CO5611175A2 - 1,2-dihidropirazol-3-onas como mediadores de citosina - Google Patents
1,2-dihidropirazol-3-onas como mediadores de citosinaInfo
- Publication number
- CO5611175A2 CO5611175A2 CO04094890A CO04094890A CO5611175A2 CO 5611175 A2 CO5611175 A2 CO 5611175A2 CO 04094890 A CO04094890 A CO 04094890A CO 04094890 A CO04094890 A CO 04094890A CO 5611175 A2 CO5611175 A2 CO 5611175A2
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- unsubstituted
- branched
- alkyl
- hydrogen
- Prior art date
Links
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title 2
- 229940104302 cytosine Drugs 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Un compuesto que incluye todas las formas enantioméricas y diasterioméricas y las sales farmacéuticamente aceptables de las mismas; el compuesto corresponde a la fórmula: en donde R es: a) -O[CH2]nR4; o b) -NR5aR5b; R4 es alquilo C1-C10 lineal, ramificado o cíclico, sustituido o no sustituido; arilo sustituido o no sustituido; heterocíclico sustituido o no sustituido;o heteroarilo sustituido o no sustituido; el índice n es de 0 a 5; cada R5a y R5b es independientemente: a) hidrógeno; o b) -[C(R6aR6b)]mR7; cada R6a y R6b es independientemente: i) hidrógeno; ii) -OR8;iii) -N(R8)2;iv) -CO2R8;v) -CON (R8)2;vi) alquilo C1-C4 lineal, ramificado o cíclico, sustituido o no sustituido;vii) y mezclas de éstos;R7 esi) hidrógeno;ii) alquilo C1-C6 lineal, ramificado ocíclico, sustituido o no sustituido;iii) heterocíclico sustituido o nosustituido;iv) arilo sustituido o no sustituido;v) heteroarilo sustituido o nosustituido; vi) -OR8 ;vii) -N (R8) 2;-C02R8; y -CON (R8) 2; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36570102P | 2002-03-19 | 2002-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5611175A2 true CO5611175A2 (es) | 2006-02-28 |
Family
ID=28454704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04094890A CO5611175A2 (es) | 2002-03-19 | 2004-09-23 | 1,2-dihidropirazol-3-onas como mediadores de citosina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6677337B2 (es) |
| EP (1) | EP1485167A1 (es) |
| JP (1) | JP2006502093A (es) |
| KR (1) | KR20040093158A (es) |
| CN (1) | CN1642600A (es) |
| AR (1) | AR039001A1 (es) |
| AU (1) | AU2003220216A1 (es) |
| BR (1) | BR0308579A (es) |
| CA (1) | CA2477091A1 (es) |
| CO (1) | CO5611175A2 (es) |
| IL (1) | IL163712A0 (es) |
| MA (1) | MA27784A1 (es) |
| MX (1) | MXPA04009088A (es) |
| MY (1) | MY134226A (es) |
| NO (1) | NO20044413L (es) |
| NZ (1) | NZ534869A (es) |
| PE (1) | PE20040160A1 (es) |
| PL (1) | PL372882A1 (es) |
| RU (1) | RU2004130843A (es) |
| TW (1) | TW200306182A (es) |
| WO (1) | WO2003080184A1 (es) |
| ZA (1) | ZA200407135B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| MXPA05002513A (es) * | 2002-09-09 | 2005-05-27 | Amgen Inc | Derivados de 3-alcoxi-1h-pirazol y 1,2-dihidro-pirazol-3-ona 1, 4, 5-sustituida, agentes que disminuyen la interleucina y el factor de necrosis tumoral alfa (tnf-alfa) para tratamiento de inflamaciones. |
| US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
| JP2008520713A (ja) * | 2004-11-17 | 2008-06-19 | ミイカナ セラピューティクス インコーポレイテッド | キナーゼ阻害剤 |
| CA2618377A1 (en) * | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate hsp90 activity |
