CO6160230A2 - Arilsulfonamidas con efecto analgesico - Google Patents
Arilsulfonamidas con efecto analgesicoInfo
- Publication number
- CO6160230A2 CO6160230A2 CO09016433A CO09016433A CO6160230A2 CO 6160230 A2 CO6160230 A2 CO 6160230A2 CO 09016433 A CO09016433 A CO 09016433A CO 09016433 A CO09016433 A CO 09016433A CO 6160230 A2 CO6160230 A2 CO 6160230A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- twice
- substituted
- substituted once
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
1.- Compuestos de la fórmula general len la que A significa un enlace o -alquileno C1-4 o -CH2-C(O)-, B significa un enlace, -alquileno C1-3, -O- o -C(O)-, D significa un grupo de las fórmulas generales IIY significa un grupo -alquileno C1-6, eventualmente sustituido con el radical R2, en donde un grupo metileno puede estar reemplazado adicionalmente por Y1 e Y1 representa -O-, -S-, -S(O)-, -N(R2)-, -N(R2)-C(O)-, C(O)N(R2), -C(O)-, -CH(arilo)-, cicloalquileno C3-6 o -S(O)2-, R1 significa cicloalquilo C3-7- o arilo-, heteroarilo- o aril-alquilo C1-3-, que en cada caso pueden estar sustituidos con uno, dos, tres o cuatro radicales R1.1, en donde los radicales R1.1 pueden ser iguales o diferentes, yR1.1 representa H, F, CI, Br, I, alquilo C1-3-, F3C-, HO-, alquil C1-3-O- o alquil C1-3-O-alquilen C2-4-O-,R2 significa H o alquilo C1-3, en donde cada grupo metileno puede estar sustituido con hasta dos y cada grupo metilo puede estar sustituido con hasta tres átomos de fluoro, o también H3C-C(O)-, R3 significa a) -alquileno C1-6, b) un grupo cicloalquileno C3-6, sustituido una vez, dos o tres veces con R3.1, c) un grupo cicloalquenileno C3-6, sustituido una vez o dos veces con R3.1, que está condensado con un anillo de fenilo a través del enlace insaturado, d) -N(R3)-, e) un grupo arileno sustituido una vez o dos veces con R3.1, f) un grupo heteroarileno sustituido una vez o dos veces con R3.1, g) un anillo heterocíclico de 4 a 7 miembros, saturado, sustituido una o dos veces con R3.1, h) un anillo heterociclico de 5 a 7 miembros, insaturado, sustituido una o dos veces con R3.1, que está condensado a través de los enlaces insaturados con uno o dos anillos de fenilo o i) un aza-heterobiciclo de 8 a 10 miembros, saturado, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006039003A DE102006039003A1 (de) | 2006-08-19 | 2006-08-19 | Neue Verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6160230A2 true CO6160230A2 (es) | 2010-05-20 |
Family
ID=38925625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09016433A CO6160230A2 (es) | 2006-08-19 | 2009-02-19 | Arilsulfonamidas con efecto analgesico |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7858618B2 (es) |
| EP (3) | EP2284166B1 (es) |
| JP (3) | JP5291623B2 (es) |
| KR (1) | KR20090047535A (es) |
| CN (1) | CN101516867A (es) |
| AR (1) | AR062426A1 (es) |
| AU (1) | AU2007287652A1 (es) |
| BR (1) | BRPI0715645A2 (es) |
| CA (1) | CA2663598A1 (es) |
| CL (1) | CL2007002407A1 (es) |
| CO (1) | CO6160230A2 (es) |
| DE (1) | DE102006039003A1 (es) |
| EA (1) | EA200900279A1 (es) |
| IL (1) | IL197021A0 (es) |
| MX (1) | MX2009001791A (es) |
| NO (2) | NO20090079L (es) |
| SG (3) | SG169339A1 (es) |
| TW (1) | TW200815394A (es) |
| WO (1) | WO2008022945A1 (es) |
| ZA (1) | ZA200810782B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006039003A1 (de) | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
| DE102007034620A1 (de) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
| EP2025675A1 (de) * | 2007-08-14 | 2009-02-18 | Boehringer Ingelheim International GmbH | Arylsulfonamide mit analgetischer Wirkung |
| CA2712582A1 (en) * | 2008-02-06 | 2009-08-13 | Norbert Hauel | Aryl sulfonamides as effective analgesics |
| PE20091782A1 (es) * | 2008-04-08 | 2009-11-15 | Gruenenthal Chemie | Derivados de sulfonamida sustituida |
| EP2300466B1 (en) | 2008-06-20 | 2014-08-06 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
| CN102099339A (zh) * | 2008-07-18 | 2011-06-15 | 武田药品工业株式会社 | 苯并氮杂衍生物及其作为组胺h3拮抗剂的用途 |
| BRPI0914556A2 (pt) * | 2008-08-12 | 2015-08-04 | Boehringer Ingelheim Int | Processo para a preparação de compostos de piperazina substituídos por cicloalquila |
| US8207335B2 (en) * | 2009-02-13 | 2012-06-26 | Boehringer Ingelheim International Gmbh | Process for making certain compounds having B1 antagonistic activity |
| CA2810702A1 (en) * | 2010-09-13 | 2012-03-22 | Microbiotix, Inc. | Inhibitors of viral entry into mammalian cells |
| WO2014009319A1 (en) | 2012-07-11 | 2014-01-16 | Boehringer Ingelheim International Gmbh | Indolinone derivatives anticancer compounds |
| KR101735705B1 (ko) | 2015-09-22 | 2017-05-15 | 주식회사 에코시안 | 건물 에너지 효율화 평가 방법 및 장치 |
| CN105153168A (zh) * | 2015-09-29 | 2015-12-16 | 上海天慈国际药业有限公司 | N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法 |
| KR101645157B1 (ko) | 2015-11-10 | 2016-08-02 | 주식회사 넥스미디어 | 통합 음식 제공 서비스 방법 및 장치 |
| NZ762985A (en) | 2017-09-22 | 2024-03-22 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| HUE061607T2 (hu) | 2017-10-18 | 2023-07-28 | Jubilant Epipad LLC | Imidazopiridin vegyületek mint PAD inhibitorok |
| CN111386265A (zh) | 2017-11-06 | 2020-07-07 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物 |
| EP3704120B1 (en) | 2017-11-24 | 2024-03-06 | Jubilant Episcribe LLC | Heterocyclic compounds as prmt5 inhibitors |
| BR112020018610A2 (pt) | 2018-03-13 | 2020-12-29 | Jubilant Prodel LLC | Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1100635B (de) | 1958-04-22 | 1961-03-02 | Rhone Poulenc Sa | Verfahren zur Herstellung von Phenthiazinderivaten |
| EP0173552B1 (en) | 1984-08-24 | 1991-10-09 | The Upjohn Company | Recombinant dna compounds and the expression of polypeptides such as tpa |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| MXPA02004985A (es) | 1999-11-26 | 2003-10-14 | Shionogi & Co | Antagonistas del neuropeptido y, y5. |
| FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
| FR2840897B1 (fr) * | 2002-06-14 | 2004-09-10 | Fournier Lab Sa | Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique |
| CA2509881A1 (en) | 2002-12-19 | 2004-07-08 | Elan Pharmaceuticals, Inc. | Substituted n-phenyl sulfonamide bradykinin antagonists |
| JP4593559B2 (ja) * | 2003-03-25 | 2010-12-08 | ラボラトワール フルニエ エス・アー | ベンゼンスルホンアミド誘導体、その製造方法、及び、痛みを治療するためのその使用 |
