DE60331586D1 - Festphase fluorierung von uracil - Google Patents
Festphase fluorierung von uracilInfo
- Publication number
- DE60331586D1 DE60331586D1 DE60331586T DE60331586T DE60331586D1 DE 60331586 D1 DE60331586 D1 DE 60331586D1 DE 60331586 T DE60331586 T DE 60331586T DE 60331586 T DE60331586 T DE 60331586T DE 60331586 D1 DE60331586 D1 DE 60331586D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- tracer
- fluoration
- uracil
- solid phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 title 2
- 239000007790 solid phase Substances 0.000 title 1
- 229940035893 uracil Drugs 0.000 title 1
- 239000000700 radioactive tracer Substances 0.000 abstract 4
- 150000001412 amines Chemical class 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- -1 trifluoromethylsulphonate (triflate) anion Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0229683.8A GB0229683D0 (en) | 2002-12-20 | 2002-12-20 | Preparation of radiopharmaceuticals |
| PCT/GB2003/005577 WO2004056400A1 (en) | 2002-12-20 | 2003-12-19 | Solid-phase fluorination of uracil and cytosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60331586D1 true DE60331586D1 (de) | 2010-04-15 |
Family
ID=9950058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60331586T Expired - Lifetime DE60331586D1 (de) | 2002-12-20 | 2003-12-19 | Festphase fluorierung von uracil |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7504208B2 (de) |
| EP (1) | EP1572249B1 (de) |
| JP (1) | JP2006510707A (de) |
| AT (1) | ATE459377T1 (de) |
| AU (1) | AU2003290297A1 (de) |
| DE (1) | DE60331586D1 (de) |
| ES (1) | ES2341102T3 (de) |
| GB (1) | GB0229683D0 (de) |
| WO (1) | WO2004056400A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| GB0407952D0 (en) * | 2004-04-08 | 2004-05-12 | Amersham Plc | Fluoridation method |
| US7485283B2 (en) | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| US7824659B2 (en) * | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
| GB0524851D0 (en) * | 2005-12-06 | 2006-01-11 | Ge Healthcare Ltd | Radiolabelling method using polymers |
| WO2009073273A2 (en) * | 2007-10-03 | 2009-06-11 | Ge Healthcare Limited | Perfluoro-aryliodonium salts in nucleophilic aromatic 18f-fluorination |
| CA2967254C (en) | 2008-02-29 | 2019-03-26 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including imaging cancer |
| US9302990B2 (en) | 2008-10-21 | 2016-04-05 | Nutech Ventures | Fluorination of aromatic ring systems |
| AU2015264872B2 (en) * | 2008-10-21 | 2018-02-22 | Board Of Regents Of The University Of Nebraska | Fluorination of aromatic ring systems |
| EP2537826B1 (de) | 2008-10-21 | 2017-03-08 | Nutech Ventures, Inc. | Fluorierung aromatischer Ringsysteme |
| DK2419096T3 (da) | 2009-04-15 | 2020-02-03 | Lantheus Medical Imaging Inc | Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre |
| US8377704B2 (en) * | 2009-10-20 | 2013-02-19 | Nutech Ventures | Detection and quantification of anions |
| US8546578B2 (en) * | 2010-02-04 | 2013-10-01 | Nutech Ventures | Iodonium Cyclophanes for SECURE arene functionalization |
| CN113058046A (zh) | 2010-02-08 | 2021-07-02 | 兰休斯医疗成像公司 | 用于合成显像剂和其中间体的方法和装置 |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| CN105237483B (zh) * | 2015-11-10 | 2018-04-20 | 东华大学 | 一种对称型嘧啶基碘鎓盐及其制备方法 |
| USD813317S1 (en) | 2017-03-30 | 2018-03-20 | Chrome Cherry Design Studio (Pty) Ltd | Tape forming a toy building block base |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3808097A (en) * | 1972-11-28 | 1974-04-30 | Energy Commission | Production of fluorine-18 labeled 5-fluorouracil |
| US5312592A (en) * | 1990-06-13 | 1994-05-17 | Scanditronix Ab | Disposable kit for preparation |
| BE1010280A3 (fr) * | 1996-05-02 | 1998-05-05 | Coincidence S A | Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose. |
| DE19951715C1 (de) | 1999-10-27 | 2001-03-22 | Rossendorf Forschzent | 18F-Radiotracer und deren Verwendung zum Monitoring der Expression der Cytosin-Deaminase nach Gentransfer sowie Verfahren zur Herstellung der 18F-Radiotracer |
| GB0115927D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
-
2002
- 2002-12-20 GB GBGB0229683.8A patent/GB0229683D0/en not_active Ceased
-
2003
- 2003-12-19 US US10/538,904 patent/US7504208B2/en not_active Expired - Fee Related
- 2003-12-19 AU AU2003290297A patent/AU2003290297A1/en not_active Abandoned
- 2003-12-19 EP EP03782657A patent/EP1572249B1/de not_active Expired - Lifetime
- 2003-12-19 WO PCT/GB2003/005577 patent/WO2004056400A1/en active Application Filing
- 2003-12-19 ES ES03782657T patent/ES2341102T3/es not_active Expired - Lifetime
- 2003-12-19 JP JP2004561655A patent/JP2006510707A/ja not_active Withdrawn
- 2003-12-19 DE DE60331586T patent/DE60331586D1/de not_active Expired - Lifetime
- 2003-12-19 AT AT03782657T patent/ATE459377T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1572249A1 (de) | 2005-09-14 |
| WO2004056400A1 (en) | 2004-07-08 |
| ATE459377T1 (de) | 2010-03-15 |
| AU2003290297A1 (en) | 2004-07-14 |
| GB0229683D0 (en) | 2003-01-29 |
| US20060120958A1 (en) | 2006-06-08 |
| ES2341102T3 (es) | 2010-06-15 |
| US7504208B2 (en) | 2009-03-17 |
| JP2006510707A (ja) | 2006-03-30 |
| EP1572249B1 (de) | 2010-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |