CO6160230A2 - Arilsulfonamidas con efecto analgesico - Google Patents
Arilsulfonamidas con efecto analgesicoInfo
- Publication number
- CO6160230A2 CO6160230A2 CO09016433A CO09016433A CO6160230A2 CO 6160230 A2 CO6160230 A2 CO 6160230A2 CO 09016433 A CO09016433 A CO 09016433A CO 09016433 A CO09016433 A CO 09016433A CO 6160230 A2 CO6160230 A2 CO 6160230A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- twice
- substituted
- substituted once
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Abstract
1.- Compuestos de la fórmula general len la que A significa un enlace o -alquileno C1-4 o -CH2-C(O)-, B significa un enlace, -alquileno C1-3, -O- o -C(O)-, D significa un grupo de las fórmulas generales IIY significa un grupo -alquileno C1-6, eventualmente sustituido con el radical R2, en donde un grupo metileno puede estar reemplazado adicionalmente por Y1 e Y1 representa -O-, -S-, -S(O)-, -N(R2)-, -N(R2)-C(O)-, C(O)N(R2), -C(O)-, -CH(arilo)-, cicloalquileno C3-6 o -S(O)2-, R1 significa cicloalquilo C3-7- o arilo-, heteroarilo- o aril-alquilo C1-3-, que en cada caso pueden estar sustituidos con uno, dos, tres o cuatro radicales R1.1, en donde los radicales R1.1 pueden ser iguales o diferentes, yR1.1 representa H, F, CI, Br, I, alquilo C1-3-, F3C-, HO-, alquil C1-3-O- o alquil C1-3-O-alquilen C2-4-O-,R2 significa H o alquilo C1-3, en donde cada grupo metileno puede estar sustituido con hasta dos y cada grupo metilo puede estar sustituido con hasta tres átomos de fluoro, o también H3C-C(O)-, R3 significa a) -alquileno C1-6, b) un grupo cicloalquileno C3-6, sustituido una vez, dos o tres veces con R3.1, c) un grupo cicloalquenileno C3-6, sustituido una vez o dos veces con R3.1, que está condensado con un anillo de fenilo a través del enlace insaturado, d) -N(R3)-, e) un grupo arileno sustituido una vez o dos veces con R3.1, f) un grupo heteroarileno sustituido una vez o dos veces con R3.1, g) un anillo heterocíclico de 4 a 7 miembros, saturado, sustituido una o dos veces con R3.1, h) un anillo heterociclico de 5 a 7 miembros, insaturado, sustituido una o dos veces con R3.1, que está condensado a través de los enlaces insaturados con uno o dos anillos de fenilo o i) un aza-heterobiciclo de 8 a 10 miembros, saturado, ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006039003A DE102006039003A1 (de) | 2006-08-19 | 2006-08-19 | Neue Verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6160230A2 true CO6160230A2 (es) | 2010-05-20 |
Family
ID=38925625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09016433A CO6160230A2 (es) | 2006-08-19 | 2009-02-19 | Arilsulfonamidas con efecto analgesico |
Country Status (20)
Country | Link |
---|---|
US (2) | US7858618B2 (es) |
EP (3) | EP2402329B1 (es) |
JP (3) | JP5291623B2 (es) |
KR (1) | KR20090047535A (es) |
CN (1) | CN101516867A (es) |
AR (1) | AR062426A1 (es) |
AU (1) | AU2007287652A1 (es) |
BR (1) | BRPI0715645A2 (es) |
CA (1) | CA2663598A1 (es) |
CL (1) | CL2007002407A1 (es) |
CO (1) | CO6160230A2 (es) |
DE (1) | DE102006039003A1 (es) |
EA (1) | EA200900279A1 (es) |
IL (1) | IL197021A0 (es) |
MX (1) | MX2009001791A (es) |
NO (2) | NO20090079L (es) |
SG (3) | SG169339A1 (es) |
TW (1) | TW200815394A (es) |
WO (1) | WO2008022945A1 (es) |
ZA (1) | ZA200810782B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006039003A1 (de) | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
DE102007034620A1 (de) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
EP2025675A1 (de) * | 2007-08-14 | 2009-02-18 | Boehringer Ingelheim International GmbH | Arylsulfonamide mit analgetischer Wirkung |
US20110046106A1 (en) * | 2008-02-06 | 2011-02-24 | Boehringer Ingelheim International Gmbh | Aryl sulfonamides as effective analgesics |
RU2503674C2 (ru) * | 2008-04-08 | 2014-01-10 | Грюненталь Гмбх | Замещенные производные сульфонамида |
JP2011525183A (ja) | 2008-06-20 | 2011-09-15 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なイミダゾピリジンおよびイミダゾピラジン化合物 |
