CO5721010A2 - Compuestos derivados de la deshidrofenilahistina, su metodo sintetico de preparacion y sus composiciones farmaceuticas - Google Patents

Compuestos derivados de la deshidrofenilahistina, su metodo sintetico de preparacion y sus composiciones farmaceuticas

Info

Publication number
CO5721010A2
CO5721010A2 CO05018564A CO05018564A CO5721010A2 CO 5721010 A2 CO5721010 A2 CO 5721010A2 CO 05018564 A CO05018564 A CO 05018564A CO 05018564 A CO05018564 A CO 05018564A CO 5721010 A2 CO5721010 A2 CO 5721010A2
Authority
CO
Colombia
Prior art keywords
sub
dehydrophenylhysine
preparation
aldehyde
pharmaceutical compositions
Prior art date
Application number
CO05018564A
Other languages
English (en)
Inventor
Yoshio Hayashi
Jennifer Grodberg
Michael Palladino
Original Assignee
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc filed Critical Nereus Pharmaceuticals Inc
Publication of CO5721010A2 publication Critical patent/CO5721010A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

1.- Un compuesto de formula en dondeR es un atomo de hidrogeno o un grupo metilo;R1 es un atomo de hidrogeno, un grupo N,N-dialquil(C1-C3)amino, un grupo N,N-dialquil(C1-C3)amino-N-oxido, un grupo N-alquil(C1-C3)-N-bencilamino, un grupo N-acil(C1-C4)-N-alquil(C1-C3)amino, un grupo N-[N,N-dimetilaminoalquil(C1-C4)amino]acetil-N-alquil(C1-C3)amino o una cadena de formulaEn dondeA es un atomo de hidrogeno, un fenilo o un anillo heteroarilo de cinco- o seis- miembros que tiene de uno a tres hetero atomos seleccionados de nitrogeno, oxigeno y azufre;X es O, S, SO, SO2 y NR6, y R6 es un atomo del hidrogeno, un alquilo C1-C3 lineal o ramificado, un grupo C1-C3 alcoxicarbonilo o un grupo benciloxicarbonilo;Y es un grupo C6H4, un anillo heteroarilo de cinco- o seis-miembros que tiene de uno a tres hetero atomos seleccionados de nitrogeno, oxigeno.y azufre o es O, S, SO, SO2 o NR6 donde R6 tiene el significado dado antes;r es un n·mero entero de 1 a 3;m es un n·mero entero de 1 a 6; n es un n·mero entero de 0 a 2;o R1 forma un enlace junto con R2;R2 es un atomo de hidrogeno o forma un enlace junto con R1;R3 es un grupo hidroxilo o forma un grupo=N-O-R5 junto con R4 y R5 es un atomo del hidrogeno, un alquilo C1-C5 lineal o ramificado, ...
CO05018564A 2002-08-02 2005-02-28 Compuestos derivados de la deshidrofenilahistina, su metodo sintetico de preparacion y sus composiciones farmaceuticas CO5721010A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40107402P 2002-08-02 2002-08-02
US41112802P 2002-09-16 2002-09-16
US45006303P 2003-02-24 2003-02-24

Publications (1)

Publication Number Publication Date
CO5721010A2 true CO5721010A2 (es) 2007-01-31

Family

ID=32600863

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05018564A CO5721010A2 (es) 2002-08-02 2005-02-28 Compuestos derivados de la deshidrofenilahistina, su metodo sintetico de preparacion y sus composiciones farmaceuticas

Country Status (20)

Country Link
US (4) US7064201B2 (es)
EP (1) EP1529044B1 (es)
JP (1) JP4616649B2 (es)
KR (2) KR101049100B1 (es)
CN (1) CN100540548C (es)
AT (1) ATE374767T1 (es)
AU (1) AU2003302721B2 (es)
BR (2) BRPI0313363A8 (es)
CA (1) CA2494049C (es)
CO (1) CO5721010A2 (es)
DE (1) DE60316688T2 (es)
DK (1) DK1529044T5 (es)
ES (1) ES2295695T3 (es)
HK (2) HK1078080A1 (es)
IL (2) IL166628A0 (es)
MX (1) MXPA05001217A (es)
NZ (1) NZ538433A (es)
PT (1) PT1529044E (es)
WO (1) WO2004054498A2 (es)
ZA (1) ZA200501616B (es)

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ES2295695T3 (es) 2008-04-16
ATE374767T1 (de) 2007-10-15
US7956058B2 (en) 2011-06-07
WO2004054498A2 (en) 2004-07-01
US20060223822A1 (en) 2006-10-05
AU2003302721A1 (en) 2004-07-09
DE60316688D1 (de) 2007-11-15
ZA200501616B (en) 2005-11-30
US20060217553A1 (en) 2006-09-28
JP4616649B2 (ja) 2011-01-19
NZ538433A (en) 2008-02-29
AU2003302721B2 (en) 2009-10-08
EP1529044A2 (en) 2005-05-11
PT1529044E (pt) 2008-01-14
CA2494049A1 (en) 2004-07-01
BRPI0313363A8 (pt) 2019-01-02
KR20050083610A (ko) 2005-08-26
KR20110039500A (ko) 2011-04-18
IL166628A0 (en) 2006-01-15
CN1684955A (zh) 2005-10-19
DK1529044T3 (da) 2008-02-04
US7064201B2 (en) 2006-06-20
US20050090667A1 (en) 2005-04-28
EP1529044B1 (en) 2007-10-03
MXPA05001217A (es) 2005-05-16
BR0313363A (pt) 2005-08-09
HK1078080A1 (en) 2006-03-03
DE60316688T2 (de) 2008-07-17
DK1529044T5 (da) 2008-04-21
US7674903B2 (en) 2010-03-09
IL166628A (en) 2012-08-30
HK1084388A1 (en) 2006-07-28
CA2494049C (en) 2011-10-18
JP2006511534A (ja) 2006-04-06
KR101049100B1 (ko) 2011-07-15
WO2004054498A3 (en) 2004-11-25
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CN100540548C (zh) 2009-09-16
US20060223823A1 (en) 2006-10-05

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