CO6321258A2 - Benzofuropirimidinonas como inhibidores de proteina de quinasa - Google Patents

Benzofuropirimidinonas como inhibidores de proteina de quinasa

Info

Publication number
CO6321258A2
CO6321258A2 CO10088575A CO10088575A CO6321258A2 CO 6321258 A2 CO6321258 A2 CO 6321258A2 CO 10088575 A CO10088575 A CO 10088575A CO 10088575 A CO10088575 A CO 10088575A CO 6321258 A2 CO6321258 A2 CO 6321258A2
Authority
CO
Colombia
Prior art keywords
optionally substituted
alkyl
aryl
halo
aminoalkyl
Prior art date
Application number
CO10088575A
Other languages
English (en)
Spanish (es)
Inventor
David S Brown
Hongwang Du
Maurizio Franzini
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40383673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6321258(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of CO6321258A2 publication Critical patent/CO6321258A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CO10088575A 2007-12-21 2010-07-21 Benzofuropirimidinonas como inhibidores de proteina de quinasa CO6321258A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US890707P 2007-12-21 2007-12-21
US7097108P 2008-03-25 2008-03-25

Publications (1)

Publication Number Publication Date
CO6321258A2 true CO6321258A2 (es) 2011-09-20

Family

ID=40383673

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10088575A CO6321258A2 (es) 2007-12-21 2010-07-21 Benzofuropirimidinonas como inhibidores de proteina de quinasa

Country Status (20)

Country Link
US (1) US20090247559A1 (zh)
EP (1) EP2097419B1 (zh)
JP (1) JP2011507908A (zh)
KR (1) KR20100098714A (zh)
CN (1) CN101965351A (zh)
AR (1) AR069869A1 (zh)
AT (1) ATE510839T1 (zh)
AU (1) AU2008345560A1 (zh)
BR (1) BRPI0821573A2 (zh)
CA (1) CA2712358A1 (zh)
CL (1) CL2008003873A1 (zh)
CO (1) CO6321258A2 (zh)
EA (1) EA019785B1 (zh)
IL (1) IL206416A0 (zh)
MX (1) MX2010006799A (zh)
NZ (1) NZ586936A (zh)
PE (1) PE20091669A1 (zh)
TW (1) TW200930375A (zh)
WO (1) WO2009086264A1 (zh)
ZA (1) ZA201004243B (zh)

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DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
PL2361250T3 (pl) 2008-12-22 2014-01-31 Merck Patent Gmbh Nowe polimorficzne formy diwodorofosforanu 6-(1-metylo-1H-pirazolo-4-ylo)-2-{3-[5-(2-morfolino-4-ylo-etoksy)-pirymidyno-2-ylo]-benzylo}2H-pirydazyno-3-onowego oraz sposoby ich otrzymywania
US9744183B2 (en) 2009-07-06 2017-08-29 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
DK2734208T3 (en) 2011-07-19 2017-06-19 Wave Life Sciences Ltd PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
RU2015104762A (ru) 2012-07-13 2018-08-31 Уэйв Лайф Сайенсес Лтд. Хиральный контроль
CN104684923B (zh) 2012-07-13 2018-09-28 株式会社新日本科学 手性核酸佐剂
EP2872485B1 (en) 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Asymmetric auxiliary group
CN102875558A (zh) * 2012-11-05 2013-01-16 贵州大学 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
CN103044370A (zh) * 2012-12-28 2013-04-17 山东邹平大展新材料有限公司 一种5-（哌嗪-1-基）苯并呋喃-2-甲酰胺的制备方法
CN104045642B (zh) * 2013-03-14 2016-08-24 上海医药工业研究院 含嘧啶或吡啶的稠环化合物及其作为抗肿瘤药物的应用
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
PT3094728T (pt) 2014-01-16 2022-05-19 Wave Life Sciences Ltd Desenho quiral
JP6569908B2 (ja) 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 抗がん剤組成物
US9676757B2 (en) 2014-02-27 2017-06-13 Merck Patent Gmbh Heterocyclic compounds as NaV channel inhibitors and uses thereof
WO2015152319A1 (ja) * 2014-04-02 2015-10-08 株式会社 三和化学研究所 ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法
KR101837565B1 (ko) 2014-08-06 2018-03-12 삼성에스디아이 주식회사 유기 화합물, 유기 광전자 소자 및 표시 장치
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
EP3538523B1 (en) 2016-11-08 2021-05-19 Cancer Research Technology Limited Pyrimidinone derivatives as cdc7 inhibitors
NL2021185B1 (en) 2018-06-26 2020-01-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Combination Therapy and Use Thereof for Treating Cancer
MA53726A (fr) 2018-09-25 2022-05-11 Incyte Corp Composés pyrazolo[4,3-d]pyrimidine en tant que modulateurs des alk2 et/ou fgfr
CN111689947B (zh) * 2019-03-13 2023-07-14 鲁南制药集团股份有限公司 替加氟-l-脯氨酸共晶体及其制备方法
JP2023512281A (ja) * 2020-02-03 2023-03-24 ゲイン セラピューティクス エスアー Ｍｐｓ１を処置するための併用療法
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
EP4227308A1 (en) * 2020-10-05 2023-08-16 Japan Tobacco Inc. Tetrahydrobenzofurodiazepinone compounds and pharmaceutical applications thereof
US20240092783A1 (en) 2021-03-18 2024-03-21 Merck Patent Gmbh Heteroaromatic compounds for organic electroluminescent devices
WO2023156386A2 (en) * 2022-02-16 2023-08-24 Duke Street Bio Limited Pharmaceutical compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112248A0 (en) * 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
WO2002051849A1 (fr) 2000-12-26 2002-07-04 Daiichi Pharmaceutical Co., Ltd. Inhibiteurs cdk4
CA2444598A1 (en) * 2001-04-20 2003-10-31 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of gsk-3
US7345046B2 (en) * 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents
WO2006023381A1 (en) * 2004-08-16 2006-03-02 Taigen Biotechnology Pyrimidinone compounds
EP1812113A1 (en) * 2004-11-11 2007-08-01 Argenta Discovery Limited Pyrimidine compounds as histamine modulators
EP1776982A1 (en) * 2005-10-18 2007-04-25 Argenta Discovery Limited Pyrimidine compounds as histamine modulators

Also Published As

Publication number Publication date
TW200930375A (en) 2009-07-16
EA019785B1 (ru) 2014-06-30
AR069869A1 (es) 2010-02-24
BRPI0821573A2 (pt) 2016-08-09
AU2008345560A1 (en) 2009-07-09
EP2097419A1 (en) 2009-09-09
NZ586936A (en) 2012-07-27
JP2011507908A (ja) 2011-03-10
CA2712358A1 (en) 2009-07-09
ATE510839T1 (de) 2011-06-15
IL206416A0 (en) 2010-12-30
ZA201004243B (en) 2011-03-30
EA201070786A1 (ru) 2011-02-28
CN101965351A (zh) 2011-02-02
MX2010006799A (es) 2010-10-05
KR20100098714A (ko) 2010-09-08
US20090247559A1 (en) 2009-10-01
PE20091669A1 (es) 2009-12-06
CL2008003873A1 (es) 2009-06-26
WO2009086264A1 (en) 2009-07-09
EP2097419B1 (en) 2011-05-25

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