CO6210821A2 - Metodo para la produccion de clorhidrato de prasugrel de lata pureza - Google Patents
Metodo para la produccion de clorhidrato de prasugrel de lata purezaInfo
- Publication number
- CO6210821A2 CO6210821A2 CO09093300A CO09093300A CO6210821A2 CO 6210821 A2 CO6210821 A2 CO 6210821A2 CO 09093300 A CO09093300 A CO 09093300A CO 09093300 A CO09093300 A CO 09093300A CO 6210821 A2 CO6210821 A2 CO 6210821A2
- Authority
- CO
- Colombia
- Prior art keywords
- compound represented
- formula
- solvent
- prasugrel
- hydraulate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
1.- Un método para producir un clorhidrato de prasugrel, que comprende las etapas de: (i) cloración de un compuesto representado por la fórmula:al agregar un agente de cloración opcionalmente a gotas a este en un solvente; (ii) reacción del compuesto resultante representado por la fórmula:con un compuesto representado por la fórmula general:en donde R representa un grupo protector para un grupo hidroxilo, o una sal del mismo en un solvente en presencia de una base; (iii) acetilación del compuesto resultante representado por la fórmula general:en donde R tiene el mismo significado al dado anteriormente, mediante la reacción de un agente de acetilación con este en un solvente en presencia de una base y un catalizador de acilación; y (iv) la adición de ácido clorhídrico, opcionalmente a gotas, al compuesto resultante representado por la fórmula:
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007053093 | 2007-03-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6210821A2 true CO6210821A2 (es) | 2010-10-20 |
Family
ID=39738173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09093300A CO6210821A2 (es) | 2007-03-02 | 2009-09-02 | Metodo para la produccion de clorhidrato de prasugrel de lata pureza |
Country Status (25)
Country | Link |
---|---|
US (2) | US20100094013A1 (es) |
EP (1) | EP2123656B1 (es) |
JP (1) | JP5363307B2 (es) |
KR (1) | KR101505212B1 (es) |
CN (2) | CN101675058A (es) |
AU (1) | AU2008222000B2 (es) |
BR (1) | BRPI0808034A2 (es) |
CA (1) | CA2679925C (es) |
CO (1) | CO6210821A2 (es) |
CY (1) | CY1115518T1 (es) |
DK (1) | DK2123656T3 (es) |
ES (1) | ES2487190T3 (es) |
HK (1) | HK1136278A1 (es) |
HR (1) | HRP20140668T1 (es) |
IL (1) | IL200647A (es) |
MX (1) | MX2009009413A (es) |
MY (1) | MY151726A (es) |
NZ (1) | NZ579993A (es) |
PL (1) | PL2123656T3 (es) |
PT (1) | PT2123656E (es) |
RU (1) | RU2435776C2 (es) |
SI (1) | SI2123656T1 (es) |
TW (1) | TWI417295B (es) |
WO (1) | WO2008108291A1 (es) |
ZA (1) | ZA200906850B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009011619A (es) | 2007-04-27 | 2010-01-18 | Cydex Pharmaceuticals Inc | Formulaciones que contienen clopidogrel y eter sulfoalquilico-ciclodextrina y metodos de uso. |
US20100261908A1 (en) * | 2007-11-09 | 2010-10-14 | Dr. Reddy's Laboratories Ltd. | Processes for the preparation of prasugrel , and its salts and polymorphs |
CN101684124B (zh) * | 2008-09-22 | 2013-11-13 | 广州赫尔氏药物开发有限公司 | 新的具有抗凝血作用的化合物 |
CN103936756B (zh) * | 2008-09-22 | 2017-09-19 | 广州赫尔氏药物开发有限公司 | 具有抗凝血作用的化合物 |
CN101486635B (zh) * | 2009-02-27 | 2012-10-10 | 上海医药工业研究院 | α-环丙基羰基-2-氟苄基卤素的制备方法 |
WO2010132711A1 (en) | 2009-05-13 | 2010-11-18 | Cydex Pharmaceuticals, Inc. | Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same |
CN101993447A (zh) * | 2009-08-26 | 2011-03-30 | 浙江华海药业股份有限公司 | 一种人工合成普拉格雷的方法 |
HU229031B1 (en) | 2009-12-21 | 2013-07-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing prasurgel and its intermediate |
HU229035B1 (en) | 2009-12-21 | 2013-07-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing prasurgel |
CN101735241A (zh) * | 2009-12-24 | 2010-06-16 | 浙江普洛家园药业有限公司 | 普拉格雷中间体及其制备方法 |
CN102869668A (zh) | 2010-03-09 | 2013-01-09 | 斯索恩有限公司 | 制备普拉格雷的方法 |
US20130053569A1 (en) * | 2010-03-23 | 2013-02-28 | Jayaraman Venkat Raman | Process for the preparation of prasugrel hcl salt |
WO2012001486A1 (en) * | 2010-06-28 | 2012-01-05 | Mayuka Labs Pvt. Ltd. | An improved process for the preparation of prasugrel hydrochloride and its intermediates |
WO2012018791A2 (en) * | 2010-08-06 | 2012-02-09 | Dr. Reddy's Laboratories Ltd. | Preparation of prasugrel hydrochloride |
CN101948479B (zh) * | 2010-09-29 | 2013-01-30 | 横店集团家园化工有限公司 | 普拉格雷中间体及其制备方法 |
HUP1000565A2 (en) | 2010-10-22 | 2012-05-02 | Egis Gyogyszergyar Nyrt | Process for the preparation of pharmaceutically active compound and intermediers |
CN102101827B (zh) * | 2010-11-15 | 2013-07-03 | 山东新华制药股份有限公司 | 一种普拉格雷中间体α-环丙羰基-2-氟苄基卤的制备方法 |
US9556196B2 (en) | 2011-04-14 | 2017-01-31 | Guangzhou Heershi Pharma Development Co., Ltd | Anti-platelet compound addition salt |
CN102746318A (zh) * | 2011-04-20 | 2012-10-24 | 上海信谊药厂有限公司 | 用于制备普拉格雷盐酸盐的方法 |
CN102276623A (zh) * | 2011-06-13 | 2011-12-14 | 安徽省虹升生物科技有限公司 | 一种利用有机硅保护剂进行制备普拉格雷的新方法 |
CN102838618A (zh) | 2011-06-22 | 2012-12-26 | 广东东阳光药业有限公司 | 一种制备普拉格雷的方法及普拉格雷盐酸盐新晶型 |
WO2013024399A1 (en) * | 2011-08-12 | 2013-02-21 | Alembic Pharmaceuticals Limited | Improved method for quantitative determination of prasugrel hydrochloride |
CN102977115B (zh) * | 2012-11-16 | 2015-01-21 | 江苏先声药业有限公司 | 普拉格雷游离碱的合成新方法 |
CN105085541A (zh) * | 2014-05-07 | 2015-11-25 | 江苏先声药业有限公司 | 一种普拉格雷类似物的制备方法 |
HU231079B1 (hu) | 2016-06-23 | 2020-06-29 | Richter Gedeon Nyrt. | Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával |
CN112047959A (zh) * | 2020-10-21 | 2020-12-08 | 深圳市祥根生物科技有限公司 | 一种普拉格雷开环氯代杂质的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI101150B (fi) * | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
JP3840662B2 (ja) * | 1994-10-07 | 2006-11-01 | 宇部興産株式会社 | 2−シリルオキシ−テトラヒドロチエノピリジン類、その塩およびその製造方法 |
WO2002004461A1 (fr) * | 2000-07-06 | 2002-01-17 | Sankyo Company, Limited | Sels d'addition acides de dérivés hydropyridine |
JP4001199B2 (ja) * | 2000-07-06 | 2007-10-31 | 第一三共株式会社 | ヒドロピリジン誘導体酸付加塩 |
PT1350511E (pt) * | 2000-12-25 | 2008-10-28 | Ube Industries | Composições medicinais contendo aspirina |
JP4029974B2 (ja) * | 2001-12-21 | 2008-01-09 | 第一三共株式会社 | ヒドロピリジン誘導体酸付加塩を含有する医薬 |
JP2006525328A (ja) * | 2003-05-05 | 2006-11-09 | イーライ リリー アンド カンパニー | 心疾患の治療方法 |
TWI318571B (en) * | 2005-06-10 | 2009-12-21 | Lilly Co Eli | Formulation of a thienopyridine platelet aggregation inhibitor |
TWI392681B (zh) * | 2006-04-06 | 2013-04-11 | Daiichi Sankyo Co Ltd | 高純度普拉格雷及其酸加成鹽之製法 |
-
2008
- 2008-02-29 AU AU2008222000A patent/AU2008222000B2/en active Active
- 2008-02-29 CN CN200880014554A patent/CN101675058A/zh active Pending
- 2008-02-29 CN CN2011103661430A patent/CN102424686A/zh active Pending
- 2008-02-29 TW TW097107016A patent/TWI417295B/zh active
- 2008-02-29 JP JP2009502556A patent/JP5363307B2/ja active Active
- 2008-02-29 RU RU2009136445/04A patent/RU2435776C2/ru active
- 2008-02-29 MX MX2009009413A patent/MX2009009413A/es active IP Right Grant
- 2008-02-29 EP EP08712139.8A patent/EP2123656B1/en active Active
- 2008-02-29 CA CA2679925A patent/CA2679925C/en active Active
- 2008-02-29 PL PL08712139T patent/PL2123656T3/pl unknown
- 2008-02-29 ES ES08712139.8T patent/ES2487190T3/es active Active
- 2008-02-29 NZ NZ579993A patent/NZ579993A/en not_active IP Right Cessation
- 2008-02-29 MY MYPI20093639 patent/MY151726A/en unknown
- 2008-02-29 BR BRPI0808034-8A2A patent/BRPI0808034A2/pt not_active Application Discontinuation
- 2008-02-29 DK DK08712139.8T patent/DK2123656T3/da active
- 2008-02-29 SI SI200831267T patent/SI2123656T1/sl unknown
- 2008-02-29 KR KR1020097018316A patent/KR101505212B1/ko active IP Right Grant
- 2008-02-29 WO PCT/JP2008/053617 patent/WO2008108291A1/ja active Application Filing
- 2008-02-29 PT PT87121398T patent/PT2123656E/pt unknown
- 2008-02-29 US US12/449,810 patent/US20100094013A1/en not_active Abandoned
-
2009
- 2009-08-31 IL IL200647A patent/IL200647A/en active IP Right Grant
- 2009-09-02 CO CO09093300A patent/CO6210821A2/es not_active Application Discontinuation
- 2009-10-01 ZA ZA200906850A patent/ZA200906850B/xx unknown
-
2010
- 2010-03-17 HK HK10102810.2A patent/HK1136278A1/xx unknown
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2012
- 2012-12-06 US US13/706,548 patent/US20130345428A1/en not_active Abandoned
-
2014
- 2014-07-14 HR HRP20140668AT patent/HRP20140668T1/hr unknown
- 2014-09-02 CY CY20141100700T patent/CY1115518T1/el unknown
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Legal Events
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