CO6351823A2 - Método de identificación de factores de riesgo de la enfermedad - Google Patents

Método de identificación de factores de riesgo de la enfermedad

Info

Publication number
CO6351823A2
CO6351823A2 CO11028662A CO11028662A CO6351823A2 CO 6351823 A2 CO6351823 A2 CO 6351823A2 CO 11028662 A CO11028662 A CO 11028662A CO 11028662 A CO11028662 A CO 11028662A CO 6351823 A2 CO6351823 A2 CO 6351823A2
Authority
CO
Colombia
Prior art keywords
disease
identification
genetic variant
alzheimer
interest
Prior art date
Application number
CO11028662A
Other languages
English (en)
Spanish (es)
Inventor
Allen D Roses
Original Assignee
Zinfandel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669605&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6351823(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zinfandel Pharmaceuticals Inc filed Critical Zinfandel Pharmaceuticals Inc
Publication of CO6351823A2 publication Critical patent/CO6351823A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
CO11028662A 2008-08-12 2011-03-09 Método de identificación de factores de riesgo de la enfermedad CO6351823A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8820308P 2008-08-12 2008-08-12
US18667309P 2009-06-12 2009-06-12
US22464709P 2009-07-10 2009-07-10

Publications (1)

Publication Number Publication Date
CO6351823A2 true CO6351823A2 (es) 2011-12-20

Family

ID=41669605

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11028662A CO6351823A2 (es) 2008-08-12 2011-03-09 Método de identificación de factores de riesgo de la enfermedad

Country Status (31)

