SI2079688T1 - Spojine glukagon receptorskih antagonistov, sestavki vsebujoči take spojine in njihova farmacevtska raba - Google Patents

Spojine glukagon receptorskih antagonistov, sestavki vsebujoči take spojine in njihova farmacevtska raba

Info

Publication number
SI2079688T1
SI2079688T1 SI200731049T SI200731049T SI2079688T1 SI 2079688 T1 SI2079688 T1 SI 2079688T1 SI 200731049 T SI200731049 T SI 200731049T SI 200731049 T SI200731049 T SI 200731049T SI 2079688 T1 SI2079688 T1 SI 2079688T1
Authority
SI
Slovenia
Prior art keywords
compounds
compositions containing
receptor antagonist
pharmaceutical use
glucagon receptor
Prior art date
Application number
SI200731049T
Other languages
English (en)
Inventor
John E. Stelmach
Emma R. Parmee
James R. Tata
Keith G. Rosauer
Ronald M. Kim
Amy R. Bittner
Jiang Chang
Christopher Joseph Sinz
Original Assignee
Merck Sharp & Dohme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38982644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2079688(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp filed Critical Merck Sharp & Dohme Corp
Publication of SI2079688T1 publication Critical patent/SI2079688T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
SI200731049T 2006-10-03 2007-09-27 Spojine glukagon receptorskih antagonistov, sestavki vsebujoči take spojine in njihova farmacevtska raba SI2079688T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84896706P 2006-10-03 2006-10-03
EP07838940A EP2079688B1 (en) 2006-10-03 2007-09-27 Glucagon receptor antagonist compounds, compositions containing such compounds and their pharmaceutical use
PCT/US2007/020858 WO2008042223A1 (en) 2006-10-03 2007-09-27 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use

Publications (1)

Publication Number Publication Date
SI2079688T1 true SI2079688T1 (sl) 2012-12-31

Family

ID=38982644

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200731049T SI2079688T1 (sl) 2006-10-03 2007-09-27 Spojine glukagon receptorskih antagonistov, sestavki vsebujoči take spojine in njihova farmacevtska raba

Country Status (30)

Country Link
US (3) US20100004158A1 (sl)
EP (1) EP2079688B1 (sl)
JP (1) JP2010505828A (sl)
KR (1) KR20090076907A (sl)
CN (1) CN101535252A (sl)
AR (1) AR063022A1 (sl)
AU (1) AU2007305430B2 (sl)
BR (1) BRPI0717305A2 (sl)
CA (1) CA2664004C (sl)
CL (1) CL2007002841A1 (sl)
CO (1) CO6190512A2 (sl)
CR (1) CR10694A (sl)
DK (1) DK2079688T3 (sl)
EA (1) EA017800B1 (sl)
EC (1) ECSP099225A (sl)
ES (1) ES2390296T3 (sl)
GE (1) GEP20125506B (sl)
IL (1) IL197788A0 (sl)
MA (1) MA31963B1 (sl)
MX (1) MX2009003611A (sl)
NO (1) NO342172B1 (sl)
PE (1) PE20080676A1 (sl)
PL (1) PL2079688T3 (sl)
PT (1) PT2079688E (sl)
SI (1) SI2079688T1 (sl)
TN (1) TN2009000111A1 (sl)
TW (1) TW200821284A (sl)
UA (1) UA96308C2 (sl)
WO (1) WO2008042223A1 (sl)
ZA (1) ZA200901694B (sl)

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AU2008212816B2 (en) 2007-02-09 2014-08-07 Metabasis Therapeutics, Inc. Novel antagonists of the glucagon receptor
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MX2010009736A (es) 2008-03-05 2010-09-30 Takeda Pharmaceutical Compuesto heterociclico.
US8623818B2 (en) 2008-05-16 2014-01-07 Merck Sharp & Dohme Corp. Glucagon receptor antagonists, compositions, and methods for their use
BRPI0918004B8 (pt) 2008-08-13 2021-05-25 Metabasis Therapeutics Inc compostos antagonistas e agonistas inversos de receptores de glucagon, composição farmacêutica e uso dos compostos
US8436015B2 (en) * 2008-09-15 2013-05-07 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US8361959B2 (en) * 2008-10-03 2013-01-29 Merck Sharp & Dohme Corp. Spiro-imidazolone derivatives as glucagon receptor antagonists
US8445538B2 (en) * 2008-12-19 2013-05-21 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds
WO2010080971A1 (en) 2009-01-12 2010-07-15 Merck Sharp & Dohme Corp. Crystalline polymorphic forms of an antidiabetic compound
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US8318667B2 (en) 2009-02-25 2012-11-27 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP2480077B1 (en) 2009-09-22 2015-02-18 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
TW201427658A (zh) 2012-12-10 2014-07-16 Merck Sharp & Dohme 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
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Also Published As

Publication number Publication date
EP2079688B1 (en) 2012-07-25
CL2007002841A1 (es) 2008-02-08
KR20090076907A (ko) 2009-07-13
AU2007305430B2 (en) 2011-07-21
BRPI0717305A2 (pt) 2014-03-25
EP2079688A1 (en) 2009-07-22
EA200970342A1 (ru) 2009-10-30
CR10694A (es) 2009-05-25
JP2010505828A (ja) 2010-02-25
NO20091734L (no) 2009-06-04
PE20080676A1 (es) 2008-06-12
UA96308C2 (ru) 2011-10-25
IL197788A0 (en) 2009-12-24
US20100144824A1 (en) 2010-06-10
CA2664004A1 (en) 2008-04-10
US20100004158A1 (en) 2010-01-07
WO2008042223A1 (en) 2008-04-10
MX2009003611A (es) 2009-04-22
AR063022A1 (es) 2008-12-23
CA2664004C (en) 2013-07-23
GEP20125506B (en) 2012-04-25
CO6190512A2 (es) 2010-08-19
ZA200901694B (en) 2010-01-27
EA017800B1 (ru) 2013-03-29
US7687534B2 (en) 2010-03-30
NO342172B1 (no) 2018-04-09
AU2007305430A1 (en) 2008-04-10
ECSP099225A (es) 2009-07-31
DK2079688T3 (da) 2012-11-05
ES2390296T3 (es) 2012-11-08
CN101535252A (zh) 2009-09-16
US7968589B2 (en) 2011-06-28
PT2079688E (pt) 2012-11-22
TW200821284A (en) 2008-05-16
US20080085926A1 (en) 2008-04-10
MA31963B1 (fr) 2011-01-03
TN2009000111A1 (en) 2010-08-19
PL2079688T3 (pl) 2013-01-31

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