AU2009272486A1 (en) * | 2008-07-18 | 2010-01-21 | Takeda Pharmaceutical Company Limited. | Benzazepine derivatives and their use as hstamine H3 antagonists |
BRPI0914556A2 (pt) * | 2008-08-12 | 2015-08-04 | Boehringer Ingelheim Int | Processo para a preparação de compostos de piperazina substituídos por cicloalquila |
US8207335B2 (en) * | 2009-02-13 | 2012-06-26 | Boehringer Ingelheim International Gmbh | Process for making certain compounds having B1 antagonistic activity |
EP2616073A4 (en) * | 2010-09-13 | 2015-02-18 | Microbiotix Inc | INHIBITORS OF IMMERSION OF VIRUSES IN MAMMALIAN HOST CELLS |
WO2014009319A1 (en) | 2012-07-11 | 2014-01-16 | Boehringer Ingelheim International Gmbh | Indolinone derivatives anticancer compounds |
KR101735705B1 (ko) | 2015-09-22 | 2017-05-15 | 주식회사 에코시안 | 건물 에너지 효율화 평가 방법 및 장치 |
CN105153168A (zh) * | 2015-09-29 | 2015-12-16 | 上海天慈国际药业有限公司 | N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法 |
KR101645157B1 (ko) | 2015-11-10 | 2016-08-02 | 주식회사 넥스미디어 | 통합 음식 제공 서비스 방법 및 장치 |
WO2019058393A1 (en) | 2017-09-22 | 2019-03-28 | Jubilant Biosys Limited | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PAD |
SG11202003463XA (en) | 2017-10-18 | 2020-05-28 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
CN111386265A (zh) | 2017-11-06 | 2020-07-07 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物 |
MX2020005363A (es) | 2017-11-24 | 2020-10-01 | Jubilant Episcribe Llc | Compuestos heterociclicos como inhibidores de prmt5. |
EP3765453A1 (en) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1100635B (de) | 1958-04-22 | 1961-03-02 | Rhone Poulenc Sa | Verfahren zur Herstellung von Phenthiazinderivaten |
DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
EP1249233B9 (en) | 1999-11-26 | 2009-08-05 | Shionogi & Co., Ltd. | Npyy5 antagonists |
FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
FR2840897B1 (fr) * | 2002-06-14 | 2004-09-10 | Fournier Lab Sa | Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique |
EP1572678A4 (en) | 2002-12-19 | 2008-05-07 | Elan Pharm Inc | SUBSTITUTED N-PHENYL SULPHONAMIDES ALSBRADYKININ ANTAGONISTS |
BRPI0408689B8 (pt) * | 2003-03-25 | 2021-05-25 | Laboratoires Fournier S A | derivados de benzenosulfonamida, método para preparação e utilização disso para o tratamento da dor |
CA2553676A1 (en) * | 2004-01-28 | 2005-08-11 | Research Development Foundation | Human soluble neuropilin-1 primary polyadenylation signal and uses thereof |
US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
EP1799637A1 (en) * | 2004-09-23 | 2007-06-27 | Amgen, Inc | Substituted sulfonamidopropionamides and methods of use |
US20080090863A1 (en) | 2004-09-30 | 2008-04-17 | Taisho Pharmaceutical Co., Ltd. | Pyridine Derivatives and Their Use as Medicaments for Treating Diseases Related to Mch Receptor |
DE102005013967A1 (de) * | 2004-11-05 | 2006-10-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
WO2006071775A2 (en) | 2004-12-29 | 2006-07-06 | Elan Pharmaceuticals, Inc. | Novel compounds useful for bradykinin b1 receptor antagonism |
DE102006039003A1 (de) | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
CA2687931C (en) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
DE102007034620A1 (de) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
US8394805B2 (en) | 2007-08-14 | 2013-03-12 | Boehringer Ingelheim International Gmbh | Compounds |
EP2212281B1 (de) * | 2007-08-14 | 2011-03-23 | Boehringer Ingelheim International GmbH | Arylsulfonamide mit analgetischer wirkung |
DE102007046887A1 (de) * | 2007-09-28 | 2009-04-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von (1R,5S)-Anhydroecgoninestersalzen |
-
2006
- 2006-08-19 DE DE102006039003A patent/DE102006039003A1/de not_active Withdrawn
-
2007
- 2007-08-14 EA EA200900279A patent/EA200900279A1/ru unknown
- 2007-08-14 JP JP2009525021A patent/JP5291623B2/ja active Active
- 2007-08-14 EP EP11176839.6A patent/EP2402329B1/de active Active
- 2007-08-14 EP EP10178252.2A patent/EP2284166B1/de active Active
- 2007-08-14 AU AU2007287652A patent/AU2007287652A1/en not_active Abandoned
- 2007-08-14 KR KR1020097005665A patent/KR20090047535A/ko not_active Application Discontinuation
- 2007-08-14 CA CA002663598A patent/CA2663598A1/en not_active Abandoned
- 2007-08-14 CN CNA2007800345486A patent/CN101516867A/zh active Pending
- 2007-08-14 SG SG201100468-6A patent/SG169339A1/en unknown
- 2007-08-14 BR BRPI0715645-6A patent/BRPI0715645A2/pt not_active IP Right Cessation
- 2007-08-14 WO PCT/EP2007/058408 patent/WO2008022945A1/de active Application Filing
- 2007-08-14 SG SG201100467-8A patent/SG169338A1/en unknown
- 2007-08-14 EP EP07788420.3A patent/EP2061779B1/de active Active
- 2007-08-14 SG SG201100466-0A patent/SG169337A1/en unknown
- 2007-08-14 MX MX2009001791A patent/MX2009001791A/es not_active Application Discontinuation
- 2007-08-17 CL CL2007002407A patent/CL2007002407A1/es unknown
- 2007-08-17 TW TW096130620A patent/TW200815394A/zh unknown
- 2007-08-17 AR ARP070103674A patent/AR062426A1/es not_active Application Discontinuation
- 2007-08-17 US US11/840,395 patent/US7858618B2/en active Active
-
2008
- 2008-12-22 ZA ZA200810782A patent/ZA200810782B/xx unknown
-
2009
- 2009-01-07 NO NO20090079A patent/NO20090079L/no unknown
- 2009-02-12 IL IL197021A patent/IL197021A0/en unknown
- 2009-02-19 CO CO09016433A patent/CO6160230A2/es unknown
- 2009-03-09 NO NO20091025A patent/NO20091025L/no not_active Application Discontinuation
-
2010
- 2010-10-05 US US12/898,295 patent/US8252785B2/en active Active
-
2012
- 2012-04-10 JP JP2012089586A patent/JP5529202B2/ja active Active
-
2013
- 2013-04-03 JP JP2013078105A patent/JP5650781B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6160230A2 (es) | Arilsulfonamidas con efecto analgesico | |
AR125414A2 (es) | INHIBIDORES DE INTEGRINA avb6 | |
PE20091381A1 (es) | Inhibidores del virus de la hepatitis c | |
AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
CL2017000992A1 (es) | Compuestos de indol carboxamida utiles como inhibidores de cinasa | |
PE20181298A1 (es) | Inhibidores de bromodominio bivalentes y usos de los mismos | |
AR101692A1 (es) | Compuestos y métodos para inhibir histonas demetilasas | |
EA200801160A1 (ru) | Алкоксиалкилзамещённые спироциклические тетрамовые и тетроновые кислоты | |
EA201792046A1 (ru) | Модуляторы рецептора андрогенов и их применение | |
AR063015A1 (es) | Derivados de quinazolinona 5-sustituida y composiciones que los comprenden y metodos para utilizarlos en el tratamiento del cancer | |
ECSP099091A (es) | Profarmaco de compuesto de cinamida | |
AR053554A1 (es) | Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos | |
EA201100037A1 (ru) | Органические соединения | |
PE20151781A1 (es) | Piridonamidas como moduladores de canales de sodio | |
AR055620A1 (es) | Derivados de cicloalcano-carboxamidas | |
AR065322A1 (es) | 2-aminooxazolinas comoligandos de taar1 | |
CR10420A (es) | Derivados biciclicos como inhibibidores de cetp | |
AR052943A1 (es) | Derivados de 2-(4-oxo-4h-quinazolin-3-il)acetamida | |
ES2436020T3 (es) | Derivados de sulfonamida sustituidos | |
AR071120A1 (es) | Derivados de diosmetina, su procedimiento de preparacion, las composiciones farmaceuticas que los contienen y su uso en el tratamiento de las enfermedades venosas cronicas. | |
EA201000884A1 (ru) | Производные 1,2-дизамещенного 4-бензиламинопирролидина в качестве ингибиторов белка-переносчика холестерилового эфира, используемые для лечения заболеваний, таких как гиперлипидемия или артериосклероз | |
CY1110190T1 (el) | Παραγωγα πιπεραζινυλιου χρησιμα στην αγωγη των νοσων στις οποιες μεσολαβει ο υποδοχεας gpr38 | |
AR078549A1 (es) | Antagonistas de la via de wnt y composiciones farmaceuticas que los contienen | |
BR112015031432A2 (pt) | compostos de carbazol carboxamida úteis como inibidores de cinase | |
AR042067A1 (es) | Derivados de anilinopirazol utiles en el tratamiento de la diabetes |