Country Link
US (4) US8815508B2 (https=)
EP (2) EP2324126B1 (https=)
JP (4) JP5833922B2 (https=)
KR (3) KR20160127181A (https=)
CN (3) CN104611421B (https=)
AU (3) AU2009282114B2 (https=)
BR (1) BRPI0917948A2 (https=)
CA (1) CA2735578C (https=)
CL (1) CL2011000298A1 (https=)
CO (1) CO6351823A2 (https=)
CY (1) CY1115412T1 (https=)
DK (1) DK2324126T3 (https=)
DO (1) DOP2011000052A (https=)
EA (1) EA021399B1 (https=)
ES (1) ES2463766T3 (https=)
GE (1) GEP20146107B (https=)
HR (1) HRP20140709T1 (https=)
IL (2) IL211140A (https=)
MA (1) MA32619B1 (https=)
ME (1) ME01898B (https=)
MX (1) MX2011001671A (https=)
NZ (3) NZ619895A (https=)
PE (3) PE20151924A1 (https=)
PL (1) PL2324126T3 (https=)
PT (1) PT2324126E (https=)
RS (1) RS53383B (https=)
SG (1) SG193793A1 (https=)
SI (1) SI2324126T1 (https=)
SM (1) SMT201400088B (https=)
WO (1) WO2010019550A2 (https=)
ZA (1) ZA201101095B (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846315B2 (en) * 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
ME01898B (me) 2008-08-12 2014-12-20 Zinfandel Pharmaceuticals Inc Metoda za identifikaciju faktora rizika od alchajmerove bolesti
US9646134B2 (en) 2010-05-25 2017-05-09 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
EP3657507A1 (en) 2010-05-25 2020-05-27 The Regents of The University of California Bambam: parallel comparative analysis of high-throughput sequencing data
AU2013204020B2 (en) * 2011-01-10 2016-03-31 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
AU2012205798B2 (en) 2011-01-10 2016-02-25 Takeda Pharmaceutical Company Limited Methods and drug products for treating Alzheimer's disease
BR112013017444A2 (pt) * 2011-01-10 2016-09-27 Zinfandel Pharmaceuticals Inc método de determinar o risco para o desenvolvimento da doença de alzheimer em um indivíduo, de tratar um indivíduo para a doença de alzheimer e de determinar um risco para desenvolver a doença de alzheimer em um paciente
US20120231457A1 (en) * 2011-03-10 2012-09-13 Nikolaos Tezapsidis Compositions and methods for assessing a genetic risk of developing late-onset alzheimer's disease (load)
US8718950B2 (en) 2011-07-08 2014-05-06 The Medical College Of Wisconsin, Inc. Methods and apparatus for identification of disease associated mutations
US20130080182A1 (en) * 2011-09-26 2013-03-28 Athleticode Inc. Methods For Using DNA Testing To Screen For Genotypes Relevant To Athleticism, Health And Risk Of Injury
WO2013106084A1 (en) * 2012-01-09 2013-07-18 Takeda Pharmaceutical Company Limited Methods and drug products for treating alzheimer's disease
GB201209689D0 (en) * 2012-05-31 2012-07-18 Imp Innovations Ltd Methods
US10586612B2 (en) 2013-03-01 2020-03-10 Actx, Inc. Cloud-like medical-information service
JPWO2015174544A1 (ja) * 2014-05-16 2017-04-20 国立研究開発法人国立精神・神経医療研究センター 精神疾患判定マーカー
CA2992616C (en) 2015-07-23 2023-01-03 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
KR102481305B1 (ko) * 2016-05-20 2022-12-26 세다르스-신나이 메디칼 센터 유전자에 기반한 염증성 장 질환의 진단
CN105969885A (zh) * 2016-06-24 2016-09-28 江苏雄鸣医药科技有限公司 一种阿尔兹海默症的基因诊断试剂盒
US11352625B2 (en) 2017-01-12 2022-06-07 Duke University Compositions and methods for disrupting the molecular mechanisms associated with mitochondrial dysfunction and neurodegenerative disease
CN110891417B (zh) * 2017-03-21 2023-05-23 杰克逊实验室 表达人APOE4和小鼠Trem2 p.R47H的遗传修饰小鼠及其使用方法
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
EP3662290A4 (en) 2017-07-31 2021-03-31 Quest Diagnostics Investments LLC Apolipoprotein e isotype detection by mass spectrometry
CA3078313A1 (en) * 2017-10-31 2019-05-09 Ge Healthcare Limited Medical system for diagnosing cognitive disease pathology and/or outcome
JP2021519963A (ja) * 2018-01-31 2021-08-12 キュアレーター, インコーポレイテッド 患者の生活の質、関与度及び持続性を改善するための疾患因子の早期フィードバック
KR102303638B1 (ko) * 2018-04-13 2021-09-23 사회복지법인 삼성생명공익재단 알츠하이머성 치매가 발병될 가능성 평가방법
WO2019215085A1 (en) 2018-05-07 2019-11-14 Biotx.Ai Gmbh Method for predicting the risk of late-onset alzheimer's diseases
EP3794345B1 (en) * 2018-05-18 2025-02-26 Anavex Life Sciences Corp. Optimized sigma-1 agonist method of responder selection and treatment
EP3626835A1 (en) * 2018-09-18 2020-03-25 Sistemas Genómicos, S.L. Method for genotypically identifying both alleles of at least one locus of a subject's hla gene
KR102127903B1 (ko) * 2019-01-29 2020-06-29 연세대학교 산학협력단 염증성 호흡기 질환의 진단용 바이오마커
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
AU2020285475A1 (en) * 2019-05-30 2021-12-23 PolygenRx Pty Ltd A method of treatment or prophylaxis
CN111187825A (zh) * 2020-01-15 2020-05-22 丁玎 阿尔兹海默症的tomm40基因及apoe基因的易感位点的检测方法及试剂盒
CN111593107A (zh) * 2020-01-15 2020-08-28 丁玎 阿尔兹海默症易感位点rs10119与rs71352238的检测方法及试剂盒
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
KR102535235B1 (ko) * 2020-11-25 2023-05-26 서울대학교산학협력단 알츠하이머병 발병 위험도 예측을 위한 단일염기다형성 마커 및 이의 용도
RU2757522C1 (ru) * 2021-06-02 2021-10-18 Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) СПОСОБ ПРОГНОЗИРОВАНИЯ РАЗВИТИЯ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 1 и 2 ТИПА (варианты)
US12367979B2 (en) 2021-07-21 2025-07-22 The Catholic University Of Korea Industry-Academic Cooperation Foundation Method and apparatus for determining dementia risk factors using deep learning
KR102770667B1 (ko) * 2022-04-22 2025-02-21 사회복지법인 삼성생명공익재단 유럽-동아시아인 데이터 기반 알츠하이머병 치매의 발병 위험군 또는 조기 증상 발현 위험군, 기억상실형 경도인지장애의 발병 위험군 및/또는 아밀로이드β 침착에 대한 PET 양성 위험군을 예측하기 위한 정보를 제공하는 방법

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US663780A (en) * 1898-09-09 1900-12-11 Wheeler & Wilson Mfg Co Trimming attachment for sewing-machines.
US4302204A (en) 1979-07-02 1981-11-24 The Board Of Trustees Of Leland Stanford Junior University Transfer and detection of nucleic acids
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US6060237A (en) * 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5112460A (en) * 1986-10-21 1992-05-12 Northeastern University High performance microcapillary gel electrophoresis
SG59988A1 (en) * 1987-09-04 1999-02-22 Beecham Group Plc Substituted thiazolidinedione derivatives
US5595883A (en) 1990-06-01 1997-01-21 E. R. Squibb & Sons, Inc. Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid
US5171750A (en) 1991-09-26 1992-12-15 The United States Of America As Represented By The Department Of Health And Human Services Substituted phenserines as specific inhibitors of acetylcholinesterase
TW263504B (https=) 1991-10-03 1995-11-21 Pfizer
US5326770A (en) * 1992-07-17 1994-07-05 The Du Pont Merck Pharmaceutical Company Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
EP0915090A1 (en) * 1992-09-10 1999-05-12 Eli Lilly And Company Compounds useful as hypoglycemic agents and for treating Alzheimer's disease
JP3265577B2 (ja) * 1992-10-13 2002-03-11 デューク・ユニバーシティ アポリポ蛋白eの4型イソ型の測定法
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
ES2100129B1 (es) * 1995-10-11 1998-02-16 Medichem Sa Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
JPH09176162A (ja) 1995-12-22 1997-07-08 Toubishi Yakuhin Kogyo Kk チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
US6128587A (en) 1997-01-14 2000-10-03 The Regents Of The University Of California Method and apparatus using Bayesian subfamily identification for sequence analysis
US5904824A (en) * 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
EP1006794B1 (en) * 1997-03-12 2007-11-28 Robert W. Esmond A method for treating or preventing alzheimer's disease
DE69809827D1 (de) * 1997-03-31 2003-01-16 Korea Res Inst Chem Tech Chinolinische Sulfid-Derivate als NMDA Rezeptor-Antagonisten und Verfahren zu ihrer Herstellung
CA2311125C (en) * 1997-11-19 2011-01-18 Takeda Chemical Industries, Ltd. Apoptosis inhibitor
US6964868B1 (en) 1998-01-28 2005-11-15 Nuvelo, Inc. Human genes and gene expression products II
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
JP2002534055A (ja) 1998-05-14 2002-10-15 カイロン コーポレイション ヒト遺伝子および遺伝子発現産物v
CA2330829C (en) 1998-06-16 2011-08-02 Variagenics, Inc. Methods for treating a neurological disease by determining bche genotype
JP2002526124A (ja) 1998-10-01 2002-08-20 ノヴァ モレキュラー インク. 変異型gpiiia対立遺伝子および/または変異型gpiib対立遺伝子の存在を決定することにより、神経系疾患のリスクを有する対象を治療又は同定する方法
ES2229781T3 (es) * 1998-11-10 2005-04-16 Genset Metodos programas y aparatos para identificar regiones genomicas que albergan un gen asociado con un rasgo detectable.
US6191154B1 (en) * 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
CN1078616C (zh) * 1998-12-16 2002-01-30 中国科学院上海生命科学研究中心 一种检测样品中是否存在老年痴呆病基因的方法和试剂盒
JP2000273040A (ja) * 1999-01-19 2000-10-03 Sankyo Co Ltd トログリタゾンを含有するアポトーシス抑制剤
US6401043B1 (en) 1999-04-26 2002-06-04 Variagenics, Inc. Variance scanning method for identifying gene sequence variances
WO2000066102A2 (en) 1999-04-29 2000-11-09 City Of Hope Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (age's)
US6573049B1 (en) 1999-07-26 2003-06-03 Nuvelo, Inc. Genotyping of the paraoxonase 1 gene for prognosing, diagnosing, and treating a disease
DE19936719A1 (de) 1999-08-06 2001-02-15 Gruenenthal Gmbh Substituierte 1,5-Dihydropyrrol-2-on-Derivate
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
AR030920A1 (es) 1999-11-16 2003-09-03 Smithkline Beecham Plc Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6532467B1 (en) * 2000-04-10 2003-03-11 Sas Institute Inc. Method for selecting node variables in a binary decision tree structure
US6432985B2 (en) * 2000-04-25 2002-08-13 Hoffmann-La Roche Inc. Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
WO2002030860A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
MXPA03003024A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de sulfoxido y bis-sulfoxido y composiciones para el control de colesterol y usos relacionados.
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
AU2002211666A1 (en) * 2000-10-11 2002-04-22 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
AU1846102A (en) 2000-11-24 2002-06-03 Cardimmune Ltd Methods employing and compositions containing defined oxidized phospholipids forprevention and treatment of atherosclerosis
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6495335B2 (en) 2000-12-07 2002-12-17 Mario Chojkier Compositions and methods for diagnosing alzheimer's disease
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
US6680299B2 (en) * 2001-07-27 2004-01-20 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
US20050020694A1 (en) 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US6828462B2 (en) 2001-11-07 2004-12-07 Merz Pharma Gmbh & Co. Kgaa Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists
US7132244B2 (en) * 2001-11-21 2006-11-07 Syn X Pharma, Inc. Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
US7052849B2 (en) 2001-11-23 2006-05-30 Syn X Pharma, Inc. Protein biopolymer markers predictive of insulin resistance
US7135297B2 (en) 2001-11-23 2006-11-14 Nanogen Inc. Protein biopolymer markers indicative of insulin resistance
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
JPWO2004005510A1 (ja) 2002-07-05 2005-11-04 塩野義製薬株式会社 新規Nogo受容体様ポリペプチドおよびそのDNA
US20040265849A1 (en) * 2002-11-22 2004-12-30 Applera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
CN100571701C (zh) * 2002-12-24 2009-12-23 贝卢斯健康(国际)有限公司 治疗β淀粉样蛋白相关疾病的治疗性制品
WO2004075010A2 (en) * 2003-02-14 2004-09-02 Intergenetics Incorporated Statistically identifying an increased risk for disease
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
US20050004179A1 (en) * 2003-05-22 2005-01-06 Pedersen Ward A. Methods and materials for treating, detecting, and reducing the risk of developing Alzheimer's Disease
WO2005003766A2 (en) 2003-06-13 2005-01-13 Whitehead Institute For Biomedical Research Methods of regulating metabolism and mitochondrial function
US8084645B2 (en) 2003-09-19 2011-12-27 Chugai Seiyaku Kabushiki Kaisha 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors
JP2007526764A (ja) 2004-01-22 2007-09-20 ジェネッサンス ファーマシューティカルズ,インコーポレイティド アルツハイマー病の発症年齢に関連するapoe遺伝子マーカー
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2006054297A2 (en) 2004-11-17 2006-05-26 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
WO2006083854A2 (en) * 2005-01-31 2006-08-10 Perlegen Sciences, Inc. Genetic basis of alzheimer's disease and diagnosis and treatment thereof
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
WO2007038115A2 (en) 2005-09-22 2007-04-05 Sb Pharmco Puerto Rico Inc. Ppar-gamma agonists for improvement of cognitive function in apoe4 negative patients
US7608412B2 (en) 2005-10-05 2009-10-27 Auburn University P62 as a diagnostic tool for alzheimer's disease
UA96441C2 (ru) 2006-03-16 2011-11-10 Метаболик Солюшнз Девелопмент Компани Фармацевтическая композиция, которая содержит аналог тиазолидиндиона митоглитазон, для лечения заболеваний, опосредованных метаболическим воспалением
US20080045582A1 (en) 2006-05-15 2008-02-21 Issam Zineh ENA-78 Gene Polymorphisms and Protein Concentrations as Diagnostic and Prognostic Tools
CA2653974A1 (en) 2006-05-30 2008-02-14 Mayo Foundation For Medical Education And Research Detecting and treating dementia
US7651840B2 (en) * 2006-07-14 2010-01-26 Celera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
AU2007299920A1 (en) 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
US20090042849A1 (en) 2006-12-06 2009-02-12 Yochai Birnbaum Phosphorylation of 5-lipoxygenase at ser523 and uses thereof
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
GB0702537D0 (en) 2007-02-12 2007-03-21 Leuven K U Res & Dev Treatment for excessive adiposity
US20080286876A1 (en) 2007-05-14 2008-11-20 Chissoe Stephanie GENES ASSOCIATED WITH ALZHEIMER'S DISEASE - Hltdip
WO2008147562A2 (en) 2007-05-25 2008-12-04 Childrens's Medical Center Corporation Dietary formulations and methods for treatment of inflammation and other disorders
TW200914006A (en) 2007-07-12 2009-04-01 Takeda Pharmaceutical Coated preparation
WO2010123720A1 (en) 2009-04-23 2010-10-28 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
US8846315B2 (en) * 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
ME01898B (me) * 2008-08-12 2014-12-20 Zinfandel Pharmaceuticals Inc Metoda za identifikaciju faktora rizika od alchajmerove bolesti
US20100136584A1 (en) 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
US20100092470A1 (en) 2008-09-22 2010-04-15 Icb International, Inc. Antibodies, analogs and uses thereof
EP2358912B1 (en) 2008-10-30 2016-10-12 Caris Life Sciences Switzerland Holdings GmbH Methods for assessing rna patterns
GB2463401B (en) 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
WO2011109440A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics
AU2009326965A1 (en) 2008-12-12 2011-06-23 Poxel Tetrahydrotriazine compounds for treating diseases associated with AMPK activity
CA2751227C (en) 2009-02-02 2021-10-26 Laila Nutraceuticals Composition from sphaeranthus indicus and garcinia mangostana for the control of metabolic syndrome
CA2709621A1 (en) 2009-09-11 2011-03-11 Electrophoretics Limited Markers and methods relating to the assessment of alzheimer's disease
US8426151B2 (en) 2010-02-10 2013-04-23 Companion Diagnostics Inc. Systems and methods for the detection of biomarkers
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
AU2012205798B2 (en) * 2011-01-10 2016-02-25 Takeda Pharmaceutical Company Limited Methods and drug products for treating Alzheimer's disease

