation of cycloheptapyridine CGRP receptor antagonists
US8748429B2 (en) * 2011-04-12 2014-06-10 Bristol-Myers Squibb Company CGRP receptor antagonists
MX352171B (es) * 2012-02-27 2017-11-13 Bristol Myers Squibb Co Sal de hemisulfato de n-(5s,6s,9r)-5-amino-6-(2,3-difluorofenil)-6 ,7,8,9-tetrahidro-5h-ciclohepta[b]piridin-9-il-4-(2-oxo-2,3-dihid ro-1h-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxilato.
EP2846801B1 (en) * 2012-05-09 2017-04-05 Merck Sharp & Dohme Corp. Pyridine cgrp receptor antagonists
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
TW201718574A (zh) * 2015-08-12 2017-06-01 美國禮來大藥廠 Ｃｇｒｐ受體拮抗劑
GB201519195D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
GB201519196D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
GB201519194D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP receptor antagonists
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
SG11202009199YA (en) 2018-03-25 2020-10-29 Biohaven Pharm Holding Co Ltd Rimegepant for cgrp related disorders
CN114805206A (zh) * 2021-01-27 2022-07-29 奥锐特药业(天津)有限公司 高光学纯度瑞美吉泮中间体的工业化制备方法
AU2022230300A1 (en) 2021-03-02 2023-09-21 Cgrp Diagnostics Gmbh Treatment and/or reduction of occurrence of migraine
WO2023026205A1 (en) 2021-08-24 2023-03-02 Cgrp Diagnostics Gmbh Preventative treatment of migraine
CN115850266A (zh) * 2021-09-26 2023-03-28 奥锐特药业(天津)有限公司 瑞美吉泮新晶型及其制备方法
CN116554164A (zh) * 2022-01-27 2023-08-08 奥锐特药业(天津)有限公司 一种瑞美吉泮的制备方法
WO2023175632A1 (en) * 2022-03-17 2023-09-21 Msn Laboratories Private Limited, R&D Center Solid state forms of (5s,6s,9r)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate and processes for preparation thereof
CN116478211B (zh) * 2022-04-19 2023-10-24 石家庄迪斯凯威医药科技有限公司 一种新型cgrp受体拮抗剂及其用途
CN115060824B (zh) * 2022-06-14 2024-03-12 浙江宏元药业股份有限公司 一种瑞米吉泮中间体对映异构体杂质的液相色谱检测方法
CN117466893A (zh) * 2022-07-29 2024-01-30 熙源安健医药（上海）有限公司 吡啶并环庚烷类衍生物及其制备方法和用途
CN115677694A (zh) * 2022-11-30 2023-02-03 南通常佑药业科技有限公司 一种瑞美吉泮的合成方法
CN117486798A (zh) * 2023-12-21 2024-02-02 南京威凯尔生物医药科技有限公司 一种瑞美吉泮中间体盐酸盐的晶型及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2355B1 (en) 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
US7855294B2 (en) 2004-03-05 2010-12-21 Banyu Pharmaceutical Co., Ltd. Cycloalkanopyridine derivative
US8039460B2 (en) 2004-10-13 2011-10-18 Merck Sharp & Dohme Corp. CGRP receptor antagonists
US20060084708A1 (en) 2004-10-14 2006-04-20 Bayer Materialscience Llc Rigid foams with good insulation properties and a process for the production of such foams
US7745427B2 (en) 2004-10-22 2010-06-29 Merck Sharp & Dohme Corp. CGRP receptor antagonists
CA2649158A1 (en) 2006-04-10 2007-10-25 Merck & Co., Inc. Process for the preparation of pyridine heterocycle cgrp antagonist intermediate
US8143403B2 (en) 2008-04-11 2012-03-27 Bristol-Myers Squibb Company CGRP receptor antagonists
US8044043B2 (en) 2008-04-11 2011-10-25 Bristol-Myers Squibb Company CGRP receptor antagonists
US8314117B2 (en) * 2009-10-14 2012-11-20 Bristol-Myers Squibb Company CGRP receptor antagonists

Also Published As

Publication number Publication date
FR22C1044I2 (fr) 2023-11-17
FR22C1044I1 (fr) 2022-09-30
EA020409B1 (ru) 2014-10-30
MX2012004182A (es) 2012-05-29
JP5836279B2 (ja) 2015-12-24
JP2013508281A (ja) 2013-03-07
HRP20140111T1 (hr) 2014-03-14
CL2012000925A1 (es) 2012-08-31
SMT201400019B (it) 2014-05-07
NO2022033I1 (no) 2022-07-22
JP6109874B2 (ja) 2017-04-05
CA2968176A1 (en) 2011-04-21
KR101990755B1 (ko) 2019-06-18
CA2777518A1 (en) 2011-04-21
US8314117B2 (en) 2012-11-20
JP2017125054A (ja) 2017-07-20
AR078638A1 (es) 2011-11-23
NZ599281A (en) 2013-01-25
BR112012008828A2 (pt) 2020-09-15
IL219120A (en) 2016-12-29
TWI465448B (zh) 2014-12-21
DK2488512T3 (en) 2014-02-24
EP2488512B1 (en) 2013-11-27
AU2010306954A1 (en) 2012-05-03
KR101875353B1 (ko) 2018-07-05
AR110069A2 (es) 2019-02-20
PL2488512T3 (pl) 2014-04-30
JP6258537B2 (ja) 2018-01-10
KR20180080343A (ko) 2018-07-11
WO2011046997A1 (en) 2011-04-21
HK1169390A1 (en) 2013-01-25
TW201118096A (en) 2011-06-01
BR112012008828B1 (pt) 2021-11-23
EA201270561A1 (ru) 2012-12-28
KR20170081737A (ko) 2017-07-12
KR101755742B1 (ko) 2017-07-07
US20110251223A1 (en) 2011-10-13
PE20121137A1 (es) 2012-08-30
RS53149B (en) 2014-06-30
ZA201203452B (en) 2014-10-29
SI2488512T1 (sl) 2014-02-28
US20130053570A1 (en) 2013-02-28
JP2015163625A (ja) 2015-09-10
CN102656159A (zh) 2012-09-05
KR20120087940A (ko) 2012-08-07
HUS2200033I1 (hu) 2022-08-28
LTPA2022516I1 (es) 2022-08-25
CA2777518C (en) 2017-07-04
ES2441192T3 (es) 2014-02-03
CN102656159B (zh) 2015-07-01
CA2968176C (en) 2019-11-26
AU2010306954B2 (en) 2016-05-26
IL219120A0 (en) 2012-06-28
NL301187I2 (nl) 2022-08-04
TN2012000139A1 (en) 2013-09-19
PT2488512E (pt) 2014-02-24
EP2488512A1 (en) 2012-08-22

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