CO6190512A2 - Compuestos antagonistas del receptor de glucagon composiciones que contienen dichos compuestos y procedimientos de uso - Google Patents

Compuestos antagonistas del receptor de glucagon composiciones que contienen dichos compuestos y procedimientos de uso

Info

Publication number
CO6190512A2
CO6190512A2 CO09033167A CO09033167A CO6190512A2 CO 6190512 A2 CO6190512 A2 CO 6190512A2 CO 09033167 A CO09033167 A CO 09033167A CO 09033167 A CO09033167 A CO 09033167A CO 6190512 A2 CO6190512 A2 CO 6190512A2
Authority
CO
Colombia
Prior art keywords
alkyl
alkenyl
alkoxy
optionally substituted
group
Prior art date
Application number
CO09033167A
Other languages
English (en)
Inventor
John E Stelmach
Emma R Parmee
James R Tata
Keith Rosauer
Ronald Kim
Amy R Bittner
Jiang Chang
Christopher Joseph Sinz
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38982644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6190512(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CO6190512A2 publication Critical patent/CO6190512A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

1.- Un compuesto representado por la fórmula I:o una de sus sales o solvatos farmacéuticamente aceptables, en la que: el anillo A representa un grupo fenilo o naftilo; cada R1 y R2 representa H o se selecciona del grupo consistente en halo, CN, OH, NO2, CO2Ra, NRaRb, S(O)pRa, alquilo C1-10, alquenilo C2-10 o alcoxi C1-10, estando las porciones alquilo y alquenilo de alquilo C1-10, alquenilo C2-10 y alcoxi C1-10 opcionalmente sustituidas con 1-5 átomos de halo hasta perhalo; y además opcionalmente sustituidas con 1 grupo seleccionado de OH, oxo y alcoxi C1-6; p representa 0, 1 ó 2; cada Ra y Rb representa independientemente H o alquilo C1-4 opcionalmente sustituido con 1-5 átomos de halo hasta perhalo; y además opcionalmente sustituidos con 1 grupo seleccionado de OH, oxo y alcoxi C1-6;R3 representa alquilo C1-6 o alquenilo C2-6, cada uno opcionalmente sustituido con 1-5 átomos de halo hasta perhalo y, además opcionalmente sustituidos con 1 grupo seleccionado de OH, oxo y alcoxi C1-6 y R4 representa H o alquilo C1-4 opcionalmente sustituido con 1-3 átomos de halo hasta perhalo y 1 anillo fenilo. 2.- Un compuesto según la reivindicación 1, en el que el anillo A representa fenilo. 3.- Un compuesto según la reivindicación 1, en el que el anillo A representa naftilo. 4.- Un compuesto según la reivindicación 1, en el que cada R1 representa H o se selecciona del grupo consistente en halo seleccionado de fluoro y cloro; SCH3; CN, alquilo C1-6, alquenilo C2-4 y alcoxi C1-6, estando las porciones alquilo y alquenilo de SCH3, alquilo C1-6, alquenilo C2-4 y alcoxi C1-6 opcionalmente sustituidas con 1-3 átomos de fluoro. 5.- Un compuesto según la reivindicación 4, en el que cada R1 representa H o se selecciona del grupo consistente en fluoro, cloro; SCH3, CN, alquilo C1-6, alquenilo C2-4 y alcoxi C1-6, estando las porciones alquilo y alquenilo de SCH3, alquilo C1-6, alquenilo C2-4 y alcoxi C1-6 opcionalmente sustituidas con 1-3 átomos de fluoro.
CO09033167A 2006-10-03 2009-03-31 Compuestos antagonistas del receptor de glucagon composiciones que contienen dichos compuestos y procedimientos de uso CO6190512A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84896706P 2006-10-03 2006-10-03

Publications (1)

Publication Number Publication Date
CO6190512A2 true CO6190512A2 (es) 2010-08-19

Family

ID=38982644

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09033167A CO6190512A2 (es) 2006-10-03 2009-03-31 Compuestos antagonistas del receptor de glucagon composiciones que contienen dichos compuestos y procedimientos de uso

Country Status (30)

Country Link
US (3) US20100004158A1 (es)
EP (1) EP2079688B1 (es)
JP (1) JP2010505828A (es)
KR (1) KR20090076907A (es)
CN (1) CN101535252A (es)
AR (1) AR063022A1 (es)
AU (1) AU2007305430B2 (es)
BR (1) BRPI0717305A2 (es)
CA (1) CA2664004C (es)
CL (1) CL2007002841A1 (es)
CO (1) CO6190512A2 (es)
CR (1) CR10694A (es)
DK (1) DK2079688T3 (es)
EA (1) EA017800B1 (es)
EC (1) ECSP099225A (es)
ES (1) ES2390296T3 (es)
GE (1) GEP20125506B (es)
IL (1) IL197788A0 (es)
MA (1) MA31963B1 (es)
MX (1) MX2009003611A (es)
NO (1) NO342172B1 (es)
PE (1) PE20080676A1 (es)
PL (1) PL2079688T3 (es)
PT (1) PT2079688E (es)
SI (1) SI2079688T1 (es)
TN (1) TN2009000111A1 (es)
TW (1) TW200821284A (es)
UA (1) UA96308C2 (es)
WO (1) WO2008042223A1 (es)
ZA (1) ZA200901694B (es)

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Also Published As

Publication number Publication date
ES2390296T3 (es) 2012-11-08
BRPI0717305A2 (pt) 2014-03-25
CA2664004A1 (en) 2008-04-10
MX2009003611A (es) 2009-04-22
US7687534B2 (en) 2010-03-30
KR20090076907A (ko) 2009-07-13
EP2079688A1 (en) 2009-07-22
TW200821284A (en) 2008-05-16
EA200970342A1 (ru) 2009-10-30
ZA200901694B (en) 2010-01-27
US20100004158A1 (en) 2010-01-07
PT2079688E (pt) 2012-11-22
NO20091734L (no) 2009-06-04
WO2008042223A1 (en) 2008-04-10
EP2079688B1 (en) 2012-07-25
US7968589B2 (en) 2011-06-28
CA2664004C (en) 2013-07-23
IL197788A0 (en) 2009-12-24
UA96308C2 (ru) 2011-10-25
JP2010505828A (ja) 2010-02-25
US20100144824A1 (en) 2010-06-10
AU2007305430A1 (en) 2008-04-10
ECSP099225A (es) 2009-07-31
PL2079688T3 (pl) 2013-01-31
CL2007002841A1 (es) 2008-02-08
AR063022A1 (es) 2008-12-23
AU2007305430B2 (en) 2011-07-21
NO342172B1 (no) 2018-04-09
TN2009000111A1 (en) 2010-08-19
MA31963B1 (fr) 2011-01-03
GEP20125506B (en) 2012-04-25
CR10694A (es) 2009-05-25
DK2079688T3 (da) 2012-11-05
PE20080676A1 (es) 2008-06-12
EA017800B1 (ru) 2013-03-29
CN101535252A (zh) 2009-09-16
SI2079688T1 (sl) 2012-12-31
US20080085926A1 (en) 2008-04-10

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