| US7563787B2 (en) * | 2005-09-30 | 2009-07-21 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
| JP2010529193A (ja) * | 2007-06-11 | 2010-08-26 | ミイカナ セラピューティクス インコーポレイテッド | 置換ピラゾール化合物 |
| WO2018192793A1 (en) | 2017-04-20 | 2018-10-25 | Basf Se | Substituted rhodanine derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4663327A (en) * | 1984-05-23 | 1987-05-05 | Bayer Aktiengesellschaft | 1-heteroaryl-4-aryl-pyrazolin-5-ones |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| CA2430539C (en) * | 2000-12-05 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| WO2002092573A2 (en) * | 2001-05-16 | 2002-11-21 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
| US6566357B1 (en) * | 2001-09-20 | 2003-05-20 | The Procter & Gamble Co. | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
-
2003
- 2003-03-05 US US10/382,060 patent/US6677337B2/en not_active Expired - Fee Related
- 2003-03-12 NZ NZ534869A patent/NZ534869A/en unknown
- 2003-03-12 AU AU2003220216A patent/AU2003220216A1/en not_active Abandoned
- 2003-03-12 KR KR10-2004-7014642A patent/KR20040093158A/ko active IP Right Grant
- 2003-03-12 BR BR0308579-1A patent/BR0308579A/pt not_active IP Right Cessation
- 2003-03-12 WO PCT/US2003/007635 patent/WO2003080184A1/en active Application Filing
- 2003-03-12 JP JP2003578007A patent/JP2006502093A/ja active Pending
- 2003-03-12 RU RU2004130843/04A patent/RU2004130843A/ru not_active Application Discontinuation
- 2003-03-12 EP EP03716512A patent/EP1485167A1/en not_active Withdrawn
- 2003-03-12 MX MXPA04009088A patent/MXPA04009088A/es unknown
- 2003-03-12 IL IL16371203A patent/IL163712A0/xx unknown
- 2003-03-12 PL PL03372882A patent/PL372882A1/xx not_active Application Discontinuation
- 2003-03-12 CN CNA038062003A patent/CN1642600A/zh active Pending
- 2003-03-12 CA CA002477091A patent/CA2477091A1/en not_active Abandoned
- 2003-03-14 PE PE2003000262A patent/PE20040160A1/es not_active Application Discontinuation
- 2003-03-14 TW TW092105683A patent/TW200306182A/zh unknown
- 2003-03-18 AR ARP030100936A patent/AR039001A1/es not_active Application Discontinuation
- 2003-03-18 MY MYPI20030939A patent/MY134226A/en unknown
-
2004
- 2004-09-07 ZA ZA200407135A patent/ZA200407135B/en unknown
- 2004-09-09 MA MA27850A patent/MA27784A1/fr unknown
- 2004-09-23 CO CO04094890A patent/CO5611175A2/es not_active Application Discontinuation
- 2004-10-18 NO NO20044413A patent/NO20044413L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2477091A1 (en) | 2003-10-02 |
| PE20040160A1 (es) | 2004-04-30 |
| PL372882A1 (en) | 2005-08-08 |
| TW200306182A (en) | 2003-11-16 |
| NZ534869A (en) | 2006-09-29 |
| CN1642600A (zh) | 2005-07-20 |
| ZA200407135B (en) | 2005-09-21 |
| JP2006502093A (ja) | 2006-01-19 |
| NO20044413L (no) | 2004-10-18 |
| MY134226A (en) | 2007-11-30 |
| KR20040093158A (ko) | 2004-11-04 |
| WO2003080184A1 (en) | 2003-10-02 |
| EP1485167A1 (en) | 2004-12-15 |
| MXPA04009088A (es) | 2004-12-06 |
| AU2003220216A1 (en) | 2003-10-08 |
| US20030225082A1 (en) | 2003-12-04 |
| IL163712A0 (en) | 2005-12-18 |
| BR0308579A (pt) | 2005-01-25 |
| AR039001A1 (es) | 2005-02-02 |
| MA27784A1 (fr) | 2006-03-01 |
| RU2004130843A (ru) | 2005-08-27 |
| US6677337B2 (en) | 2004-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |