CO5640107A2 - Derivados de 7-([1,4]dioxan-2-il)-benzotiazol como ligandos del receptor de adenosina - Google Patents

Derivados de 7-([1,4]dioxan-2-il)-benzotiazol como ligandos del receptor de adenosina

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Publication number
CO5640107A2
CO5640107A2 CO05103899A CO05103899A CO5640107A2 CO 5640107 A2 CO5640107 A2 CO 5640107A2 CO 05103899 A CO05103899 A CO 05103899A CO 05103899 A CO05103899 A CO 05103899A CO 5640107 A2 CO5640107 A2 CO 5640107A2
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CO
Colombia
Prior art keywords
lower alkyl
dioxan
unsubstituted
substituted
hydroxy
Prior art date
Application number
CO05103899A
Other languages
English (en)
Inventor
Alexander Flohr
Roger David Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5640107A2 publication Critical patent/CO5640107A2/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1.- Compuestos de la fórmula general en la que R1 es (RS)-[1,4]dioxan-2-ilo o (R)-[1,4]dioxan-2-ilo o (S)[1,4]dioxan-2-ilo;R2 es a) - (CH2)n-piridin-2, 3 ó 4-ilo sin sustituir o sustituido por - alquilo inferior, - (CH2)m-O-alquilo inferior, - (CH2)mNRAND#39R", - (CH2)mmorfolinilo, - (CH2)m-pirrolidin-1-ilo, - (CH2)m-piperidin-1-ilo sin sustituir o sustituido por hidroxi, - (CH2)m-O-(CH2) o-CF3, - (CH2)n-O-(CH2)m-cicloalquilo, - (CH2)m-O-(CH2) o-O--alquilo inferior, - (CH2)m-O-(CH2)o-2-oxo-pirrolidin-1-ilo, - (CH2)m-O-tetrahidropiran-4-ilo, - (CH2)m-O- (CH2) o-morfolinilo, - di- o tetra-hidropiran-4-ilo, o - azetidin-1-ilo sin sustituir o sustituido por halógeno, alcoxi inferior o hidroxi; oes b) - (CH2)n-piperidin-1-ilo, sin sustituir o mono- o di-sustituido por - hidroxi,- hidroxi-alquilo inferior,- alquilo inferior o- (CH2)m-O-alquilo inferior; oes c) -(CH2)n-fenilo sin sustituir o móno- o di-sustituido por- halógeno,- alquilo inferior, - alcoxi inferior o - (CH2)n-NRAND#39R"; o(es d) - benzo[1.3]dioxol-5-ilo; o - (CH2)n-morfolinilo; o - (CH2)n-tetrahidropiran -4 - ilo; o - (CH2)n-O-alquilo inferior; o - (CH2)n-cicloalquilo; o - (CH2) n-C (O) -NRAND#39 RAND#39 AND#39; o- (CH2) n-2-oxo-pirrolidin-1-ilo; o- (CH2)nNRAND#39R"; o- 2-oxa-5-aza-biciclo[2.2.1]heptan-5-ilo; o ...
CO05103899A 2003-04-14 2005-10-11 Derivados de 7-([1,4]dioxan-2-il)-benzotiazol como ligandos del receptor de adenosina CO5640107A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03008038 2003-04-14

Publications (1)

Publication Number Publication Date
CO5640107A2 true CO5640107A2 (es) 2006-05-31

Family

ID=33104055

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05103899A CO5640107A2 (es) 2003-04-14 2005-10-11 Derivados de 7-([1,4]dioxan-2-il)-benzotiazol como ligandos del receptor de adenosina

Country Status (20)

Country Link
US (1) US6872833B2 (es)
EP (1) EP1615919B1 (es)
JP (1) JP4426569B2 (es)
KR (1) KR100700422B1 (es)
CN (1) CN100447140C (es)
AR (1) AR043845A1 (es)
AT (1) ATE370947T1 (es)
AU (1) AU2004228193B2 (es)
BR (1) BRPI0409402A (es)
CA (1) CA2520852C (es)
CL (1) CL2004000761A1 (es)
CO (1) CO5640107A2 (es)
DE (1) DE602004008447T2 (es)
ES (1) ES2291868T3 (es)
MX (1) MXPA05011102A (es)
NO (1) NO20054794L (es)
RU (1) RU2005135154A (es)
TW (1) TW200427685A (es)
WO (1) WO2004089949A1 (es)
ZA (1) ZA200508180B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1796673A2 (en) * 2004-09-23 2007-06-20 Reddy US Therapeutics, Inc. Novel pyrimidine compounds, process for their preparation and compositions containing them
US7756037B2 (en) * 2006-08-14 2010-07-13 Cisco Technology, Inc. Oversubscription of guaranteed bandwidth
DE102011005232A1 (de) 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
US9243001B2 (en) 2013-03-15 2016-01-26 Epizyme, Inc. Substituted benzene compounds
AU2014254392B2 (en) * 2013-03-15 2018-05-24 Epizyme, Inc. Substituted benzene compounds
RS64035B1 (sr) * 2017-08-01 2023-04-28 Merck Patent Gmbh Derivati tiazolopiridina kao antagonisti receptora adenozina

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0112395A (pt) * 2000-06-21 2003-07-08 Hoffmann La Roche Derivados de benzotiazol
AU2002226634B2 (en) * 2001-03-30 2007-01-25 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
US6620811B2 (en) 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6734179B2 (en) 2001-12-12 2004-05-11 Hoffmann-La Roche Inc. Benzothiazoles

Also Published As

Publication number Publication date
EP1615919B1 (en) 2007-08-22
ATE370947T1 (de) 2007-09-15
AR043845A1 (es) 2005-08-17
ES2291868T3 (es) 2008-03-01
RU2005135154A (ru) 2006-06-27
DE602004008447D1 (de) 2007-10-04
AU2004228193B2 (en) 2009-07-23
NO20054794L (no) 2005-10-27
CA2520852C (en) 2011-10-11
JP4426569B2 (ja) 2010-03-03
AU2004228193A1 (en) 2004-10-21
EP1615919A1 (en) 2006-01-18
ZA200508180B (en) 2007-03-28
KR100700422B1 (ko) 2007-03-28
US6872833B2 (en) 2005-03-29
JP2006522765A (ja) 2006-10-05
US20040204584A1 (en) 2004-10-14
KR20050111795A (ko) 2005-11-28
BRPI0409402A (pt) 2006-04-25
WO2004089949A1 (en) 2004-10-21
CL2004000761A1 (es) 2005-02-04
TW200427685A (en) 2004-12-16
DE602004008447T2 (de) 2008-05-21
CA2520852A1 (en) 2004-10-21
CN100447140C (zh) 2008-12-31
MXPA05011102A (es) 2005-12-12
CN1774437A (zh) 2006-05-17

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