| US7557197B2 (en) * | 2004-01-28 | 2009-07-07 | Oregon Health & Science University | Human soluble neuropilin-1 primary polyadenylation signal and uses thereof |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| WO2006036664A1 (en) | 2004-09-23 | 2006-04-06 | Amgen Inc. | Substituted sulfonamidopropionamides and methods of use |
| JP2008514546A (ja) | 2004-09-30 | 2008-05-08 | 大正製薬株式会社 | ピリジン誘導体及びその使用に関連する治療法 |
| DE102005013967A1 (de) | 2004-11-05 | 2006-10-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US20060217362A1 (en) | 2004-12-29 | 2006-09-28 | Tung Jay S | Novel compounds useful for bradykinin B1 receptor antagonism |
| DE102006039003A1 (de) | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
| CA2687931C (en) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| DE102007034620A1 (de) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
| EP2212281B1 (de) * | 2007-08-14 | 2011-03-23 | Boehringer Ingelheim International GmbH | Arylsulfonamide mit analgetischer wirkung |
| MX2010001664A (es) | 2007-08-14 | 2010-03-10 | Boehringer Ingelheim Int | Nuevos compuestos. |
| DE102007046887A1 (de) * | 2007-09-28 | 2009-04-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von (1R,5S)-Anhydroecgoninestersalzen |
-
2006
- 2006-08-19 DE DE102006039003A patent/DE102006039003A1/de not_active Withdrawn
-
2007
- 2007-08-14 SG SG201100468-6A patent/SG169339A1/en unknown
- 2007-08-14 MX MX2009001791A patent/MX2009001791A/es not_active Application Discontinuation
- 2007-08-14 AU AU2007287652A patent/AU2007287652A1/en not_active Abandoned
- 2007-08-14 EP EP10178252.2A patent/EP2284166B1/de active Active
- 2007-08-14 WO PCT/EP2007/058408 patent/WO2008022945A1/de active Application Filing
- 2007-08-14 BR BRPI0715645-6A patent/BRPI0715645A2/pt not_active IP Right Cessation
- 2007-08-14 CN CNA2007800345486A patent/CN101516867A/zh active Pending
- 2007-08-14 KR KR1020097005665A patent/KR20090047535A/ko not_active Application Discontinuation
- 2007-08-14 JP JP2009525021A patent/JP5291623B2/ja active Active
- 2007-08-14 CA CA002663598A patent/CA2663598A1/en not_active Abandoned
- 2007-08-14 EP EP07788420.3A patent/EP2061779B1/de active Active
- 2007-08-14 SG SG201100466-0A patent/SG169337A1/en unknown
- 2007-08-14 EP EP11176839.6A patent/EP2402329B1/de active Active
- 2007-08-14 EA EA200900279A patent/EA200900279A1/ru unknown
- 2007-08-14 SG SG201100467-8A patent/SG169338A1/en unknown
- 2007-08-17 US US11/840,395 patent/US7858618B2/en active Active
- 2007-08-17 AR ARP070103674A patent/AR062426A1/es not_active Application Discontinuation
- 2007-08-17 TW TW096130620A patent/TW200815394A/zh unknown
- 2007-08-17 CL CL2007002407A patent/CL2007002407A1/es unknown
-
2008
- 2008-12-22 ZA ZA200810782A patent/ZA200810782B/xx unknown
-
2009
- 2009-01-07 NO NO20090079A patent/NO20090079L/no unknown
- 2009-02-12 IL IL197021A patent/IL197021A0/en unknown
- 2009-02-19 CO CO09016433A patent/CO6160230A2/es unknown
- 2009-03-09 NO NO20091025A patent/NO20091025L/no not_active Application Discontinuation
-
2010
- 2010-10-05 US US12/898,295 patent/US8252785B2/en active Active
-
2012
- 2012-04-10 JP JP2012089586A patent/JP5529202B2/ja active Active
-
2013
- 2013-04-03 JP JP2013078105A patent/JP5650781B2/ja active Active
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