Also Published As

Publication number Publication date
EP2789695B1 (en) 2019-10-30
JP6815372B2 (ja) 2021-01-20
NZ591107A (en) 2012-08-31
IL211140A0 (en) 2011-04-28
EP2324126A4 (en) 2012-05-30
SI2324126T1 (sl) 2014-07-31
CN102177436A (zh) 2011-09-07
SMT201400088B (it) 2014-09-08
WO2010019550A4 (en) 2011-01-13
KR20110063453A (ko) 2011-06-10
US20180363060A1 (en) 2018-12-20
EA021399B1 (ru) 2015-06-30
PL2324126T3 (pl) 2014-09-30
AU2009282114B2 (en) 2016-04-07
US20150073025A1 (en) 2015-03-12
AU2009282114A1 (en) 2010-02-18
EA201170332A1 (ru) 2011-10-31
EP2789695A1 (en) 2014-10-15
KR20160127181A (ko) 2016-11-02
US10865449B2 (en) 2020-12-15
AU2016204678A1 (en) 2016-07-21
GEP20146107B (en) 2014-06-10
KR20180053432A (ko) 2018-05-21
MA32619B1 (fr) 2011-09-01
KR101729340B1 (ko) 2017-04-24
CN104611421A (zh) 2015-05-13
PT2324126E (pt) 2014-06-02
AU2016204678B2 (en) 2018-04-19
US20110189165A1 (en) 2011-08-04
NZ619895A (en) 2015-12-24
JP2019076095A (ja) 2019-05-23
RS53383B (sr) 2014-10-31
EP2324126A2 (en) 2011-05-25
US8815508B2 (en) 2014-08-26
HK1153511A1 (en) 2012-03-30
SG193793A1 (en) 2013-10-30
JP2018075005A (ja) 2018-05-17
AU2018202373A1 (en) 2018-04-26
CA2735578C (en) 2018-10-23
MX2011001671A (es) 2011-06-17
CN104805198B (zh) 2019-04-26
US20210095345A1 (en) 2021-04-01
WO2010019550A3 (en) 2010-04-22
CN104611421B (zh) 2018-08-07
ME01898B (me) 2014-12-20
JP2016047058A (ja) 2016-04-07
JP5833922B2 (ja) 2015-12-16
HRP20140709T1 (hr) 2014-09-26
AU2009282114A2 (en) 2011-04-28
IL239277A0 (en) 2015-07-30
DOP2011000052A (es) 2011-04-15
PE20110565A1 (es) 2011-09-02
CN104805198A (zh) 2015-07-29
ZA201101095B (en) 2012-07-25
IL211140A (en) 2015-06-30
JP2012500004A (ja) 2012-01-05
CL2011000298A1 (es) 2012-07-13
BRPI0917948A2 (pt) 2017-06-20
WO2010019550A2 (en) 2010-02-18
NZ710443A (en) 2019-03-29
EP2324126B1 (en) 2014-04-23
CA2735578A1 (en) 2010-02-18
ES2463766T3 (es) 2014-05-29
CN102177436B (zh) 2015-05-13
PE20151924A1 (es) 2016-01-13
PE20150362A1 (es) 2015-03-20
CY1115412T1 (el) 2017-01-04
DK2324126T3 (da) 2014-06-16

Similar Documents

Publication Publication Date Title
CO6351823A2 (es) Método de identificación de factores de riesgo de la enfermedad
CO6331372A2 (es) Inhibidor de parp 4-yodo-3-nitrobenzamida o un metabolito de la misma
CO2021009163A2 (es) Composiciones de agente de arni de proteína precursora de amiloide (app) y método de uso de las mismas
UY31816A (es) Agente para el tratamiento y/o prevención de una enfemedad autoinmune y para la formación de células t reguladoras
ES2571104T3 (es) Estabilización del ARN y extracción del ARN presente en células intactas dentro de una muestra de sangre
AR047841A1 (es) Metodos y composiciones para el tratamiento de transtornos inmunoinflamatorios
MX2009002936A (es) Biomarcadores de la modulacion de objetivo, eficacia, diagnostico, y/o pronostico para los inhibidores de raf.
BRPI0710123A2 (pt) Previsão de heterose e outros traços por análise de transcriptoma.
BR112013030366A2 (pt) método, aparelho e produto de programa de computador
AR088827A1 (es) Metodos para tratar, diagnosticar, y monitorear la enfermedad de alzheimer
CR9686A (es) Metodo para la prediccion de la respuesta a un tratamiento
CR20170406A (es) Arni variante
CY1112579T1 (el) Μεθοδοι και συνθεσεις για τη διαγνωση του ηλικιακου εκφυλισμου της ωχρας κηλιδας
PA8800801A1 (es) Regimenes de inmunoterapia dependientes del estado apoe
BR112013024190A2 (pt) microdispositivo para detectar ou tratar doença e métodos para fabricar microdispositivo e para detectar doença em indivíduo em necessidade do mesmo
MX2015012176A (es) Metodos de usar zscan4 para rejuvenecer celulas humanas.
CL2008001057A1 (es) Agente para el tratamiento de micosis producida por saprolegnia, achlya y/o aphanomyces en peces, el cual comprende al menos un fungicida seleccionado entre a) inhibidores de l a mitosis y division celular, b) inhiidores de la sintesis de ergosterol o, c) derivados de piridina, benzopiranona, carbonitrilo,quinolinas, entre otras.
CL2013003307A1 (es) Agente que comprende ciazofamida o fenamidona; y su uso para tratar micosis en peces e invertebrados en todos sus estadios de desarrollo causada por hongos de los generos saprolegnia, achlya y aphanomyces (div.sol.n°1056-08).
CL2023003123A1 (es) Métodos de identificación de pacientes con posibilidad de beneficiarse de tratamiento con inhibidor de telomerasa
AR072949A1 (es) Analisis de sustratos que tienen agentes depositados sobre los mismos
CL2013000709A1 (es) Composicion que contiene nifurtimox y un antihelmintico seleccionado de: pf1022, emopdepsido, tribendimidina, amidantel, bay d 9216, praziquantel o benzoato de bencilo; util en el tratamiento de enfermedades causadas por giardias (div. sol. 1577-10).
ECSP11010884A (es) Método de identificación de factores de riesgo de la enfermedad
NI201000069A (es) Composiciones para inhalación que comprenden ácido de monteleukast y un inhibidor pde-4 o un corticosteroide inhalado.
DOP2012000316A (es) Metodo para diagnosticar una respuesta al tratamiento en sujetos con esclerosis multiple
NO20082129L (no) Middel til nedbrytning av nukleinsyrer samt fremgangsmate for nedbrytning av nukleinsyrer

Legal Events

Date Code Title Description
FC Application refused